Detailed information for compound 953354

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 255.335 | Formula: C15H13NOS
  • H donors: 1 H acceptors: 2 LogP: 4.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)sc(n2)c1ccc(cc1)O
  • InChi: 1S/C15H13NOS/c1-2-10-3-8-13-14(9-10)18-15(16-13)11-4-6-12(17)7-5-11/h3-9,17H,2H2,1H3
  • InChiKey: UCEZTXXRIXTZME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0079 0.2235 0.2628
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0088 0.2493 0.3209
Loa Loa (eye worm) hypothetical protein 0.0181 0.5327 0.6266
Echinococcus multilocularis cpg binding protein 0.0034 0.0848 0.1091
Loa Loa (eye worm) hypothetical protein 0.0159 0.465 0.547
Onchocerca volvulus 0.0181 0.5327 0.9648
Brugia malayi hypothetical protein 0.0079 0.2235 0.2628
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0084 0.0108
Schistosoma mansoni hypothetical protein 0.0088 0.2493 0.4749
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.168 0.2163
Echinococcus multilocularis musashi 0.0029 0.0694 0.0894
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0088 0.2493 0.2933
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0659 0.058
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0694 0.0817
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.1142 0.3667
Loa Loa (eye worm) hypothetical protein 0.0014 0.0245 0.0288
Trichomonas vaginalis hypothetical protein 0.0009 0.0084 0.0047
Echinococcus granulosus intermediate filament protein 0.0029 0.0694 0.0894
Echinococcus multilocularis tar DNA binding protein 0.007 0.1959 0.2522
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0659 0.0776
Schistosoma mansoni smad 0.0009 0.0084 0.016
Schistosoma mansoni survival motor neuron protein 0.0053 0.1446 0.2753
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0659 0.1256
Loa Loa (eye worm) hypothetical protein 0.0029 0.0694 0.0817
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5824 0.6835
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0659 0.0776
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0084 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0084 0.0047
Echinococcus granulosus GPCR family 2 0.005 0.1352 0.174
Loa Loa (eye worm) hypothetical protein 0.0088 0.2493 0.2933
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0245 0.0315
Schistosoma mansoni cpg binding protein 0.0034 0.0848 0.1615
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.465 0.547
Echinococcus granulosus Smad4 0.0009 0.0084 0.0108
Loa Loa (eye worm) Smad1 0.0009 0.0084 0.0099
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0291 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.168 0.161
Onchocerca volvulus 0.0032 0.0793 0.1304
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.4708 0.5538
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.1261 0.4082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.168 0.161
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0084 0.016
Onchocerca volvulus 0.0029 0.0694 0.1123
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.4641 0.4595
Echinococcus multilocularis smad 0.0009 0.0084 0.0108
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0659 0.058
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.168 0.1934
Schistosoma mansoni hypothetical protein 0.0179 0.5251 1
Echinococcus granulosus cpg binding protein 0.0034 0.0848 0.1091
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.168 0.2163
Echinococcus multilocularis lamin dm0 0.0029 0.0694 0.0894
Loa Loa (eye worm) hypothetical protein 0.0109 0.3124 0.3674
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.5824 0.6835
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1877 0.3576
Echinococcus granulosus expressed protein 0.0103 0.2968 0.382
Echinococcus granulosus tar DNA binding protein 0.007 0.1959 0.2522
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0659 0.0727
Mycobacterium tuberculosis Conserved hypothetical protein 0.0176 0.5185 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.1446 0.17
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.168 0.1977
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.1261 0.1439
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0103 0.2968 1
Schistosoma mansoni cpg binding protein 0.0032 0.0793 0.151
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.1261 0.1439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.1352 0.174
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0066 0.0084
Schistosoma mansoni intermediate filament proteins 0.0029 0.0694 0.1323
Brugia malayi MH1 domain containing protein 0.0009 0.0084 0.0099
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.3621 0.4259
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0084 0.0099
Schistosoma mansoni lamin 0.0029 0.0694 0.1323
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 1 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.1261 0.4082
Loa Loa (eye worm) TAR-binding protein 0.007 0.1959 0.2305
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0245 0.0315
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.1352 0.174
Loa Loa (eye worm) histone methyltransferase 0.001 0.0125 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.1256 0.1182
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.1256 0.1182
Brugia malayi MH2 domain containing protein 0.0125 0.3621 0.4259
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0285 0.8501 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0084 0.0099
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0285 0.8501 1
Schistosoma mansoni Smad4 0.0009 0.0084 0.016
Echinococcus granulosus smad 0.0009 0.0084 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.465 0.547
Schistosoma mansoni lamin 0.0029 0.0694 0.1323
Trichomonas vaginalis chaperonin, putative 0.0027 0.0659 0.0727
Brugia malayi MH1 domain containing protein 0.0009 0.0084 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1778 0.5873
Brugia malayi hypothetical protein 0.0181 0.5327 0.6266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.465 0.547
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.1261 0.4082
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0103 0.2968 0.5653
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.1256 0.1182
Echinococcus granulosus polyphosphoinositide phosphatase 0.0009 0.0084 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.168 0.1934
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0088 0.2493 0.2933
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.168 0.1934
Toxoplasma gondii hypothetical protein 0.0054 0.1466 0.4793
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Brugia malayi Smad1 0.0009 0.0084 0.0099
Echinococcus granulosus mitochondrial import inner membrane translocase 0.0009 0.0084 0.0108
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim22 0.0009 0.0084 0.016
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0659 0.058
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0125 0.016
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.1142 1
Onchocerca volvulus Glucosylceramidase homolog 0.0187 0.5518 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.168 0.161
Schistosoma mansoni smad1 5 8 and 0.0009 0.0084 0.016
Schistosoma mansoni smad1 5 8 and 0.0009 0.0084 0.016
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.3621 0.4259
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.4708 0.8967
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.1142 0.4723
Echinococcus multilocularis expressed protein 0.0103 0.2968 0.382
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.7769 1
Mycobacterium ulcerans hypothetical protein 0.0176 0.5185 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0335 1 1
Brugia malayi MH2 domain containing protein 0.0009 0.0084 0.0099
Echinococcus granulosus geminin 0.0179 0.5251 0.6758
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.168 0.161
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0066 0.0084
Onchocerca volvulus 0.0029 0.0694 0.1123
Echinococcus granulosus lamin dm0 0.0029 0.0694 0.0894
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0121 0.0142
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0084 0.0108
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.168 1
Brugia malayi RNA recognition motif domain containing protein 0.007 0.1959 0.2305
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Brugia malayi MH2 domain containing protein 0.0009 0.0084 0.0099
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0009 0.0084 0.0099
Schistosoma mansoni hypothetical protein 0.005 0.1352 0.2575
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0659 0.0849
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0084 0.0108
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.168 0.5535
Trypanosoma brucei protein kinase, putative 0.0061 0.168 0.161
Echinococcus multilocularis Smad4 0.0009 0.0084 0.0108
Schistosoma mansoni hypothetical protein 0.005 0.1352 0.2575
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0694 0.0817
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0088 0.2493 0.8354
Echinococcus multilocularis lamin 0.0029 0.0694 0.0894
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0659 0.0776
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0659 0.1995
Echinococcus multilocularis geminin 0.0179 0.5251 0.6758
Loa Loa (eye worm) hypothetical protein 0.0028 0.0678 0.0798
Schistosoma mansoni hypothetical protein 0.005 0.1352 0.2575
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.168 0.161
Brugia malayi CXXC zinc finger family protein 0.0032 0.0793 0.0932
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.168 0.161
Onchocerca volvulus 0.0053 0.1446 0.2506
Schistosoma mansoni hypothetical protein 0.0179 0.5251 1
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0103 0.2968 1
Schistosoma mansoni cpg binding protein 0.0034 0.0848 0.1615
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0158 0.4641 0.4595
Schistosoma mansoni mitochondrial import inner membrane translocase subunit Tim17 0.0009 0.0084 0.016
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0088 0.2493 0.2933
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.168 0.32
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0088 0.2493 0.8354
Schistosoma mansoni hypothetical protein 0.005 0.1352 0.2575
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0066 0.0084
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.168 0.161
Echinococcus multilocularis mitochondrial import inner membrane translocase 0.0009 0.0084 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.8501 1
Loa Loa (eye worm) RNA binding protein 0.007 0.1959 0.2305
Brugia malayi TAR-binding protein 0.007 0.1959 0.2305
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0158 0.4641 0.4595
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0659 0.1995
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0793 0.0932
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0659 0.1256
Schistosoma mansoni tar DNA-binding protein 0.007 0.1959 0.3732
Loa Loa (eye worm) hypothetical protein 0.0009 0.0084 0.0099
Brugia malayi hypothetical protein 0.0261 0.7769 0.9139
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0659 0.0849
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0066 0.0125
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.1352 0.174
Schistosoma mansoni hypothetical protein 0.0109 0.3124 0.5949
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0088 0.2493 0.8354
Brugia malayi RNA binding protein 0.007 0.1959 0.2305
Schistosoma mansoni tar DNA-binding protein 0.007 0.1959 0.3732
Loa Loa (eye worm) hypothetical protein 0.0261 0.7769 0.9139
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0103 0.2968 1
Loa Loa (eye worm) acetyltransferase 0.0161 0.4708 0.5538
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.1352 0.159
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.3124 0.3674
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0335 1 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.1959 0.3732
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Echinococcus multilocularis GPCR, family 2 0.005 0.1352 0.174
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.1959 0.2305
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.4708 0.606
Schistosoma mansoni tar DNA-binding protein 0.007 0.1959 0.3732
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.168 0.2163
Echinococcus multilocularis mitochondrial import inner membrane translocase 0.0009 0.0084 0.0108
Loa Loa (eye worm) hypothetical protein 0.005 0.1352 0.159
Schistosoma mansoni smad1 5 8 and 0.0009 0.0084 0.016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0229 0.0269
Schistosoma mansoni hypothetical protein 0.0053 0.1446 0.2753
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.1352 0.174
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.168 0.1934
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.1256 0.1182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.1352 0.159
Brugia malayi MAP kinase sur-1 0.0061 0.168 0.1977
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0694 0.0817
Brugia malayi Probable mitochondrial import inner membrane translocase subunitTim17 0.0009 0.0084 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0229 0.0269
Echinococcus granulosus lamin 0.0029 0.0694 0.0894
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0659 0.1995
Schistosoma mansoni tar DNA-binding protein 0.007 0.1959 0.3732
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0103 0.2968 0.3491
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0125 0.016
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0103 0.2968 0.3491
Toxoplasma gondii TIM10 family protein, putative 0.0103 0.2968 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0291 0.0342
Brugia malayi intermediate filament protein 0.0029 0.0694 0.0817
Brugia malayi Latrophilin receptor protein 2 0.005 0.1352 0.159
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.1569 0.1497
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.5518 0.6472
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0659 0.1256
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0066 0.0084
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.168 0.2163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.4571 0.5884
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.7769 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.1261 0.1623

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.529 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.932 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.927 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.836 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.823 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.794 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.762 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.751 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.749 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.734 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) > 100 uM Antiproliferative activity against estrogen receptor positive human MCF7 cells after 72 hrs by MTT assay ChEMBL. 18666770

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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