TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.451 | Formula: C14H10N4S3
H donors: 2 H acceptors: 2 LogP: 3.85 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NNc1nc(nc2c1c(cs2)c1cccs1)c1cccs1
InChi: 1S/C14H10N4S3/c15-18-13-11-8(9-3-1-5-19-9)7-21-14(11)17-12(16-13)10-4-2-6-20-10/h1-7H,15H2,(H,16,17,18)
InChiKey: QJXRWYSSYVNBQB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0299	0.7612	0.7604
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0572	0.1683
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0112	0.2359	0.3034
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0156	0.3587	0.3565
Echinococcus multilocularis	NCK adaptor protein	0.0232	0.5736	0.5721
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0232	0.5736	0.5721
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	insulin receptor	0.0035	0.021	0.0177
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0122	0.2653	0.3423
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0232	0.5736	0.7512
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0035	0.021	0.0177
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0048	0.0572	0.054
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0035	0.021	0.0177
Schistosoma mansoni	GTPase activating protein	0.012	0.2591	0.2566
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0808	0.0777
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	tensin	0.012	0.2591	0.2566
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0112	0.2359	0.2333
Schistosoma mansoni	tyrosine protein kinase	0.0035	0.021	0.0177
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0123	0.2659	0.7414
Schistosoma mansoni	tyrosine kinase	0.0156	0.3587	0.3565
Echinococcus multilocularis	tyrosine protein kinase shark	0.0384	1	1
Echinococcus multilocularis	intersectin 2	0.0113	0.2397	0.2372
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	suppressor of cytokine signaling 7	0.012	0.2591	0.2566
Schistosoma mansoni	hypothetical protein	0.012	0.2591	0.2566
Schistosoma mansoni	protein kinase	0.0038	0.0278	0.0246
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0299	0.7612	0.7604
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.1167	0.1137
Echinococcus multilocularis	signal transduction protein lnk realted	0.012	0.2591	0.2566
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0057	0.0808	0.2781
Echinococcus granulosus	integrin linked protein kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Plasmodium falciparum	protein kinase, putative	0.0038	0.0278	0.1886
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0035	0.021	0.0184
Trichomonas vaginalis	STE family protein kinase	0.0082	0.1511	0.6053
Brugia malayi	RhoGAP domain containing protein	0.0127	0.2773	0.3583
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0572	0.0664
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	tensin	0.012	0.2591	0.2566
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Onchocerca volvulus		0.019	0.4543	1
Trichomonas vaginalis	STE family protein kinase	0.0082	0.1511	0.6053
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.012	0.2591	0.2566
Loa Loa (eye worm)	guanylate kinase	0.0112	0.2359	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	C-fyn	0.0112	0.2359	0.2333
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0384	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	natriuretic peptide receptor 1	0.0035	0.021	0.0177
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0035	0.021	0.0177
Echinococcus multilocularis	protein kinase	0.0035	0.021	0.0177
Schistosoma mansoni	suppressor of cytokine signaling	0.012	0.2591	0.2566
Schistosoma mansoni	hypothetical protein	0.0112	0.2359	0.2333
Echinococcus granulosus	protein kinase C gamma type	0.0066	0.108	0.105
Echinococcus multilocularis	transfer RNA-Ala	0.0112	0.2359	0.2333
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1262	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Brugia malayi	Guanylyl cyclase protein 23	0.0035	0.021	0.0184
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0042	0.0393	0.036
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0057	0.0808	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.012	0.2591	0.2566
Echinococcus granulosus	N chimaerin	0.0127	0.2773	0.2749
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.2359	1
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0268	0.6731	0.672
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.012	0.2591	0.3341
Schistosoma mansoni	tensin-related	0.012	0.2591	0.2566
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0035	0.021	0.0585
Echinococcus granulosus	cyclin dependent kinase	0.0048	0.0572	0.054
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Echinococcus granulosus	SH2 domain containing protein 7	0.012	0.2591	0.2566
Echinococcus granulosus	protein kinase	0.0035	0.021	0.0177
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.2359	1
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0112	0.2359	0.6578
Echinococcus granulosus	activin receptor type	0.0038	0.0278	0.0246
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Echinococcus multilocularis	SH2 domain containing protein 7	0.012	0.2591	0.2566
Echinococcus granulosus	protein tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus granulosus	cyclin dependent kinase 5	0.0048	0.0572	0.054
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0035	0.021	0.0177
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0232	0.5736	0.7512
Entamoeba histolytica	protein kinase, putative	0.0047	0.0532	0.1483
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Trypanosoma brucei	protein kinase, putative	0.0057	0.0808	0.2781
Loa Loa (eye worm)	p53BP2	0.0112	0.2359	0.3034
Schistosoma mansoni	tensin	0.012	0.2591	0.2566
Trypanosoma brucei	cdc2-related kinase 1	0.0048	0.0572	0.1683
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0057	0.0808	0.0976
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Echinococcus multilocularis	expressed protein	0.0112	0.2359	0.2333
Echinococcus granulosus	activated cdc42 kinase 1	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Schistosoma mansoni	protein kinase	0.0082	0.1511	0.1482
Entamoeba histolytica	SH2 domain containing protein	0.012	0.2591	0.7224
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0808	0.2781
Brugia malayi	STAT protein, DNA binding domain containing protein	0.012	0.2591	0.3341
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.012	0.2591	0.2566
Echinococcus multilocularis	insulin receptor	0.0035	0.021	0.0177
Echinococcus granulosus	SHC transforming protein 3	0.012	0.2591	0.2566
Schistosoma mansoni	growth factor receptor-bound protein	0.0232	0.5736	0.5721
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0572	0.1683
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.012	0.2591	0.2566
Leishmania major	hypothetical protein, conserved	0.0112	0.2359	1
Schistosoma mansoni	run and tbc1 domain containing	0.0112	0.2359	0.2333
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0082	0.1511	0.6053
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0299	0.7612	0.7604
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.021	0.0184
Echinococcus multilocularis	cyclin dependent kinase	0.0048	0.0572	0.054
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0299	0.7612	0.7604
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.012	0.2591	0.2566
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.021	0.0177
Trypanosoma cruzi	cdc2-related kinase 1	0.0048	0.0572	0.1683
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0572	0.0664
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	SRC-1	0.0299	0.7612	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0156	0.3587	0.4662
Echinococcus granulosus	tyrosine kinase	0.0187	0.4467	0.4449
Schistosoma mansoni	dynamin-associated protein	0.0112	0.2359	0.2333
Echinococcus granulosus	suppressor of cytokine signaling 6	0.012	0.2591	0.2566
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	epidermal growth factor receptor	0.0035	0.021	0.0177
Schistosoma mansoni	vav2	0.0129	0.2835	0.2811
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0112	0.2359	0.496
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0112	0.2359	0.3034
Echinococcus granulosus	kinase suppressor of Ras 1	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0268	0.6731	0.672
Loa Loa (eye worm)	hypothetical protein	0.0232	0.5736	0.7512
Echinococcus multilocularis	protein kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0047	0.0532	0.0611
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0156	0.3587	0.3565
Onchocerca volvulus		0.0156	0.3587	0.7792
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0042	0.0405	0.0373
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.012	0.2591	0.2566
Schistosoma mansoni	ephrin receptor	0.0035	0.021	0.0177
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	hypothetical protein	0.012	0.2591	0.2566
Echinococcus granulosus	hypothetical protein	0.012	0.2591	0.2566
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.012	0.2591	0.2566
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Brugia malayi	Receptor family ligand binding region containing protein	0.0035	0.021	0.0184
Schistosoma mansoni	hypothetical protein	0.0112	0.2359	0.2333
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Brugia malayi	Src substrate cortactin	0.0112	0.2359	0.3034
Brugia malayi	Protein kinase domain containing protein	0.0156	0.3587	0.4662
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0156	0.3587	0.3565
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0035	0.021	0.0177
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Brugia malayi	tRNA modification GTPase TrmE family protein	0.012	0.2591	0.3341
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	integrin linked protein kinase	0.0035	0.021	0.0177
Brugia malayi	SH3 domain containing protein	0.0112	0.2359	0.3034
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK/ALK protein kinase	0.0035	0.021	0.0184
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0114	0.2421	0.2396
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0035	0.021	0.0177
Brugia malayi	Raf kinase	0.0035	0.021	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Brugia malayi	MAP kinase sur-1	0.0057	0.0808	0.0976
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0278	0.0317
Echinococcus multilocularis	protein tyrosine kinase	0.0035	0.021	0.0177
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Echinococcus multilocularis	FL cytokine receptor	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0112	0.2359	0.6578
Brugia malayi	Variant SH3 domain containing protein	0.0232	0.5736	0.7512
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0156	0.3587	0.4662
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0035	0.021	0.0177
Trypanosoma brucei	conserved protein	0.0112	0.2359	1
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0082	0.1511	0.1909
Loa Loa (eye worm)	TK/CSK protein kinase	0.007	0.1167	0.1452
Onchocerca volvulus		0.0112	0.2359	0.496
Echinococcus multilocularis	Spectrin alpha actinin	0.0112	0.2359	0.2333
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Echinococcus granulosus	RNA directed DNA polymerase	0.0042	0.0405	0.0373
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0112	0.2359	0.6578
Echinococcus granulosus	dual specificity mitogen activated protein	0.0082	0.1511	0.1482
Brugia malayi	integrin-linked kinase	0.0035	0.021	0.0184
Trypanosoma brucei	protein kinase, putative	0.0038	0.0278	0.0317
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	ephrin receptor	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Brugia malayi	C-terminal src kinase protein 1	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0588	0.0685
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0299	0.7612	0.7604
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0035	0.021	0.0184
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0057	0.0808	0.2781
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0048	0.0572	0.1683
Echinococcus granulosus	tyrosine kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK protein kinase	0.0187	0.4467	0.5829
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0112	0.2359	0.2333
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0572	0.054
Trichomonas vaginalis	STE family protein kinase	0.0082	0.1511	0.6053
Brugia malayi	hypothetical protein	0.0035	0.021	0.0184
Onchocerca volvulus		0.0156	0.3587	0.7792
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.1167	0.1137
Schistosoma mansoni	serine/threonine RGC	0.0035	0.021	0.0177
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0057	0.0808	0.2781
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0045	0.047	0.0529
Entamoeba histolytica	hypothetical protein, conserved	0.0035	0.021	0.0585
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0127	0.2773	0.3583
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0038	0.0278	0.0246
Brugia malayi	Furin-like cysteine rich region family protein	0.0035	0.021	0.0184
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0808	0.2781
Echinococcus multilocularis	tyrosine protein kinase	0.0035	0.021	0.0177
Schistosoma mansoni	sorting nexin	0.0112	0.2359	0.2333
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Schistosoma mansoni	tensin-related	0.012	0.2591	0.2566
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0268	0.6731	0.672
Echinococcus granulosus	SH2 motif	0.012	0.2591	0.2566
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0073	0.1262	0.1233
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	transfer RNA-Thr	0.0035	0.021	0.0177
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.012	0.2591	0.2566
Schistosoma mansoni	dreadlocks/dock	0.0112	0.2359	0.2333
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0299	0.7612	0.7604
Brugia malayi	Spectrin alpha chain	0.0112	0.2359	0.3034
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0035	0.021	0.0184
Giardia lamblia	Kinase, CMGC CDK	0.0048	0.0572	0.2781
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1262	0.1233
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Loa Loa (eye worm)	thyroid receptor interactor	0.0112	0.2359	0.3034
Brugia malayi	hypothetical protein	0.0035	0.021	0.0184
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.1167	0.1137
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.1167	0.1137
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0038	0.0278	0.0246
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.012	0.2591	0.2566
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0035	0.021	0.0177
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0048	0.0572	0.6053
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Echinococcus multilocularis	serine threonine protein kinase	0.0066	0.108	0.105
Echinococcus granulosus	activated cdc42 kinase 1	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0808	0.2781
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Trypanosoma cruzi	cdc2-related kinase 1	0.0048	0.0572	0.1683
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0035	0.021	0.0184
Brugia malayi	Variant SH3 domain containing protein	0.0127	0.2773	0.3583
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	tyrosin kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0047	0.0532	0.0611
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Schistosoma mansoni	apoptosis stimulating of P53	0.0112	0.2359	0.2333
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0035	0.021	0.0177
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Brugia malayi	protein-tyrosine kinase	0.0112	0.2359	0.3034
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0035	0.021	0.0177
Entamoeba histolytica	unconventional myosin IB	0.0112	0.2359	0.6578
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0405	0.0443
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0187	0.4467	0.4449
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0808	0.2781
Onchocerca volvulus		0.012	0.2591	0.5494
Brugia malayi	p70 ribosomal S6 kinase beta	0.0045	0.047	0.0529
Onchocerca volvulus		0.0112	0.2359	0.496
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0057	0.0808	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0035	0.021	0.0177
Echinococcus granulosus	src region	0.0112	0.2359	0.2333
Onchocerca volvulus		0.0156	0.3587	0.7792
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0572	0.1683
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	SH2 domain-containing protein	0.0154	0.3547	0.461
Echinococcus granulosus	mitogen activated protein kinase	0.0057	0.0808	0.0777
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Echinococcus granulosus	SH2 motif	0.012	0.2591	0.2566
Brugia malayi	SH2 domain containing protein	0.0156	0.3587	0.4662
Schistosoma mansoni	tyrosine kinase	0.0268	0.6731	0.672
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0114	0.2421	0.2396
Loa Loa (eye worm)	TK protein kinase	0.0067	0.1091	0.1352
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Schistosoma mansoni	shc transforming protein	0.012	0.2591	0.2566
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0071	0.0038
Entamoeba histolytica	protein kinase, putative	0.0067	0.1091	0.3041
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0035	0.021	0.0177
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Leishmania major	protein kinase, putative	0.0038	0.0278	0.0317
Echinococcus granulosus	receptor type guanylyl cyclase	0.0035	0.021	0.0177
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/EPH protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0048	0.0572	0.0664
Giardia lamblia	Kinase, STE STE20	0.0082	0.1511	1
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0048	0.0572	0.1683
Echinococcus multilocularis	tyrosine protein kinase csk	0.007	0.1167	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Plasmodium falciparum	protein kinase 5	0.0048	0.0572	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Entamoeba histolytica	cell division protein kinase 2, putative	0.0048	0.0572	0.1594
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0112	0.2359	0.2333
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Echinococcus granulosus	tyrosine protein kinase Srms	0.0156	0.3587	0.3565
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/ABL protein kinase	0.0156	0.3587	0.4662
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Brugia malayi	Tensin	0.012	0.2591	0.3341
Onchocerca volvulus		0.012	0.2591	0.5494
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/Met protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	Dab2-interacting protein-like	0.0112	0.2359	0.2333
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0127	0.2773	0.2749
Echinococcus granulosus	growth factor receptor bound protein 2	0.0232	0.5736	0.5721
Onchocerca volvulus		0.012	0.2591	0.5494
Giardia lamblia	Kinase, CMGC MAPK	0.0057	0.0808	0.4594
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Brugia malayi	Variant SH3 domain containing protein	0.0112	0.2359	0.3034
Schistosoma mansoni	protein kinase	0.0038	0.0278	0.0246
Echinococcus multilocularis	cyclin dependent kinase 5	0.0048	0.0572	0.054
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0112	0.2359	0.3034
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Brugia malayi	hypothetical protein	0.012	0.2591	0.3341
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Schistosoma mansoni	cell polarity protein	0.0112	0.2359	0.2333
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0057	0.0808	0.0777
Echinococcus multilocularis	epidermal growth factor receptor	0.0035	0.021	0.0177
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0057	0.0808	0.2781
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0268	0.6731	0.672
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	hypothetical protein, conserved	0.0112	0.2359	0.6578
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0112	0.2359	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0035	0.021	0.0184
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0082	0.1511	0.1909
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Onchocerca volvulus		0.0112	0.2359	0.496
Onchocerca volvulus		0.0114	0.2427	0.5117
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0299	0.7612	0.7604
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Schistosoma mansoni	hypothetical protein	0.0035	0.021	0.0177
Loa Loa (eye worm)	SH2 domain-containing protein	0.012	0.2591	0.3341
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Brugia malayi	hypothetical protein	0.0156	0.3587	0.4662
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0112	0.2359	0.2333
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Onchocerca volvulus		0.0156	0.3587	0.7792
Brugia malayi	Sex muscle abnormal protein 5	0.0232	0.5736	0.7512
Echinococcus multilocularis	RNA directed DNA polymerase	0.0042	0.0405	0.0373
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0232	0.5736	0.5721
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0187	0.4467	0.4449
Schistosoma mansoni	protein kinase	0.0038	0.0278	0.0246
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis		0.012	0.2591	0.2566
Echinococcus granulosus	Spectrin alpha actinin	0.0112	0.2359	0.2333
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0112	0.2359	0.2333
Entamoeba histolytica	protein kinase domain containing protein	0.0038	0.0278	0.0776
Entamoeba histolytica	tyrosin kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0035	0.021	0.0177
Brugia malayi	Variant SH3 domain containing protein	0.0124	0.2691	0.3473
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0035	0.021	0.0184
Echinococcus granulosus	epidermal growth factor receptor	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0067	0.1091	0.1061
Schistosoma mansoni	nck2/grb4	0.0232	0.5736	0.5721
Echinococcus granulosus	SH2 domain containing adapter protein F	0.012	0.2591	0.2566
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0112	0.2359	0.2333
Onchocerca volvulus		0.012	0.2591	0.5494
Echinococcus multilocularis	activin receptor type	0.0038	0.0278	0.0246
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0035	0.021	0.0184
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Schistosoma mansoni	adapter molecule crk	0.0232	0.5736	0.5721
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0503	0.0573
Echinococcus multilocularis	endophilin A3	0.0112	0.2359	0.2333
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Schistosoma mansoni	serine/threonine protein kinase	0.0147	0.3355	0.3333
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0278	0.0317
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	growth factor receptor-bound protein	0.0232	0.5736	0.5721
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0127	0.2773	0.2749
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0112	0.2359	0.2333
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0112	0.2359	0.2333
Entamoeba histolytica	receptor protein kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0035	0.021	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.012	0.2591	0.3341
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Brugia malayi	protein-tyrosine kinase	0.0187	0.4467	0.5829
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	STAT protein	0.012	0.2591	0.3341
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Schistosoma mansoni	tyrosine kinase	0.0299	0.7612	0.7604
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0035	0.021	0.0184
Echinococcus multilocularis	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus granulosus	mitogen activated protein kinase 3	0.0057	0.0808	0.0777
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus multilocularis	SHC transforming protein 3	0.012	0.2591	0.2566
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0112	0.2359	0.2333
Brugia malayi	cell division control protein 2 homolog	0.0048	0.0572	0.0664
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0299	0.7612	0.7604
Entamoeba histolytica	protein kinase, putative	0.0045	0.047	0.131
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.012	0.2591	0.5494
Echinococcus multilocularis	tyrosine kinase	0.0156	0.3587	0.3565
Loa Loa (eye worm)	TK/DDR protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.012	0.2591	0.3341
Echinococcus granulosus	tensin	0.012	0.2591	0.2566
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0156	0.3587	0.4662
Echinococcus multilocularis	protein kinase c epsilon type	0.0031	0.0071	0.0038
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	tensin	0.012	0.2591	0.2566
Echinococcus granulosus	signal transduction protein lnk realted	0.012	0.2591	0.2566
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0035	0.021	0.0177
Brugia malayi	Guanylate kinase family protein	0.0112	0.2359	0.3034
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0393	0.036
Brugia malayi	Myosin tail family protein	0.0112	0.2359	0.3034
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0038	0.0278	0.0317
Trypanosoma brucei	cdc2-related kinase 3	0.0048	0.0572	0.1683
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0035	0.021	0.0184
Echinococcus granulosus	cyclin dependent kinase 1	0.0048	0.0572	0.054
Echinococcus multilocularis	SH2 motif	0.012	0.2591	0.2566
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0035	0.021	0.0585
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0035	0.021	0.0177
Entamoeba histolytica	hypothetical protein	0.0114	0.2421	0.675
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.1167	0.1137
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0127	0.2773	0.2749
Echinococcus multilocularis	SH2 motif	0.012	0.2591	0.2566
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0082	0.1511	0.1482
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	SH2 motif	0.012	0.2591	0.2566
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Echinococcus granulosus	c src tyrosine kinase	0.0302	0.7688	0.768
Trypanosoma cruzi	cdc2-related kinase 3	0.0048	0.0572	0.1683
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0152	0.3471	0.345
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Echinococcus granulosus	raf serine:threonine protein kinase	0.0042	0.0393	0.036
Schistosoma mansoni	sorbin	0.0112	0.2359	0.2333
Loa Loa (eye worm)	TK/RYK protein kinase	0.0035	0.021	0.0184
Echinococcus multilocularis	activated cdc42 kinase 1	0.0035	0.021	0.0177
Plasmodium vivax	protein kinase Crk2	0.0048	0.0572	1
Echinococcus granulosus	nostrin	0.0112	0.2359	0.2333
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Entamoeba histolytica	ankyrin repeat protein	0.0035	0.021	0.0585
Onchocerca volvulus		0.012	0.2591	0.5494
Loa Loa (eye worm)	TK/FER protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	TK/FAK protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Onchocerca volvulus	Putative cortactin	0.0112	0.2359	0.496
Schistosoma mansoni	tyrosine kinase	0.0264	0.6623	0.6612
Schistosoma mansoni	formin binding protein and related proteins	0.0112	0.2359	0.2333
Entamoeba histolytica	hypothetical protein, conserved	0.0112	0.2359	0.6578
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2359	1
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0114	0.2421	0.2396
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Schistosoma mansoni	suppressor of cytokine signaling	0.012	0.2591	0.2566
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0054	0.0736	0.0881
Entamoeba histolytica	cysteine surface protein, putative	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0112	0.2359	0.2333
Trypanosoma cruzi	cdc2-related kinase 3	0.0048	0.0572	0.1683
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0156	0.3587	1
Echinococcus granulosus	intersectin 2	0.0113	0.2397	0.2372
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0035	0.021	0.0177
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0127	0.2773	0.2749
Schistosoma mansoni	SH2A	0.012	0.2591	0.2566
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	c src tyrosine kinase	0.0302	0.7688	0.768
Echinococcus granulosus	tyrosine protein kinase csk	0.007	0.1167	0.1137
Schistosoma mansoni	tyrosine kinase	0.0302	0.7688	0.768
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0299	0.7612	0.7604
Echinococcus multilocularis	heat shock protein 70	0.0035	0.021	0.0177
Entamoeba histolytica	tyrosin kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	tyrosine protein kinase Blk	0.0187	0.4467	0.4449
Entamoeba histolytica	hypothetical protein	0.0035	0.021	0.0585
Trichomonas vaginalis	p67phox protein, putative	0.0112	0.2359	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0046	0.0511	0.0584
Loa Loa (eye worm)	protein-tyrosine kinase	0.0112	0.2359	0.3034
Loa Loa (eye worm)	SH2 domain-containing protein	0.012	0.2591	0.3341
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Giardia lamblia	Kinase, CMGC CDK	0.0048	0.0572	0.2781
Echinococcus granulosus	endophilin A3	0.0112	0.2359	0.2333
Onchocerca volvulus		0.0156	0.3587	0.7792
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Onchocerca volvulus		0.012	0.2591	0.5494
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0035	0.021	0.0177
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0572	0.054
Echinococcus granulosus	tyrosine kinase	0.0156	0.3587	0.3565
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.012	0.2591	0.2566
Echinococcus multilocularis	epidermal growth factor receptor	0.0035	0.021	0.0177
Brugia malayi	Tyrosine-protein kinase abl-1	0.0268	0.6731	0.8832
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0123	0.2659	0.7414
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0035	0.021	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Echinococcus granulosus	tyrosine protein kinase	0.0035	0.021	0.0177
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase, putative	0.0047	0.0532	0.1483
Brugia malayi	ephrin receptor 1 precursor	0.0035	0.021	0.0184
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0301	0.768	0.7673
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0572	0.054
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.012	0.2591	0.2566
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0112	0.2359	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0152	0.3471	0.345
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0808	0.2781
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0112	0.2359	0.2333
Entamoeba histolytica	tyrosin kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0572	0.054
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0082	0.1511	0.6053
Loa Loa (eye worm)	TK/ACK protein kinase	0.0035	0.021	0.0184
Brugia malayi	SH2 domain containing protein	0.019	0.4543	0.593
Echinococcus granulosus	ephrin type A receptor 4 A	0.0035	0.021	0.0177
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Entamoeba histolytica	receptor protein kinase, putative	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0035	0.021	0.0177
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.012	0.2591	0.2566
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK/INSR protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0156	0.3587	0.3565
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0187	0.4467	0.4449
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0035	0.021	0.0177
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0808	0.2781
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0082	0.1511	0.6053
Echinococcus granulosus	NCK adaptor protein	0.0232	0.5736	0.5721
Echinococcus multilocularis	nostrin	0.0112	0.2359	0.2333
Schistosoma mansoni	protein tyrosine kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	TK/ROR protein kinase	0.0035	0.021	0.0184
Entamoeba histolytica	hypothetical protein	0.0112	0.2359	0.6578
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0038	0.0278	0.1142
Brugia malayi	Protein kinase domain containing protein	0.0156	0.3587	0.4662
Echinococcus granulosus	protein kinase c epsilon type	0.0031	0.0071	0.0038
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0187	0.4467	0.4449
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Echinococcus granulosus	expressed conserved protein	0.012	0.2591	0.2566
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Schistosoma mansoni	signal transduction protein lnk-related	0.012	0.2591	0.2566
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Brugia malayi	SRC-1	0.0299	0.7612	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0057	0.0808	0.0777
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0047	0.0532	0.1498
Entamoeba histolytica	serine/threonine kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0112	0.2359	0.2333
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0054	0.0736	0.0881
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0299	0.7612	0.7604
Brugia malayi	Peripheral plasma membrane protein CASK	0.0112	0.2359	0.3034
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0035	0.021	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0035	0.021	0.0184
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0112	0.2359	0.2333
Echinococcus granulosus	tyrosine protein kinase HCK	0.0067	0.1091	0.1061
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Entamoeba histolytica	cell division protein kinase 2, putative	0.0048	0.0572	0.1594
Echinococcus granulosus	expressed protein	0.0112	0.2359	0.2333
Brugia malayi	SH2 domain containing protein	0.012	0.2591	0.3341
Loa Loa (eye worm)	hypothetical protein	0.0156	0.3587	0.4662
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0035	0.021	0.0184
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.2359	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.012	0.2591	0.3341
Trichomonas vaginalis	AGC family protein kinase	0.0047	0.0532	0.1498
Schistosoma mansoni	tyrosine kinase	0.0299	0.7612	0.7604
Entamoeba histolytica	ankyrin repeat protein	0.0035	0.021	0.0585
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0299	0.7612	0.7604
Entamoeba histolytica	protein kinase domain containing protein	0.0035	0.021	0.0585
Schistosoma mansoni	tyrosine kinase	0.0035	0.021	0.0177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.012	0.2591	0.2566
Schistosoma mansoni	protein kinase	0.0035	0.021	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2359	0.3034
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	Protein kinase C brain isozyme	0.0073	0.1262	0.1233
Loa Loa (eye worm)	hypothetical protein	0.012	0.2591	0.3341
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Echinococcus granulosus	tyrosine protein kinase pr2	0.0035	0.021	0.0177
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0112	0.2359	0.2333
Entamoeba histolytica	tyrosine kinase, putative	0.0035	0.021	0.0585
Loa Loa (eye worm)	TK/FER protein kinase	0.0156	0.3587	0.4662
Onchocerca volvulus		0.0112	0.2359	0.496
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0572	0.0664
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0035	0.021	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0035	0.021	0.0184
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0124	0.2691	0.3473
Loa Loa (eye worm)	TK protein kinase	0.0035	0.021	0.0184
Brugia malayi	Protein kinase c protein 2	0.0053	0.0694	0.0826
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0035	0.021	0.0585
Entamoeba histolytica	protein kinase, putative	0.0035	0.021	0.0585
Echinococcus multilocularis	N chimaerin	0.0127	0.2773	0.2749
Schistosoma mansoni	tensin	0.012	0.2591	0.2566
Schistosoma mansoni	eps8-related protein	0.0112	0.2359	0.2333
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0112	0.2359	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.012	0.2591	0.5494
Brugia malayi	Variant SH3 domain containing protein	0.0232	0.5736	0.7512
Brugia malayi	Tyrosine-protein kinase PR2	0.0035	0.021	0.0184
Toxoplasma gondii	AGC kinase	0.0045	0.047	0.4351
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0035	0.021	0.0184

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	> 10 uM	Growth inhibition of human K562 cells after 48 hrs by XTT assay	ChEMBL.	25108079
IC50 (binding)	= 0.47 uM	Inhibition of human FLT3 using 10 uM ATP	ChEMBL.	25108079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3327134

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 926133