Detailed information for compound 938699

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.417 | Formula: C20H26O5
  • H donors: 0 H acceptors: 1 LogP: 4.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(O[C@@H]1O[C@@]2(C)CC[C@@H]3[C@]1(CCC[C@H]3C)OO2)Cc1ccccc1
  • InChi: 1S/C20H26O5/c1-14-7-6-11-20-16(14)10-12-19(2,24-25-20)23-18(20)22-17(21)13-15-8-4-3-5-9-15/h3-5,8-9,14,16,18H,6-7,10-13H2,1-2H3/t14-,16+,18-,19-,20+/m1/s1
  • InChiKey: MJJUSKUKYJUPQQ-OKKMPTANSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0038 0.0143 0.1047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0226 0.0226
Entamoeba histolytica diacylglycerol kinase, putative 0.0051 0.024 0.0215
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0492 0.369 0.369
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0175 0.0175
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.003 0.003
Schistosoma mansoni cpg binding protein 0.0092 0.056 0.056
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.026 0.026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.2596 0.7036
Loa Loa (eye worm) hypothetical protein 0.0216 0.1532 0.1532
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0051 0.0242 0.0322
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0511 0.0511
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0463 0.0463
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0091 0.2777
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0715 0.0715
Echinococcus granulosus phd:f box containing protein 0.0053 0.026 0.026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0522 0.0522
Mycobacterium ulcerans diacylglycerol kinase 0.0051 0.024 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0181
Schistosoma mansoni survival motor neuron protein 0.01 0.0628 0.0628
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.1146 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.034 0.0199
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0749 0.0614
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0166 0.0166
Schistosoma mansoni intermediate filament proteins 0.0085 0.0511 0.0511
Schistosoma mansoni diacylglycerol kinase theta 0.0051 0.024 0.024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0749 0.0614
Trichomonas vaginalis sphingosine kinase, putative 0.0051 0.024 0.0318
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.003 0.003
Schistosoma mansoni cathepsin D (A01 family) 0.015 0.1018 0.1018
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0091 0.0581
Onchocerca volvulus 0.0063 0.034 0.0924
Schistosoma mansoni cpg binding protein 0.0092 0.056 0.056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0226 0.0226
Trichomonas vaginalis set domain proteins, putative 0.049 0.3673 0.5421
Trichomonas vaginalis bmru protein, putative 0.0051 0.024 0.0318
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0051 0.0242 0.0242
Echinococcus multilocularis lamin dm0 0.0085 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0111 0.0715 0.0715
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0053 0.026 0.2093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.034 0.034
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0071 0.0071
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0201 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.024 0.9131
Schistosoma mansoni hypothetical protein 0.0111 0.0715 0.0715
Plasmodium falciparum phd finger protein, putative 0.0117 0.0758 1
Giardia lamblia PHD finger protein 15 0.0117 0.0758 0.1089
Plasmodium vivax JmjC domain containing protein 0.0053 0.026 0.32
Entamoeba histolytica diacylglycerol kinase, putative 0.0051 0.024 0.0215
Brugia malayi PHD-finger family protein 0.0043 0.0181 0.0492
Echinococcus granulosus snurportin 1 0.0337 0.2477 0.2477
Trichomonas vaginalis diacylglycerol kinase, putative 0.0051 0.024 0.0318
Loa Loa (eye worm) fli-1 protein 0.0241 0.1724 0.1724
Brugia malayi Diacylglycerol kinase protein 2 0.0051 0.024 0.0649
Echinococcus granulosus sodium channel protein 0.0042 0.0171 0.0171
Schistosoma mansoni cathepsin D (A01 family) 0.015 0.1018 0.1018
Brugia malayi jmjC domain containing protein 0.0053 0.026 0.0705
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0758 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0201 0.0058
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0051 0.024 0.9131
Mycobacterium tuberculosis Probable reductase 0.0104 0.0658 0.0522
Schistosoma mansoni hypothetical protein 0.0241 0.1725 0.1725
Echinococcus granulosus jumonji domain containing protein 0.0163 0.1116 0.1116
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1711 0.1711
Onchocerca volvulus Huntingtin homolog 0.0123 0.0802 0.2184
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0044 0.0788
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.034 0.0199
Leishmania major sphingosine kinase A, B, putative 0.0051 0.024 0.6805
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0144 0.1615
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.034 0.034
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0044 0.0184 0.2165
Brugia malayi Thioredoxin reductase 0.0046 0.0201 0.0545
Trypanosoma cruzi diacylglycerol kinase, putative 0.0051 0.024 0.9131
Plasmodium falciparum diacylglycerol kinase, putative 0.0051 0.024 0.2922
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0051 0.024 0.0318
Brugia malayi jmjC domain containing protein 0.0053 0.026 0.0705
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0715 0.0715
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.0715 0.0715
Echinococcus multilocularis PHD finger protein rhinoceros 0.0117 0.0758 0.0758
Schistosoma mansoni hypothetical protein 0.0051 0.024 0.024
Leishmania major hypothetical protein, conserved 0.0051 0.024 0.6805
Loa Loa (eye worm) hypothetical protein 0.13 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0154 0.0154
Loa Loa (eye worm) PHD-finger family protein 0.0117 0.0758 0.0758
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0143 0.5001
Brugia malayi Pre-SET motif family protein 0.0063 0.034 0.092
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0166 0.0166
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0144 0.0144
Echinococcus multilocularis snurportin 1 0.0337 0.2477 0.2477
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0069
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0144 0.039
Loa Loa (eye worm) diacylglycerol kinase 2 0.0051 0.024 0.024
Echinococcus granulosus cpg binding protein 0.0092 0.056 0.056
Schistosoma mansoni ap endonuclease 0.0038 0.0144 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0226 0.0226
Schistosoma mansoni ets-related 0.0241 0.1724 0.1724
Leishmania major hypothetical protein, conserved 0.0053 0.026 0.7453
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.026 0.026
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0299 0.0299
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0432 0.322 0.3121
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0038 0.0143 0.5001
Brugia malayi Pre-SET motif family protein 0.0431 0.321 0.8701
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0628 0.1703
Loa Loa (eye worm) hypothetical protein 0.0051 0.024 0.024
Toxoplasma gondii PHD-finger domain-containing protein 0.0038 0.0143 0.1047
Leishmania major hypothetical protein, conserved 0.0051 0.024 0.6805
Echinococcus granulosus Diacylglycerol kinase zeta 0.0051 0.024 0.024
Plasmodium falciparum plasmepsin VI 0.0051 0.0242 0.2958
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.1299 0.1299
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0051 0.024 0.0318
Echinococcus multilocularis geminin 0.0349 0.2569 0.2569
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0091 0.2777
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1711 0.1711
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0441 0.3291 0.3291
Echinococcus multilocularis ceramide kinase 0.0051 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0241 0.1725 0.1725
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0299 0.0299
Echinococcus granulosus intermediate filament protein 0.0085 0.0511 0.0511
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.0171 0.0171
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0051 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0111 0.0715 0.0715
Loa Loa (eye worm) ceramide kinase 0.0051 0.024 0.024
Plasmodium vivax plasmepsin IV, putative 0.0051 0.0242 0.2958
Echinococcus multilocularis GPCR, family 2 0.0111 0.0715 0.0715
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0201 0.0201
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0184 0.2165
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.034 0.034
Schistosoma mansoni sphingosine kinase A B 0.13 1 1
Onchocerca volvulus 0.0085 0.0511 0.1391
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.321 0.321
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0053 0.026 0.026
Echinococcus multilocularis JmjC domain containing protein 4 0.0053 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0166 0.0166
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0201 0.2396
Loa Loa (eye worm) jmjC domain-containing protein 0.0053 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0349 0.2569 0.2569
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0044 0.0027
Schistosoma mansoni lamin 0.0085 0.0511 0.0511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0226 0.0226
Brugia malayi diacylglycerol kinase 0.0051 0.024 0.0649
Echinococcus multilocularis lamin 0.0085 0.0511 0.0511
Mycobacterium ulcerans hypothetical protein 0.13 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.024 0.0318
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0226 0.0226
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0091 0.0091
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0051 0.024 0.024
Onchocerca volvulus Ceramide kinase 1 homolog 0.0051 0.024 0.0652
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0884 0.6754 0.6746
Plasmodium vivax importin-beta 2, putative 0.0032 0.0091 0.0889
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0044 0.0027
Echinococcus multilocularis survival motor neuron protein 1 0.0492 0.369 0.369
Mycobacterium tuberculosis Diacylglycerol kinase 0.0051 0.024 0.0097
Schistosoma mansoni hypothetical protein 0.0349 0.2569 0.2569
Brugia malayi Importin beta-1 subunit 0.0032 0.0091 0.0246
Schistosoma mansoni hypothetical protein 0.1235 0.9497 0.9497
Echinococcus granulosus PHD finger protein rhinoceros 0.0117 0.0758 0.0758
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0201 0.0546
Entamoeba histolytica hypothetical protein, conserved 0.13 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0884 0.6754 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0144 0.3761
Brugia malayi hypothetical protein 0.0492 0.369 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0051 0.024 0.0215
Echinococcus granulosus jumonji domain containing 1A 0.0053 0.026 0.026
Plasmodium falciparum glutathione reductase 0.0046 0.0201 0.2396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.034 0.0199
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.026
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0149 0.0149
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0144 0.0176
Echinococcus granulosus peregrin 0.0117 0.0758 0.0758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0226 0.0226
Toxoplasma gondii diacylglycerol kinase, putative 0.0051 0.024 0.1911
Entamoeba histolytica hypothetical protein 0.0026 0.0044 0.0019
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Trichomonas vaginalis sphingosine kinase, putative 0.0051 0.024 0.0318
Brugia malayi jmjC domain containing protein 0.0441 0.3291 0.892
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0053 0.026 0.2093
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0144 0.0119
Echinococcus multilocularis cpg binding protein 0.0092 0.056 0.056
Brugia malayi jmjC domain containing protein 0.0205 0.1442 0.391
Loa Loa (eye worm) hypothetical protein 0.0051 0.0242 0.0242
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0307 0.0307
Plasmodium falciparum thioredoxin reductase 0.0046 0.0201 0.2396
Echinococcus multilocularis peregrin 0.0117 0.0758 0.0758
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.034 0.2803
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0053 0.026 1
Brugia malayi Fli-1 protein 0.0241 0.1724 0.4674
Toxoplasma gondii PHD-finger domain-containing protein 0.0117 0.0758 0.6539
Plasmodium falciparum importin beta, putative 0.0032 0.0091 0.0889
Mycobacterium tuberculosis Conserved protein 0.13 1 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0201 0.0201
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0144 0.0144
Schistosoma mansoni diacylglycerol kinase theta 0.0051 0.024 0.024
Echinococcus granulosus survival motor neuron protein 1 0.0492 0.369 0.369
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0051 0.024 0.9131
Schistosoma mansoni ran 0.0023 0.0026 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0201 0.0201
Brugia malayi Ceramide kinase 0.0051 0.024 0.0649
Echinococcus multilocularis lysine specific demethylase 6a 0.0053 0.026 0.026
Plasmodium falciparum diacylglycerol kinase, putative 0.0051 0.024 0.2922
Leishmania major diacylglycerol kinase-like protein 0.0051 0.024 0.6805
Loa Loa (eye worm) hypothetical protein 0.004 0.0154 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0226 0.0226
Trypanosoma brucei diacylglycerol kinase, putative 0.0051 0.024 0.9131
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0051 0.024 0.1911
Brugia malayi AF-10 protein 0.0038 0.0143 0.0387
Plasmodium vivax glutathione reductase, putative 0.0046 0.0201 0.2396
Trichomonas vaginalis bmru protein, putative 0.0051 0.024 0.0318
Brugia malayi MH2 domain containing protein 0.0239 0.1711 0.4639
Schistosoma mansoni jumonji domain containing protein 0.0362 0.2676 0.2676
Plasmodium vivax diacylglycerol kinase, putative 0.0051 0.024 0.2922
Schistosoma mansoni ran 0.0023 0.0026 0.0026
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0463 0.0463
Loa Loa (eye worm) hypothetical protein 0.0352 0.2596 0.2596
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0884 0.6754 0.6746
Loa Loa (eye worm) hypothetical protein 0.0051 0.024 0.024
Schistosoma mansoni protein phosphatase 2C 0.0053 0.026 0.026
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.034 1
Echinococcus multilocularis dnaJ subfamily B 0.1235 0.9497 0.9497
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0149 0.0149
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0051 0.0242 0.0242
Plasmodium falciparum JmjC domain-containing protein, putative 0.0053 0.026 0.32
Entamoeba histolytica diacylglycerol kinase, putative 0.0051 0.024 0.0215
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0749 0.0355
Loa Loa (eye worm) hypothetical protein 0.0068 0.0374 0.0374
Brugia malayi Bromodomain containing protein 0.0117 0.0758 0.2055
Onchocerca volvulus 0.01 0.0628 0.1711
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0051 0.024 0.9131
Trypanosoma brucei trypanothione reductase 0.0046 0.0201 0.7486
Loa Loa (eye worm) hypothetical protein 0.0034 0.0111 0.0111
Schistosoma mansoni sphingoid long chain base kinase 0.13 1 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0802 0.0802
Echinococcus multilocularis jumonji domain containing 1A 0.0053 0.026 0.026
Schistosoma mansoni phd/f-box containing protein 0.0053 0.026 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.034 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0144 0.0176
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0463 0.0463
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0658 0.0522
Onchocerca volvulus Huntingtin homolog 0.0123 0.0802 0.2184
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0226 0.0226
Brugia malayi RNA, U transporter 1 0.009 0.0545 0.1478
Toxoplasma gondii thioredoxin reductase 0.0046 0.0201 0.1567
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0051 0.024 0.1911
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0749 0.0614
Loa Loa (eye worm) hypothetical protein 0.0051 0.024 0.024
Schistosoma mansoni phosphatidylserine receptor 0.0053 0.026 0.026
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.034 0.034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0715 0.1937
Echinococcus granulosus JmjC domain containing protein 4 0.0053 0.026 0.026
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0432 0.322 0.3121
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0511 0.1385
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0144 0.0176
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0051 0.024 0.0318
Echinococcus multilocularis phd:f box containing protein 0.0053 0.026 0.026
Echinococcus granulosus lysine specific demethylase 5A 0.0205 0.1442 0.1442
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0071 0.0071
Brugia malayi hypothetical protein 0.0051 0.024 0.0649
Plasmodium falciparum plasmepsin II 0.0051 0.0242 0.2958
Onchocerca volvulus 0.0085 0.0511 0.1391
Onchocerca volvulus 0.0051 0.024 0.0652
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0242 0.0242
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.011 0.0126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.034 0.034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.034 0.0199
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0149 0.0403
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.011 0.0126
Echinococcus granulosus geminin 0.0349 0.2569 0.2569
Echinococcus multilocularis sphingosine kinase 1 0.13 1 1
Brugia malayi jmjC domain containing protein 0.0053 0.026 0.0705
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.034 0.034
Brugia malayi CXXC zinc finger family protein 0.0087 0.0522 0.1414
Brugia malayi Eye-specific diacylglycerol kinase 0.0051 0.024 0.0649
Brugia malayi hypothetical protein 0.0123 0.0802 0.2174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0144 0.5046
Schistosoma mansoni hypothetical protein 0.0111 0.0715 0.0715
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.2596 0.7036
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.034 0.034
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.026 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0051 0.024 0.024
Loa Loa (eye worm) jmjC domain-containing protein 0.0241 0.1731 0.1731
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0144 0.5
Schistosoma mansoni lamin 0.0085 0.0511 0.0511
Brugia malayi F/Y-rich N-terminus family protein 0.0067 0.0367 0.0996
Plasmodium vivax SET domain protein, putative 0.0063 0.034 0.4286
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0044 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Onchocerca volvulus Alhambra homolog 0.0117 0.0758 0.2064
Brugia malayi latrophilin 2 splice variant baaae 0.0241 0.1725 0.4676
Leishmania major importin beta-1 subunit, putative 0.0026 0.0044 0.0587
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0658 0.0522
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.034 0.034
Brugia malayi glutathione reductase 0.0046 0.0201 0.0545
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.2596 0.2596
Echinococcus multilocularis jumonji domain containing protein 0.0163 0.1116 0.1116
Echinococcus granulosus GPCR family 2 0.0111 0.0715 0.0715
Echinococcus granulosus dnaJ subfamily B 0.1235 0.9497 0.9497
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0051 0.0242 0.1934
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0715 0.1937
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0658 0.0522
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0511 0.0511
Echinococcus granulosus Diacylglycerol kinase theta 0.0051 0.024 0.024
Brugia malayi intermediate filament protein 0.0085 0.0511 0.1385
Echinococcus granulosus importin subunit beta 1 0.0032 0.0091 0.0091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0658 0.0522
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0071 0.0071
Schistosoma mansoni jumonji/arid domain-containing protein 0.0205 0.1442 0.1442
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.034 0.2808
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.003 0.003
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0051 0.024 0.024
Echinococcus multilocularis lysine specific demethylase 5A 0.02 0.1404 0.1404
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0201 0.0201
Echinococcus granulosus lamin dm0 0.0085 0.0511 0.0511
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0042 0.0171 0.4613
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0201 0.7486
Brugia malayi Ets-domain containing protein 0.0079 0.0463 0.1256
Trypanosoma cruzi Sphingosine kinase 0.0051 0.024 0.9131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0144 0.5046
Brugia malayi jmjC domain containing protein 0.0053 0.026 0.0705
Schistosoma mansoni hypothetical protein 0.0038 0.0143 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0175 0.0175
Echinococcus granulosus lamin 0.0085 0.0511 0.0511
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0226 0.0614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Onchocerca volvulus 0.049 0.3673 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0144 0.0144
Toxoplasma gondii PHD-finger domain-containing protein 0.0117 0.0758 0.6539
Schistosoma mansoni hypothetical protein 0.0117 0.0758 0.0758
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0053 0.026 1
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0051 0.024 0.9131
Loa Loa (eye worm) jmjC domain-containing protein 0.0205 0.1442 0.1442
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.024 0.9131
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.2477 0.2477
Trypanosoma cruzi Sphingosine kinase 0.0051 0.024 0.9131
Echinococcus granulosus lysine specific demethylase 6a 0.0053 0.026 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0329 0.0329
Echinococcus multilocularis Diacylglycerol kinase theta 0.0051 0.024 0.024
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0658 0.0522
Plasmodium vivax diacylglycerol kinase, putative 0.0051 0.024 0.2922
Brugia malayi diacylglycerol kinase 0.0051 0.024 0.0649
Brugia malayi Ets-domain containing protein 0.0079 0.0463 0.1256
Schistosoma mansoni ap endonuclease 0.0038 0.0144 0.0144
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0051 0.024 0.024
Treponema pallidum fructose-bisphosphate aldolase 0.0884 0.6754 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0144 0.1056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0144 0.5046
Loa Loa (eye worm) hypothetical protein 0.0063 0.034 0.034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Onchocerca volvulus 0.0087 0.0522 0.1421
Trypanosoma cruzi diacylglycerol kinase, putative 0.0051 0.024 0.9131
Brugia malayi PHD-finger family protein 0.0117 0.0758 0.2055
Trichomonas vaginalis diacylglycerol kinase, putative 0.0051 0.024 0.0318
Echinococcus multilocularis sodium channel protein 0.0042 0.0171 0.0171
Schistosoma mansoni hypothetical protein 0.01 0.0628 0.0628
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.034 0.034
Toxoplasma gondii aspartyl protease ASP1 0.0051 0.0242 0.1934
Schistosoma mansoni hypothetical protein 0.0111 0.0715 0.0715
Trypanosoma brucei Sphingosine kinase 0.0051 0.024 0.9131
Loa Loa (eye worm) hypothetical protein 0.0085 0.0511 0.0511
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0051 0.0242 0.0242
Schistosoma mansoni gabp alpha 0.0079 0.0463 0.0463
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.034 0.034
Leishmania major trypanothione reductase 0.0046 0.0201 0.5579
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Schistosoma mansoni cpg binding protein 0.0087 0.0522 0.0522
Plasmodium falciparum plasmepsin I 0.0051 0.0242 0.2958
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0432 0.322 1
Schistosoma mansoni hypothetical protein 0.0337 0.2477 0.2477
Plasmodium falciparum plasmepsin IV 0.0051 0.0242 0.2958
Loa Loa (eye worm) hypothetical protein 0.0123 0.0802 0.0802
Echinococcus granulosus ceramide kinase 0.0051 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0117 0.0758 0.0758
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.003 0.003
Schistosoma mansoni jumonji domain containing protein 0.0053 0.026 0.026
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0144 0.1615
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0117 0.0758 0.0758
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0441 0.3291 0.3291
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0051 0.024 0.024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0205 0.1442 0.1442
Leishmania major diacylglycerol kinase, putative 0.0051 0.024 0.6805
Schistosoma mansoni importin beta-1 0.0032 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0084 0.0499 0.0499
Plasmodium vivax aspartyl proteinase, putative 0.0051 0.0242 0.2958
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0884 0.6754 1
Echinococcus multilocularis musashi 0.0085 0.0511 0.0511
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0715 0.0715

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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