Detailed information for compound 934271

Basic information

Technical information
  • TDR Targets ID: 934271
  • Name: (2R,3R,4S,5S)-2-[6-(cyclopentylamino)purin-9- yl]-5-(methylsulfanylmethyl)oxolane-3,4-diol
  • MW: 365.451 | Formula: C16H23N5O3S
  • H donors: 3 H acceptors: 5 LogP: 0.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1
  • InChi: 1S/C16H23N5O3S/c1-25-6-10-12(22)13(23)16(24-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-3-5-9/h7-10,12-13,16,22-23H,2-6H2,1H3,(H,17,18,20)/t10-,12-,13-,16-/m1/s1
  • InChiKey: IRSFOARXPSIPGE-XNIJJKJLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5S)-2-[6-(cyclopentylamino)purin-9-yl]-5-(methylsulfanylmethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5S)-2-[6-(cyclopentylamino)-9-purinyl]-5-[(methylthio)methyl]tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5S)-2-[6-(cyclopentylamino)purin-9-yl]-5-[(methylthio)methyl]tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0067 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Schistosoma mansoni neuropeptide receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.005 0.0228
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus granulosus ras GTP exchange factor 0.0006 0.002 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0067 0.0078
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.005 0.0058
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.005 0.0058
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0118 0.1439 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.005 0.0228
Echinococcus granulosus son of sevenless 1 0.0006 0.002 0.0023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0698 0.0816
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0009 0.005 0.0058
Brugia malayi ORL1-like opioid receptor 0.0009 0.005 0.0228
Onchocerca volvulus 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0067 0.0304
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.005 0.0058
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0048 0.0551 0.2619
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0166 0.205 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni neuropeptide receptor 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.005 0.0058
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.005 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0051 0.006
Onchocerca volvulus 0.0009 0.005 0.0228
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.005 0.0058
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.003 0.0035
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.002 0.0023
Schistosoma mansoni amine GPCR 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni cpg binding protein 0.0028 0.0299 0.035
Schistosoma mansoni hypothetical protein 0.0009 0.005 0.0058
Brugia malayi neuropeptide F receptor 0.0009 0.005 0.0228
Trichomonas vaginalis helicase, putative 0.0006 0.0022 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.005 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.005 0.0058
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0051 0.006
Schistosoma mansoni biogenic amine receptor 0.0009 0.005 0.0058
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0067 0.0078
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.005 0.0058
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0166 0.205 0.2396
Schistosoma mansoni amine GPCR 0.0009 0.005 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0033
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0698 0.3238
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0067 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Schistosoma mansoni neuropeptide receptor 0.0009 0.005 0.0058
Brugia malayi steroid hormone receptor 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0234
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5047 0.5899
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni opsin-like receptor 0.0009 0.005 0.0058
Brugia malayi AKH receptor 0.0009 0.005 0.0228
Brugia malayi RasGEF domain containing protein 0.0006 0.002 0.0089
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.005 0.0228
Schistosoma mansoni dep domain containing protein 0.0009 0.0051 0.006
Echinococcus multilocularis serotonin receptor 0.0009 0.005 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0067 0.0304
Brugia malayi GnHR receptor homolog 0.0009 0.005 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0166 0.205 1
Brugia malayi follicle stimulating hormone receptor 0.0009 0.005 0.0228
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus neuropeptide receptor 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0048 0.0551 0.2513
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0067 0.0078
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0067 0.0304
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0051 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0067 0.0304
Brugia malayi CXXC zinc finger family protein 0.0028 0.0299 0.1363
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0067 0.0078
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.005 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0007 0.0008
Brugia malayi G-protein coupled receptor 0.0009 0.005 0.0228
Echinococcus granulosus g protein coupled receptor 0.0009 0.005 0.0058
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.005 0.0058
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.002 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0067 0.0078
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.005 0.0058
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.005 0.0058
Brugia malayi Dopamine receptor protein 1 0.0009 0.005 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5047 0.5899
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.2194 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.005 0.0058
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0067 0.0304
Echinococcus granulosus FTZ F1 alpha 0.001 0.0067 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0067 0.0304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0051 0.006
Echinococcus multilocularis g protein coupled receptor 0.0009 0.005 0.0058
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.005 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.002 0.0089
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0067 0.0304
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.005 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0067 0.0078
Schistosoma mansoni hypothetical protein 0.0401 0.5047 0.5899
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi neuropeptide F receptor 0.0009 0.005 0.0228
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.005 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.005 0.0058
Schistosoma mansoni cpg binding protein 0.003 0.0319 0.0373
Brugia malayi N-terminal motif family protein 0.0006 0.002 0.0089
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0033
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.005 0.0058
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0166 0.205 1
Brugia malayi RE15519p 0.0009 0.005 0.0228
Echinococcus multilocularis allatostatin A receptor 0.0009 0.005 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Onchocerca volvulus 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0067 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.002 0.0023
Echinococcus multilocularis somatostatin receptor 0.0009 0.005 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.8555 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0067 0.0304
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis g protein coupled receptor 0.0009 0.005 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.005 0.0058
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.005 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0051 0.006
Echinococcus granulosus neuropeptide receptor 0.0009 0.005 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0067 0.0304
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0166 0.205 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.005 0.0058
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0166 0.205 1
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0166 0.205 0.9342
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Onchocerca volvulus 0.0009 0.0051 0.0234
Schistosoma mansoni cpg binding protein 0.003 0.0319 0.0373
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0067 0.0078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0067 0.0078
Echinococcus granulosus g protein coupled receptor 0.0009 0.005 0.0058
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0166 0.205 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.002 0.0089
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.005 0.0058
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0067 0.0078
Echinococcus granulosus somatostatin receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0033
Brugia malayi G-protein coupled receptor 0.0009 0.005 0.0228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.005 0.0058
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.002 0.0023
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.005 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.005 0.0058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.005 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.005 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0007 0.0033
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0051 0.0234
Brugia malayi Serotonin receptor 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi larval opioid receptor 0.0009 0.005 0.0228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0048 0.0551 0.0644
Schistosoma mansoni histamine h1 receptor 0.0009 0.005 0.0058
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.005 0.0058
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.005 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0022 0.0011
Echinococcus granulosus serotonin receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0051 0.006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.005 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0022 0.0011
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni biogenic amine receptor 0.0009 0.005 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0009 0.005 0.0058
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis orexin receptor type 2 0.0009 0.005 0.0058
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0791 1 1
Brugia malayi nuclear receptor RXR 0.0005 0.0007 0.0033
Brugia malayi hypothetical protein 0.0005 0.0007 0.0033
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0016 0.0018
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0048 0.0551 0.2619
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0067 0.0304
Brugia malayi Serotonin receptor 0.0009 0.005 0.0228
Echinococcus granulosus cpg binding protein 0.003 0.0319 0.0373
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi hypothetical protein 0.0009 0.0051 0.0234
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0791 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0299 0.1363
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0177 0.2194 1
Brugia malayi Dopamine receptor protein 2 0.0009 0.005 0.0228
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.005 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0698 0.0816
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Echinococcus granulosus g-protein coupled receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus fmrfamide receptor 0.0009 0.005 0.0058
Brugia malayi N-terminal motif family protein 0.0006 0.002 0.0089
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0166 0.205 0.9342
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0166 0.205 1
Brugia malayi Dopamine receptor 0.0009 0.005 0.0228
Schistosoma mansoni coup transcription factor 0.001 0.0067 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0067 0.0304
Schistosoma mansoni thyroid hormone receptor 0.001 0.0067 0.0078
Echinococcus granulosus sex peptide receptor 0.0009 0.005 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0067 0.0078
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.002 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0048 0.0551 0.2513
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0051 0.006
Onchocerca volvulus 0.0009 0.005 0.0228
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0166 0.205 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.005 0.0058
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus g protein coupled receptor 0.0009 0.005 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0304
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0067 0.0304
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.005 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni opsin-like receptor 0.0009 0.005 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.005 0.0058
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.005 0.0228
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.005 0.0228
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Brugia malayi ecdysteroid receptor 0.001 0.0067 0.0304
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0067 0.0078
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.005 0.0228
Echinococcus multilocularis sex peptide receptor 0.0009 0.005 0.0058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0698 0.0816
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0067 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.005 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0234
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0051 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Schistosoma mansoni nuclear hormone receptor 0.001 0.0067 0.0078
Echinococcus granulosus orexin receptor type 2 0.0009 0.005 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.8555 1
Brugia malayi hypothetical protein 0.0009 0.0051 0.0234
Schistosoma mansoni thyroid hormone receptor 0.001 0.0067 0.0078
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.005 0.0228
Schistosoma mansoni dishevelled 0.0009 0.0051 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi RasGEF domain containing protein 0.0006 0.002 0.0089
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.0011
Schistosoma mansoni opsin-like receptor 0.0009 0.005 0.0058
Echinococcus multilocularis cpg binding protein 0.003 0.0319 0.0373
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0051 0.006
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus multilocularis g protein coupled receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0234
Brugia malayi hypothetical protein 0.0005 0.0007 0.0033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.062 0.2844
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0698 0.0816
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0067 0.0078
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.005 0.0058
Brugia malayi nuclear hormone receptor 0.001 0.0067 0.0304
Onchocerca volvulus 0.0006 0.002 0.0089
Echinococcus granulosus Protein son of sevenless 0.0006 0.002 0.0023
Brugia malayi putative neuropeptide receptor 0.0009 0.005 0.0228
Brugia malayi G protein-coupled receptor 0.0009 0.005 0.0228
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.005 0.0058
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0051 0.0234
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.005 0.0058
Schistosoma mansoni amine GPCR 0.0009 0.005 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0067 0.0078
Brugia malayi nuclear receptor NHR-88 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0033
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0166 0.205 0.2396
Echinococcus granulosus allatostatin A receptor 0.0009 0.005 0.0058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.005 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0067 0.0304
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0051 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0067 0.0304
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.0228
Brugia malayi DIX domain containing protein 0.0009 0.0051 0.0234
Echinococcus multilocularis son of sevenless 1 0.0006 0.002 0.0023
Brugia malayi N-terminal motif family protein 0.0177 0.2194 1
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus multilocularis neuropeptide receptor 0.0009 0.005 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0701 0.0819
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.005 0.0058
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.005 0.0058
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0007 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.005 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0166 0.205 0.2396
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0067 0.0304
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.005 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.005 0.0228
Onchocerca volvulus 0.0009 0.005 0.0228
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0051 0.0234
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0007 0.0033
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0048 0.0551 0.0644
Schistosoma mansoni neuropeptide receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.002 0.0089
Schistosoma mansoni hypothetical protein 0.0009 0.005 0.0058
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0051 0.0234
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.005 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.005 0.0058
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.002 0.0023
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.005 0.0058
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0006 0.002 0.0089
Brugia malayi RasGEF domain containing protein 0.0006 0.002 0.0089
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.005 0.0058
Brugia malayi Melatonin receptor type 1A 0.0009 0.005 0.0228
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.005 0.0058
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.005 0.0058
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.005 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0067 0.0304
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.005 0.0228
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.005 0.0228
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0007 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0067 0.0304
Echinococcus granulosus hypothetical protein 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.005 0.0058
Schistosoma mansoni hypothetical protein 0.0009 0.005 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.003 0.0035
Schistosoma mansoni adenoreceptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0166 0.205 1
Onchocerca volvulus 0.0009 0.005 0.0228
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.005 0.0228
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0051 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus neuropeptide s receptor 0.0009 0.005 0.0058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.006
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.005 0.0058
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Schistosoma mansoni amine GPCR 0.0009 0.005 0.0058
Schistosoma mansoni ras GTP exchange factor 0.0006 0.002 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.005 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.005 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0067 0.0304
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.005 0.0228
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0067 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0089
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.005 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.005 0.0058
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0048 0.0551 0.0644
Echinococcus granulosus microtubule associated protein 2 0.0677 0.8555 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0067 0.0304
Onchocerca volvulus 0.0009 0.005 0.0228
Onchocerca volvulus 0.0028 0.0299 0.1363
Schistosoma mansoni amine GPCR 0.0009 0.005 0.0058
Schistosoma mansoni dishevelled 0.0009 0.0051 0.006
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.005 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.0051 0.0234
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0166 0.205 0.5
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0791 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0067 0.0078
Schistosoma mansoni hypothetical protein 0.0009 0.005 0.0058
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.002 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Brugia malayi sulfakinin receptor protein 0.0009 0.005 0.0228
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0048 0.0551 0.2502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0067 0.0078
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Echinococcus multilocularis Protein son of sevenless 0.0006 0.002 0.0023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.005 0.0228
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0051 0.006
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0067 0.0078
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.005 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0022 0.0011
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.005 0.0058
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0067 0.0078
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0048 0.0551 0.0644
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.005 0.0058
Schistosoma mansoni biogenic amine receptor 0.0009 0.005 0.0058
Brugia malayi hypothetical protein 0.0009 0.005 0.0228
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0051 0.006
Onchocerca volvulus 0.0009 0.005 0.0228
Echinococcus multilocularis serotonin receptor 0.0009 0.005 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0067 0.0078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.003 0.0035
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0051 0.006
Echinococcus multilocularis neuropeptide receptor 0.0009 0.005 0.0058
Schistosoma mansoni myosin xvIII 0.0009 0.005 0.0058
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0009 0.005 0.0228
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0067 0.0304
Loa Loa (eye worm) hypothetical protein 0.0006 0.002 0.0089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0067 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0067 0.0304
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.005 0.0058

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 40.2 % Intrinsic activity for maximum stimulation of [35S]-GTP-gammaS, binding to adenosine A1 receptor in rat brain membranes ChEMBL. 9438026
EC50 (functional) = 99 nM Effective concentration for [35S]-GTP-gammaS, binding to adenosine A1 receptor in rat brain membranes ChEMBL. 9438026
Ki (binding) = 59 nM Displacement of [3H]-DPCPX from rat cortical membranes Adenosine A1 receptor ChEMBL. 10212125
Ki (binding) = 59 nM Binding affinity against adenosine A1 receptor using [3H]-DPCPX in rat cortical membranes in the absence of GTP ChEMBL. 9438026
Ki (binding) = 74 nM Binding affinity athuman Adenosine A3 receptor expressed in HEK 293 cells by [125I]-AB-MECA displacement. ChEMBL. 10212125
Ki (binding) = 199 nM Binding affinity against adenosine A1 receptor using [3H]-DPCPX in rat cortical membranes in the presence of GTP. ChEMBL. 9438026
Ki (binding) = 13540 nM Displacement of [3H]-CGS- 21980 from Adenosine A2A receptor of rat striatal membranes ChEMBL. 10212125
Ki (binding) = 13.5 uM Binding affinity against Adenosine A2A receptor using [3H]-CGS- 21680 as the radioligand in rat striatal membranes ChEMBL. 9438026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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