Detailed information for compound 943483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 602.644 | Formula: C31H37F3N4O5
  • H donors: 4 H acceptors: 5 LogP: 2.13 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCOC(=O)Cc1cccc(c1)c1c[nH]c(n1)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC[C@H](CC1)CN
  • InChi: 1S/C29H36N4O3.C2HF3O2/c1-2-36-27(34)17-22-9-6-10-24(15-22)26-19-31-28(32-26)25(16-20-7-4-3-5-8-20)33-29(35)23-13-11-21(18-30)12-14-23;3-2(4,5)1(6)7/h3-10,15,19,21,23,25H,2,11-14,16-18,30H2,1H3,(H,31,32)(H,33,35);(H,6,7)/t21-,23-,25-;/m0./s1
  • InChiKey: AVANNKANBWVKGX-IELCCSRCSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) Starlite/ChEMBL References
Homo sapiens coagulation factor XI Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References
Homo sapiens kallikrein B, plasma (Fletcher factor) 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus glycoprotein Antigen 5 coagulation factor VII (serum prothrombin conversion accelerator) 466 aa 384 aa 23.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus cGMP dependent protein kinase 1 0.0266 0.0402 0.0443
Schistosoma mansoni growth hormone secretagogue receptor 0.0335 0.0743 0.0743
Schistosoma mansoni hypothetical protein 0.0203 0.0088 0.0088
Schistosoma mansoni voltage-gated potassium channel 0.0399 0.106 0.106
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0266 0.0402 0.0443
Echinococcus granulosus tm gpcr rhodopsin 0.0335 0.0743 0.0818
Trypanosoma cruzi cAMP response protein 1 0.0266 0.0402 0.6896
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0203 0.0088 0.1623
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0335 0.0743 0.0818
Brugia malayi G protein-coupled receptor F59B2.13 0.0335 0.0743 0.0818
Loa Loa (eye worm) neuropeptide F receptor 0.0335 0.0743 0.0723
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0584 0.1979 0.2102
Schistosoma mansoni myosin xvIII 0.0335 0.0743 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0402 0.0402
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0266 0.0402 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0266 0.0402 0.6896
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.1882 0.8423 1
Schistosoma mansoni biogenic amine receptor 0.0335 0.0743 0.0743
Mycobacterium tuberculosis Conserved hypothetical protein 0.0266 0.0402 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0266 0.0402 0.0477
Brugia malayi Cytochrome P450 family protein 0.064 0.2257 0.2485
Echinococcus granulosus g protein coupled receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0266 0.0402 0.0349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0266 0.0402 0.6896
Echinococcus granulosus allatostatin A receptor 0.0335 0.0743 0.0818
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0266 0.0402 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0335 0.0743 0.0818
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0335 0.0743 0.0723
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0584 0.1979 0.2179
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0266 0.0402 0.0443
Brugia malayi neuropeptide F receptor 0.0335 0.0743 0.0818
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0335 0.0743 0.0818
Leishmania major hypothetical protein, conserved 0.0266 0.0402 0.6896
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0266 0.0402 0.0349
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus patatin phospholipase domain containing protein 0.0266 0.0402 0.0443
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0399 0.106 0.1167
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Onchocerca volvulus 0.0335 0.0743 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0335 0.0743 0.0818
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0266 0.0402 0.6896
Loa Loa (eye worm) cytochrome P450 family protein 0.064 0.2257 0.2394
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Onchocerca volvulus 0.0335 0.0743 1
Trypanosoma cruzi protein kinase A regulatory subunit 0.0266 0.0402 0.6896
Onchocerca volvulus 0.0335 0.0743 1
Toxoplasma gondii PAN domain-containing protein 0.0713 0.2618 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Brugia malayi sulfakinin receptor protein 0.0335 0.0743 0.0818
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0266 0.0402 0.0349
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0266 0.0402 0.124
Brugia malayi Cytochrome P450 family protein 0.0203 0.0088 0.0097
Leishmania major protein kinase A regulatory subunit, putative 0.0266 0.0402 0.6896
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Schistosoma mansoni 60S ribosomal protein L21 0.0318 0.0658 0.0658
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0266 0.0402 0.0402
Trypanosoma brucei cAMP response protein 1, putative 0.0266 0.0402 0.74
Brugia malayi Cytochrome P450 family protein 0.0294 0.0543 0.0598
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni opsin-like receptor 0.0335 0.0743 0.0743
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.2028 0.9146 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Mycobacterium ulcerans regulatory protein 0.0266 0.0402 0.6896
Echinococcus multilocularis neuropeptide FF receptor 2 0.0335 0.0743 0.0728
Brugia malayi Egg laying defective protein 4 0.0266 0.0402 0.0443
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0335 0.0743 0.0728
Echinococcus granulosus orexin receptor type 2 0.0335 0.0743 0.0818
Echinococcus multilocularis serotonin receptor 0.0335 0.0743 0.0728
Leishmania major cytochrome p450-like protein 0.0294 0.0543 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis g protein coupled receptor 0.0335 0.0743 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0402 0.0477
Brugia malayi N-terminal motif family protein 0.0266 0.0402 0.0443
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0335 0.0743 0.0743
Echinococcus granulosus neuropeptide Y receptor 0.0335 0.0743 0.0818
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0266 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni amine GPCR 0.0335 0.0743 0.0743
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.1882 0.8423 1
Brugia malayi G-protein coupled receptor 0.0335 0.0743 0.0818
Leishmania major cyclic nucleotide-binding protein-like protein 0.0266 0.0402 0.6896
Echinococcus granulosus tm gpcr rhodopsin 0.0335 0.0743 0.0818
Schistosoma mansoni biogenic amine receptor 0.0335 0.0743 0.0743
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0335 0.0743 0.0743
Mycobacterium ulcerans hypothetical protein 0.0266 0.0402 0.6896
Echinococcus granulosus g protein coupled receptor 0.0335 0.0743 0.0818
Mycobacterium ulcerans hypothetical protein 0.0266 0.0402 0.6896
Trypanosoma cruzi cAMP binding protein, putative 0.0266 0.0402 0.6896
Loa Loa (eye worm) hypothetical protein 0.0266 0.0402 0.0346
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0335 0.0743 0.0743
Echinococcus granulosus 7tm_1 domain containing protein 0.0335 0.0743 0.0818
Onchocerca volvulus 0.0335 0.0743 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis hyperpolarization activated cyclic 0.0399 0.106 0.1081
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0399 0.106 0.106
Loa Loa (eye worm) cytochrome P450 family protein 0.0294 0.0543 0.0502
Echinococcus granulosus somatostatin receptor 0.0335 0.0743 0.0818
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0402 0.0402
Schistosoma mansoni neuropeptide F-like receptor 0.0335 0.0743 0.0743
Echinococcus multilocularis voltage gated potassium channel 0.0584 0.1979 0.2102
Echinococcus granulosus neuropeptide receptor 0.0335 0.0743 0.0818
Onchocerca volvulus 0.0335 0.0743 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0266 0.0402 0.124
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0266 0.0402 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0266 0.0402 0.0349
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Treponema pallidum catabolite gene activator (Crp) 0.0266 0.0402 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0335 0.0743 0.0818
Loa Loa (eye worm) hypothetical protein 0.0584 0.1979 0.2087
Loa Loa (eye worm) hypothetical protein 0.0266 0.0402 0.0346
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus potassium voltage gated channel subfamily H 0.2015 0.9081 1
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0266 0.0402 0.0402
Onchocerca volvulus 0.0335 0.0743 1
Leishmania major hypothetical protein, unknown function 0.0266 0.0402 0.6896
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi cytochrome P450 0.0203 0.0088 0.0097
Schistosoma mansoni biogenic amine (5HT) receptor 0.0335 0.0743 0.0743
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0335 0.0743 0.0743
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0266 0.0402 0.0402
Echinococcus granulosus cytochrome P450 2K1 0.0203 0.0088 0.0097
Leishmania major regulatory subunit of protein kinase a-like protein 0.0266 0.0402 0.6896
Mycobacterium ulcerans hypothetical protein 0.0266 0.0402 0.6896
Onchocerca volvulus 0.0335 0.0743 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0335 0.0743 0.0743
Mycobacterium leprae Conserved hypothetical protein 0.0203 0.0088 0.2194
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0266 0.0402 0.0402
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0266 0.0402 0.0477
Trypanosoma cruzi Flagellar Member 6 0.0266 0.0402 0.6896
Schistosoma mansoni biogenic amine receptor 0.0335 0.0743 0.0743
Schistosoma mansoni opsin-like receptor 0.0335 0.0743 0.0743
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0266 0.0402 0.124
Echinococcus granulosus hyperpolarization activated cyclic 0.0399 0.106 0.1167
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus cGMP dependent protein kinase 1 0.0266 0.0402 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0335 0.0743 0.0818
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Echinococcus granulosus G protein coupled receptor 139 0.0335 0.0743 0.0818
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Echinococcus granulosus peptide allatostatin:somatostatin 0.0335 0.0743 0.0818
Leishmania major hypothetical protein, conserved 0.0266 0.0402 0.6896
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0335 0.0743 0.0723
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0335 0.0743 0.0728
Echinococcus granulosus neuropeptide Y receptor 0.0335 0.0743 0.0818
Brugia malayi Dopamine receptor protein 2 0.0335 0.0743 0.0818
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.2015 0.9081 0.9929
Treponema pallidum cyclic nucleotide binding protein 0.0266 0.0402 0.5
Echinococcus granulosus neuropeptide receptor 0.0335 0.0743 0.0818
Mycobacterium ulcerans transmembrane transport protein 0.0266 0.0402 0.6896
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0335 0.0743 0.0743
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0266 0.0402 0.0402
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0335 0.0743 0.0728
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Loa Loa (eye worm) melatonin receptor type 1A 0.0335 0.0743 0.0723
Leishmania major protein kinase, putative 0.0266 0.0402 0.6896
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0266 0.0402 0.0443
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0266 0.0402 0.0477
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0335 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni neuropeptide receptor 0.0335 0.0743 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Schistosoma mansoni amine GPCR 0.0335 0.0743 0.0743
Brugia malayi putative neuropeptide receptor NPR1 0.0335 0.0743 0.0818
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Echinococcus granulosus biogenic amine 5HT receptor 0.0335 0.0743 0.0818
Brugia malayi AKH receptor 0.0335 0.0743 0.0818
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) G-protein coupled receptor 0.0335 0.0743 0.0723
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0266 0.0402 0.5
Brugia malayi Tachykinin-like peptides receptor 99D 0.0335 0.0743 0.0818
Brugia malayi GnHR receptor homolog 0.0335 0.0743 0.0818
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Echinococcus granulosus hypothetical protein 0.0335 0.0743 0.0818
Schistosoma mansoni amine GPCR 0.0335 0.0743 0.0743
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0399 0.106 0.106
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0399 0.106 0.1073
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni hypothetical protein 0.0335 0.0743 0.0743
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0266 0.0402 0.0443
Echinococcus granulosus 7TM GPCR rhodopsin 0.0335 0.0743 0.0818
Trypanosoma brucei Flagellar Member 6 0.0266 0.0402 0.74
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0266 0.0402 0.0346
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0399 0.106 0.1073
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0335 0.0743 0.0723
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0266 0.0402 0.0402
Schistosoma mansoni neuropeptide receptor 0.0335 0.0743 0.0743
Brugia malayi neuropeptide F receptor 0.0335 0.0743 0.0818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Echinococcus granulosus fmrfamide receptor 0.0335 0.0743 0.0818
Brugia malayi Melatonin receptor type 1A 0.0335 0.0743 0.0818
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0335 0.0743 0.0728
Echinococcus multilocularis neuropeptide Y receptor 0.0335 0.0743 0.0728
Schistosoma mansoni voltage-gated potassium channel 0.0584 0.1979 0.1979
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0399 0.106 0.1258
Trypanosoma cruzi cytochrome P450, putative 0.0294 0.0543 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0335 0.0743 0.0818
Schistosoma mansoni opsin-like receptor 0.0335 0.0743 0.0743
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0266 0.0402 0.0349
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0335 0.0743 0.0818
Echinococcus granulosus hyperpolarization activated cyclic 0.0399 0.106 0.1167
Echinococcus granulosus serotonin receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0335 0.0743 0.0728
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0266 0.0402 0.0443
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0335 0.0743 0.0743
Treponema pallidum cyclic nucleotide binding protein 0.0266 0.0402 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0399 0.106 0.106
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0399 0.106 0.1258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0266 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis orexin receptor type 2 0.0335 0.0743 0.0728
Echinococcus multilocularis neuropeptides capa receptor 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis rhodopsin orphan GPCR 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0266 0.0402 1
Echinococcus granulosus sex peptide receptor 0.0335 0.0743 0.0818
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0266 0.0402 0.5
Loa Loa (eye worm) hypothetical protein 0.1749 0.7761 0.8471
Schistosoma mansoni alpha-1 adrenergic receptor 0.0335 0.0743 0.0743
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0266 0.0402 0.5
Trypanosoma cruzi cAMP response protein 1, putative 0.0266 0.0402 0.6896
Brugia malayi larval opioid receptor 0.0335 0.0743 0.0818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Echinococcus multilocularis neuropeptides capa receptor 0.0335 0.0743 0.0728
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0335 0.0743 0.0743
Echinococcus granulosus neuropeptides capa receptor 0.0335 0.0743 0.0818
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Echinococcus multilocularis expressed conserved protein 0.0266 0.0402 0.0349
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Treponema pallidum catabolite gene activator 0.0266 0.0402 0.5
Toxoplasma gondii PAN domain-containing protein 0.0713 0.2618 1
Brugia malayi Dopamine receptor 0.0335 0.0743 0.0818
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0266 0.0402 0.0443
Mycobacterium ulcerans transcriptional regulatory protein 0.0266 0.0402 0.6896
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0399 0.106 0.1081
Echinococcus multilocularis neuropeptide receptor 0.0335 0.0743 0.0728
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0335 0.0743 0.0743
Echinococcus granulosus g-protein coupled receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis hyperpolarization activated cyclic 0.0399 0.106 0.1081
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0399 0.106 0.106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0335 0.0743 0.0723
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0266 0.0402 0.0402
Echinococcus multilocularis fmrfamide receptor 0.0335 0.0743 0.0728
Echinococcus granulosus neuropeptide s receptor 0.0335 0.0743 0.0818
Trypanosoma brucei cAMP binding protein, putative 0.0266 0.0402 0.74
Onchocerca volvulus 0.0335 0.0743 1
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) TYRA-2 protein 0.0335 0.0743 0.0723
Brugia malayi Serotonin receptor 0.0335 0.0743 0.0818
Leishmania major hypothetical protein, conserved 0.0266 0.0402 0.6896
Brugia malayi ORL1-like opioid receptor 0.0335 0.0743 0.0818
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Schistosoma mansoni neuropeptide receptor 0.0335 0.0743 0.0743
Mycobacterium leprae Conserved hypothetical protein 0.0266 0.0402 1
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0266 0.0402 0.124
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni hypothetical protein 0.0266 0.0402 0.0402
Echinococcus granulosus neuropeptide receptor A26 0.0335 0.0743 0.0818
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0266 0.0402 0.0349
Echinococcus multilocularis sex peptide receptor 0.0335 0.0743 0.0728
Brugia malayi G-protein coupled receptor 0.0335 0.0743 0.0818
Loa Loa (eye worm) AGC/PKG protein kinase 0.0266 0.0402 0.0346
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0266 0.0402 0.0402
Brugia malayi G protein-coupled receptor 0.0335 0.0743 0.0818
Loa Loa (eye worm) cytochrome P450 family protein 0.0294 0.0543 0.0502
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Leishmania major protein kinase, putative 0.0266 0.0402 0.6896
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus rhodopsin orphan GPCR 0.0335 0.0743 0.0818
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0266 0.0402 0.0349
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0399 0.106 0.1167
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0399 0.106 0.1073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0335 0.0743 0.0728
Brugia malayi Cytochrome P450 family protein 0.0294 0.0543 0.0598
Schistosoma mansoni hypothetical protein 0.0335 0.0743 0.0743
Echinococcus multilocularis fmrfamide receptor 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Trypanosoma brucei cytochrome P450, putative 0.0294 0.0543 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0335 0.0743 0.0728
Brugia malayi RE15519p 0.0335 0.0743 0.0818
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0266 0.0402 0.0402
Echinococcus multilocularis g protein coupled receptor 0.0335 0.0743 0.0728
Schistosoma mansoni neuropeptide F-like receptor 0.0335 0.0743 0.0743
Echinococcus multilocularis serotonin receptor 0.0335 0.0743 0.0728
Echinococcus granulosus dro:myosuppressin receptor 0.0335 0.0743 0.0818
Onchocerca volvulus 0.0335 0.0743 1
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0266 0.0402 0.6896
Trypanosoma brucei protein kinase A regulatory subunit 0.0266 0.0402 0.74
Echinococcus granulosus g protein coupled receptor 0.0335 0.0743 0.0818
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0335 0.0743 0.0818
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0399 0.106 0.106
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.2015 0.9081 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0335 0.0743 0.0728
Onchocerca volvulus 0.0335 0.0743 1
Mycobacterium tuberculosis Conserved protein 0.0266 0.0402 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0335 0.0743 0.0818
Loa Loa (eye worm) G-protein coupled receptor 0.0335 0.0743 0.0723
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis neuropeptide Y receptor 0.0335 0.0743 0.0728
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0399 0.106 0.1167
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0335 0.0743 0.0728
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Echinococcus granulosus tm gpcr rhodopsin 0.0335 0.0743 0.0818
Schistosoma mansoni histamine h1 receptor 0.0335 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0335 0.0743 0.0743
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0266 0.0402 0.0477
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0335 0.0743 0.0728
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0335 0.0743 0.0818
Brugia malayi Serotonin receptor 0.0335 0.0743 0.0818
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0266 0.0402 0.124
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0399 0.106 0.1167
Onchocerca volvulus 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni hypothetical protein 0.0335 0.0743 0.0743
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.2015 0.9081 1
Brugia malayi putative neuropeptide receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis neuropeptide s receptor 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus granulosus cGMP dependent protein kinase 0.0266 0.0402 0.0443
Mycobacterium leprae putative cytochrome p450 0.0203 0.0088 0.2194
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0266 0.0402 0.124
Brugia malayi Dopamine receptor protein 1 0.0335 0.0743 0.0818
Mycobacterium tuberculosis Conserved hypothetical protein 0.0266 0.0402 1
Loa Loa (eye worm) hypothetical protein 0.2028 0.9146 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0266 0.0402 0.0402
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Onchocerca volvulus 0.0335 0.0743 1
Mycobacterium ulcerans hypothetical protein 0.0266 0.0402 0.6896
Schistosoma mansoni amine GPCR 0.0335 0.0743 0.0743
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0266 0.0402 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0399 0.106 0.1081
Schistosoma mansoni voltage-gated potassium channel 0.0318 0.0658 0.0658
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0335 0.0743 0.0728
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0335 0.0743 0.0743
Loa Loa (eye worm) neuropeptide F receptor 0.0335 0.0743 0.0723
Brugia malayi follicle stimulating hormone receptor 0.0335 0.0743 0.0818
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0399 0.106 0.1081
Onchocerca volvulus Neuropeptide F receptor homolog 0.0335 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0335 0.0743 0.0723
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0266 0.0402 0.5
Brugia malayi hypothetical protein 0.0335 0.0743 0.0818
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0335 0.0743 0.0728
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0335 0.0743 0.0818
Echinococcus multilocularis neuropeptide receptor A26 0.0335 0.0743 0.0728
Loa Loa (eye worm) CYP4Cod1 0.0294 0.0543 0.0502
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0335 0.0743 0.0743
Schistosoma mansoni voltage-gated potassium channel 0.22 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0335 0.0743 0.0728
Schistosoma mansoni cytochrome P450 0.0203 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0335 0.0743 0.0743
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0266 0.0402 0.0443
Trypanosoma cruzi cytochrome P450, putative 0.0294 0.0543 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0335 0.0743 0.0728
Echinococcus multilocularis g protein coupled receptor 0.0335 0.0743 0.0728
Echinococcus granulosus voltage gated potassium channel 0.0584 0.1979 0.2179
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.0402 0.0402
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0266 0.0402 0.0349
Echinococcus multilocularis G-protein coupled receptor, putative 0.0335 0.0743 0.0728
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0266 0.0402 0.74
Loa Loa (eye worm) hypothetical protein 0.0335 0.0743 0.0723
Brugia malayi Cyclic-nucleotide gated cation channel 0.0399 0.106 0.1167
Schistosoma mansoni amine GPCR 0.0335 0.0743 0.0743
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0294 0.0543 1
Echinococcus multilocularis allatostatin A receptor 0.0335 0.0743 0.0728
Schistosoma mansoni neuropeptide receptor 0.0335 0.0743 0.0743
Schistosoma mansoni adenoreceptor 0.0335 0.0743 0.0743
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0584 0.1979 0.2179
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0266 0.0402 0.74
Plasmodium falciparum cGMP-dependent protein kinase 0.0266 0.0402 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0335 0.0743 0.0743
Echinococcus multilocularis neuropeptide receptor 0.0335 0.0743 0.0728
Echinococcus multilocularis dro:myosuppressin receptor 0.0335 0.0743 0.0728
Schistosoma mansoni voltage-gated potassium channel 0.0584 0.1979 0.1979
Echinococcus granulosus tachykinin peptides receptor 99D 0.0335 0.0743 0.0818
Echinococcus multilocularis somatostatin receptor 0.0335 0.0743 0.0728
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0335 0.0743 0.0818
Schistosoma mansoni neuropeptide f receptor 76f 0.0335 0.0743 0.0743
Echinococcus multilocularis g-protein coupled receptor 0.0335 0.0743 0.0728
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0335 0.0743 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0335 0.0743 0.0743
Echinococcus granulosus neuropeptides capa receptor 0.0335 0.0743 0.0818

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 630 nM Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometrically ChEMBL. 25405503
Ki (binding) = 1470 nM Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrate ChEMBL. 25405503
Ki (binding) > 8180 nM Inhibition of human coagulation factor 10a using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysis ChEMBL. 25405503
Ki (binding) > 10900 nM Inhibition of human coagulation factor 7a using H-(D)-Ile-Pro-Arg-pNA as substrate by spectrophotometric analysis ChEMBL. 25405503

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.