Detailed view for TcCLB.510667.120

Basic information

TDR Targets ID: 41883
Trypanosoma cruzi, galactokinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.8568 | Length (AA): 463 | MW (Da): 51335 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00288   GHMP kinases N terminal domain
PF08544   GHMP kinases C terminal
PF10509   Galactokinase galactose-binding signature

Gene Ontology

Mouse over links to read term descriptions.
GO:0005534   galactose binding  
GO:0016773   phosphotransferase activity, alcohol group as acceptor  
GO:0005737   cytoplasm  
GO:0005524   ATP binding  
GO:0004335   galactokinase activity  
GO:0016301   kinase activity  
GO:0006012   galactose metabolic process  
GO:0046835   carbohydrate phosphorylation  
GO:0016310   phosphorylation  
GO:0008152   metabolic process  

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 455 2aj4 (A) 11 528 22.00 0 1 1.07 -0.16
2 453 2a2c (A) 6 455 22.00 0 1 1.05 -0.43
13 450 1pie (A) 11 393 31.00 0 1 1.21 -0.36
1 454 3v2u (C) 15 510 21.00 0 1 0.952262 0.56
10 452 2a2c (A) 16 454 24.00 0 1 1.0325 0.32
13 452 1pie (A) 11 395 28.00 0 1 1.11102 0.27
349 400 1wgd (A) 44 93 38.00 0.57 0.08 0.363511 0.91
350 430 2oi2 (A) 204 282 28.00 0.045 0.69 0.469146 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129789)

Species Accession Gene Product
Arabidopsis thaliana AT3G10700   galacturonic acid kinase
Escherichia coli b0757   galactokinase
Echinococcus granulosus EgrG_001142200   galactokinase
Entamoeba histolytica EHI_094100   galactokinase, putative
Echinococcus multilocularis EmuJ_001142200   galactokinase
Homo sapiens ENSG00000108479   galactokinase 1
Leishmania braziliensis LbrM.34.2640   galactokinase-like protein
Leishmania donovani LdBPK_352790.1   galactokinase-like protein
Leishmania infantum LinJ.35.2790   galactokinase-like protein
Leishmania major LmjF.35.2740   galactokinase-like protein
Leishmania mexicana LmxM.34.2740   galactokinase-like protein
Mus musculus ENSMUSG00000020766   galactokinase 1
Mycobacterium tuberculosis Rv0620   Probable galactokinase GalK (galactose kinase)
Mycobacterium ulcerans MUL_0692   galactokinase
Oryza sativa 4336928   Os04g0608100
Schmidtea mediterranea mk4.011992.01  
Schmidtea mediterranea mk4.003757.00  
Schmidtea mediterranea mk4.011992.00  
Trypanosoma brucei gambiense Tbg972.5.60   galactokinase, putative
Trypanosoma brucei Tb11.v5.0211   galactokinase-like protein, putative
Trypanosoma cruzi TcCLB.507009.40   galactokinase, putative
Trypanosoma cruzi TcCLB.508465.90   galactokinase, putative
Trypanosoma cruzi TcCLB.507001.110   galactokinase-like protein, putative
Trypanosoma cruzi TcCLB.510667.120   galactokinase, putative
Treponema pallidum TP0418   galactokinase

Essentiality

TcCLB.510667.120 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu630 Mycobacterium tuberculosis non-essential nmpdr
b0757 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens galactokinase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0176 0.3049 1
0.0296 0.2591 1
0.0233 0.3943 0.6982
0.0314 1 1
0.0541 1 1
0.0708 0.3159 1
0.0171 0.5642 0.6331
0.0162 1 1
0.0276 0.4475 0.4439
0.0214 0.59 1
0.0238 1 1
0.061 1 1
0.0557 1 1
0.0641 1 1
0.0668 0.3945 0.4325
0.0308 0.7379 1
0.0353 0.4499 0.4472
0.0281 0.3615 1
0.0225 0.3715 1
0.0329 0.7643 1
0.0668 0.3945 0.4325
0.0352 0.4435 0.44
0.0053 0.565 1
0.0641 1 1
0.0329 0.4445 0.4393
0.0328 0.3837 0.4463
0.0172 0.4885 1
0.0726 0.578 1
0.026 0.5724 0.8631
0.0668 0.3945 0.4325
0.0125 0.4368 0.2292
0.0281 0.3615 1
0.0344 0.4554 1
0.03 0.2897 0.3578
0.03 1 1
0.03 0.2897 0.3578
0.0553 1 1
0.0708 0.3159 1
0.0265 1 1
0.0232 0.2621 1
0.0178 0.6209 1
0.0275 1 1
0.0358 0.8321 1
0.0668 0.3945 0.4325
0.0241 0.7768 1
0.0107 0.2685 1
0.0594 1 1
0.0489 1 1
0.0107 1 1
0.0326 0.3639 1
0.0064 1 1
0.0322 0.3643 0.3643
0.0369 0.3782 0.4407
0.0726 0.578 1
0.0293 1 1
0.0064 1 1
0.0394 1 1
0.0332 0.6272 1
0.0631 0.36 1
0.0223 1 1
0.0485 0.5043 1
0.0558 1 1
0.0541 1 1
0.0051 1 1
0.0726 0.578 1
0.0327 0.339 0.4463
0.0103 0.436 1
0.016 1 1
0.0051 0.553 1
0.0178 0.2636 0.2636
0.0051 1 1
0.0668 0.3945 0.4325
0.03 1 1
0.0379 0.5984 1
0.0178 0.6209 1
0.0549 1 1
0.0668 0.3945 0.4325
0.0051 1 1
0.0051 0.3324 1
0.0241209 0.314726 1
0.0352 0.4469 0.4468
0.0089 0.3273 0.3273
0.0631 0.36 1
0.0053 0.565 1
0.0774 1 1
0.0706 0.7111 1
0.0279 0.3182 1
0.039 0.4391 0.8553
0.0119 0.3745 1
0.0304 0.4487 0.4424
0.0262 0.3067 1
0.0495 1 1
0.0276 0.2578 1
0.039 0.4391 0.8553
0.0233 1 1
0.0386 1 1
0.0301 1 1
0.0305 0.4063 0.3545
0.0337 0.5507 1
0.0386 0.8447 1
0.0668 0.3945 0.4325
0.0275 0.3195 0.3733
0.0272 0.3576 1
0.0205 0.9496 1
0.0327 0.339 0.4463
0.0343 0.4235 0.444
0.0171 0.5642 0.6331
0.0271 0.4433 0.4338
0.0171 0.3321 1
0.0262 0.3067 1
0.0343 0.4478 0.4462
0.0315 0.4792 1
0.0284 0.6254 1
0.025 0.4306 0.4339

Assayability

Assay information

  • Assay for Galactokinase (2.7.1.6 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.510667.120 (Trypanosoma cruzi), galactokinase, putative
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