TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.525 | Formula: C20H36N4O3
H donors: 0 H acceptors: 4 LogP: 1.63 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCN(C1CNC2C3C1CCNC3C1C(C2=O)NCCC1)CCOC
InChi: 1S/C20H20N4O3/c1-26-10-8-24(9-11-27-2)15-12-23-19-16-13(15)5-7-22-17(16)14-4-3-6-21-18(14)20(19)25/h3-7,12H,8-11H2,1-2H3
InChiKey: LTTYTBNHKUPCMG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0134	0.2651	0.2651
Brugia malayi	protein-tyrosine kinase	0.0205	0.45	0.5799
Brugia malayi	SH3 domain containing protein	0.0125	0.2418	0.3094
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0535	0.1666
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Brugia malayi	ephrin receptor 1 precursor	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3624	0.4661
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0171	0.3624	0.3624
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0134	0.2651	0.3397
Echinococcus granulosus	intersectin 2	0.0126	0.2456	0.2456
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.0159	0.0157
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Schistosoma mansoni	growth factor receptor-bound protein	0.0259	0.5884	0.5884
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0259	0.5884	0.5884
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0125	0.2418	0.2418
Onchocerca volvulus		0.0171	0.3624	0.7847
Echinococcus granulosus	protein kinase c epsilon type	0.0033	0.0038	0.0038
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.0159	0.0157
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0535	0.0646
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0171	0.3624	1
Schistosoma mansoni	eps8-related protein	0.0125	0.2418	0.2418
Schistosoma mansoni	cell polarity protein	0.0125	0.2418	0.2418
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0226	0.03
Echinococcus multilocularis	SH2 motif	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0333	0.7808	0.7808
Schistosoma mansoni	tensin-related	0.0134	0.2651	0.2651
Schistosoma mansoni	tensin-related	0.0134	0.2651	0.2651
Brugia malayi	hypothetical protein	0.0038	0.0159	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0038	0.0159	0.0157
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0535	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Schistosoma mansoni	apoptosis stimulating of P53	0.0125	0.2418	0.2418
Echinococcus multilocularis	RNA directed DNA polymerase	0.0046	0.037	0.037
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Onchocerca volvulus		0.0134	0.2651	0.5644
Loa Loa (eye worm)	TK/ABL protein kinase	0.0171	0.3624	0.4661
Brugia malayi	Furin-like cysteine rich region family protein	0.0038	0.0159	0.0157
Entamoeba histolytica	unconventional myosin IB	0.0125	0.2418	0.652
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0296	0.6857	0.6857
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0134	0.2651	0.2651
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0134	0.2651	0.2651
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0038	0.0159	0.0157
Schistosoma mansoni	ephrin receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0134	0.2651	0.2651
Echinococcus granulosus	kinase suppressor of Ras 1	0.0038	0.0159	0.0159
Echinococcus multilocularis	protein kinase c epsilon type	0.0033	0.0038	0.0038
Brugia malayi	hypothetical protein	0.0038	0.0159	0.0157
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0038	0.0159	0.0159
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0134	0.2651	0.3397
Brugia malayi	p70 ribosomal S6 kinase beta	0.0048	0.0434	0.0515
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Onchocerca volvulus		0.0125	0.2418	0.5116
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.1222	0.1222
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0125	0.2418	0.2418
Echinococcus granulosus	src region	0.0125	0.2418	0.2418
Onchocerca volvulus		0.0171	0.3624	0.7847
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0046	0.037	0.0431
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0125	0.2418	0.652
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0038	0.0159	0.0159
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0141	0.2833	0.2833
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0259	0.5884	0.7598
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0467	0.0558
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.033	0.7733	0.7733
Brugia malayi	Spectrin alpha chain	0.0125	0.2418	0.3094
Schistosoma mansoni	protein tyrosine kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0038	0.0159	0.0159
Schistosoma mansoni	C-fyn	0.0125	0.2418	0.2418
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase c protein 2	0.0057	0.0657	0.0804
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0141	0.2833	0.2833
Giardia lamblia	Kinase, CMGC MAPK	0.0061	0.077	0.4664
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0125	0.2418	0.2418
Schistosoma mansoni	growth factor receptor-bound protein	0.0259	0.5884	0.5884
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0134	0.2651	0.2651
Echinococcus multilocularis	nostrin	0.0125	0.2418	0.2418
Echinococcus multilocularis	endophilin A3	0.0125	0.2418	0.2418
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3624	0.4661
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0038	0.0159	0.0159
Brugia malayi	Variant SH3 domain containing protein	0.0138	0.2751	0.3526
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0038	0.0159	0.0159
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.077	0.2704
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.2651	0.2651
Loa Loa (eye worm)	protein-tyrosine kinase	0.0125	0.2418	0.3094
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0535	0.0535
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0551	0.0667
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	SRC-1	0.033	0.7733	1
Echinococcus granulosus	SHC transforming protein 3	0.0134	0.2651	0.2651
Entamoeba histolytica	protein kinase, putative	0.0125	0.2418	0.652
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.0159	0.0157
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0134	0.2651	0.2651
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0125	0.2418	0.2418
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0127	0.248	0.248
Loa Loa (eye worm)	SH2 domain-containing protein	0.0134	0.2651	0.3397
Brugia malayi	MAP kinase sur-1	0.0061	0.077	0.0951
Trichomonas vaginalis	STE family protein kinase	0.0088	0.1469	0.5797
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0125	0.2418	1
Schistosoma mansoni	formin binding protein and related proteins	0.0125	0.2418	0.2418
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis		0.0134	0.2651	0.2651
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0205	0.45	0.45
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.111	0.111
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0134	0.2651	0.5644
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Brugia malayi	hypothetical protein	0.0134	0.2651	0.3397
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0038	0.0159	0.0157
Plasmodium falciparum	protein kinase 5	0.0052	0.0535	1
Echinococcus granulosus	SH2 motif	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.033	0.7733	0.7733
Echinococcus multilocularis	integrin linked protein kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	dynamin-associated protein	0.0125	0.2418	0.2418
Echinococcus multilocularis	tyrosine kinase	0.0171	0.3624	0.3624
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0134	0.2651	0.2651
Brugia malayi	protein-tyrosine kinase	0.0125	0.2418	0.3094
Echinococcus multilocularis	activated cdc42 kinase 1	0.0038	0.0159	0.0159
Echinococcus granulosus	cyclin dependent kinase 1	0.0052	0.0535	0.0535
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Echinococcus granulosus	dual specificity mitogen activated protein	0.0088	0.1469	0.1469
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0038	0.0159	0.0157
Onchocerca volvulus		0.0125	0.2418	0.5116
Onchocerca volvulus		0.0125	0.2418	0.5116
Schistosoma mansoni	tyrosine kinase	0.033	0.7733	0.7733
Echinococcus granulosus	Protein kinase C brain isozyme	0.0079	0.1222	0.1222
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0088	0.1469	0.186
Schistosoma mansoni	sorting nexin	0.0125	0.2418	0.2418
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0061	0.077	0.2704
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Echinococcus granulosus	integrin linked protein kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0038	0.0038
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0071	0.1034	0.1034
Trypanosoma brucei	cdc2-related kinase 1	0.0052	0.0535	0.1666
Brugia malayi	SRC-1	0.033	0.7733	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.0159	0.0159
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0125	0.2418	0.3094
Onchocerca volvulus		0.0125	0.2418	0.5116
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0168	0.3527	0.3527
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0535	0.1086
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.3391	0.3391
Echinococcus multilocularis	transfer RNA-Thr	0.0038	0.0159	0.0159
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Loa Loa (eye worm)	TK protein kinase	0.0205	0.45	0.5799
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.2651	0.3397
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0259	0.5884	0.5884
Schistosoma mansoni	hypothetical protein	0.0125	0.2418	0.2418
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.0159	0.0159
Trichomonas vaginalis	STE family protein kinase	0.0088	0.1469	0.5797
Schistosoma mansoni	tyrosine kinase	0.0171	0.3624	0.3624
Schistosoma mansoni	signal transduction protein lnk-related	0.0134	0.2651	0.2651
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0535	0.0535
Echinococcus multilocularis	protein kinase	0.0038	0.0159	0.0159
Entamoeba histolytica	protein kinase, putative	0.0048	0.0434	0.0795
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Echinococcus multilocularis	Spectrin alpha actinin	0.0125	0.2418	0.2418
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0296	0.6857	0.6857
Entamoeba histolytica	hypothetical protein	0.0127	0.248	0.6698
Entamoeba histolytica	cell division protein kinase 2, putative	0.0052	0.0535	0.1086
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0088	0.1469	0.5797
Brugia malayi	Variant SH3 domain containing protein	0.0259	0.5884	0.7598
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.2833	0.3632
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.005	0.0475	0.0568
Plasmodium vivax	protein kinase Crk2	0.0052	0.0535	1
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Echinococcus granulosus	natriuretic peptide receptor 1	0.0038	0.0159	0.0159
Schistosoma mansoni	tensin	0.0134	0.2651	0.2651
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Onchocerca volvulus		0.0208	0.4575	1
Trichomonas vaginalis	STE family protein kinase	0.0088	0.1469	0.5797
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0134	0.2651	0.2651
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Schistosoma mansoni	serine/threonine protein kinase	0.0079	0.1222	0.1222
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.033	0.7733	0.7733
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0125	0.2418	0.2418
Echinococcus multilocularis	SHC transforming protein 3	0.0134	0.2651	0.2651
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0125	0.2418	0.2418
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	insulin receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.0159	0.0159
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0048	0.0434	0.0515
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus granulosus	ephrin type A receptor 4 A	0.0038	0.0159	0.0159
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.004	0.0226	0.111
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis	tyrosine protein kinase shark	0.0417	1	1
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0127	0.248	0.248
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Giardia lamblia	Kinase, STE STE20	0.0088	0.1469	1
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0136	0.2719	0.7388
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3624	0.4661
Schistosoma mansoni	tyrosine protein kinase	0.0038	0.0159	0.0159
Entamoeba histolytica	hypothetical protein, conserved	0.0125	0.2418	0.652
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.077	0.2704
Trypanosoma brucei	protein kinase, putative	0.0061	0.077	0.2704
Trichomonas vaginalis	p67phox protein, putative	0.0125	0.2418	1
Brugia malayi	Src substrate cortactin	0.0125	0.2418	0.3094
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.033	0.7733	0.7733
Echinococcus granulosus	RNA directed DNA polymerase	0.0046	0.037	0.037
Echinococcus granulosus	SH2 domain containing protein 7	0.0134	0.2651	0.2651
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0141	0.2833	0.2833
Loa Loa (eye worm)	TK/ALK protein kinase	0.0038	0.0159	0.0157
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.077	0.077
Echinococcus granulosus	cyclin dependent kinase 5	0.0052	0.0535	0.0535
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Tensin	0.0134	0.2651	0.3397
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.111	0.111
Schistosoma mansoni	hypothetical protein	0.0125	0.2418	0.2418
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.077	0.2704
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Schistosoma mansoni	shc transforming protein	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/INSR protein kinase	0.0038	0.0159	0.0157
Brugia malayi	RhoGAP domain containing protein	0.0141	0.2833	0.3632
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.0159	0.0159
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.077	0.2704
Echinococcus granulosus	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.033	0.7733	0.7733
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Leishmania major	hypothetical protein, conserved	0.0125	0.2418	1
Loa Loa (eye worm)	STAT protein	0.0134	0.2651	0.3397
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0134	0.2651	0.2651
Echinococcus multilocularis	tyrosine protein kinase	0.0038	0.0159	0.0159
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0125	0.2418	0.5116
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.033	0.7733	0.7733
Brugia malayi	Tyrosine-protein kinase abl-1	0.0296	0.6857	0.8862
Echinococcus granulosus	tyrosine protein kinase pr2	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0038	0.0159	0.0159
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0125	0.2418	0.2418
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0088	0.1469	0.186
Loa Loa (eye worm)	TK/RYK protein kinase	0.0038	0.0159	0.0157
Entamoeba histolytica	protein kinase, putative	0.0071	0.1034	0.2526
Echinococcus multilocularis	activin receptor type	0.004	0.0226	0.0226
Brugia malayi	C-terminal src kinase protein 1	0.0038	0.0159	0.0157
Loa Loa (eye worm)	p53BP2	0.0125	0.2418	0.3094
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0038	0.0159	0.0159
Brugia malayi	Peripheral plasma membrane protein CASK	0.0125	0.2418	0.3094
Echinococcus multilocularis	insulin receptor	0.0038	0.0159	0.0159
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.0159	0.0159
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Echinococcus multilocularis	SH2 domain containing protein 7	0.0134	0.2651	0.2651
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0171	0.3624	0.3624
Brugia malayi	SH2 domain containing protein	0.0208	0.4575	0.5897
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0125	0.2418	1
Echinococcus multilocularis	FL cytokine receptor	0.0038	0.0159	0.0159
Echinococcus granulosus	receptor type guanylyl cyclase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus granulosus	expressed protein	0.0125	0.2418	0.2418
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0125	0.2418	0.2418
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0205	0.45	0.45
Schistosoma mansoni	sorbin	0.0125	0.2418	0.2418
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0051	0.0496	0.1491
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.0159	0.0159
Onchocerca volvulus		0.0134	0.2651	0.5644
Schistosoma mansoni	tyrosine kinase	0.0296	0.6857	0.6857
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Schistosoma mansoni	protein kinase	0.0088	0.1469	0.1469
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0038	0.0159	0.0157
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Loa Loa (eye worm)	SH2 domain-containing protein	0.017	0.3602	0.4632
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0061	0.077	0.2704
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0159	0.0159
Onchocerca volvulus		0.0134	0.2651	0.5644
Brugia malayi	Guanylyl cyclase protein 23	0.0038	0.0159	0.0157
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Entamoeba histolytica	protein kinase domain containing protein	0.004	0.0226	0.0196
Schistosoma mansoni	dreadlocks/dock	0.0125	0.2418	0.2418
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Brugia malayi	Tyrosine-protein kinase PR2	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Leishmania major	protein kinase, putative	0.004	0.0226	0.03
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Brugia malayi	Raf kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0125	0.2418	0.2418
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Schistosoma mansoni	nck2/grb4	0.0259	0.5884	0.5884
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0038	0.0159	0.0159
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Loa Loa (eye worm)	serine/threonine protein kinase	0.0038	0.0159	0.0157
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0052	0.0535	0.1666
Echinococcus multilocularis	NCK adaptor protein	0.0259	0.5884	0.5884
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.0159	0.0159
Echinococcus multilocularis	SH2 motif	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0038	0.0159	0.0157
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0125	0.2418	0.2418
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0038	0.0159	0.0159
Echinococcus granulosus	tyrosine protein kinase Blk	0.0205	0.45	0.45
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0134	0.2651	0.5644
Echinococcus granulosus	cyclin dependent kinase	0.0052	0.0535	0.0535
Loa Loa (eye worm)	TK/ACK protein kinase	0.0038	0.0159	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0052	0.0535	0.1666
Schistosoma mansoni	protein kinase	0.004	0.0226	0.0226
Onchocerca volvulus		0.0171	0.3624	0.7847
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/Met protein kinase	0.0038	0.0159	0.0157
Trypanosoma cruzi	hypothetical protein, conserved	0.0125	0.2418	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Echinococcus multilocularis	protein kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3624	0.4661
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Schistosoma mansoni	SH2A	0.0134	0.2651	0.2651
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0061	0.077	0.2704
Echinococcus multilocularis	expressed protein	0.0125	0.2418	0.2418
Schistosoma mansoni	run and tbc1 domain containing	0.0125	0.2418	0.2418
Schistosoma mansoni	tensin	0.0134	0.2651	0.2651
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0088	0.1469	0.5797
Echinococcus granulosus	nostrin	0.0125	0.2418	0.2418
Schistosoma mansoni	tensin	0.0134	0.2651	0.2651
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0038	0.0159	0.0159
Echinococcus granulosus	SH2 motif	0.0134	0.2651	0.2651
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Schistosoma mansoni	ephrin receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	SH2 motif	0.0134	0.2651	0.2651
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2418	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0138	0.2751	0.3526
Loa Loa (eye worm)	TK/FAK protein kinase	0.0038	0.0159	0.0157
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0141	0.2833	0.2833
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0079	0.1222	0.1222
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0535	0.1666
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0125	0.2418	0.2418
Schistosoma mansoni	Dab2-interacting protein-like	0.0125	0.2418	0.2418
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.111	0.111
Loa Loa (eye worm)	hypothetical protein	0.0136	0.2713	0.3477
Echinococcus granulosus	tyrosine protein kinase Src64B	0.033	0.7733	0.7733
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0038	0.0159	0.0159
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0259	0.5884	0.7598
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0535	0.1666
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0535	0.0535
Echinococcus granulosus	raf serine:threonine protein kinase	0.0045	0.034	0.034
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0296	0.6857	0.6857
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0045	0.034	0.034
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Brugia malayi	integrin-linked kinase	0.0038	0.0159	0.0157
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0061	0.077	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Echinococcus multilocularis	cyclin dependent kinase 1	0.0052	0.0535	0.0535
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK protein kinase	0.0071	0.1034	0.1295
Trypanosoma brucei	protein kinase, putative	0.004	0.0226	0.03
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0061	0.077	0.077
Echinococcus multilocularis	tensin	0.0134	0.2651	0.2651
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Loa Loa (eye worm)	guanylate kinase	0.0125	0.2418	0.3094
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.004	0.0226	0.0226
Echinococcus granulosus	tyrosine kinase	0.0205	0.45	0.45
Echinococcus granulosus	tyrosine protein kinase HCK	0.0071	0.1034	0.1034
Echinococcus multilocularis	c src tyrosine kinase	0.0333	0.7808	0.7808
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0061	0.077	0.2704
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0226	0.03
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.2651	0.2651
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.0159	0.0159
Onchocerca volvulus		0.0134	0.2651	0.5644
Schistosoma mansoni	tyrosine kinase	0.0417	1	1
Brugia malayi	Protein kinase domain containing protein	0.0051	0.0496	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3624	0.4661
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0259	0.5884	0.7598
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0038	0.0159	0.0159
Entamoeba histolytica	protein kinase, putative	0.0051	0.0496	0.0972
Loa Loa (eye worm)	thyroid receptor interactor	0.0125	0.2418	0.3094
Schistosoma mansoni	suppressor of cytokine signaling	0.0134	0.2651	0.2651
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.077	0.2704
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.033	0.7733	0.7733
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.0159	0.0157
Onchocerca volvulus		0.0171	0.3624	0.7847
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0332	0.7801	0.7801
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0496	0.1491
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Schistosoma mansoni	tyrosine kinase	0.0284	0.6534	0.6534
Brugia malayi	hypothetical protein	0.0171	0.3624	0.4661
Echinococcus multilocularis	mitogen activated protein kinase	0.0061	0.077	0.077
Brugia malayi	SH2 domain containing protein	0.0171	0.3624	0.4661
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0296	0.6857	0.6857
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.0159	0.0157
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0159	0.0157
Trypanosoma cruzi	cdc2-related kinase 1	0.0052	0.0535	0.1666
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0127	0.248	0.248
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.033	0.7733	0.7733
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0535	0.1666
Echinococcus granulosus	mitogen activated protein kinase	0.0061	0.077	0.077
Entamoeba histolytica	SH2 domain containing protein	0.0134	0.2651	0.7192
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	tyrosine protein kinase Srms	0.0171	0.3624	0.3624
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus multilocularis	heat shock protein 70	0.0038	0.0159	0.0159
Onchocerca volvulus	Putative cortactin	0.0125	0.2418	0.5116
Echinococcus granulosus	c src tyrosine kinase	0.0333	0.7808	0.7808
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.111	0.111
Schistosoma mansoni	protein kinase	0.004	0.0226	0.0226
Echinococcus multilocularis	tensin	0.0134	0.2651	0.2651
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2418	0.3094
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0038	0.0159	0.0159
Schistosoma mansoni	protein kinase	0.004	0.0226	0.0226
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.111	0.111
Brugia malayi	Sex muscle abnormal protein 5	0.0259	0.5884	0.7598
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0205	0.45	0.45
Echinococcus granulosus	endophilin A3	0.0125	0.2418	0.2418
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0038	0.0159	0.0159
Schistosoma mansoni	adapter molecule crk	0.0259	0.5884	0.5884
Onchocerca volvulus		0.0134	0.2651	0.5644
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0038	0.0159	0.0157
Entamoeba histolytica	hypothetical protein, conserved	0.0125	0.2418	0.652
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.0159	0.0157
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0134	0.2651	0.2651
Echinococcus granulosus	tensin	0.0134	0.2651	0.2651
Onchocerca volvulus		0.0127	0.2486	0.527
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0141	0.2833	0.3632
Echinococcus multilocularis	tyrosine protein kinase csk	0.0074	0.111	0.111
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0125	0.2418	0.652
Entamoeba histolytica	protein kinase, putative	0.0136	0.2719	0.7388
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus multilocularis	transfer RNA-Ala	0.0125	0.2418	0.2418
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0171	0.3624	0.3624
Schistosoma mansoni	vav2	0.0143	0.2894	0.2894
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0134	0.2651	0.3397
Echinococcus multilocularis	cyclin dependent kinase	0.0052	0.0535	0.0535
Toxoplasma gondii	AGC kinase	0.0048	0.0434	0.4507
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0205	0.45	0.45
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Echinococcus granulosus	tyrosine protein kinase csk	0.0074	0.111	0.111
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.0159	0.0157
Brugia malayi	Myosin tail family protein	0.0125	0.2418	0.3094
Brugia malayi	Guanylate kinase family protein	0.0125	0.2418	0.3094
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0535	0.0646
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0125	0.2418	0.2418
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.0159	0.0159
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0134	0.2651	0.2651
Trypanosoma brucei	conserved protein	0.0125	0.2418	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0038	0.0159	0.0159
Echinococcus multilocularis	intersectin 2	0.0126	0.2456	0.2456
Echinococcus granulosus	growth factor receptor bound protein 2	0.0259	0.5884	0.5884
Entamoeba histolytica	hypothetical protein	0.0125	0.2418	0.652
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.033	0.7733	0.7733
Echinococcus granulosus	protein tyrosine kinase	0.0038	0.0159	0.0159
Plasmodium falciparum	protein kinase, putative	0.004	0.0226	0.1802
Schistosoma mansoni	serine/threonine RGC	0.0038	0.0159	0.0159
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.077	0.2704
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0125	0.2418	0.2418
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0125	0.2418	0.3094
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0046	0.037	0.037
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0088	0.1469	0.1469
Loa Loa (eye worm)	TK/DDR protein kinase	0.0038	0.0159	0.0157
Echinococcus granulosus	signal transduction protein lnk realted	0.0134	0.2651	0.2651
Echinococcus multilocularis	signal transduction protein lnk realted	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	cell division control protein 2 homolog	0.0052	0.0535	0.0646
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0171	0.3624	0.3624
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus granulosus	NCK adaptor protein	0.0259	0.5884	0.5884
Echinococcus multilocularis	cyclin dependent kinase 5	0.0052	0.0535	0.0535
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0038	0.0159	0.0159
Echinococcus granulosus	protein kinase C gamma type	0.0072	0.104	0.104
Echinococcus granulosus	tyrosine protein kinase Fyn	0.033	0.7733	0.7733
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0125	0.2418	0.3094
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.2651	0.3397
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0051	0.0496	0.0595
Trypanosoma cruzi	hypothetical protein, conserved	0.0125	0.2418	1
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Echinococcus granulosus	protein kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.0159	0.0159
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0125	0.2418	0.2418
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Brugia malayi	SH2 domain containing protein	0.0134	0.2651	0.3397
Echinococcus granulosus	hypothetical protein	0.0134	0.2651	0.2651
Loa Loa (eye worm)	TK/CSK protein kinase	0.0074	0.111	0.1393
Echinococcus multilocularis	protein tyrosine kinase	0.0038	0.0159	0.0159
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.004	0.0226	0.0226
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3624	0.4661
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0168	0.3527	0.3527
Echinococcus granulosus	tyrosine protein kinase Src42A	0.033	0.7733	0.7733
Echinococcus multilocularis	N chimaerin	0.0141	0.2833	0.2833
Echinococcus granulosus	tyrosine kinase	0.0171	0.3624	0.3624
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0038	0.0159	0.0159
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0052	0.0535	0.6162
Onchocerca volvulus		0.0134	0.2651	0.5644
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK protein kinase	0.0038	0.0159	0.0157
Brugia malayi	Variant SH3 domain containing protein	0.0259	0.5884	0.7598
Echinococcus granulosus	N chimaerin	0.0141	0.2833	0.2833
Schistosoma mansoni	hypothetical protein	0.0134	0.2651	0.2651
Entamoeba histolytica	protein kinase, putative	0.0051	0.0496	0.0972
Trypanosoma brucei	cdc2-related kinase 3	0.0052	0.0535	0.1666
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0535	0.1666
Giardia lamblia	Kinase, CMGC CDK	0.0052	0.0535	0.2874
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.034	0.034
Trypanosoma cruzi	hypothetical protein, conserved	0.0125	0.2418	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.2651	0.2651
Echinococcus granulosus	mitogen activated protein kinase 3	0.0061	0.077	0.077
Brugia malayi	Variant SH3 domain containing protein	0.0125	0.2418	0.3094
Echinococcus granulosus	activin receptor type	0.004	0.0226	0.0226
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0125	0.2418	0.2418
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0038	0.0159	0.0159
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Echinococcus granulosus	Spectrin alpha actinin	0.0125	0.2418	0.2418
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0134	0.2651	0.3397
Onchocerca volvulus		0.0171	0.3624	0.7847
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	SH2 domain-containing protein	0.0134	0.2651	0.3397
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Echinococcus multilocularis	serine threonine protein kinase	0.0072	0.104	0.104
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0038	0.0159	0.0157
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0061	0.077	0.2704
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.2651	0.2651
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0038	0.0159	0.0159
Echinococcus granulosus	expressed conserved protein	0.0134	0.2651	0.2651
Loa Loa (eye worm)	TK/FER protein kinase	0.0171	0.3624	0.4661
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.004	0.0226	0.03
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0052	0.0535	0.0646
Echinococcus granulosus	tyrosine protein kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	GTPase activating protein	0.0134	0.2651	0.2651
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Receptor family ligand binding region containing protein	0.0038	0.0159	0.0157
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0052	0.0535	0.0535
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0088	0.1469	0.5797
Loa Loa (eye worm)	TK/ROR protein kinase	0.0038	0.0159	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0134	0.2651	0.3397
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0134	0.2651	0.2651
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.0159	0.0157
Schistosoma mansoni	suppressor of cytokine signaling	0.0134	0.2651	0.2651
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0052	0.0535	0.0646
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0061	0.077	0.0951
Trypanosoma cruzi	cdc2-related kinase 3	0.0052	0.0535	0.1666
Schistosoma mansoni	protein kinase	0.0038	0.0159	0.0159
Schistosoma mansoni	tyrosine kinase	0.0038	0.0159	0.0159
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0159	0.0157

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 80 nM	Cytotoxicity against human A427 cells	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3347687

Bibliographic References

No literature references available for this target.

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Detailed information for compound 925034