Detailed information for compound 953451

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 957.125 | Formula: C49H68N10O10
  • H donors: 11 H acceptors: 10 LogP: 4.03 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@@H](NC(=O)[C@@H](N(C(=O)[C@@H](NC1=O)CCc1ccc(cc1)O)C)CCc1ccc(cc1)O)Cc1ccccc1)NC(=O)N[C@H](C(=O)O)CCCNC(=N)N)C
  • InChi: 1S/C49H68N10O10/c1-4-30(2)41-45(65)54-37(25-19-31-15-21-34(60)22-16-31)46(66)59(3)40(26-20-32-17-23-35(61)24-18-32)44(64)55-39(29-33-11-6-5-7-12-33)42(62)52-27-9-8-13-36(43(63)58-41)56-49(69)57-38(47(67)68)14-10-28-53-48(50)51/h5-7,11-12,15-18,21-24,30,36-41,60-61H,4,8-10,13-14,19-20,25-29H2,1-3H3,(H,52,62)(H,54,65)(H,55,64)(H,58,63)(H,67,68)(H4,50,51,53)(H2,56,57,69)/t30-,36+,37-,38-,39-,40-,41-/m0/s1
  • InChiKey: TTWROJJNRKDVPJ-FVCPQTOGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0035 0.018 0.1092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Leishmania major basic transcription factor 3a, putative 0.0076 0.0713 1
Brugia malayi Zinc carboxypeptidase family protein 0.0066 0.0584 0.1139
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0035 0.018 0.2526
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0881
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Echinococcus multilocularis heat shock protein 0.0032 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0138 0.0332
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4358 1
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0138 0.033
Giardia lamblia Grp94/Hsp90 0.0025 0.0054 0.0091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0523
Onchocerca volvulus 0.0116 0.1233 0.7474
Onchocerca volvulus 0.0023 0.0022 0.013
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0035 0.018 0.018
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0035 0.018 0.0351
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.032 0.0733
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3538 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0205 0.0523
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Onchocerca volvulus 0.0023 0.0022 0.013
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0513 0.0513
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1709 0.1709
Schistosoma mansoni lamin 0.0116 0.1233 0.2404
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0021 0.0021
Echinococcus granulosus dna polymerase eta 0.0061 0.0513 0.0513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0138 0.0317
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0021 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.1709 0.333
Echinococcus granulosus tar DNA binding protein 0.0211 0.2473 0.2473
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0205 0.0205
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Echinococcus multilocularis heat shock protein 90 0.0025 0.0054 0.0054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1587 1
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0452 0.0452
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0035 0.018 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.9938 0.9938
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0021 0.0021
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0035 0.018 0.0351
Toxoplasma gondii hypothetical protein 0.0023 0.0022 0.0049
Trypanosoma brucei unspecified product 0.0061 0.0513 0.7102
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0513 0.0513
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0148 0.165 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0021 0.0301
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus granulosus dna polymerase kappa 0.0061 0.0513 0.0513
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Onchocerca volvulus 0.0148 0.165 1
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0138 0.0317
Brugia malayi hypothetical protein 0.0113 0.1195 0.233
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.0021 0.0021
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0205 0.0471
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Echinococcus multilocularis endoplasmin 0.0025 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0076 0.0713 0.1967
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Schistosoma mansoni inositol transporter 0.0046 0.032 0.0623
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0205 0.1172
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0021 0.0042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0155 0.0849
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0021 0.0021
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0054 0.0202
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus multilocularis 0.0035 0.018 0.018
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Leishmania major DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0356 0.4358 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.002 0.0039
Toxoplasma gondii microneme protein MIC17B 0.0023 0.0022 0.0049
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.032 0.032
Echinococcus multilocularis musashi 0.0116 0.1233 0.1233
Schistosoma mansoni sodium/solute symporter 0.0046 0.032 0.0623
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Echinococcus granulosus heat shock protein 0.0032 0.0138 0.0138
Onchocerca volvulus Huntingtin homolog 0.0146 0.1629 0.9872
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.032 0.032
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.0021 0.0301
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Giardia lamblia DINP protein human, muc B family 0.0061 0.0513 0.1398
Schistosoma mansoni inositol transporter 0.0046 0.032 0.0623
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0054 0.0054
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.3538 1
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Onchocerca volvulus 0.0023 0.0022 0.0133
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0513 0.1398
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0148 0.165 0.3216
Brugia malayi GH02984p 0.0416 0.5131 1
Schistosoma mansoni DNA polymerase eta 0.0061 0.0513 0.1
Onchocerca volvulus 0.0023 0.0022 0.013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.0041 0.0253 0.0494
Loa Loa (eye worm) intermediate filament protein 0.0116 0.1233 0.2404
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Trichomonas vaginalis carboxypeptidase regulatory region-containing protein, putative 0.0031 0.0127 0.0301
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0138 0.033
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.0021 0.0301
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Echinococcus multilocularis geminin 0.0203 0.2359 0.2359
Loa Loa (eye worm) hypothetical protein 0.0232 0.2742 0.5344
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0138 0.0332
Loa Loa (eye worm) hypothetical protein 0.0145 0.1605 0.3129
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0301
Echinococcus multilocularis transcription factor btf3 0.0076 0.0713 0.0713
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0035 0.018 0.0351
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0113 0.1193 0.2326
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1195 0.1195
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1605 0.1605
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0035 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Echinococcus granulosus heat shock protein 90 0.0032 0.0138 0.0138
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0205 0.0521
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0023 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Onchocerca volvulus 0.0023 0.0022 0.013
Brugia malayi TAR-binding protein 0.0211 0.2473 0.4819
Loa Loa (eye worm) hypothetical protein 0.0146 0.1629 0.3175
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0155 0.0849
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0513 0.1398
Plasmodium vivax endoplasmin, putative 0.0032 0.0138 0.1936
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0021 0.0021
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Echinococcus granulosus endoplasmin 0.0025 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Echinococcus granulosus muscleblind protein 0.0145 0.1605 0.1605
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Echinococcus granulosus lamin dm0 0.0116 0.1233 0.1233
Brugia malayi Carboxypeptidase A2 precursor 0.0035 0.018 0.0351
Onchocerca volvulus 0.0148 0.165 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Brugia malayi Muscleblind-like protein 0.0145 0.1605 0.3129
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0054 0.0202
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.0513 0.7189
Onchocerca volvulus Carboxypeptidase D homolog 0.0066 0.0584 0.354
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0035 0.018 0.018
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0138 0.1936
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Entamoeba histolytica hypothetical protein 0.0113 0.1195 0.3338
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0301
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0452 0.0452
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Schistosoma mansoni intermediate filament proteins 0.0116 0.1233 0.2404
Schistosoma mansoni heat shock protein 0.0032 0.0138 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1709 0.1709
Onchocerca volvulus 0.0046 0.032 0.1937
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1587 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0023 0.0022 0.0049
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0416 0.5131 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0138 0.1686
Trypanosoma brucei Carboxypeptidase-like protein 0.0035 0.018 0.2294
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0494
Loa Loa (eye worm) TAR-binding protein 0.0211 0.2473 0.4819
Schistosoma mansoni endoplasmin 0.0032 0.0138 0.0269
Entamoeba histolytica transcription factor BTF3, putative 0.0076 0.0713 0.1967
Schistosoma mansoni hypothetical protein 0.0203 0.2359 0.4598
Echinococcus multilocularis lamin dm0 0.0116 0.1233 0.1233
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0035 0.018 0.2526
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Onchocerca volvulus 0.0023 0.0022 0.013
Schistosoma mansoni transcription factor btf3 0.0076 0.0713 0.139
Schistosoma mansoni protease m14 carboxypeptidase 0.0035 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0066 0.0584 0.1139
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0021 0.0301
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Loa Loa (eye worm) PDE1B protein 0.0023 0.0021 0.0042
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0339 0.066
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0138 0.0269
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0138 0.1936
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trypanosoma brucei DNA polymerase eta, putative 0.0061 0.0513 0.7102
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1195 0.233
Brugia malayi RNA binding protein 0.0211 0.2473 0.4819
Loa Loa (eye worm) hypothetical protein 0.0116 0.1233 0.2404
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.0021 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1195 0.1195
Trypanosoma brucei transcription factor BTF3, putative 0.0076 0.0713 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.04
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0202 0.2354 0.2354
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.2473 0.4819
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0499 0.0972
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0054 0.0751
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.3538 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0054 0.0751
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Echinococcus multilocularis muscleblind protein 0.0145 0.1605 0.1605
Schistosoma mansoni survival motor neuron protein 0.0047 0.0339 0.066
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0713 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Brugia malayi intermediate filament protein 0.0116 0.1233 0.2404
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.002 0.0039
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.032 0.032
Echinococcus multilocularis heat shock protein 90 0.0032 0.0138 0.0138
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0035 0.018 0.0413
Brugia malayi hypothetical protein 0.0146 0.1629 0.3175
Brugia malayi Inositol-1 0.0037 0.0205 0.04
Echinococcus granulosus heat shock protein 90 0.0025 0.0054 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0268 0.356
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Onchocerca volvulus 0.0116 0.1233 0.7474
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Brugia malayi Sodium:solute symporter family protein 0.0046 0.032 0.0623
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0513 0.3138
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2742 0.2742
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.0021 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Echinococcus granulosus solute carrier family 5 0.0046 0.032 0.032
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0513 0.3138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Leishmania major DNA polymerase eta, putative 0.0061 0.0513 0.7189
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0138 0.1686
Echinococcus multilocularis tar DNA binding protein 0.0211 0.2473 0.2473
Onchocerca volvulus 0.0047 0.0339 0.2054
Trypanosoma brucei unspecified product 0.0042 0.0268 0.356
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0035 0.018 0.018
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Loa Loa (eye worm) hypothetical protein 0.0146 0.1629 0.3175
Toxoplasma gondii microneme protein MIC4 0.0023 0.0022 0.0049
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Onchocerca volvulus 0.0035 0.018 0.1092
Toxoplasma gondii PAN/Apple domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.0021 0.0042
Trypanosoma cruzi Carboxypeptidase-like protein 0.0035 0.018 0.2526
Schistosoma mansoni inositol monophosphatase 0.0037 0.0205 0.04
Brugia malayi beta-NAC-like protein 0.0076 0.0713 0.139
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0042
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0035 0.018 0.2526
Echinococcus multilocularis solute carrier family 5 0.0046 0.032 0.032
Toxoplasma gondii subtilisin SUB12 0.0023 0.0022 0.0049
Toxoplasma gondii NAC domain-containing protein 0.0076 0.0713 0.1637
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0138 0.1936
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0513 0.7189
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.0114 0.1206 0.235
Onchocerca volvulus 0.0023 0.0022 0.013
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Loa Loa (eye worm) hypothetical protein 0.0145 0.1605 0.3129
Plasmodium falciparum basic transcription factor 3b, putative 0.0076 0.0713 1
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0054 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0043
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Toxoplasma gondii microneme protein MIC17A 0.0023 0.0022 0.0049
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2294
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.0513 0.7189
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Schistosoma mansoni hypothetical protein 0.0113 0.1195 0.233
Brugia malayi Endoplasmin precursor 0.0032 0.0138 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0211 0.2473 0.4819
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.1233 0.2404
Onchocerca volvulus 0.0035 0.018 0.1092
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) PAN domain-containing protein 0.0023 0.0022 0.0042
Brugia malayi Zinc carboxypeptidase family protein 0.0066 0.0584 0.1139
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0205 1
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0713 1
Echinococcus multilocularis lamin 0.0116 0.1233 0.1233
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.0021 0.0301
Plasmodium falciparum heat shock protein 90 0.0032 0.0138 0.1936
Schistosoma mansoni hypothetical protein 0.0203 0.2359 0.4598
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.032 0.032
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2742 0.2742
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0205 0.0523
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.032 0.032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0202 0.2354 0.2354
Loa Loa (eye worm) hypothetical protein 0.0054 0.0424 0.0827
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0138 0.1686
Onchocerca volvulus 0.0023 0.0022 0.013
Onchocerca volvulus 0.0148 0.165 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Echinococcus granulosus lamin 0.0116 0.1233 0.1233
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Plasmodium vivax basic transcription factor 3b, putative 0.0076 0.0713 1
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Onchocerca volvulus 0.0023 0.0022 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0243 0.2884 0.5622
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0513 0.1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1709 0.1709
Onchocerca volvulus 0.0023 0.0022 0.013
Toxoplasma gondii zinc carboxypeptidase, putative 0.0035 0.018 0.0413
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0054 0.0751
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.0021 0.0301
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0513 0.1397
Echinococcus granulosus geminin 0.0203 0.2359 0.2359
Schistosoma mansoni peptidase 0.0035 0.018 0.0351
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.032 0.032
Echinococcus granulosus intermediate filament protein 0.0116 0.1233 0.1233
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0148 0.165 0.165
Toxoplasma gondii flagellar/basal body protein 0.0035 0.018 0.0413
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0513 0.0513
Schistosoma mansoni high-affinity choline transporter 0.0416 0.5131 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0532 0.1037
Loa Loa (eye worm) hypothetical protein 0.0061 0.0513 0.1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Leishmania major heat shock protein 83-1 0.0032 0.0138 0.1936
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1587 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0499 0.0972
Schistosoma mansoni heat shock protein 0.0032 0.0138 0.0269
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0148 0.165 0.165
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi heat shock protein 90 0.0032 0.0138 0.0269
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.2473 0.4819
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.0513 0.3138
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2876
Toxoplasma gondii microneme protein MIC17C 0.0023 0.0022 0.0049
Trypanosoma brucei unspecified product 0.0042 0.0268 0.356
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.0021 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0513 0.7102
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi PAN domain containing protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0042
Onchocerca volvulus 0.0023 0.0022 0.013
Onchocerca volvulus 0.0023 0.0022 0.013
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Brugia malayi LD47325p 0.0031 0.0127 0.0248
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0307
Echinococcus multilocularis high affinity choline transporter 1 0.0416 0.5131 0.5131
Loa Loa (eye worm) zinc carboxypeptidase 0.0035 0.018 0.0351
Echinococcus granulosus high affinity choline transporter 1 0.0416 0.5131 0.5131
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0035 0.018 0.0451
Loa Loa (eye worm) zinc carboxypeptidase 0.0066 0.0584 0.1139
Onchocerca volvulus 0.0148 0.165 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.0021 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0513 0.1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0054 0.0091
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.0021 0.0301
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0023 0.0022 0.0049
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0532 0.1037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0127 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1709 0.333
Loa Loa (eye worm) RNA binding protein 0.0211 0.2473 0.4819
Loa Loa (eye worm) inositol-1 0.0037 0.0205 0.04
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0253 0.0494
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.079 1 1
Schistosoma mansoni endoplasmin 0.0032 0.0138 0.0269
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2294
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.0021 0.0301
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0023 0.0021 0.0301
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0021 0.0042
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0138 0.1936
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0713 0.1968
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.1709 0.333
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0301
Loa Loa (eye worm) ICD-1 protein 0.0076 0.0713 0.139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1709 0.1709
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0035 0.018 0.018
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0513 0.3138
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2526
Brugia malayi hypothetical protein 0.0232 0.2742 0.5344
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0513 0.7102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.0021 0.0049
Onchocerca volvulus Huntingtin homolog 0.0146 0.1629 0.9872
Toxoplasma gondii microneme protein, putative 0.0023 0.0022 0.0049
Echinococcus granulosus transcription factor btf3 0.0076 0.0713 0.0713
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0035 0.018 0.0451
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0513 0.1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0351
Schistosoma mansoni hypothetical protein 0.0047 0.0339 0.066
Loa Loa (eye worm) hypothetical protein 0.0243 0.2884 0.5622
Schistosoma mansoni lamin 0.0116 0.1233 0.2404
Loa Loa (eye worm) hypothetical protein 0.0054 0.0424 0.0827
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.1233 0.2404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3538 1
Loa Loa (eye worm) endoplasmin 0.0032 0.0138 0.0269
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0054 0.0202
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0035 0.018 0.2526
Echinococcus multilocularis dna polymerase eta 0.0061 0.0513 0.0513
Trypanosoma brucei heat shock protein, putative 0.0032 0.0138 0.1686
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0021 0.0301
Loa Loa (eye worm) hypothetical protein 0.0046 0.032 0.0623
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0205 0.2656
Brugia malayi Zinc carboxypeptidase family protein 0.0035 0.018 0.0351

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of human dual specificity protein phosphatase VHR expressed in Escherichia coli JM109 at 100 ug/mL ChEMBL. 11520225
Activity (binding) Inhibition of human dual specificity protein phosphatase Cdc25B expressed in Escherichia coli BL21 (DE3) at 100 ug/mL ChEMBL. 11520225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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