Detailed information for compound 926482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 577.627 | Formula: C27H39N5O9
  • H donors: 7 H acceptors: 9 LogP: -0.1 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)C(=O)NCCC(=O)O)c1ccccc1)C)[C@H](O)C)NC(=O)C)C
  • InChi: 1S/C27H39N5O9/c1-6-14(2)20(30-17(5)34)25(39)31-21(16(4)33)26(40)29-15(3)24(38)32-22(18-10-8-7-9-11-18)23(37)27(41)28-13-12-19(35)36/h7-11,14-16,20-22,33H,6,12-13H2,1-5H3,(H,28,41)(H,29,40)(H,30,34)(H,31,39)(H,32,38)(H,35,36)/t14-,15-,16+,20-,21-,22?/m0/s1
  • InChiKey: YQWGFGJKZMELKQ-XAAWJAISSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0136 0.2779 0.7383
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Entamoeba histolytica BAR/SH3 domain containing protein 0.0125 0.2479 0.6531
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni vav2 0.0143 0.2952 0.2952
Echinococcus multilocularis transfer RNA-Ala 0.0125 0.2479 0.2479
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0171 0.3699 0.3699
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0204 0.4565 0.4565
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0133 0.2712 0.3424
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0529 0.0529
Toxoplasma gondii AGC kinase 0.0047 0.0429 0.4262
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Brugia malayi Myosin tail family protein 0.0125 0.2479 0.3126
Brugia malayi Guanylate kinase family protein 0.0125 0.2479 0.3126
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0183 0.0186
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1122 0.1122
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0051 0.0529 0.0629
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus growth factor receptor bound protein 2 0.0258 0.5996 0.5996
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis intersectin 2 0.0126 0.2517 0.2517
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0133 0.2712 0.2712
Trypanosoma brucei conserved protein 0.0125 0.2479 1
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0125 0.2479 0.2479
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.076 0.2516
Plasmodium falciparum protein kinase, putative 0.004 0.025 0.1936
Schistosoma mansoni serine/threonine RGC 0.0037 0.0183 0.0183
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus protein tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0328 0.7849 0.7849
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0037 0.0183 0.0183
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0044 0.0365 0.0365
Echinococcus multilocularis dual specificity mitogen activated protein 0.0086 0.1451 0.1451
Brugia malayi Fes/CIP4 homology domain containing protein 0.0125 0.2479 0.3126
Echinococcus granulosus fch and double sh3 domains protein 2 0.0125 0.2479 0.2479
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0183 0.0186
Brugia malayi hypothetical protein 0.0171 0.3699 0.4688
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.076 0.076
Brugia malayi SH2 domain containing protein 0.0171 0.3699 0.4688
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0295 0.6984 0.6984
Schistosoma mansoni tyrosine kinase 0.0276 0.6483 0.6483
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.076 0.076
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.0529 0.0529
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0127 0.254 0.254
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0328 0.7849 0.7849
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0529 0.1508
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Srms 0.0171 0.3699 0.3699
Entamoeba histolytica SH2 domain containing protein 0.0133 0.2712 0.7192
Schistosoma mansoni protein kinase 0.004 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0037 0.0183 0.0183
Echinococcus multilocularis tensin 0.0133 0.2712 0.2712
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Onchocerca volvulus Putative cortactin 0.0125 0.2479 0.5154
Echinococcus multilocularis heat shock protein 70 0.0037 0.0183 0.0183
Schistosoma mansoni protein kinase 0.004 0.025 0.025
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1122 0.1122
Echinococcus granulosus c src tyrosine kinase 0.0331 0.7923 0.7923
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Srms 0.0204 0.4565 0.4565
Echinococcus granulosus endophilin A3 0.0125 0.2479 0.2479
Brugia malayi Sex muscle abnormal protein 5 0.0258 0.5996 0.7628
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1122 0.1122
Onchocerca volvulus 0.0133 0.2712 0.5676
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0037 0.0183 0.0186
Entamoeba histolytica hypothetical protein, conserved 0.0125 0.2479 0.6531
Schistosoma mansoni adapter molecule crk 0.0258 0.5996 0.5996
Echinococcus multilocularis kinase suppressor of Ras 1 0.0037 0.0183 0.0183
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0133 0.2712 0.2712
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1122 0.1122
Loa Loa (eye worm) RhoGAP domain-containing protein 0.014 0.2891 0.3654
Onchocerca volvulus 0.0127 0.2546 0.5304
Echinococcus granulosus tensin 0.0133 0.2712 0.2712
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0529 0.2729
Schistosoma mansoni hypothetical protein 0.0133 0.2712 0.2712
Entamoeba histolytica protein kinase, putative 0.0049 0.049 0.0874
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0529 0.1508
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.0529 0.1508
Brugia malayi Variant SH3 domain containing protein 0.0258 0.5996 0.7628
Echinococcus granulosus N chimaerin 0.014 0.2891 0.2891
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0133 0.2712 0.2712
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.076 0.2516
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.2479 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0044 0.0362 0.0362
Onchocerca volvulus 0.0171 0.3699 0.7891
Loa Loa (eye worm) SH2 domain-containing protein 0.0133 0.2712 0.3424
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Loa Loa (eye worm) TK/EGFR protein kinase 0.0037 0.0183 0.0186
Brugia malayi STAT protein, DNA binding domain containing protein 0.0133 0.2712 0.3424
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0037 0.0183 0.0183
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Echinococcus granulosus Spectrin alpha actinin 0.0125 0.2479 0.2479
Echinococcus granulosus activin receptor type 0.004 0.025 0.025
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0125 0.2479 0.2479
Echinococcus granulosus expressed conserved protein 0.0133 0.2712 0.2712
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.025 0.0292
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0133 0.2712 0.2712
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0037 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.076 0.2516
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus tyrosine protein kinase HCK 0.007 0.1048 0.1048
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase 0.0037 0.0183 0.0183
Schistosoma mansoni GTPase activating protein 0.0133 0.2712 0.2712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0529 0.0629
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus granulosus suppressor of cytokine signaling 7 0.0133 0.2712 0.2712
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0086 0.1451 0.5524
Loa Loa (eye worm) TK/ROR protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.0183 0.0186
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.0529 0.0529
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.076 0.0926
Schistosoma mansoni suppressor of cytokine signaling 0.0133 0.2712 0.2712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.0529 0.0629
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0529 0.1508
Brugia malayi cell division control protein 2 homolog 0.0051 0.0529 0.0629
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus signal transduction protein lnk realted 0.0133 0.2712 0.2712
Echinococcus multilocularis signal transduction protein lnk realted 0.0133 0.2712 0.2712
Loa Loa (eye worm) TK/DDR protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus NCK adaptor protein 0.0258 0.5996 0.5996
Loa Loa (eye worm) hypothetical protein 0.0051 0.0545 0.065
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus tyrosine protein kinase ABL1 0.0171 0.3699 0.3699
Echinococcus granulosus protein kinase C gamma type 0.007 0.1028 0.1028
Echinococcus multilocularis protein KINase family member (kin 25) 0.0037 0.0183 0.0183
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.049 0.0579
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.2479 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0125 0.2479 0.3126
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0133 0.2712 0.3424
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0125 0.2479 0.2479
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Echinococcus granulosus protein kinase 0.0037 0.0183 0.0183
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Echinococcus granulosus hypothetical protein 0.0133 0.2712 0.2712
Echinococcus granulosus tyrosine protein kinase Src42A 0.0166 0.3577 0.3577
Echinococcus granulosus dual specificity testis-specific protein kinase 0.004 0.025 0.025
Brugia malayi Protein kinase domain containing protein 0.0171 0.3699 0.4688
Echinococcus multilocularis protein tyrosine kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) TK/CSK protein kinase 0.0073 0.1122 0.1389
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Onchocerca volvulus 0.0133 0.2712 0.5676
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.0529 0.5991
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0183 0.0183
Echinococcus multilocularis N chimaerin 0.014 0.2891 0.2891
Echinococcus granulosus tyrosine protein kinase Src42A 0.0328 0.7849 0.7849
Echinococcus granulosus tyrosine kinase 0.0171 0.3699 0.3699
Echinococcus granulosus cyclin dependent kinase 0.0051 0.0529 0.0529
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0133 0.2712 0.5676
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Blk 0.0204 0.4565 0.4565
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0171 0.3699 0.7891
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/ACK protein kinase 0.0037 0.0183 0.0186
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.0529 0.1508
Schistosoma mansoni protein kinase 0.004 0.025 0.025
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine kinase 0.0037 0.0183 0.0183
Brugia malayi Protein kinase domain containing protein 0.0171 0.3699 0.4688
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Echinococcus multilocularis protein kinase 0.0037 0.0183 0.0183
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.0183 0.0183
Loa Loa (eye worm) TK/Met protein kinase 0.0037 0.0183 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0125 0.2479 1
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0037 0.0183 0.0186
Echinococcus multilocularis expressed protein 0.0125 0.2479 0.2479
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.076 0.2516
Schistosoma mansoni SH2A 0.0133 0.2712 0.2712
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0086 0.1451 0.5524
Echinococcus granulosus nostrin 0.0125 0.2479 0.2479
Schistosoma mansoni tensin 0.0133 0.2712 0.2712
Schistosoma mansoni run and tbc1 domain containing 0.0125 0.2479 0.2479
Schistosoma mansoni ephrin receptor 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0037 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0183 0.0183
Echinococcus granulosus SH2 motif 0.0133 0.2712 0.2712
Schistosoma mansoni tensin 0.0133 0.2712 0.2712
Echinococcus multilocularis SH2 motif 0.0133 0.2712 0.2712
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.0183 0.0183
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.0183 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0133 0.2712 0.5676
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.076 0.2516
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Brugia malayi Tyrosine-protein kinase PR2 0.0037 0.0183 0.0186
Entamoeba histolytica protein kinase domain containing protein 0.004 0.025 0.0191
Schistosoma mansoni dreadlocks/dock 0.0125 0.2479 0.2479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0037 0.0183 0.0183
Echinococcus multilocularis epidermal growth factor receptor 0.0037 0.0183 0.0183
Brugia malayi Raf kinase 0.0037 0.0183 0.0186
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Leishmania major protein kinase, putative 0.004 0.025 0.0292
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Echinococcus granulosus epidermal growth factor receptor kinase 0.0125 0.2479 0.2479
Schistosoma mansoni nck2/grb4 0.0258 0.5996 0.5996
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0037 0.0183 0.0183
Echinococcus multilocularis NCK adaptor protein 0.0258 0.5996 0.5996
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.0529 0.1508
Loa Loa (eye worm) serine/threonine protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0183 0.0183
Echinococcus multilocularis SH2 motif 0.0133 0.2712 0.2712
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0037 0.0183 0.0186
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0125 0.2479 0.2479
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine kinase 0.0204 0.4565 0.4565
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.004 0.025 0.116
Loa Loa (eye worm) guanylate kinase 0.0125 0.2479 0.3126
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0133 0.2712 0.2712
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.004 0.025 0.0292
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.076 0.2516
Echinococcus multilocularis c src tyrosine kinase 0.0331 0.7923 0.7923
Echinococcus multilocularis serine threonine protein kinase 0.007 0.1028 0.1028
Schistosoma mansoni tyrosine kinase 0.041 1 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0133 0.2712 0.5676
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Brugia malayi Protein kinase domain containing protein 0.0171 0.3699 0.4688
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Brugia malayi Protein kinase domain containing protein 0.0049 0.049 0.0579
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.076 0.2516
Entamoeba histolytica protein kinase, putative 0.0049 0.049 0.0874
Loa Loa (eye worm) thyroid receptor interactor 0.0125 0.2479 0.3126
Schistosoma mansoni suppressor of cytokine signaling 0.0133 0.2712 0.2712
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0258 0.5996 0.7628
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0171 0.3699 0.7891
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0037 0.0183 0.0186
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0328 0.7849 0.7849
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Lyn 0.0331 0.7916 0.7916
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Loa Loa (eye worm) TK/FAK protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0137 0.281 0.355
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Schistosoma mansoni Dab2-interacting protein-like 0.0125 0.2479 0.2479
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0125 0.2479 0.2479
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0076 0.1207 0.1207
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0529 0.1508
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.014 0.2891 0.2891
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Src64B 0.0328 0.7849 0.7849
Echinococcus multilocularis ephrin type A receptor 4 A 0.0037 0.0183 0.0183
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0258 0.5996 0.7628
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0136 0.2773 0.3502
Echinococcus granulosus RNA directed DNA polymerase 0.0044 0.0365 0.0365
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Echinococcus multilocularis RNA directed DNA polymerase 0.0044 0.0365 0.0365
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0295 0.6984 0.6984
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0529 0.1508
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0037 0.0183 0.0183
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0183 0.0186
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.076 0.2516
Brugia malayi integrin-linked kinase 0.0037 0.0183 0.0186
Trypanosoma brucei protein kinase, putative 0.004 0.025 0.0292
Loa Loa (eye worm) TK protein kinase 0.007 0.1048 0.1294
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Echinococcus multilocularis tensin 0.0133 0.2712 0.2712
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.076 0.076
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0328 0.7849 0.7849
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis SHC transforming protein 3 0.0133 0.2712 0.2712
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0125 0.2479 0.2479
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0125 0.2479 0.2479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus granulosus ephrin type A receptor 4 A 0.0037 0.0183 0.0183
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0047 0.0429 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0037 0.0183 0.0183
Echinococcus granulosus insulin receptor 0.0037 0.0183 0.0183
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0127 0.254 0.254
Echinococcus multilocularis tyrosine protein kinase shark 0.041 1 1
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0037 0.0183 0.0186
Echinococcus multilocularis dual specificity testis specific protein kinase 0.004 0.025 0.025
Schistosoma mansoni tyrosine protein kinase 0.0037 0.0183 0.0183
Brugia malayi Protein kinase domain containing protein 0.0171 0.3699 0.4688
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Giardia lamblia Kinase, STE STE20 0.0086 0.1451 1
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0136 0.2779 0.7383
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.076 0.2516
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Entamoeba histolytica hypothetical protein, conserved 0.0125 0.2479 0.6531
Trichomonas vaginalis p67phox protein, putative 0.0125 0.2479 1
Trypanosoma brucei protein kinase, putative 0.0059 0.076 0.2516
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.076 0.076
Loa Loa (eye worm) TK/ALK protein kinase 0.0037 0.0183 0.0186
Echinococcus multilocularis raf serine:threonine protein kinase 0.0044 0.0362 0.0362
Echinococcus granulosus SH2 domain containing protein 7 0.0133 0.2712 0.2712
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.014 0.2891 0.2891
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0328 0.7849 0.7849
Brugia malayi Src substrate cortactin 0.0125 0.2479 0.3126
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.3467 0.3467
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0166 0.3577 0.3577
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0529 0.0985
Onchocerca volvulus 0.0125 0.2479 0.5154
Schistosoma mansoni hypothetical protein 0.0125 0.2479 0.2479
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) TK protein kinase 0.0204 0.4565 0.5796
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0133 0.2712 0.3424
Echinococcus multilocularis growth factor receptor bound protein 2 0.0258 0.5996 0.5996
Entamoeba histolytica hypothetical protein 0.0125 0.2479 0.6531
Echinococcus multilocularis transfer RNA-Thr 0.0037 0.0183 0.0183
Schistosoma mansoni signal transduction protein lnk-related 0.0133 0.2712 0.2712
Schistosoma mansoni tyrosine kinase 0.0171 0.3699 0.3699
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.0529 0.0529
Trichomonas vaginalis STE family protein kinase 0.0086 0.1451 0.5524
Brugia malayi Variant SH3 domain containing protein 0.0258 0.5996 0.7628
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0529 0.0985
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0086 0.1451 0.5524
Echinococcus multilocularis Spectrin alpha actinin 0.0125 0.2479 0.2479
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0295 0.6984 0.6984
Entamoeba histolytica hypothetical protein 0.0127 0.254 0.6704
Entamoeba histolytica protein kinase, putative 0.0047 0.0429 0.0701
Echinococcus multilocularis protein kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) hypothetical protein 0.0048 0.0462 0.0543
Plasmodium vivax protein kinase Crk2 0.0051 0.0529 1
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Brugia malayi Variant SH3 domain containing protein 0.014 0.2891 0.3654
Schistosoma mansoni tensin 0.0133 0.2712 0.2712
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0133 0.2712 0.2712
Echinococcus granulosus natriuretic peptide receptor 1 0.0037 0.0183 0.0183
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Onchocerca volvulus 0.0206 0.4639 1
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1207 0.1207
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Trichomonas vaginalis STE family protein kinase 0.0086 0.1451 0.5524
Echinococcus granulosus suppressor of cytokine signaling 6 0.0133 0.2712 0.2712
Entamoeba histolytica protein kinase, putative 0.007 0.1048 0.246
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0086 0.1451 0.181
Loa Loa (eye worm) TK/RYK protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0125 0.2479 0.2479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0037 0.0183 0.0183
Loa Loa (eye worm) p53BP2 0.0125 0.2479 0.3126
Brugia malayi Peripheral plasma membrane protein CASK 0.0125 0.2479 0.3126
Echinococcus multilocularis activin receptor type 0.004 0.025 0.025
Brugia malayi C-terminal src kinase protein 1 0.0037 0.0183 0.0186
Brugia malayi SH2 domain containing protein 0.0206 0.4639 0.5891
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0171 0.3699 0.3699
Brugia malayi Variant SH3 domain containing protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus multilocularis SH2 domain containing protein 7 0.0133 0.2712 0.2712
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Echinococcus multilocularis insulin receptor 0.0037 0.0183 0.0183
Echinococcus granulosus epidermal growth factor receptor 0.0037 0.0183 0.0183
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0204 0.4565 0.4565
Schistosoma mansoni sorbin 0.0125 0.2479 0.2479
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.049 0.1338
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0125 0.2479 0.2479
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus granulosus expressed protein 0.0125 0.2479 0.2479
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0125 0.2479 1
Echinococcus multilocularis FL cytokine receptor 0.0037 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0295 0.6984 0.6984
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0133 0.2712 0.5676
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0037 0.0183 0.0183
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Schistosoma mansoni protein kinase 0.0086 0.1451 0.1451
Loa Loa (eye worm) SH2 domain-containing protein 0.0169 0.3652 0.4627
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Loa Loa (eye worm) TK protein kinase 0.0037 0.0183 0.0186
Echinococcus granulosus tyrosine protein kinase csk 0.0073 0.1122 0.1122
Brugia malayi Tensin 0.0133 0.2712 0.3424
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.0529 0.0529
Loa Loa (eye worm) TK/INSR protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni shc transforming protein 0.0133 0.2712 0.2712
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.076 0.076
Schistosoma mansoni hypothetical protein 0.0125 0.2479 0.2479
Echinococcus granulosus retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Brugia malayi MAP kinase sur-1 0.0059 0.076 0.0926
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0328 0.7849 0.7849
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Brugia malayi RhoGAP domain containing protein 0.014 0.2891 0.3654
Leishmania major hypothetical protein, conserved 0.0125 0.2479 1
Loa Loa (eye worm) STAT protein 0.0133 0.2712 0.3424
Schistosoma mansoni hypothetical protein 0.0133 0.2712 0.2712
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0328 0.7849 0.7849
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0125 0.2479 0.5154
Echinococcus multilocularis tyrosine protein kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) TK/FER protein kinase 0.0171 0.3699 0.4688
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Echinococcus multilocularis tyrosine protein kinase pr2 0.0037 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase pr2 0.0037 0.0183 0.0183
Trichomonas vaginalis AGC family protein kinase 0.0049 0.049 0.1338
Brugia malayi Tyrosine-protein kinase abl-1 0.0295 0.6984 0.8892
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0529 0.2729
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0362 0.0362
Schistosoma mansoni apoptosis stimulating of P53 0.0125 0.2479 0.2479
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0037 0.0183 0.0186
Loa Loa (eye worm) TK/ABL protein kinase 0.0171 0.3699 0.4688
Entamoeba histolytica unconventional myosin IB 0.0125 0.2479 0.6531
Brugia malayi Furin-like cysteine rich region family protein 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Onchocerca volvulus 0.0133 0.2712 0.5676
Echinococcus granulosus kinase suppressor of Ras 1 0.0037 0.0183 0.0183
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0037 0.0037
Schistosoma mansoni ephrin receptor 0.0037 0.0183 0.0183
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0133 0.2712 0.2712
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0133 0.2712 0.2712
Brugia malayi bone morphogenetic protein type 1 receptor 0.0037 0.0183 0.0186
Echinococcus multilocularis tyrosine protein kinase Abl 0.0295 0.6984 0.6984
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0133 0.2712 0.2712
Brugia malayi p70 ribosomal S6 kinase beta 0.0047 0.0429 0.0501
Brugia malayi cytokine inducible SH2-containing protein 5 0.0133 0.2712 0.3424
Echinococcus multilocularis natriuretic peptide receptor 1 0.0037 0.0183 0.0183
Brugia malayi hypothetical protein 0.0037 0.0183 0.0186
Echinococcus granulosus src region 0.0125 0.2479 0.2479
Onchocerca volvulus 0.0125 0.2479 0.5154
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0125 0.2479 0.2479
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1207 0.1207
Schistosoma mansoni protein kinase 0.0037 0.0183 0.0183
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Entamoeba histolytica BAR/SH3 domain containing protein 0.0125 0.2479 0.6531
Loa Loa (eye worm) hypothetical protein 0.0044 0.0365 0.042
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Onchocerca volvulus 0.0171 0.3699 0.7891
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0183 0.0186
Schistosoma mansoni tyrosine kinase 0.0037 0.0183 0.0183
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.014 0.2891 0.2891
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0037 0.0183 0.0183
Brugia malayi SH3 domain containing protein 0.0125 0.2479 0.3126
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0529 0.1508
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0133 0.2712 0.2712
Brugia malayi protein-tyrosine kinase 0.0204 0.4565 0.5796
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) hypothetical protein 0.0171 0.3699 0.4688
Brugia malayi ephrin receptor 1 precursor 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus granulosus intersectin 2 0.0126 0.2517 0.2517
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0183 0.0186
Brugia malayi tRNA modification GTPase TrmE family protein 0.0133 0.2712 0.3424
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0171 0.3699 0.3699
Onchocerca volvulus 0.0171 0.3699 0.7891
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0037 0.0037
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0258 0.5996 0.5996
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0125 0.2479 0.2479
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Schistosoma mansoni growth factor receptor-bound protein 0.0258 0.5996 0.5996
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.7849 0.7849
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0529 0.0629
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0171 0.3699 1
Schistosoma mansoni eps8-related protein 0.0125 0.2479 0.2479
Schistosoma mansoni cell polarity protein 0.0125 0.2479 0.2479
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0183 0.0186
Echinococcus multilocularis SH2 motif 0.0133 0.2712 0.2712
Schistosoma mansoni tensin-related 0.0133 0.2712 0.2712
Schistosoma mansoni tyrosine kinase 0.0331 0.7923 0.7923
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.004 0.025 0.0292
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Schistosoma mansoni tensin-related 0.0133 0.2712 0.2712
Brugia malayi hypothetical protein 0.0037 0.0183 0.0186
Echinococcus multilocularis tyrosine protein kinase csk 0.0073 0.1122 0.1122
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0037 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0133 0.2712 0.3424
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0183 0.0186
Echinococcus multilocularis tyrosine protein kinase Blk 0.0204 0.4565 0.4565
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0037 0.0183 0.0183
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0037 0.0183 0.0186
Schistosoma mansoni formin binding protein and related proteins 0.0125 0.2479 0.2479
Echinococcus multilocularis 0.0133 0.2712 0.2712
Loa Loa (eye worm) hypothetical protein 0.0125 0.2479 0.3126
Loa Loa (eye worm) protein kinase domain-containing protein 0.0037 0.0183 0.0186
Brugia malayi hypothetical protein 0.0133 0.2712 0.3424
Plasmodium falciparum protein kinase 5 0.0051 0.0529 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0133 0.2712 0.5676
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus multilocularis integrin linked protein kinase 0.0037 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0328 0.7849 0.7849
Echinococcus granulosus SH2 motif 0.0133 0.2712 0.2712
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0037 0.0183 0.0183
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.0529 0.0529
Echinococcus multilocularis activated cdc42 kinase 1 0.0037 0.0183 0.0183
Echinococcus granulosus SH2 domain containing adapter protein F 0.0133 0.2712 0.2712
Brugia malayi protein-tyrosine kinase 0.0125 0.2479 0.3126
Echinococcus multilocularis tyrosine kinase 0.0171 0.3699 0.3699
Schistosoma mansoni dynamin-associated protein 0.0125 0.2479 0.2479
Onchocerca volvulus 0.0125 0.2479 0.5154
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus granulosus dual specificity mitogen activated protein 0.0086 0.1451 0.1451
Schistosoma mansoni tyrosine kinase 0.0328 0.7849 0.7849
Onchocerca volvulus 0.0125 0.2479 0.5154
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Echinococcus granulosus integrin linked protein kinase 0.0037 0.0183 0.0183
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.076 0.2516
Schistosoma mansoni sorting nexin 0.0125 0.2479 0.2479
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0086 0.1451 0.181
Echinococcus granulosus Protein kinase C brain isozyme 0.0076 0.1207 0.1207
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0125 0.2479 0.3126
Echinococcus granulosus activated cdc42 kinase 1 0.0037 0.0183 0.0183
Brugia malayi SRC-1 0.0328 0.7849 1
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.0529 0.1508
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase HCK 0.007 0.1048 0.1048
Schistosoma mansoni C-fyn 0.0125 0.2479 0.2479
Schistosoma mansoni hypothetical protein 0.0037 0.0183 0.0183
Brugia malayi Spectrin alpha chain 0.0125 0.2479 0.3126
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0048 0.047 0.0553
Schistosoma mansoni protein tyrosine kinase 0.0037 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0328 0.7849 0.7849
Loa Loa (eye worm) hypothetical protein 0.0258 0.5996 0.7628
Brugia malayi Protein kinase c protein 2 0.0055 0.0649 0.0783
Echinococcus granulosus fibroblast growth factor receptor 4 0.0037 0.0183 0.0183
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0125 0.2479 0.2479
Schistosoma mansoni growth factor receptor-bound protein 0.0258 0.5996 0.5996
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.014 0.2891 0.2891
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.076 0.4555
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0037 0.0183 0.0186
Brugia malayi Protein kinase domain containing protein 0.0171 0.3699 0.4688
Echinococcus multilocularis endophilin A3 0.0125 0.2479 0.2479
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0133 0.2712 0.2712
Echinococcus multilocularis nostrin 0.0125 0.2479 0.2479
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.0183 0.0186
Loa Loa (eye worm) protein-tyrosine kinase 0.0125 0.2479 0.3126
Brugia malayi SH2 domain containing protein 0.0133 0.2712 0.3424
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.076 0.2516
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0133 0.2712 0.2712
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.0183 0.0183
Brugia malayi Variant SH3 domain containing protein 0.0137 0.281 0.355
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0037 0.0183 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.2479 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0183 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0529 0.1508
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0125 0.2479 0.6531
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0037 0.0183 0.0186
Loa Loa (eye worm) SRC-1 0.0328 0.7849 1
Echinococcus granulosus SHC transforming protein 3 0.0133 0.2712 0.2712
Loa Loa (eye worm) TK/EPH protein kinase 0.0037 0.0183 0.0186
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.076 1
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0125 0.2479 1
Trichomonas vaginalis STE family protein kinase 0.0086 0.1451 0.5524
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0127 0.254 0.254
Loa Loa (eye worm) SH2 domain-containing protein 0.0133 0.2712 0.3424
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0125 0.2479 0.2479
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0133 0.2712 0.2712

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 50 uM Inhibition of Plasmodium falciparum SUB1 ChEMBL. 25129616

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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