Detailed information for compound 936262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.352 | Formula: C17H12N2O6S
  • H donors: 2 H acceptors: 6 LogP: 2.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1ccc(c2c1cccc2)S(=O)(=O)O
  • InChi: 1S/C17H12N2O6S/c20-17(11-4-3-5-12(10-11)19(21)22)18-15-8-9-16(26(23,24)25)14-7-2-1-6-13(14)15/h1-10H,(H,18,20)(H,23,24,25)
  • InChiKey: NCZLNQBFXROZSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0121 0.2438 1
Loa Loa (eye worm) STAT protein 0.013 0.2671 0.3406
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase Src42A 0.032 0.7771 0.7771
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0767 0.2641
Echinococcus granulosus tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Brugia malayi RhoGAP domain containing protein 0.0136 0.2852 0.3639
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/INSR protein kinase 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0121 0.2438 0.2438
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0767 0.2641
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Schistosoma mansoni shc transforming protein 0.013 0.2671 0.2671
Echinococcus granulosus tyrosine protein kinase csk 0.0072 0.1114 0.1114
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0533 0.0533
Brugia malayi Tensin 0.013 0.2671 0.3406
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Brugia malayi Tyrosine-protein kinase abl-1 0.0287 0.6899 0.8872
Echinococcus multilocularis tyrosine protein kinase pr2 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase pr2 0.0036 0.0166 0.0166
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.032 0.7771 0.7771
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0121 0.2438 0.5129
Echinococcus multilocularis tyrosine protein kinase 0.0036 0.0166 0.0166
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.013 0.2671 0.2671
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0121 0.2438 0.2438
Schistosoma mansoni sorbin 0.0121 0.2438 0.2438
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0199 0.4521 0.4521
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.0494 0.144
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0121 0.2438 1
Echinococcus multilocularis FL cytokine receptor 0.0036 0.0166 0.0166
Echinococcus granulosus receptor type guanylyl cyclase 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus granulosus expressed protein 0.0121 0.2438 0.2438
Brugia malayi SH2 domain containing protein 0.0201 0.4596 0.5895
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0166 0.3649 0.3649
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis insulin receptor 0.0036 0.0166 0.0166
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus multilocularis tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Echinococcus multilocularis SH2 domain containing protein 7 0.013 0.2671 0.2671
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0036 0.0166 0.0166
Loa Loa (eye worm) p53BP2 0.0121 0.2438 0.3105
Brugia malayi Peripheral plasma membrane protein CASK 0.0121 0.2438 0.3105
Echinococcus multilocularis activin receptor type 0.0039 0.0234 0.0234
Brugia malayi C-terminal src kinase protein 1 0.0036 0.0166 0.0167
Entamoeba histolytica protein kinase, putative 0.0069 0.1039 0.2504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0121 0.2438 0.2438
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0085 0.1463 0.1843
Loa Loa (eye worm) TK/RYK protein kinase 0.0036 0.0166 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) SH2 domain-containing protein 0.0165 0.3619 0.4631
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0036 0.0166 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Schistosoma mansoni protein kinase 0.0085 0.1463 0.1463
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine kinase 0.0287 0.6899 0.6899
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0166 0.0166
Onchocerca volvulus 0.013 0.2671 0.5654
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0533 0.1053
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0085 0.1463 0.5706
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Brugia malayi Variant SH3 domain containing protein 0.0251 0.5921 0.7608
Echinococcus multilocularis protein kinase 0.0036 0.0166 0.0166
Entamoeba histolytica protein kinase, putative 0.0046 0.0432 0.0763
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0287 0.6899 0.6899
Echinococcus multilocularis Spectrin alpha actinin 0.0121 0.2438 0.2438
Entamoeba histolytica hypothetical protein 0.0123 0.25 0.67
Trichomonas vaginalis STE family protein kinase 0.0085 0.1463 0.5706
Schistosoma mansoni tyrosine kinase 0.0166 0.3649 0.3649
Schistosoma mansoni signal transduction protein lnk-related 0.013 0.2671 0.2671
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0533 0.0533
Echinococcus multilocularis growth factor receptor bound protein 2 0.0251 0.5921 0.5921
Loa Loa (eye worm) TK protein kinase 0.0199 0.4521 0.5798
Loa Loa (eye worm) protein-tyrosine phosphatase 0.013 0.2671 0.3406
Schistosoma mansoni hypothetical protein 0.0121 0.2438 0.2438
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis transfer RNA-Thr 0.0036 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.3416 0.3416
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Onchocerca volvulus 0.0121 0.2438 0.5129
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0162 0.3543 0.3543
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0533 0.1053
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1217 0.1217
Trichomonas vaginalis STE family protein kinase 0.0085 0.1463 0.5706
Echinococcus granulosus suppressor of cytokine signaling 6 0.013 0.2671 0.2671
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Onchocerca volvulus 0.0201 0.4596 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus natriuretic peptide receptor 1 0.0036 0.0166 0.0166
Schistosoma mansoni tensin 0.013 0.2671 0.2671
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.013 0.2671 0.2671
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Plasmodium vivax protein kinase Crk2 0.005 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0465 0.0553
Brugia malayi Variant SH3 domain containing protein 0.0136 0.2852 0.3639
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0123 0.25 0.25
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0039 0.0234 0.1126
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis tyrosine protein kinase shark 0.0403 1 1
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0046 0.0432 0.051
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus granulosus ephrin type A receptor 4 A 0.0036 0.0166 0.0166
Echinococcus granulosus insulin receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis SHC transforming protein 3 0.013 0.2671 0.2671
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0121 0.2438 0.2438
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0121 0.2438 0.2438
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.032 0.7771 0.7771
Echinococcus granulosus RNA directed DNA polymerase 0.0044 0.0368 0.0368
Echinococcus granulosus SH2 domain containing protein 7 0.013 0.2671 0.2671
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0136 0.2852 0.2852
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0767 0.0767
Loa Loa (eye worm) TK/ALK protein kinase 0.0036 0.0166 0.0167
Brugia malayi Src substrate cortactin 0.0121 0.2438 0.3105
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.032 0.7771 0.7771
Trichomonas vaginalis p67phox protein, putative 0.0121 0.2438 1
Trypanosoma brucei protein kinase, putative 0.0059 0.0767 0.2641
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0767 0.2641
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Entamoeba histolytica hypothetical protein, conserved 0.0121 0.2438 0.6524
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0166 0.3649 0.467
Schistosoma mansoni tyrosine protein kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Giardia lamblia Kinase, STE STE20 0.0085 0.1463 1
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0132 0.2739 0.7386
Echinococcus multilocularis endophilin A3 0.0121 0.2438 0.2438
Brugia malayi Protein kinase domain containing protein 0.0166 0.3649 0.467
Echinococcus multilocularis SH2 domain containing adapter protein F 0.013 0.2671 0.2671
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Echinococcus multilocularis nostrin 0.0121 0.2438 0.2438
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0121 0.2438 0.2438
Schistosoma mansoni growth factor receptor-bound protein 0.0251 0.5921 0.5921
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0036 0.0166 0.0167
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0767 0.4629
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0136 0.2852 0.2852
Echinococcus granulosus fibroblast growth factor receptor 4 0.0036 0.0166 0.0166
Brugia malayi Protein kinase c protein 2 0.0055 0.0654 0.0797
Schistosoma mansoni hypothetical protein 0.0036 0.0166 0.0166
Schistosoma mansoni C-fyn 0.0121 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0251 0.5921 0.7608
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0048 0.0473 0.0563
Brugia malayi Spectrin alpha chain 0.0121 0.2438 0.3105
Echinococcus multilocularis tyrosine protein kinase Fgr 0.032 0.7771 0.7771
Schistosoma mansoni protein tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0123 0.25 0.25
Loa Loa (eye worm) SH2 domain-containing protein 0.013 0.2671 0.3406
Brugia malayi MAP kinase sur-1 0.0059 0.0767 0.0943
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0121 0.2438 1
Trichomonas vaginalis STE family protein kinase 0.0085 0.1463 0.5706
Schistosoma mansoni tyrosine-protein kinase zap-70 0.013 0.2671 0.2671
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0121 0.2438 0.2438
Entamoeba histolytica protein kinase, putative 0.0121 0.2438 0.6524
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/EPH protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) SRC-1 0.032 0.7771 1
Echinococcus granulosus SHC transforming protein 3 0.013 0.2671 0.2671
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0533 0.0533
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.0051 0.0549 0.0661
Loa Loa (eye worm) protein-tyrosine kinase 0.0121 0.2438 0.3105
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0166 0.0166
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0036 0.0166 0.0166
Brugia malayi Variant SH3 domain containing protein 0.0133 0.277 0.3534
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0767 0.2641
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.013 0.2671 0.2671
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0533 0.0533
Echinococcus multilocularis activated cdc42 kinase 1 0.0036 0.0166 0.0166
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine kinase 0.0166 0.3649 0.3649
Schistosoma mansoni dynamin-associated protein 0.0121 0.2438 0.2438
Echinococcus granulosus SH2 domain containing adapter protein F 0.013 0.2671 0.2671
Brugia malayi protein-tyrosine kinase 0.0121 0.2438 0.3105
Schistosoma mansoni tyrosine kinase 0.032 0.7771 0.7771
Echinococcus multilocularis integrin linked protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus SH2 motif 0.013 0.2671 0.2671
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.013 0.2671 0.5654
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Brugia malayi hypothetical protein 0.013 0.2671 0.3406
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Loa Loa (eye worm) protein kinase domain-containing protein 0.0036 0.0166 0.0167
Plasmodium falciparum protein kinase 5 0.005 0.0533 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus multilocularis tyrosine protein kinase csk 0.0072 0.1114 0.1114
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0036 0.0166 0.0167
Schistosoma mansoni formin binding protein and related proteins 0.0121 0.2438 0.2438
Echinococcus multilocularis 0.013 0.2671 0.2671
Echinococcus multilocularis tyrosine protein kinase Blk 0.0199 0.4521 0.4521
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0036 0.0166 0.0166
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0166 0.0166
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0121 0.2438 0.3105
Brugia malayi SRC-1 0.032 0.7771 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase HCK 0.0069 0.1039 0.1039
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0533 0.1613
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0085 0.1463 0.1843
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0767 0.2641
Schistosoma mansoni sorting nexin 0.0121 0.2438 0.2438
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus granulosus integrin linked protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus Protein kinase C brain isozyme 0.0076 0.1217 0.1217
Schistosoma mansoni tyrosine kinase 0.032 0.7771 0.7771
Onchocerca volvulus 0.0121 0.2438 0.5129
Onchocerca volvulus 0.0121 0.2438 0.5129
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus granulosus dual specificity mitogen activated protein 0.0085 0.1463 0.1463
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0036 0.0166 0.0167
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0251 0.5921 0.5921
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0121 0.2438 0.2438
Onchocerca volvulus 0.0166 0.3649 0.7861
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0038 0.0038
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Echinococcus granulosus tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Schistosoma mansoni growth factor receptor-bound protein 0.0251 0.5921 0.5921
Brugia malayi tRNA modification GTPase TrmE family protein 0.013 0.2671 0.3406
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0166 0.0167
Echinococcus granulosus intersectin 2 0.0122 0.2476 0.2476
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0166 0.3649 0.3649
Brugia malayi ephrin receptor 1 precursor 0.0036 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Loa Loa (eye worm) hypothetical protein 0.0166 0.3649 0.467
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.013 0.2671 0.2671
Brugia malayi protein-tyrosine kinase 0.0199 0.4521 0.5798
Brugia malayi SH3 domain containing protein 0.0121 0.2438 0.3105
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0533 0.1613
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Schistosoma mansoni tensin-related 0.013 0.2671 0.2671
Brugia malayi hypothetical protein 0.0036 0.0166 0.0167
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0234 0.0297
Echinococcus multilocularis SH2 motif 0.013 0.2671 0.2671
Schistosoma mansoni tensin-related 0.013 0.2671 0.2671
Schistosoma mansoni tyrosine kinase 0.0322 0.7846 0.7846
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0166 0.0167
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0166 0.3649 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0533 0.0641
Schistosoma mansoni cell polarity protein 0.0121 0.2438 0.2438
Schistosoma mansoni eps8-related protein 0.0121 0.2438 0.2438
Brugia malayi p70 ribosomal S6 kinase beta 0.0046 0.0432 0.051
Brugia malayi hypothetical protein 0.0036 0.0166 0.0167
Brugia malayi cytokine inducible SH2-containing protein 5 0.013 0.2671 0.3406
Echinococcus multilocularis natriuretic peptide receptor 1 0.0036 0.0166 0.0166
Schistosoma mansoni ephrin receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis suppressor of cytokine signaling 7 0.013 0.2671 0.2671
Echinococcus granulosus kinase suppressor of Ras 1 0.0036 0.0166 0.0166
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus multilocularis tyrosine protein kinase Abl 0.0287 0.6899 0.6899
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.013 0.2671 0.2671
Echinococcus multilocularis suppressor of cytokine signaling 7 0.013 0.2671 0.2671
Brugia malayi bone morphogenetic protein type 1 receptor 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/ABL protein kinase 0.0166 0.3649 0.467
Entamoeba histolytica unconventional myosin IB 0.0121 0.2438 0.6524
Brugia malayi Furin-like cysteine rich region family protein 0.0036 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Onchocerca volvulus 0.013 0.2671 0.5654
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Giardia lamblia Kinase, CMGC CDK 0.005 0.0533 0.2827
Echinococcus multilocularis RNA directed DNA polymerase 0.0044 0.0368 0.0368
Schistosoma mansoni apoptosis stimulating of P53 0.0121 0.2438 0.2438
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0136 0.2852 0.2852
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0044 0.0368 0.0428
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Entamoeba histolytica BAR/SH3 domain containing protein 0.0121 0.2438 0.6524
Onchocerca volvulus 0.0166 0.3649 0.7861
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Echinococcus granulosus src region 0.0121 0.2438 0.2438
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Onchocerca volvulus 0.0121 0.2438 0.5129
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0121 0.2438 0.2438
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.1217 0.1217
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0121 0.2438 0.3105
Brugia malayi Protein-tyrosine phosphatase containing protein 0.013 0.2671 0.3406
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.0494 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.2438 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Echinococcus granulosus protein kinase C gamma type 0.0069 0.1036 0.1036
Echinococcus multilocularis protein KINase family member (kin 25) 0.0036 0.0166 0.0166
Echinococcus granulosus NCK adaptor protein 0.0251 0.5921 0.5921
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0533 0.0533
Echinococcus granulosus tyrosine protein kinase ABL1 0.0166 0.3649 0.3649
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Brugia malayi cell division control protein 2 homolog 0.005 0.0533 0.0641
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK/DDR protein kinase 0.0036 0.0166 0.0167
Echinococcus granulosus signal transduction protein lnk realted 0.013 0.2671 0.2671
Echinococcus multilocularis signal transduction protein lnk realted 0.013 0.2671 0.2671
Onchocerca volvulus 0.013 0.2671 0.5654
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus granulosus tyrosine protein kinase Src42A 0.032 0.7771 0.7771
Echinococcus multilocularis N chimaerin 0.0136 0.2852 0.2852
Echinococcus granulosus tyrosine kinase 0.0166 0.3649 0.3649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0533 0.6108
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0166 0.0166
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0039 0.0234 0.0234
Brugia malayi Protein kinase domain containing protein 0.0166 0.3649 0.467
Echinococcus granulosus tyrosine protein kinase Src42A 0.0162 0.3543 0.3543
Loa Loa (eye worm) TK/CSK protein kinase 0.0072 0.1114 0.1392
Echinococcus multilocularis protein tyrosine kinase 0.0036 0.0166 0.0166
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Echinococcus granulosus hypothetical protein 0.013 0.2671 0.2671
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0121 0.2438 0.2438
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Echinococcus granulosus protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.013 0.2671 0.2671
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0767 0.2641
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0036 0.0166 0.0166
Echinococcus granulosus expressed conserved protein 0.013 0.2671 0.2671
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0234 0.0297
Echinococcus granulosus tyrosine protein kinase HCK 0.0069 0.1039 0.1039
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0036 0.0166 0.0167
Brugia malayi STAT protein, DNA binding domain containing protein 0.013 0.2671 0.3406
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Loa Loa (eye worm) SH2 domain-containing protein 0.013 0.2671 0.3406
Loa Loa (eye worm) TK/EGFR protein kinase 0.0036 0.0166 0.0167
Onchocerca volvulus 0.0166 0.3649 0.7861
Echinococcus granulosus activin receptor type 0.0039 0.0234 0.0234
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0121 0.2438 0.2438
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus Spectrin alpha actinin 0.0121 0.2438 0.2438
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0767 0.0767
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.013 0.2671 0.2671
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.2438 1
Schistosoma mansoni hypothetical protein 0.013 0.2671 0.2671
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0533 0.1613
Entamoeba histolytica protein kinase, putative 0.0049 0.0494 0.0939
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0533 0.1613
Giardia lamblia Kinase, CMGC CDK 0.005 0.0533 0.2827
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Brugia malayi Variant SH3 domain containing protein 0.0251 0.5921 0.7608
Echinococcus granulosus N chimaerin 0.0136 0.2852 0.2852
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0533 0.1613
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0767 0.0943
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Schistosoma mansoni suppressor of cytokine signaling 0.013 0.2671 0.2671
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0533 0.0641
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0085 0.1463 0.5706
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Echinococcus granulosus suppressor of cytokine signaling 7 0.013 0.2671 0.2671
Brugia malayi Receptor family ligand binding region containing protein 0.0036 0.0166 0.0167
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0533 0.0533
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0533 0.0641
Schistosoma mansoni GTPase activating protein 0.013 0.2671 0.2671
Echinococcus granulosus tyrosine protein kinase 0.0036 0.0166 0.0166
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Schistosoma mansoni protein kinase 0.0039 0.0234 0.0234
Echinococcus multilocularis heat shock protein 70 0.0036 0.0166 0.0166
Onchocerca volvulus Putative cortactin 0.0121 0.2438 0.5129
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus c src tyrosine kinase 0.0322 0.7846 0.7846
Echinococcus multilocularis tyrosine protein kinase csk 0.0072 0.1114 0.1114
Schistosoma mansoni protein kinase 0.0039 0.0234 0.0234
Echinococcus multilocularis tensin 0.013 0.2671 0.2671
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase Srms 0.0166 0.3649 0.3649
Entamoeba histolytica SH2 domain containing protein 0.013 0.2671 0.7192
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0533 0.1613
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0533 0.1613
Onchocerca volvulus 0.0124 0.2506 0.5281
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.032 0.7771 0.7771
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0166 0.0167
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Schistosoma mansoni tyrosine kinase 0.0273 0.6517 0.6517
Brugia malayi hypothetical protein 0.0166 0.3649 0.467
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0767 0.0767
Brugia malayi SH2 domain containing protein 0.0166 0.3649 0.467
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0287 0.6899 0.6899
Echinococcus granulosus tensin 0.013 0.2671 0.2671
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0123 0.25 0.25
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0136 0.2852 0.3639
Echinococcus multilocularis tyrosine protein kinase csk 0.0072 0.1114 0.1114
Echinococcus granulosus tensin C1 domain containing phosphatase 0.013 0.2671 0.2671
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Onchocerca volvulus 0.013 0.2671 0.5654
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0036 0.0166 0.0167
Entamoeba histolytica hypothetical protein, conserved 0.0121 0.2438 0.6524
Echinococcus multilocularis kinase suppressor of Ras 1 0.0036 0.0166 0.0166
Schistosoma mansoni adapter molecule crk 0.0251 0.5921 0.5921
Echinococcus granulosus endophilin A3 0.0121 0.2438 0.2438
Echinococcus multilocularis tyrosine protein kinase Srms 0.0199 0.4521 0.4521
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase csk 0.0072 0.1114 0.1114
Brugia malayi Sex muscle abnormal protein 5 0.0251 0.5921 0.7608
Brugia malayi Myosin tail family protein 0.0121 0.2438 0.3105
Brugia malayi Guanylate kinase family protein 0.0121 0.2438 0.3105
Echinococcus granulosus tyrosine protein kinase csk 0.0072 0.1114 0.1114
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0166 0.0167
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0199 0.4521 0.4521
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0533 0.0533
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.013 0.2671 0.3406
Toxoplasma gondii AGC kinase 0.0046 0.0432 0.443
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0166 0.3649 0.3649
Echinococcus multilocularis transfer RNA-Ala 0.0121 0.2438 0.2438
Schistosoma mansoni vav2 0.0139 0.2913 0.2913
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Entamoeba histolytica protein kinase, putative 0.0132 0.2739 0.7386
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Entamoeba histolytica BAR/SH3 domain containing protein 0.0121 0.2438 0.6524
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0044 0.0368 0.0368
Echinococcus multilocularis dual specificity mitogen activated protein 0.0085 0.1463 0.1463
Echinococcus granulosus fch and double sh3 domains protein 2 0.0121 0.2438 0.2438
Brugia malayi Fes/CIP4 homology domain containing protein 0.0121 0.2438 0.3105
Plasmodium falciparum protein kinase, putative 0.0039 0.0234 0.1843
Schistosoma mansoni serine/threonine RGC 0.0036 0.0166 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0767 0.2641
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.032 0.7771 0.7771
Echinococcus granulosus protein tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis intersectin 2 0.0122 0.2476 0.2476
Echinococcus granulosus growth factor receptor bound protein 2 0.0251 0.5921 0.5921
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0121 0.2438 0.2438
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis suppressor of cytokine signaling 6 0.013 0.2671 0.2671
Trypanosoma brucei conserved protein 0.0121 0.2438 1
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.005 0.0533 0.0641
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis raf serine:threonine protein kinase 0.0043 0.0347 0.0347
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0533 0.1613
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0533 0.0533
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0287 0.6899 0.6899
Echinococcus granulosus raf serine:threonine protein kinase 0.0043 0.0347 0.0347
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase csk 0.0072 0.1114 0.1114
Loa Loa (eye worm) hypothetical protein 0.0132 0.2733 0.3485
Echinococcus granulosus tyrosine protein kinase Src64B 0.032 0.7771 0.7771
Echinococcus multilocularis ephrin type A receptor 4 A 0.0036 0.0166 0.0166
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0251 0.5921 0.7608
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0121 0.2438 0.2438
Schistosoma mansoni Dab2-interacting protein-like 0.0121 0.2438 0.2438
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0076 0.1217 0.1217
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0533 0.1613
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0136 0.2852 0.2852
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0133 0.277 0.3534
Loa Loa (eye worm) TK/FAK protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Echinococcus multilocularis tensin 0.013 0.2671 0.2671
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0767 0.0767
Trypanosoma brucei protein kinase, putative 0.0039 0.0234 0.0297
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) TK protein kinase 0.0069 0.1039 0.1294
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Brugia malayi integrin-linked kinase 0.0036 0.0166 0.0167
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0767 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Brugia malayi Protein kinase domain containing protein 0.0166 0.3649 0.467
Brugia malayi Protein kinase domain containing protein 0.0049 0.0494 0.059
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0166 0.0166
Onchocerca volvulus 0.013 0.2671 0.5654
Schistosoma mansoni tyrosine kinase 0.0403 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0767 0.2641
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.013 0.2671 0.2671
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0234 0.0297
Echinococcus multilocularis serine threonine protein kinase 0.0069 0.1036 0.1036
Echinococcus multilocularis c src tyrosine kinase 0.0322 0.7846 0.7846
Echinococcus granulosus tyrosine kinase 0.0199 0.4521 0.4521
Loa Loa (eye worm) guanylate kinase 0.0121 0.2438 0.3105
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0039 0.0234 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Echinococcus granulosus tyrosine protein kinase Lyn 0.0322 0.7839 0.7839
Loa Loa (eye worm) TK protein kinase 0.0036 0.0166 0.0167
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase Src64B 0.032 0.7771 0.7771
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0166 0.0167
Onchocerca volvulus 0.0166 0.3649 0.7861
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0767 0.2641
Brugia malayi SH2 domain containing protein 0.013 0.2671 0.3406
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0251 0.5921 0.7608
Echinococcus multilocularis receptor type guanylyl cyclase 0.0036 0.0166 0.0166
Loa Loa (eye worm) thyroid receptor interactor 0.0121 0.2438 0.3105
Entamoeba histolytica protein kinase, putative 0.0049 0.0494 0.0939
Schistosoma mansoni suppressor of cytokine signaling 0.013 0.2671 0.2671
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Schistosoma mansoni nck2/grb4 0.0251 0.5921 0.5921
Echinococcus granulosus epidermal growth factor receptor kinase 0.0121 0.2438 0.2438
Brugia malayi Raf kinase 0.0036 0.0166 0.0167
Schistosoma mansoni protein kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK/FER protein kinase 0.0166 0.3649 0.467
Loa Loa (eye worm) hypothetical protein 0.0121 0.2438 0.3105
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0494 0.144
Leishmania major protein kinase, putative 0.0039 0.0234 0.0297
Entamoeba histolytica protein kinase domain containing protein 0.0039 0.0234 0.0194
Schistosoma mansoni dreadlocks/dock 0.0121 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Brugia malayi Tyrosine-protein kinase PR2 0.0036 0.0166 0.0167
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0167
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0036 0.0166 0.0166
Brugia malayi Guanylyl cyclase protein 23 0.0036 0.0166 0.0167
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0767 0.2641
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0166 0.0166
Onchocerca volvulus 0.013 0.2671 0.5654
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0036 0.0166 0.0167
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0121 0.2438 0.2438
Schistosoma mansoni tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis SH2 motif 0.013 0.2671 0.2671
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0166 0.0166
Entamoeba histolytica hypothetical protein 0.0121 0.2438 0.6524
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0533 0.1613
Loa Loa (eye worm) serine/threonine protein kinase 0.0036 0.0166 0.0167
Echinococcus multilocularis NCK adaptor protein 0.0251 0.5921 0.5921
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0036 0.0166 0.0166
Brugia malayi Variant SH3 domain containing protein 0.0121 0.2438 0.3105
Brugia malayi Protein kinase domain containing protein 0.0166 0.3649 0.467
Echinococcus multilocularis tyrosine kinase 0.0036 0.0166 0.0166
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0166 0.0166
Loa Loa (eye worm) TK/Met protein kinase 0.0036 0.0166 0.0167
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0036 0.0166 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.2438 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0166 0.0166
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis protein kinase 0.0036 0.0166 0.0166
Onchocerca volvulus 0.0166 0.3649 0.7861
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2438 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0036 0.0166 0.0166
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0533 0.1613
Loa Loa (eye worm) TK/ACK protein kinase 0.0036 0.0166 0.0167
Brugia malayi Protein kinase domain containing protein 0.0036 0.0166 0.0167
Schistosoma mansoni protein kinase 0.0039 0.0234 0.0234
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.013 0.2671 0.5654
Echinococcus granulosus cyclin dependent kinase 0.005 0.0533 0.0533
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0036 0.0166 0.0166
Echinococcus granulosus tyrosine protein kinase Blk 0.0199 0.4521 0.4521
Echinococcus multilocularis SH2 motif 0.013 0.2671 0.2671
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0166 0.0166
Echinococcus multilocularis tyrosine protein kinase Fyn 0.032 0.7771 0.7771
Schistosoma mansoni ephrin receptor 0.0036 0.0166 0.0166
Schistosoma mansoni tensin 0.013 0.2671 0.2671
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0036 0.0166 0.0166
Echinococcus granulosus SH2 motif 0.013 0.2671 0.2671
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0166 0.0166
Schistosoma mansoni tensin 0.013 0.2671 0.2671
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0085 0.1463 0.5706
Echinococcus granulosus nostrin 0.0121 0.2438 0.2438
Schistosoma mansoni run and tbc1 domain containing 0.0121 0.2438 0.2438
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0767 0.2641
Echinococcus multilocularis expressed protein 0.0121 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.013 0.2671 0.3406
Schistosoma mansoni SH2A 0.013 0.2671 0.2671

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 10 % Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells at 100 uM using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay ChEMBL. 25275824
Inhibition (binding) = 23 % Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells at 100 uM using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay ChEMBL. 25275824
Inhibition (binding) = 29 % Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells at 100 uM using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide by fluorescence assay ChEMBL. 25275824

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.