Detailed information for compound 972291

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.343 | Formula: C19H18O5
  • H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=C\c2cc(O)c3c(c2)occ3)cc(c1OC)OC
  • InChi: 1S/C19H18O5/c1-21-17-10-13(11-18(22-2)19(17)23-3)5-4-12-8-15(20)14-6-7-24-16(14)9-12/h4-11,20H,1-3H3/b5-4-
  • InChiKey: CKGOZQOFJSRSSW-PLNGDYQASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0049 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Onchocerca volvulus 0.0075 0.1454 0.1467
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0215 0.0247
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0129 0.2573 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0014 0.0153 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1505 0.5845
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0304 0.0334
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0023 0.0023
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0089 0.1735 0.202
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0469 0.0544
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.8575 1
Trypanosoma brucei unspecified product 0.0021 0.0304 0.117
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.019 0.0218
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0023 0.0023
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Brugia malayi beta-lactamase family protein 0.0075 0.1454 0.1692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0048
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0416 0.1607
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Trypanosoma brucei unspecified product 0.0014 0.0168 0.0643
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Brugia malayi Probable ClpP-like protease 0.0078 0.1505 0.1752
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0519 0.0602
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0304 0.117
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0941 0.4744
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0003 0.0004
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.1454 0.5645
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.1639 0.6364
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1128 0.1314
Echinococcus granulosus Smad4 0.0017 0.0215 0.0228
Echinococcus granulosus dna polymerase kappa 0.0021 0.0304 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1927 0.2245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1053 0.4085
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1454 0.5645
Schistosoma mansoni Smad4 0.0007 0.0023 0.0027
Brugia malayi MH2 domain containing protein 0.0007 0.0023 0.0023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0304 0.0334
Echinococcus multilocularis geminin 0.0333 0.6868 0.8139
Brugia malayi hypothetical protein 0.0076 0.1463 0.1703
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.085 0.0987
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.1454 0.1692
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1128 0.1314
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1505 0.5845
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0304 0.117
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Brugia malayi N-terminal motif family protein 0.0175 0.3545 0.4132
Echinococcus granulosus dnaJ subfamily B 0.0407 0.8432 1
Loa Loa (eye worm) DIX domain-containing protein 0.0014 0.0153 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0519 0.0602
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Toxoplasma gondii ABC1 family protein 0.0075 0.1454 0.5645
Loa Loa (eye worm) hypothetical protein 0.006 0.1128 0.1312
Brugia malayi MH2 domain containing protein 0.0017 0.0215 0.0247
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.164 0.191
Schistosoma mansoni hypothetical protein 0.0012 0.0114 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Schistosoma mansoni hypothetical protein 0.0067 0.1276 0.1513
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1927 0.2245
Schistosoma mansoni cpg binding protein 0.003 0.0504 0.0597
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.085 0.0987
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0084 0.164 0.1674
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0379 0.7839 0.9295
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.01 0.0091
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1128 0.4377
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0304 0.0307
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0049 0.0058
Brugia malayi CXXC zinc finger family protein 0.0029 0.0469 0.0544
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.0053
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0049 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0304 0.0116
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Onchocerca volvulus 0.0075 0.1454 0.1467
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0519 0.059
Leishmania major hypothetical protein, conserved 0.0075 0.1454 0.5645
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.1069 0.1244
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.019 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.1454 0.1692
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0089 0.1735 0.202
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0049 0.0058
Loa Loa (eye worm) hypothetical protein 0.0084 0.164 0.191
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.019 0.0726
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0416 0.1607
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.1454 0.1289
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0129 0.2573 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0941 0.1092
Brugia malayi isocitrate dehydrogenase 0.0015 0.019 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.085 0.0983
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.1454 0.5645
Echinococcus multilocularis Smad4 0.0017 0.0215 0.0228
Mycobacterium leprae Probable lipase LipE 0.0075 0.1454 0.952
Brugia malayi hypothetical protein 0.0017 0.0222 0.0255
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0304 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0168 0.0643
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0304 0.117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0519 0.059
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.1454 0.1289
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0304 0.117
Onchocerca volvulus 0.0471 0.9776 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0063 0.0075
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.3545 0.3611
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0014 0.0153 0.0133
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.1454 0.1289
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.1454 0.1701
Mycobacterium ulcerans beta-lactamase 0.0075 0.1454 0.5645
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0129 0.2573 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0215 0.0228
Loa Loa (eye worm) hypothetical protein 0.0175 0.3545 0.4132
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.004 0.0706 0.2735
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus granulosus cpg binding protein 0.003 0.0504 0.0571
Echinococcus multilocularis smad 0.0017 0.0215 0.0228
Loa Loa (eye worm) histone methyltransferase 0.0011 0.01 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1463 0.1735
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.1454 0.1701
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1505 0.5845
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0153 0.0154
Schistosoma mansoni smad 0.0017 0.0215 0.0255
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Brugia malayi Pre-SET motif family protein 0.006 0.1128 0.1312
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0416 0.0482
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1128 0.1314
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0084 0.164 0.1923
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.004 0.0706 0.2735
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Schistosoma mansoni protein kinase 0.0379 0.7839 0.9297
Schistosoma mansoni hypothetical protein 0.0333 0.6868 0.8145
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.019 0.0726
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0044 0.0802 0.3449
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.019 0.0726
Schistosoma mansoni hypothetical protein 0.0407 0.8432 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0084 0.164 0.191
Brugia malayi hypothetical protein 0.0026 0.0416 0.0482
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.004 0.0706 0.2735
Mycobacterium leprae conserved hypothetical protein 0.0075 0.1454 0.952
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0519 0.0602
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0801 0.0815
Brugia malayi MH1 domain containing protein 0.0017 0.0215 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1128 0.1338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.085 0.0983
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.085 0.0983
Loa Loa (eye worm) hypothetical protein 0.0078 0.1505 0.1752
Onchocerca volvulus 0.0087 0.1706 0.1725
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0941 0.1092
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0049 0.0053
Plasmodium vivax SET domain protein, putative 0.006 0.1128 0.4377
Schistosoma mansoni dishevelled 0.0014 0.0153 0.0181
Brugia malayi Pre-SET motif family protein 0.0414 0.8575 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0941 0.0766
Mycobacterium ulcerans hypothetical protein 0.0075 0.1454 0.5645
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.1454 0.1289
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0432 0.1669
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1454 0.1724
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0304 0.0307
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0084 0.164 0.1923
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0114 0.0108
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0215 0.0255
Brugia malayi hypothetical protein 0.0009 0.0049 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.1454 0.1289
Brugia malayi MH1 domain containing protein 0.0017 0.0215 0.0247
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0084 0.1639 0.6364
Echinococcus granulosus dna polymerase eta 0.0021 0.0304 0.0334
Loa Loa (eye worm) hypothetical protein 0.0098 0.1927 0.2245
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Brugia malayi RasGEF domain containing protein 0.0011 0.0101 0.0114
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0129 0.2573 0.3051
Onchocerca volvulus 0.0075 0.1454 0.1467
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.1454 0.1289
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1505 0.1763
Brugia malayi hypothetical protein 0.0009 0.0049 0.0053
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0379 0.7839 0.9295
Mycobacterium ulcerans lipase LipD 0.0075 0.1454 0.5645
Loa Loa (eye worm) hypothetical protein 0.0067 0.1276 0.1484
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0153 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0519 0.059
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.019 0.0726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.085 0.1008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.019 0.0726
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0215 0.0247
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0215 0.0228
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0044 0.0802 0.0624
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Loa Loa (eye worm) hypothetical protein 0.0087 0.1706 0.1986
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Leishmania major hypothetical protein, conserved 0.0026 0.0416 0.1607
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0049 0.0053
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0049 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0416 0.1607
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0304 0.0116
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0304 0.036
Schistosoma mansoni protein kinase 0.0379 0.7839 0.9297
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0129 0.2573 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.1454 0.1724
Schistosoma mansoni smad1 5 8 and 0.0017 0.0215 0.0255
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0084 0.164 0.1674
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0941 0.0766
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Echinococcus multilocularis cpg binding protein 0.003 0.0504 0.0571
Schistosoma mansoni hypothetical protein 0.0076 0.1463 0.1735
Schistosoma mansoni smad 0.0007 0.0023 0.0027
Brugia malayi beta-lactamase family protein 0.0075 0.1454 0.1692
Echinococcus multilocularis segment polarity protein dishevelled 0.0014 0.0153 0.0154
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1463 0.1712
Toxoplasma gondii hypothetical protein 0.0027 0.0432 0.1669
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1454 0.1483
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0304 0.0351
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0215 0.0228
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1505 0.1763
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0049 0.0053
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0023 0.0023
Echinococcus granulosus PKC activated phosphatase 1 inhibitor 0.0087 0.1706 0.2001
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0801 0.093
Brugia malayi beta-lactamase 0.0075 0.1454 0.1692
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Loa Loa (eye worm) hypothetical protein 0.0021 0.0304 0.0351
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0049 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.4964 0.5787
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.019 0.0726
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0049 0.0031
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0084 0.1639 0.6364
Toxoplasma gondii hypothetical protein 0.0009 0.0049 0.0178
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.0053
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0129 0.2573 0.3032
Trichomonas vaginalis set domain proteins, putative 0.0471 0.9776 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0432 0.1669
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1505 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0215 0.0228
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1454 0.5645
Schistosoma mansoni hypothetical protein 0.0333 0.6868 0.8145
Schistosoma mansoni hypothetical protein 0.0031 0.0519 0.0616
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0129 0.2573 1
Echinococcus multilocularis PKC activated phosphatase 1 inhibitor 0.0087 0.1706 0.2001
Trypanosoma brucei unspecified product 0.0014 0.0168 0.0643
Schistosoma mansoni Smad4 0.0017 0.0215 0.0255
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0097 0.011
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0049 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0304 0.117
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Brugia malayi DIX domain containing protein 0.0014 0.0153 0.0174
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0416 0.1607
Schistosoma mansoni cpg binding protein 0.003 0.0504 0.0597
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.019 0.0225
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0063 0.0048
Leishmania major DNA polymerase eta, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0023 0.0023
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.004 0.0706 0.082
Plasmodium vivax hypothetical protein, conserved 0.0075 0.1454 0.5645
Loa Loa (eye worm) hypothetical protein 0.0075 0.1454 0.1692
Trichomonas vaginalis esterase, putative 0.0075 0.1454 0.1483
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0304 0.117
Schistosoma mansoni Smad4 0.0007 0.0023 0.0027
Loa Loa (eye worm) beta-lactamase 0.0075 0.1454 0.1692
Echinococcus granulosus GPCR family 2 0.0031 0.0519 0.059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1927 0.2245
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0101 0.0114
Brugia malayi Isocitrate dehydrogenase 0.0015 0.019 0.0218
Schistosoma mansoni protein phosphatase 1 inhibitor potentiated by protein kinase C 0.0087 0.1706 0.2023
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1505 0.5845
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Brugia malayi MH2 domain containing protein 0.0017 0.0215 0.0247
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0114 0.0108
Onchocerca volvulus 0.0009 0.0049 0.0026
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0129 0.2573 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0416 0.1607
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.1454 0.1289
Loa Loa (eye worm) hypothetical protein 0.0014 0.0153 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1454 0.5645
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0416 0.1607
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0066
Loa Loa (eye worm) nuclear factor I 0.0009 0.006 0.0066
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0129 0.2573 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0416 0.1607
Schistosoma mansoni dishevelled 0.0014 0.0153 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1189 0.141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.085 0.0983
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0129 0.2573 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.019 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0304 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.01 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0304 0.117
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0304 0.036
Loa Loa (eye worm) hypothetical protein 0.0009 0.006 0.0066
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.004 0.0706 0.2735
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.004 0.0706 0.2735
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0129 0.2573 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0519 0.059
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Leishmania major DNA polymerase kappa, putative 0.0021 0.0304 0.117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1463 0.1712
Echinococcus granulosus segment polarity protein dishevelled 0.0014 0.0153 0.0154
Schistosoma mansoni dep domain containing protein 0.0009 0.0049 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.1454 0.1483
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0063 0.0048
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.019 0.0726
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0049 0.0031
Echinococcus multilocularis dna polymerase eta 0.0021 0.0304 0.0334
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1505 0.1785
Schistosoma mansoni cpg binding protein 0.0029 0.0469 0.0556
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0129 0.2573 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0129 0.2573 0.2998
Echinococcus granulosus smad 0.0017 0.0215 0.0228
Brugia malayi MH2 domain containing protein 0.0242 0.4964 0.5787
Brugia malayi Smad1 0.0017 0.0215 0.0247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1128 0.1338
Entamoeba histolytica hypothetical protein 0.0076 0.1463 0.5108
Brugia malayi MH1 domain containing protein 0.0009 0.006 0.0066
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0129 0.2573 1
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1276 0.1484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0304 0.117
Loa Loa (eye worm) Smad1 0.0017 0.0215 0.0247
Brugia malayi hypothetical protein 0.0087 0.1706 0.1986
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.4964 0.5787
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.8432 1
Onchocerca volvulus 0.006 0.1128 0.1133
Echinococcus granulosus geminin 0.0333 0.6868 0.8139
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0519 0.0602
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0129 0.2573 0.2629
Echinococcus multilocularis GPCR, family 2 0.0031 0.0519 0.059
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.019 0.0198
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0063 0.0048
Onchocerca volvulus 0.0029 0.0469 0.0457
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0129 0.2573 1
Schistosoma mansoni DNA polymerase eta 0.0021 0.0304 0.036
Mycobacterium tuberculosis Conserved protein 0.0075 0.1454 0.1289
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.1454 0.1483

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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