Detailed information for compound 976381

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 315.453 | Formula: C17H17NOS2
  • H donors: 1 H acceptors: 1 LogP: 3.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1/C(=C/c2ccc(s2)C)/CNC/C/1=C\c1ccc(s1)C
  • InChi: 1S/C17H17NOS2/c1-11-3-5-15(20-11)7-13-9-18-10-14(17(13)19)8-16-6-4-12(2)21-16/h3-8,18H,9-10H2,1-2H3/b13-7+,14-8+
  • InChiKey: QJEOPPOVNQRHSW-FNCQTZNRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0339 0.1121 1
Echinococcus granulosus tyrosine kinase 0.0419 0.1397 0.1395
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0095 0.0093
Echinococcus granulosus atrial natriuretic peptide receptor 0.0419 0.1397 0.1395
Brugia malayi Receptor family ligand binding region containing protein 0.0419 0.1397 0.3571
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0064 0.0444
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0009
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0095 0.013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.002 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.002 0.0051
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.2097 0.718 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0124 0.3815
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0095 0.0244
Brugia malayi Receptor family ligand binding region containing protein 0.0419 0.1397 0.3571
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.0075 0.0186
Schistosoma mansoni tyrosine kinase 0.0419 0.1397 0.1936
Onchocerca volvulus 0.005 0.0124 0.0885
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0079 0.9798
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0091 0.2797
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0076 0.0534
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0124 0.0873
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0076 0.2336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Echinococcus multilocularis lamin dm0 0.0026 0.0041 0.0039
Brugia malayi hypothetical protein 0.0419 0.1397 0.3571
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0076 0.0075
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0164 0.0415
Schistosoma mansoni hypothetical protein 0.2107 0.7214 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0419 0.1397 0.3568
Brugia malayi nuclear receptor NHR-88 0.002 0.002 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0164 0.0228
Echinococcus multilocularis cpg binding protein 0.0189 0.0604 0.0602
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0095 0.067
Onchocerca volvulus 0.0297 0.0974 0.6972
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.002 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0124 0.017
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0455 0.063
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.2097 0.718 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.008 1
Echinococcus multilocularis expressed protein 0.0018 0.0014 0.0012
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0004
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0076 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Echinococcus multilocularis receptor type guanylyl cyclase 0.0419 0.1397 0.1395
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0063 0.0167 0.517
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0321 0.0816
Schistosoma mansoni Smad4 0.0016 0.0006 0.0009
Onchocerca volvulus 0.0015 0.0002 0.0014
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1237 0.4217 0.4216
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Echinococcus multilocularis nmda type glutamate receptor 0.0419 0.1397 0.1395
Schistosoma mansoni DNA polymerase eta 0.0042 0.0095 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0124 0.017
Loa Loa (eye worm) glutamate receptor 2 0.0818 0.2771 0.7082
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0095 0.0093
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0095 0.0239
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0079 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Brugia malayi hypothetical protein 0.0145 0.045 0.1151
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0079 0.0077
Schistosoma mansoni cellular tumor antigen P53 0.0096 0.0282 0.0392
Echinococcus granulosus receptor type guanylyl cyclase 0.0419 0.1397 0.1395
Echinococcus granulosus glutamate NMDA receptor subunit 0.0818 0.2771 0.277
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.002 0.0018
Echinococcus granulosus expressed protein 0.0033 0.0067 0.0065
Schistosoma mansoni ferritin 0.0018 0.0014 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0076 0.0534
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0321 0.0445
Chlamydia trachomatis glutamine binding protein 0.2097 0.718 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.008 0.02
Brugia malayi intermediate filament protein 0.0026 0.0041 0.0105
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0321 0.0445
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0271 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0105 0.0103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0095 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.011 0.3373
Mycobacterium ulcerans lipoprotein LpqF 0.0063 0.0167 0.023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0095 0.067
Giardia lamblia Kinase, PLK 0.0093 0.0271 1
Brugia malayi Augmenter of liver regeneration 0.0036 0.0075 0.0191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.002 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0791 0.2677 0.2676
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0164 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0105 0.0145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.002 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0124 0.017
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0075 0.2277
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0076 0.0534
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0064 0.1942
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.002 0.0018
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0105 0.0263
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0079 0.9798
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0014 0.0017
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.002 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Schistosoma mansoni hypothetical protein 0.0126 0.0386 0.0535
Trypanosoma brucei unspecified product 0.0029 0.0051 0.1527
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Entamoeba histolytica hypothetical protein 0.0145 0.045 0.3213
Onchocerca volvulus 0.0015 0.0002 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0124 0.0873
Schistosoma mansoni ferritin 0.0018 0.0014 0.002
Echinococcus granulosus FTZ F1 alpha 0.002 0.002 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.2271 0.227
Echinococcus granulosus glutamate receptor 1 0.0331 0.1092 0.109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.002 0.0028
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0041 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Brugia malayi MH2 domain containing protein 0.0234 0.0757 0.1935
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0016
Entamoeba histolytica hypothetical protein 0.0145 0.045 0.3213
Brugia malayi steroid hormone receptor 0.002 0.002 0.0051
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0105 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.1527
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0075 0.0521
Echinococcus granulosus metabotropic glutamate receptor 5 0.0419 0.1397 0.1395
Schistosoma mansoni glutamate receptor kainate 0.0818 0.2771 0.3842
Onchocerca volvulus 0.0026 0.0041 0.0294
Schistosoma mansoni cpg binding protein 0.0189 0.0604 0.0837
Brugia malayi 6-phosphofructokinase 0.0107 0.0321 0.0821
Echinococcus granulosus glutamate receptor 2 0.1568 0.5358 0.5357
Schistosoma mansoni hypothetical protein 0.0049 0.0122 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0321 1
Brugia malayi 6-phosphofructokinase 0.0107 0.0321 0.0821
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0095 0.2927
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0063 0.0167 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Schistosoma mansoni protein kinase 0.0419 0.1397 0.1936
Loa Loa (eye worm) CXXC zinc finger family protein 0.0179 0.0569 0.1449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.002 0.0018
Leishmania major extracellular receptor, putative 0.0419 0.1397 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0067 0.0165
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.002 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0014 0.0383
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0122 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0016 0.0446
Schistosoma mansoni hypothetical protein 0.0507 0.17 0.2356
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0002 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.049 0.1251
Onchocerca volvulus 0.0026 0.0041 0.0294
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0075 0.0649
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0051 0.1544
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.045 0.0624
Echinococcus granulosus glutamate receptor 4 0.0331 0.1092 0.109
Leishmania major DNA polymerase eta, putative 0.0042 0.0095 0.067
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0818 0.2771 0.277
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.002 0.0018
Echinococcus multilocularis dna polymerase eta 0.0042 0.0095 0.0093
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0091 0.2797
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0076 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0002 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.002 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.0075 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.002 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0321 1
Echinococcus multilocularis muscleblind protein 1 0.0479 0.1603 0.1601
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0321 1
Plasmodium falciparum zinc finger protein, putative 0.0021 0.0024 0.2843
Schistosoma mansoni apoferritin-2 0.0018 0.0014 0.002
Brugia malayi Probable ATP-dependent helicase DHX35 0.016 0.0504 0.1287
Loa Loa (eye worm) hypothetical protein 0.0156 0.049 0.1247
Loa Loa (eye worm) hypothetical protein 0.0049 0.0122 0.0306
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0016
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.2097 0.718 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0321 0.2287
Schistosoma mansoni glutamate receptor AMPA 0.0818 0.2771 0.3842
Loa Loa (eye worm) hypothetical protein 0.0107 0.0319 0.0811
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.002 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.002 0.0028
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0011
Trichomonas vaginalis rotamase, putative 0.0033 0.0064 0.1942
Schistosoma mansoni cpg binding protein 0.0179 0.0569 0.0788
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0124 0.017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0095 0.2927
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0051 0.0353
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0319 0.0816
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0095 0.0239
Brugia malayi AMP-binding enzyme family protein 0.005 0.0124 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Entamoeba histolytica hypothetical protein 0.0021 0.0024 0.0159
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0079 0.009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.002 0.0051
Brugia malayi nuclear hormone receptor 0.002 0.002 0.0051
Schistosoma mansoni coup transcription factor 0.002 0.002 0.0028
Echinococcus multilocularis glutamate receptor subunit protein glur 0.1149 0.3912 0.3911
Trypanosoma brucei unspecified product 0.0042 0.0095 0.2927
Leishmania major DNA polymerase kappa, putative 0.0042 0.0095 0.067
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.002 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0122 0.0306
Trichomonas vaginalis hypothetical protein 0.0022 0.0026 0.0766
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0271 0.1929
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0271 0.1929
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.002 0.0018
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.008 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Loa Loa (eye worm) hypothetical protein 0.0096 0.0282 0.0717
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0321 0.0816
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0055 0.0142 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Loa Loa (eye worm) hypothetical protein 0.0479 0.1603 0.4094
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0076 0.2336
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0455 0.0453
Echinococcus multilocularis muscleblind protein 0.0479 0.1603 0.1601
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.049 0.1247
Schistosoma mansoni ap endonuclease 0.0037 0.0079 0.0109
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0095 0.067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0122 0.0311
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0419 0.1397 0.1395
Loa Loa (eye worm) RNA binding protein 0.0062 0.0164 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Schistosoma mansoni metabotropic glutamate receptor 0.0419 0.1397 0.1936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.002 0.0047
Echinococcus granulosus geminin 0.0507 0.17 0.1698
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0073 0.0099
Schistosoma mansoni hypothetical protein 0.0818 0.2771 0.3842
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0419 0.1397 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.038 0.1261 0.1747
Loa Loa (eye worm) hypothetical protein 0.016 0.0504 0.1283
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0271 0.0693
Echinococcus granulosus glutamate receptor subunit protein glur 0.1149 0.3912 0.3911
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1568 0.5358 0.5357
Brugia malayi Smad1 0.0016 0.0006 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0011
Brugia malayi AMP-binding enzyme family protein 0.005 0.0124 0.0316
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0076 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0079 0.0196
Onchocerca volvulus Bile acid receptor homolog 0.002 0.002 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.002 0.0047
Onchocerca volvulus 0.0419 0.1397 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1237 0.4217 0.4216
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0051 0.6305
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0095 0.013
Brugia malayi TAR-binding protein 0.0062 0.0164 0.042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Echinococcus granulosus tar DNA binding protein 0.0062 0.0164 0.0162
Trichomonas vaginalis rotamase, putative 0.0033 0.0067 0.2027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0095 0.067
Loa Loa (eye worm) hypothetical protein 0.0331 0.1092 0.2788
Loa Loa (eye worm) hypothetical protein 0.0331 0.1092 0.2788
Schistosoma mansoni ferritin light chain 0.0018 0.0014 0.002
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0818 0.2771 0.277
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0037 0.008 0.02
Loa Loa (eye worm) hypothetical protein 0.0297 0.0974 0.2486
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0386 0.0384
Schistosoma mansoni hypothetical protein 0.0049 0.0122 0.0169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.008 0.0109
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.013 0.04 0.0555
Schistosoma mansoni ATP-binding cassette transporter 0.0818 0.2771 0.3842
Echinococcus granulosus muscleblind protein 0.0479 0.1603 0.1601
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0051 0.6305
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0079 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Echinococcus multilocularis FTZ F1 alpha 0.002 0.002 0.0018
Entamoeba histolytica hypothetical protein 0.0419 0.1397 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.049 0.1251
Onchocerca volvulus 0.0015 0.0002 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.045 0.0448
Brugia malayi metabotropic glutamate receptor type 2 0.0419 0.1397 0.3571
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0271 0.0376
Echinococcus granulosus dna polymerase eta 0.0042 0.0095 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0079 0.0549
Loa Loa (eye worm) histone methyltransferase 0.0055 0.0142 0.0359
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0073 0.0099
Echinococcus granulosus GPCR family 2 0.0049 0.0122 0.012
Echinococcus granulosus microtubule associated protein 2 0.0673 0.2271 0.227
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0419 0.1397 0.3571
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0419 0.1397 0.3568
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.002 0.0028
Brugia malayi ecdysteroid receptor 0.002 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Echinococcus granulosus metabotropic glutamate receptor 2 0.0419 0.1397 0.1395
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0124 0.0873
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0321 0.2287
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0002 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Loa Loa (eye worm) RGC/RGC protein kinase 0.0419 0.1397 0.3568
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0095 0.2927
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0095 0.2927
Schistosoma mansoni hypothetical protein 0.0507 0.17 0.2356
Loa Loa (eye worm) hypothetical protein 0.0331 0.1092 0.2788
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.002 0.0028
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0386 0.0384
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0079 0.0201
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0124 0.017
Schistosoma mansoni tyrosine kinase 0.0419 0.1397 0.1936
Schistosoma mansoni ap endonuclease 0.0037 0.0079 0.0109
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0095 0.0132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.002 0.0028
Schistosoma mansoni glutamate receptor NMDA 0.1237 0.4217 0.5846
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0076 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.002 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0122 0.012
Schistosoma mansoni myst-related protein 0.0021 0.0024 0.0033
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0311
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0095 0.013
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1237 0.4217 0.4216
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0044 0.0105 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Brugia malayi Muscleblind-like protein 0.0479 0.1603 0.4097
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0064 0.0444
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0091 0.2797
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0321 0.0319
Echinococcus granulosus tumor protein p63 0.0656 0.2214 0.2212
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0419 0.1397 0.3568
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.004 0.0055
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1568 0.5358 0.5357
Echinococcus granulosus glutamate receptor 2 0.075 0.2538 0.2536
Brugia malayi RNA binding protein 0.0062 0.0164 0.042
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0124 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0076 0.2336
Brugia malayi Glutamate receptor 2 precursor 0.1149 0.3912 1
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0122 0.012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0105 0.0103
Loa Loa (eye worm) RGC/RGC protein kinase 0.0419 0.1397 0.3568
Loa Loa (eye worm) hypothetical protein 0.0037 0.008 0.02
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0164 0.042
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0321 0.0445
Schistosoma mansoni hypothetical protein 0.0049 0.0122 0.0169
Onchocerca volvulus 0.0419 0.1397 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0076 0.0191
Schistosoma mansoni ferritin 0.0018 0.0014 0.002
Trypanosoma brucei beta lactamase 0.0063 0.0167 0.517
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0075 0.9295
Mycobacterium ulcerans hypothetical protein 0.005 0.0124 0.017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0076 0.2336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.002 0.0047
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0095 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.011 0.3373
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.1527
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0079 0.0107
Brugia malayi Guanylyl cyclase protein 23 0.0419 0.1397 0.3571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0105 0.0145
Schistosoma mansoni myst-related protein 0.0021 0.0024 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0016 0.0446
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0321 0.0445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0096
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1237 0.4217 0.4216
Echinococcus granulosus lamin dm0 0.0026 0.0041 0.0039
Trichomonas vaginalis ferritin, putative 0.0018 0.0014 0.0383
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0064 0.0444
Leishmania major hypothetical protein, conserved 0.0036 0.0075 0.0521
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1237 0.4217 0.4216
Brugia malayi CXXC zinc finger family protein 0.0179 0.0569 0.1453
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0051 0.044
Echinococcus multilocularis musashi 0.0026 0.0041 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0079 0.1242
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0124 0.0873
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0164 0.0228
Echinococcus multilocularis tyrosine kinase 0.0419 0.1397 0.1395
Brugia malayi Metabotropic glutamate receptor precursor. 0.0419 0.1397 0.3571
Echinococcus multilocularis glutamate receptor 4 0.0331 0.1092 0.109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.002 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.2915 1 1
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0044 0.0105 0.0103
Schistosoma mansoni glutamate receptor kainate 0.0818 0.2771 0.3842
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0055 0.0142 0.014
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0321 0.2287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.045 0.0448
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0818 0.2771 0.277
Schistosoma mansoni smad 0.0016 0.0006 0.0009
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0064 0.0554
Echinococcus granulosus lamin 0.0026 0.0041 0.0039
Onchocerca volvulus 0.0015 0.0002 0.0014
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.0075 0.0649
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0076 0.0075
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0076 0.115
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0076 0.0534
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.2271 0.3148
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0002 0.0005
Echinococcus multilocularis smad 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0311
Trichomonas vaginalis helicase, putative 0.0041 0.0091 0.2797
Schistosoma mansoni metabotropic glutamate receptor 0.0419 0.1397 0.1936
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0164 0.0415
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0095 0.2927
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0271 0.8432
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0321 0.2287
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0079 0.24
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0271 0.1929
Trypanosoma cruzi ISWI complex protein 0.0019 0.0016 0.0102
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0311
Loa Loa (eye worm) glutamate receptor 1 0.1149 0.3912 1
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0122 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Echinococcus multilocularis tumor protein p63 0.0656 0.2214 0.2212
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0122 0.012
Schistosoma mansoni hypothetical protein 0.0107 0.0319 0.0443
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.002 0.0047
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0271 0.1929
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0002 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0095 0.067
Echinococcus granulosus intermediate filament protein 0.0026 0.0041 0.0039
Loa Loa (eye worm) DEAH box polypeptide 35 0.016 0.0504 0.1283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.002 0.0051
Echinococcus multilocularis NMDA receptor 0.0818 0.2771 0.277
Schistosoma mansoni glutamate receptor kainate 0.0818 0.2771 0.3842
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0051 0.1544
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0004
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0051 0.0052
Brugia malayi F/Y-rich N-terminus family protein 0.0055 0.014 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0164 0.0228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.002 0.0018
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.008 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0455 0.063
Echinococcus granulosus expressed protein 0.0018 0.0014 0.0012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0124 0.017
Loa Loa (eye worm) hypothetical protein 0.0479 0.1603 0.4094
Echinococcus granulosus ferritin 0.0018 0.0014 0.0012
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0051 0.6305
Schistosoma mansoni intermediate filament proteins 0.0026 0.0041 0.0057
Giardia lamblia DINP protein human, muc B family 0.0042 0.0095 0.2007
Loa Loa (eye worm) steroid hormone receptor 0.002 0.002 0.0047
Echinococcus multilocularis geminin 0.0507 0.17 0.1698
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.008 1
Trypanosoma brucei polo-like protein kinase 0.0093 0.0271 0.8432
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.002 0.0051
Schistosoma mansoni ferritin 0.0018 0.0014 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.002 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.0757 0.1931
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0321 0.0319
Brugia malayi phosphofructokinase 0.0107 0.0321 0.0821
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0271 0.0269
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0818 0.2771 0.277
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0419 0.1397 0.1395
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1237 0.4217 0.4216
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0067 0.2027
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.013 0.04 0.0555
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.2097 0.718 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.0075 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0073 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0026 0.0766
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0076 0.0075
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.002 0.0051
Entamoeba histolytica hypothetical protein 0.0145 0.045 0.3213
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.002 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0164 0.0228
Onchocerca volvulus 0.0096 0.0282 0.2022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.002 0.0018
Echinococcus granulosus cpg binding protein 0.0189 0.0604 0.0602
Schistosoma mansoni lamin 0.0026 0.0041 0.0057
Schistosoma mansoni rotamase 0.0033 0.0067 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0105 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0105 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Echinococcus multilocularis nmda type glutamate receptor 0.2915 1 1
Trypanosoma brucei unspecified product 0.0029 0.0051 0.1527
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.2097 0.718 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0124 0.017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0044 0.0105 0.0103
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0064 0.0444
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.002 0.0028
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0095 0.013
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.0075 0.0521
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0124 0.017
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0321 0.2287
Schistosoma mansoni glutamate receptor NMDA 0.0818 0.2771 0.3842
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0164 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.002 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.002 0.0051
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0079 0.24
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.0075 0.9295
Brugia malayi hypothetical protein 0.0297 0.0974 0.249
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0051 0.6305
Trypanosoma brucei ISWI complex protein 0.0019 0.0016 0.0446
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.002 0.0144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0079 0.24
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.002 0.0144
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0009
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0014 0.0017
Schistosoma mansoni kinase 0.0047 0.0114 0.0158
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0014 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.002 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0124 0.3815
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0271 0.194
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0041 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0095 0.2927
Brugia malayi Steroid receptor seven-up type 2 0.002 0.002 0.0051
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0079 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0105 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0321 1
Onchocerca volvulus 0.002 0.002 0.0144
Schistosoma mansoni glutamate receptor AMPA 0.0818 0.2771 0.3842
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0095 0.067
Schistosoma mansoni nuclear hormone receptor 0.002 0.002 0.0028
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0051 0.044
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.002 0.0051
Echinococcus multilocularis lamin 0.0026 0.0041 0.0039
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0076 0.0195
Echinococcus multilocularis glutamate receptor 2 0.1568 0.5358 0.5357
Echinococcus granulosus Smad4 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.01
Schistosoma mansoni ferritin light chain 0.0018 0.0014 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0079 0.0549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Entamoeba histolytica hypothetical protein 0.0145 0.045 0.3213
Toxoplasma gondii exonuclease III APE 0.0037 0.0079 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0026 0.0766
Schistosoma mansoni hypothetical protein 0.0145 0.045 0.0624
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0004
Brugia malayi Glutamate receptor 1 precursor 0.1149 0.3912 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0016 0.0446
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.0075 0.0073
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0095 0.0244
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0079 0.0077
Echinococcus granulosus smad 0.0016 0.0006 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0091 0.2797
Echinococcus multilocularis glutamate receptor 2 0.1149 0.3912 0.3911
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Trypanosoma cruzi extracellular receptor, putative 0.0419 0.1397 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.008 0.02
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.002 0.0028
Echinococcus multilocularis ferritin 0.0018 0.0014 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0079 0.0107
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0004
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.008 0.02
Brugia malayi AMP-binding enzyme family protein 0.005 0.0124 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0095 0.2927
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0321 0.0816
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0818 0.2771 0.277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0073 0.0099
Echinococcus granulosus nmda type glutamate receptor 0.0419 0.1397 0.1395
Loa Loa (eye worm) glutamate receptor 0.0419 0.1397 0.3568
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0095 0.067
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0321 0.0428
Echinococcus multilocularis expressed protein 0.0033 0.0067 0.0065
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0041 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0044 0.0105 0.0103
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0047
Echinococcus multilocularis glutamate receptor 2 0.075 0.2538 0.2536
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0002 0.0005
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0124 0.0873
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0271 0.0688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.002 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0124 0.0873
Schistosoma mansoni lamin 0.0026 0.0041 0.0057
Onchocerca volvulus 0.0179 0.0569 0.407
Schistosoma mansoni apoferritin-2 0.0018 0.0014 0.002
Echinococcus granulosus dnaJ subfamily B 0.2107 0.7214 0.7214
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0818 0.2771 0.277
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0419 0.1397 0.1395
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0067 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0105 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.0757 0.1931
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0051 0.1527
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0051 0.044
Schistosoma mansoni hypothetical protein 0.0049 0.0122 0.0169
Loa Loa (eye worm) hypothetical protein 0.0419 0.1397 0.3568
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0002 0.0003
Echinococcus multilocularis GPCR, family 2 0.0049 0.0122 0.012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.002 0.0028
Schistosoma mansoni cpg binding protein 0.0189 0.0604 0.0837
Echinococcus granulosus dna polymerase kappa 0.0042 0.0095 0.0093
Loa Loa (eye worm) RGC/RGC protein kinase 0.0419 0.1397 0.3568
Echinococcus multilocularis dnaJ subfamily B 0.2107 0.7214 0.7214

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 65.2 uM Antiproliferative activity against human SF268 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
GI50 (functional) = 80.7 uM Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
GI50 (functional) = 99.3 uM Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
Inhibition (binding) Inhibition of ALR2 in Fischer-344 rat lens at 100 uM ChEMBL. 21514701
LC50 (ADMET) > 100 uM Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
LC50 (ADMET) > 100 uM Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
LC50 (ADMET) > 100 uM Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
TGI (functional) > 100 uM Antiproliferative activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
TGI (functional) > 100 uM Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701
TGI (functional) > 100 uM Antiproliferative activity against human SF268 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21514701

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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