TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.087 | Formula: C16H12Br2N2O2
H donors: 2 H acceptors: 1 LogP: 4.35 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(Br)c(c(c1O)/C=N/c1ccc2c(c1)cc[nH]2)Br
InChi: 1S/C16H12Br2N2O2/c1-22-14-7-12(17)15(18)11(16(14)21)8-20-10-2-3-13-9(6-10)4-5-19-13/h2-8,19,21H,1H3/b20-8+
InChiKey: ODPRKOBQVGOMRM-DNTJNYDQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine kinase 6	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	hypothetical protein, conserved	protein tyrosine kinase 6	134 aa	127 aa	26.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0009	0.0072	0.032
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0009	0.0072	0.032
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Echinococcus multilocularis	endophilin A3	0.0009	0.0072	0.032
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Entamoeba histolytica	protein kinase, putative	0.0009	0.0072	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	General substrate transporter	0.0088	0.1918	0.851
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0201	0.0305
Schistosoma mansoni	apoptosis stimulating of P53	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0911	0.4042
Echinococcus granulosus	c src tyrosine kinase	0.0009	0.0072	0.032
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0201	0.5052
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0435	1	1
Leishmania major	hypothetical protein, conserved	0.0009	0.0072	0.1029
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0103	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.386
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0597	0.2648
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0009	0.0072	0.032
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0201	0.6328
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2583
Echinococcus multilocularis	Spectrin alpha actinin	0.0009	0.0073	0.0322
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0009	0.0072	0.032
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Brugia malayi	Guanylate kinase family protein	0.0009	0.0072	0.032
Onchocerca volvulus		0.0014	0.0201	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3724	0.5632
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0009	0.0072	0.032
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0295	0.1311
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	intersectin 2	0.0009	0.0072	0.032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0072	0.032
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0295	0.9279
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0295	0.5075
Onchocerca volvulus		0.0014	0.0201	1
Schistosoma mansoni	adapter molecule crk	0.0009	0.0072	0.032
Schistosoma mansoni	dynamin-associated protein	0.0009	0.0072	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0911	0.4042
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6849
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	p67phox protein, putative	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0911	0.4042
Leishmania major	hypothetical protein, conserved	0.0014	0.0201	0.2874
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0597	0.0597
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2583
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0597	0.2648
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0597	0.0597
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0597	0.0903
Schistosoma mansoni	nck2/grb4	0.0009	0.0072	0.032
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Schistosoma mansoni	Dab2-interacting protein-like	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0597	0.0597
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Brugia malayi	Cam kinase protein 1	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0009	0.0072	0.032
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0009	0.0072	0.1208
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Echinococcus granulosus	src region	0.0009	0.0072	0.032
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0009	0.0072	0.032
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Onchocerca volvulus		0.0014	0.0201	1
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Echinococcus granulosus	Spectrin alpha actinin	0.0009	0.0073	0.0322
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0295	0.4215
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0201	0.2874
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2253	1
Onchocerca volvulus		0.0014	0.0201	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0295	0.1311
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0295	0.4215
Loa Loa (eye worm)	thyroid receptor interactor	0.0009	0.0072	0.032
Echinococcus granulosus	General substrate transporter	0.0088	0.1918	0.851
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0597	0.0903
Onchocerca volvulus		0.0011	0.0118	0.353
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3724	0.3724
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0911	0.4042
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.2583
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0011	0.0118	0.0523
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	SRC-1	0.0009	0.0072	0.032
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0295	0.4949
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0009	0.0072	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Echinococcus granulosus	intersectin 2	0.0009	0.0072	0.032
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0201	0.5052
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	1
Brugia malayi	protein-tyrosine kinase	0.0009	0.0072	0.032
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Schistosoma mansoni	serine/threonine protein kinase	0.0009	0.0072	0.032
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.1769
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0295	0.4215
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0597	0.8517
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0072	0.032
Entamoeba histolytica	unconventional myosin IB	0.0009	0.0072	0.1208
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0009	0.0072	0.032
Plasmodium falciparum	protein kinase 7	0.029	0.6612	0.6612
Brugia malayi	Spectrin alpha chain	0.0009	0.0073	0.0322
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0597	0.2648
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0009	0.0072	0.032
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0894
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0295	0.1311
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0009	0.0072	0.032
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.2648
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0201	0.6328
Giardia lamblia	Sugar-proton symporter	0.0014	0.0201	0.346
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0072	0.032
Schistosoma mansoni	hypothetical protein	0.0009	0.0072	0.032
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0009	0.0072	0.032
Schistosoma mansoni	ap endonuclease	0.0018	0.0295	0.1311
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0009	0.0072	0.032
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	1
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0201	0.5052
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0009	0.0072	0.032
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3724	0.3724
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0072	0.032
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0911	0.4042
Giardia lamblia	Hexose transporter	0.0014	0.0201	0.346
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.2583
Entamoeba histolytica	hypothetical protein, conserved	0.0009	0.0072	0.1208
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0295	0.7409
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	1
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0009	0.0072	0.032
Schistosoma mansoni	sorting nexin	0.0009	0.0072	0.032
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0201	0.2874
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8651
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Echinococcus granulosus	expressed protein	0.0009	0.0072	0.032
Loa Loa (eye worm)	protein-tyrosine kinase	0.0009	0.0072	0.032
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.1769
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Brugia malayi	Src substrate cortactin	0.0009	0.0072	0.032
Plasmodium vivax	sugar transporter, putative	0.0014	0.0201	0.0201
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Brugia malayi	Myosin tail family protein	0.0009	0.0072	0.032
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0009	0.0072	0.032
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0911	0.4042
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Schistosoma mansoni	dreadlocks/dock	0.0009	0.0072	0.032
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.1987
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Onchocerca volvulus		0.0014	0.0201	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0295	0.1311
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0295	0.4215
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Mycobacterium ulcerans	sugar transporter	0.0014	0.0201	0.5052
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0597	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Echinococcus multilocularis	c src tyrosine kinase	0.0009	0.0072	0.032
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0009	0.0072	0.032
Loa Loa (eye worm)	sugar transporter	0.0103	0.2253	1
Loa Loa (eye worm)	p53BP2	0.0009	0.0072	0.032
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Brugia malayi	SRC-1	0.0009	0.0072	0.032
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0201	0.0305
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Onchocerca volvulus	Putative transporter	0.0014	0.0201	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	1
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0072	0.032
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Schistosoma mansoni	cell polarity protein	0.0009	0.0072	0.032
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Onchocerca volvulus		0.0014	0.0201	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0072	0.032
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0009	0.0072	0.032
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0072	0.032
Schistosoma mansoni	run and tbc1 domain containing	0.0009	0.0072	0.032
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0597	0.2648
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Onchocerca volvulus		0.0014	0.0201	1
Leishmania major	protein kinase, putative	0.0031	0.0597	0.8517
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0009	0.0072	0.032
Schistosoma mansoni	tyrosine kinase	0.0009	0.0072	0.032
Onchocerca volvulus		0.0014	0.0201	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0295	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0295	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0009	0.0072	0.032
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0295	0.0295
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0597	0.0597
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0597	0.0597
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2253	0.3408
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0894
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.8651
Onchocerca volvulus		0.0014	0.0201	1
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0201	0.0305
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	tyrosine kinase	0.0009	0.0072	0.032
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0009	0.0072	0.032
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0009	0.0072	0.1029
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0295	0.1311
Schistosoma mansoni	hypothetical protein	0.0009	0.0073	0.0322
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.2583
Schistosoma mansoni	formin binding protein and related proteins	0.0009	0.0072	0.032
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein, conserved	0.0009	0.0072	0.1208
Onchocerca volvulus		0.0014	0.0201	1
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.8651
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0072	0.1029
Plasmodium falciparum	hexose transporter	0.0103	0.2253	0.2253
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Brugia malayi	Peripheral plasma membrane protein CASK	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	glucose transporter	0.0014	0.0201	0.0894
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0201	0.6819
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Echinococcus multilocularis	transfer RNA-Ala	0.0009	0.0072	0.032
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Toxoplasma gondii	protein kinase, putative	0.029	0.6612	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	tyrosine kinase	0.0009	0.0072	0.032
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	Tyrosine-protein kinase abl-1	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0009	0.0072	0.032
Echinococcus multilocularis	expressed protein	0.0009	0.0072	0.032
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.2648
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Echinococcus granulosus	nostrin	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.1769
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0009	0.0072	0.032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0911	0.4042
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Schistosoma mansoni	C-fyn	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0009	0.0072	0.1208
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0072	0.032
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	1
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Toxoplasma gondii	exonuclease III APE	0.0018	0.0295	0.0447
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0072	0.032
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0072	0.032
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0009	0.0072	0.032
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0072	0.1029
Schistosoma mansoni	sorbin	0.0009	0.0072	0.032
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.8651
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0295	0.1311
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Onchocerca volvulus		0.0014	0.0201	1
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0552	0.2448
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0894
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0894
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0295	0.1311
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0072	0.032
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0201	0.0201
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0009	0.0072	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0103	0.2253	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0009	0.0072	0.032
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0597	0.0597
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0072	0.032
Trypanosoma brucei	conserved protein	0.0009	0.0072	0.1029
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0295	0.0295
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0552	0.2448
Loa Loa (eye worm)	guanylate kinase	0.0009	0.0072	0.032
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	1
Echinococcus multilocularis	nostrin	0.0009	0.0072	0.032
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	0.4019
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0201	0.2874
Plasmodium vivax	hexose transporter	0.0103	0.2253	0.2253
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0201	0.0894
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0009	0.0072	0.032
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0009	0.0072	0.032
Onchocerca volvulus		0.0014	0.0201	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0072	0.032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0894
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2583
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0009	0.0072	0.032
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.5469
Schistosoma mansoni	tyrosine kinase	0.0009	0.0072	0.032
Onchocerca volvulus		0.0014	0.0201	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0894
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0201	0.0305
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0201	0.2874
Brugia malayi	SH3 domain containing protein	0.0009	0.0072	0.032
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0911	0.4042
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0582	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0009	0.0072	0.032
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0597	0.0597
Schistosoma mansoni	eps8-related protein	0.0009	0.0072	0.032
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0009	0.0072	0.032
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.8651
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0072	0.1029
Echinococcus granulosus	endophilin A3	0.0009	0.0072	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2253	1
Entamoeba histolytica	hypothetical protein	0.0009	0.0072	0.1208
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.2583
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0009	0.0072	0.032
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0009	0.0072	0.032
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0009	0.0072	0.032
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0582	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.2648
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.9752
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0911	0.4042

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.27 uM	Inhibition of GST-tagged PTK6 (unknown origin) assessed as phosphorylated tyrosines after 20 mins by ELISA	ChEMBL.	25205190
IC50 (binding)	= 3.49 uM	Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay	ChEMBL.	25205190

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3335249

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 931587