Detailed information for compound 1121629

Basic information

Technical information
  • TDR Targets ID: 1121629
  • Name: ethyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin- 9-yl)methyl]phenyl]acetate
  • MW: 399.444 | Formula: C20H25N5O4
  • H donors: 2 H acceptors: 4 LogP: 2.22 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1nc(N)c2c(n1)n(Cc1cccc(c1)CC(=O)OCC)c(=O)[nH]2
  • InChi: 1S/C20H25N5O4/c1-3-5-9-29-19-23-17(21)16-18(24-19)25(20(27)22-16)12-14-8-6-7-13(10-14)11-15(26)28-4-2/h6-8,10H,3-5,9,11-12H2,1-2H3,(H,22,27)(H2,21,23,24)
  • InChiKey: ZBCHPELLPQXWIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetic acid ethyl ester
  • 2-[3-[(6-amino-2-butoxy-8-keto-7H-purin-9-yl)methyl]phenyl]acetic acid ethyl ester
  • ethyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]ethanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens toll-like receptor 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis endoplasmin 0.0042 0.0189 0.0187
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0303 0.3052 0.3051
Brugia malayi Aspartyl aminopeptidase 0.0076 0.0561 0.0652
Entamoeba histolytica hypothetical protein 0.0073 0.053 0.0852
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0463 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Echinococcus multilocularis L aminoadipate semialdehyde 0.0168 0.1577 0.1576
Entamoeba histolytica hexokinase 2 0.0161 0.15 0.2411
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.1197 0.1393
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0258 0.0677
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0149 0.0171
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.018 0.0178
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0369 0.3782 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0137 0.1231 0.123
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0275 0.0319
Schistosoma mansoni hypothetical protein 0.0043 0.0202 0.0235
Echinococcus multilocularis hexokinase type 2 0.0161 0.15 0.1498
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0232 0.023
Plasmodium falciparum thioredoxin reductase 0.0033 0.0095 0.0157
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0085 0.0082
Leishmania major phosphomannomutase, putative 0.0044 0.0219 0.0253
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0557 0.0812
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0309 0.3126 0.3642
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0051 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0303 0.3052 0.3051
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni bromodomain containing protein 0.0144 0.1311 0.1527
Brugia malayi Hexokinase family protein 0.005 0.0278 0.0323
Brugia malayi Cytochrome P450 family protein 0.0113 0.0974 0.1134
Trypanosoma brucei phosphomannomutase 0.0044 0.0219 0.0253
Schistosoma mansoni lipoxygenase 0.012 0.1047 0.122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.018 0.0262
Echinococcus granulosus caspase 8 0.0054 0.0321 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0379 0.0638
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0059 0.0383 0.034
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0156 0.1449 0.1687
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0134
Leishmania major hexokinase, putative 0.0161 0.15 0.1746
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0379 0.0714
Echinococcus multilocularis caspase 0.0201 0.1935 0.1934
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0219 0.0253
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0529 0.0527
Echinococcus granulosus heat shock protein 0.0044 0.0219 0.0217
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.2382 0.3471
Mycobacterium ulcerans 6-phosphofructokinase 0.022 0.2145 0.2498
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Echinococcus granulosus galactokinase 0.0369 0.3782 0.3781
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.013 0.0149
Brugia malayi mevalonate kinase family protein 0.0369 0.3782 0.4407
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0181
Schistosoma mansoni galactokinase 0.0369 0.3782 0.4408
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0134
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0309 0.3126 0.3643
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0076 0.0561 0.0638
Echinococcus granulosus Mevalonate galactokinase 0.0369 0.3782 0.3781
Entamoeba histolytica hypothetical protein 0.0073 0.053 0.0852
Echinococcus granulosus caspase 0.0201 0.1935 0.1934
Leishmania major hypothetical protein, conserved 0.043 0.4455 0.5192
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.025 0.0254
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0557 0.0556
Brugia malayi 6-phosphofructokinase 0.022 0.2145 0.2498
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.4353 0.6343
Echinococcus granulosus microtubule associated protein 2 0.067 0.708 0.708
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0225 0.026
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0219 0.0239
Leishmania major eukaryotic translation initiation factor-like 0.0036 0.013 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0148 0.1357 0.1356
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.012 0.0123
Plasmodium falciparum metacaspase-like protein 0.0054 0.0321 0.0599
Brugia malayi hypothetical protein 0.0306 0.3087 0.3596
Leishmania major phosphomannose isomerase 0.0491 0.5118 0.5964
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0117 0.0304
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0557 0.0649
Trypanosoma brucei Metacaspase-4 0.0054 0.0321 0.0372
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.0321 0.0373
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0093
Brugia malayi PHD-finger family protein 0.0059 0.0379 0.0439
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0781 0.078
Echinococcus granulosus chromobox protein 1 0.0073 0.0536 0.0535
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.0552
Leishmania major basic transcription factor 3a, putative 0.0071 0.0508 0.059
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.018 0.0209
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0117 0.0119
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0109
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0491 0.5118 0.5117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.018 0.0262
Treponema pallidum hexokinase (hxk) 0.0161 0.15 0.2293
Schistosoma mansoni polycystin 1-related 0.0059 0.0379 0.0441
Trypanosoma brucei galactokinase-like protein, putative 0.0156 0.1449 0.1687
Plasmodium vivax SET domain protein, putative 0.006 0.0394 0.0669
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0289 0.2902 0.767
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.018 0.0178
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0189 0.0204
Leishmania major hexokinase, putative 0.0161 0.15 0.1746
Echinococcus multilocularis hexokinase 0.0161 0.15 0.1498
Entamoeba histolytica serine/threonine protein kinase, putative 0.0303 0.3052 0.4906
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0258 0.0298
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0232 0.027
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0117 0.0134
Trypanosoma cruzi homoserine kinase 0.0369 0.3782 0.4407
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Echinococcus multilocularis protein patched 0.0044 0.0219 0.0218
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0225 0.0328
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0095 0.0109
Entamoeba histolytica transcription factor BTF3, putative 0.0071 0.0508 0.0816
Echinococcus granulosus pyruvate kinase 0.0035 0.0117 0.0115
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.0156 0.1449 0.1687
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.018 0.0209
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.0806 0.858 1
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0189 0.0218
Brugia malayi 6-phosphofructokinase 0.022 0.2145 0.2498
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0379 0.0377
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0309 0.3126 0.4947
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0289 0.2902 0.338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.018 0.0178
Onchocerca volvulus 0.0032 0.0085 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0181
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0309 0.3126 0.3125
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0266 0.2651 0.7008
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0036 0.013 0.0149
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.018 0.0178
Mycobacterium ulcerans glutaminase 0.0265 0.2642 0.3078
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0076 0.0561 0.0902
Schistosoma mansoni hypothetical protein 0.0073 0.053 0.0617
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.017
Trypanosoma cruzi ISWI complex protein 0.0031 0.0071 0.0081
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.1197 0.1196
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0168 0.1577 0.1837
Onchocerca volvulus 0.0048 0.0258 0.0237
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0583 0.6136 0.6136
Toxoplasma gondii hexokinase 0.0161 0.15 0.2928
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0095 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0225 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0508 0.0575
Echinococcus granulosus caspase 3 0.0147 0.1346 0.1345
Trypanosoma cruzi homoserine kinase 0.0369 0.3782 0.4407
Trypanosoma cruzi galactokinase, putative 0.0369 0.3782 0.4407
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0129 0.1144 0.3023
Schistosoma mansoni hypothetical protein 0.0042 0.0189 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0109
Loa Loa (eye worm) galactokinase 0.0369 0.3782 0.5512
Schistosoma mansoni endoplasmin 0.0044 0.0219 0.0255
Loa Loa (eye worm) hypothetical protein 0.0078 0.0583 0.085
Schistosoma mansoni rab6-interacting 0.0059 0.0379 0.0441
Echinococcus multilocularis transcription factor btf3 0.0071 0.0508 0.0506
Trichomonas vaginalis hypothetical protein 0.0035 0.012 0.0123
Leishmania major mevalonate kinase, putative 0.0369 0.3782 0.4407
Schistosoma mansoni patched 1 0.0044 0.0219 0.0255
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.018 0.0178
Brugia malayi Bromodomain containing protein 0.008 0.0605 0.0704
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0036 0.013 0.025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0103 0.0268
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0208
Plasmodium vivax basic transcription factor 3b, putative 0.0071 0.0508 0.0893
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.1197 0.1393
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0059 0.0383 0.0616
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.011 0.0108
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0491 0.5118 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.0383 0.0648
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0369 0.3782 0.739
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0076 0.0561 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.018 0.0208
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.025 0.0513
Echinococcus granulosus citrate lyase subunit beta protein 0.005 0.0275 0.0273
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0258 0.0298
Loa Loa (eye worm) glutathione reductase 0.0096 0.0781 0.1138
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.0321 0.0311
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0773 0.0771
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0081 0.008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Loa Loa (eye worm) aspartyl aminopeptidase 0.0076 0.0561 0.0817
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0219 0.0253
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0515 0.0513
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0201 0.1935 0.1934
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0303 0.3052 0.3556
Schistosoma mansoni glutaminase 0.0265 0.2642 0.3079
Schistosoma mansoni coup transcription factor 0.0041 0.018 0.0209
Echinococcus granulosus neuropeptide receptor A26 0.0935 1 1
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0369 0.3782 0.4407
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0117 0.0304
Schistosoma mansoni mannose-6-phosphate isomerase 0.0491 0.5118 0.5964
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0176 0.1665 0.1927
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0777 0.089
Brugia malayi CHE-14 protein 0.0044 0.0219 0.0254
Loa Loa (eye worm) hypothetical protein 0.0044 0.0219 0.032
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.0806 0.858 1
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.018 0.0262
Echinococcus multilocularis pyruvate kinase 0.0035 0.0117 0.0115
Brugia malayi beta-NAC-like protein 0.0071 0.0508 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni thyroid hormone receptor 0.0041 0.018 0.0209
Echinococcus multilocularis heat shock protein 90 0.0044 0.0219 0.0217
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0059 0.0383 0.047
Brugia malayi glutaminase DH11.1 0.0265 0.2642 0.3078
Loa Loa (eye worm) hypothetical protein 0.0025 0 0.0001
Loa Loa (eye worm) hexokinase type II 0.0161 0.15 0.2186
Entamoeba histolytica hexokinase 1 0.0161 0.15 0.2411
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0463 0.0539
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0491 0.5118 0.5964
Trypanosoma cruzi hexokinase, putative 0.0161 0.15 0.1746
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0036 0.013 0.0149
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0369 0.3782 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0243 0.2394 0.6327
Brugia malayi serine/threonine-protein kinase plk-2 0.0303 0.3052 0.3556
Brugia malayi nuclear hormone receptor 0.0041 0.018 0.0208
Trypanosoma brucei metacaspase MCA3 0.0054 0.0321 0.0372
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0095 0.0078
Schistosoma mansoni hypothetical protein 0.0043 0.0202 0.0235
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.1197 0.1393
Entamoeba histolytica phosphofructokinase, putative 0.022 0.2145 0.3448
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.018 0.0208
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0219 0.0352
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0258 0.0414
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0258 0.0414
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.2145 0.2487
Schistosoma mansoni pyruvate kinase 0.0035 0.0117 0.0136
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0243 0.2394 0.6327
Giardia lamblia PHD finger protein 15 0.0059 0.0379 0.0334
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.018 0.0178
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.005 0.0275 0.0319
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.011 0.0128
Echinococcus granulosus aspartyl aminopeptidase 0.0076 0.0561 0.0559
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0326 0.331 0.6458
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.018 0.0146
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0309 0.3126 0.3642
Giardia lamblia Kinase, PLK 0.0303 0.3052 0.3485
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0076 0.0561 0.1479
Echinococcus multilocularis geminin 0.0343 0.3494 0.3493
Loa Loa (eye worm) cytochrome P450 0.0025 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0071 0.0508 0.0816
Schistosoma mansoni hypothetical protein 0.0343 0.3494 0.4072
Schistosoma mansoni caspase-7 (C14 family) 0.0201 0.1935 0.2255
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0081 0.008
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0219 0.0253
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0321 0.0623
Echinococcus granulosus heat shock protein 90 0.0038 0.0149 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0225 0.026
Echinococcus granulosus Niemann Pick C1 protein 0.0148 0.1357 0.1356
Schistosoma mansoni 6-phosphofructokinase 0.022 0.2145 0.25
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0095 0.0109
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.018 0.0178
Leishmania major pyruvate kinase 0.0035 0.0117 0.0134
Trypanosoma cruzi galactokinase-like protein, putative 0.0213 0.2065 0.2405
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0076 0.0561 0.0999
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0189 0.0496
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.013 0.0149
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.108 0.1256
Schistosoma mansoni microtubule-associated protein tau 0.067 0.708 0.8252
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0123
Onchocerca volvulus Serine\/threonine kinase homolog 0.0303 0.3052 0.3516
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0379 0.0377
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0117 0.0134
Trypanosoma cruzi fucose kinase, putative 0.0213 0.2065 0.2405
Loa Loa (eye worm) hypothetical protein 0.0048 0.0258 0.0375
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0134
Entamoeba histolytica hypothetical protein 0.0073 0.053 0.0852
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0773 0.09
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0095 0.011
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0536 0.0609
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.018 0.0178
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0076 0.0561 0.0652
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0102 0.0856 0.0996
Loa Loa (eye worm) hypothetical protein 0.0048 0.0258 0.0375
Onchocerca volvulus Putative phosphomannomutase 0.0044 0.0219 0.0192
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.018 0.0209
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.1197 0.1393
Schistosoma mansoni hypothetical protein 0.0343 0.3494 0.4072
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0081 0.0093
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0076 0.0561 0.0652
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0076 0.0561 0.0652
Mycobacterium ulcerans homoserine kinase 0.0369 0.3782 0.4407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0103 0.0268
Plasmodium falciparum glutathione reductase 0.0033 0.0095 0.0157
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.1197 0.1395
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.018 0.0208
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0219 0.0253
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.026 0.2581 0.258
Entamoeba histolytica galactokinase, putative 0.0369 0.3782 0.608
Plasmodium falciparum glutathione reductase 0.0096 0.0781 0.1502
Echinococcus granulosus histone acetyltransferase KAT2B 0.0176 0.1665 0.1664
Trypanosoma brucei trypanothione reductase 0.0096 0.0781 0.0909
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0226 0.2213 0.2212
Brugia malayi Hsp90 protein 0.003 0.0055 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0181
Brugia malayi jmjC domain containing protein 0.0193 0.1852 0.2156
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0055 0.0054
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0583 0.6136 0.7152
Trichomonas vaginalis Citrate lyase beta chain, putative 0.005 0.0275 0.0304
Loa Loa (eye worm) glutaminase 0.0265 0.2642 0.3851
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.022 0.2145 0.5669
Echinococcus multilocularis protein dispatched 1 0.0051 0.0288 0.0287
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0076 0.0561 0.0638
Trypanosoma brucei ISWI complex protein 0.0031 0.0071 0.0081
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0176 0.1665 0.3252
Echinococcus multilocularis expressed conserved protein 0.0097 0.08 0.0798
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0125 0.0143
Treponema pallidum fructose-bisphosphate aldolase 0.0591 0.6221 1
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0219 0.0218
Leishmania major trypanothione reductase 0.0096 0.0781 0.0909
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Brugia malayi Cytochrome P450 family protein 0.0045 0.0225 0.026
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0117 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.018 0.0178
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0076 0.0561 0.0652
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0309 0.3126 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0852 0.1242
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0309 0.3126 0.4555
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0095 0.0109
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0189 0.0496
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0059 0.0383 0.0746
Onchocerca volvulus 0.0806 0.858 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0379 0.0377
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0149 0.0063
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0202 0.1948 0.2269
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.0806 0.858 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0117 0.0072
Brugia malayi Bromodomain containing protein 0.0093 0.0756 0.0879
Entamoeba histolytica acetyltransferase, GNAT family 0.0156 0.1438 0.2312
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.001 0.0009
Echinococcus granulosus L aminoadipate semialdehyde 0.0168 0.1577 0.1576
Leishmania major metacaspase, putative 0.0054 0.0321 0.0372
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.025 0.0421
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.037 0.0368
Trypanosoma cruzi polo-like protein kinase, putative 0.0303 0.3052 0.3556
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.0156 0.1449 0.3827
Trichomonas vaginalis galactokinase, putative 0.0369 0.3782 0.4399
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0081 0.0119
Schistosoma mansoni hypothetical protein 0.0032 0.0081 0.0094
Entamoeba histolytica aminopeptidase, putative 0.0076 0.0561 0.0902
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Plasmodium vivax metacaspase 1, putative 0.0054 0.0321 0.0524
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.0383 0.0722
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0219 0.0218
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.025 0.0486
Trypanosoma cruzi galactokinase, putative 0.0369 0.3782 0.4407
Schistosoma mansoni hypothetical protein 0.0031 0.0071 0.0082
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0117 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Trichomonas vaginalis mevalonate kinase, putative 0.0156 0.1449 0.1674
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0193 0.1852 0.185
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.022 0.2145 0.5669
Brugia malayi Endoplasmin precursor 0.0044 0.0219 0.0253
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.012 0.0123
Brugia malayi ecdysteroid receptor 0.0041 0.018 0.0208
Plasmodium falciparum heat shock protein 90, putative 0.0168 0.1581 0.3068
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.1197 0.1196
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.018 0.0209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.018 0.0262
Loa Loa (eye worm) ICD-1 protein 0.0071 0.0508 0.074
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0591 0.6221 1
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0508 0.0575
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0117 0.0134
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0218 0.2126 0.562
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0189 0.0218
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Schistosoma mansoni hypothetical protein 0.0025 0.0002 0.0002
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0869 0.1011
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.018 0.0146
Echinococcus granulosus mannose 6 phosphate isomerase 0.0491 0.5118 0.5117
Trypanosoma cruzi hypothetical protein, conserved 0.043 0.4455 0.5192
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0109
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0491 0.5118 0.7457
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0781 0.2062
Trypanosoma cruzi mevalonate kinase, putative 0.0369 0.3782 0.4407
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.0383 0.0951
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0176 0.1665 0.318
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Echinococcus granulosus endoplasmin 0.0042 0.0189 0.0187
Leishmania major hypothetical protein, conserved 0.0031 0.0071 0.0081
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.025 0.0486
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0394 0.0767
Plasmodium falciparum histone acetyltransferase GCN5 0.0156 0.1438 0.279
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.0552
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.022 0.2145 0.3346
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0463 0.0675
Echinococcus multilocularis chromobox protein 1 0.0073 0.0536 0.0535
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0125 0.0137
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0326 0.331 0.3848
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.018 0.0178
Schistosoma mansoni hexokinase 0.0161 0.15 0.1748
Echinococcus multilocularis phosphomannomutase 0.0044 0.0219 0.0217
Echinococcus granulosus hexokinase 0.0161 0.15 0.1498
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0217 0.0236
Loa Loa (eye worm) hypothetical protein 0.0104 0.0869 0.1266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Echinococcus granulosus transcription factor btf3 0.0071 0.0508 0.0506
Trichomonas vaginalis galactokinase, putative 0.0369 0.3782 0.4399
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0095 0.0109
Schistosoma mansoni zinc finger protein 0.0031 0.0071 0.0082
Echinococcus multilocularis neuropeptide s receptor 0.0935 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0536 0.0781
Loa Loa (eye worm) hypothetical protein 0.0369 0.3782 0.5512
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0095 0.0094
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0329 0.048
Trichomonas vaginalis galactokinase, putative 0.0369 0.3782 0.4399
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0055 0.0063
Echinococcus granulosus geminin 0.0343 0.3494 0.3493
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0303 0.3052 0.4448
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0773 0.0771
Toxoplasma gondii heat shock protein 90, putative 0.0044 0.0219 0.0425
Echinococcus multilocularis hexokinase 0.0161 0.15 0.1498
Plasmodium falciparum heat shock protein 90 0.0044 0.0219 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Echinococcus granulosus hexokinase type 2 0.0161 0.15 0.1498
Brugia malayi galactokinase family protein 0.0369 0.3782 0.4407
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0036 0.013 0.0128
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.108 0.2107
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0326 0.331 0.643
Trichomonas vaginalis phosphomannomutase, putative 0.0044 0.0219 0.0238
Echinococcus granulosus zinc finger protein 0.0055 0.034 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.018 0.0208
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0536 0.0609
Mycobacterium ulcerans galactokinase 0.0369 0.3782 0.4407
Brugia malayi Hexokinase family protein 0.0101 0.0841 0.0978
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0557 0.0649
Onchocerca volvulus 0.0059 0.0379 0.038
Loa Loa (eye worm) hypothetical protein 0.0168 0.1577 0.2299
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0095 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0394 0.0459
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.1197 0.1393
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0869 0.0867
Trypanosoma brucei metacaspase 0.0054 0.0321 0.0372
Loa Loa (eye worm) hypothetical protein 0.0143 0.1302 0.1897
Onchocerca volvulus 0.0072 0.0526 0.0552
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0258 0.0677
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0095 0.0093
Mycobacterium tuberculosis Probable dehydrogenase 0.0218 0.2126 0.562
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0379 0.0552
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0773 0.09
Onchocerca volvulus 0.0161 0.15 0.1695
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0202 0.1948 0.3805
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0168 0.1577 0.1838
Schistosoma mansoni pyruvate kinase 0.0035 0.0117 0.0136
Onchocerca volvulus 0.0479 0.4991 0.579
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.108 0.1256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Schistosoma mansoni hypothetical protein 0.0032 0.0081 0.0094
Echinococcus multilocularis N acetylgalactosamine kinase 0.0369 0.3782 0.3781
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.041 0.1079
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0081 0.008
Loa Loa (eye worm) glutaminase 2 0.0265 0.2642 0.3851
Schistosoma mansoni chromobox protein 0.0073 0.0536 0.0625
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0258 0.0298
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0103 0.0268
Leishmania major heat shock protein, putative 0.003 0.0055 0.0063
Trypanosoma brucei hexokinase 0.0161 0.15 0.1746
Brugia malayi hypothetical protein 0.0073 0.053 0.0616
Trypanosoma cruzi metacaspase, putative 0.0054 0.0321 0.0372
Schistosoma mansoni chromobox protein 0.0073 0.0536 0.0625
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0134
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.2145 0.2498
Schistosoma mansoni mevalonate kinase 0.0369 0.3782 0.4408
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0219 0.0239
Toxoplasma gondii NAC domain-containing protein 0.0071 0.0508 0.0989
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.2145 0.2498
Plasmodium falciparum pyruvate kinase 0.0035 0.0117 0.02
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0491 0.5118 0.5964
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni kinase 0.0467 0.4856 0.5659
Trichomonas vaginalis bromodomain-containing protein, putative 0.0176 0.1665 0.1927
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Trypanosoma brucei mevalonate kinase, putative 0.0369 0.3782 0.4407
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0275 0.2754 0.3208
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0379 0.0377
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.01 0.0823 0.0958
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0491 0.5118 0.7457
Loa Loa (eye worm) hypothetical protein 0.0076 0.0561 0.0817
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.1197 0.1744
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0491 0.5118 0.5964
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0379 0.0377
Loa Loa (eye worm) hypothetical protein 0.0306 0.3087 0.4498
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.013 0.0208
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0379 0.0441
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0219 0.0352
Trypanosoma brucei hexokinase, putative 0.0161 0.15 0.1746
Echinococcus granulosus hexokinase 0.0161 0.15 0.1498
Loa Loa (eye worm) acetyltransferase 0.0583 0.6136 0.8941
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.018 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.108 0.1256
Trypanosoma cruzi Heat shock protein 83, putative 0.0044 0.0219 0.0253
Schistosoma mansoni diphosphomevalonate decarboxylase 0.0806 0.858 1
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0189 0.0276
Echinococcus granulosus FTZ F1 alpha 0.0041 0.018 0.0178
Echinococcus granulosus CREB binding protein 0.0118 0.1028 0.1026
Plasmodium vivax heat shock protein, putative 0.0168 0.1581 0.3013
Leishmania major homoserine kinase, putative 0.0369 0.3782 0.4407
Trypanosoma brucei phosphomannose isomerase 0.0491 0.5118 0.5964
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0258 0.0298
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0258 0.0298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0137 0.1231 0.123
Brugia malayi TAZ zinc finger family protein 0.0118 0.1028 0.1196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.053 0.0528
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Schistosoma mansoni cytochrome P450 0.0025 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.3052 0.3557
Onchocerca volvulus 0.0041 0.018 0.0146
Loa Loa (eye worm) hypothetical protein 0.0047 0.0242 0.0353
Onchocerca volvulus 0.0161 0.15 0.1695
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0289 0.2902 0.767
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0076 0.0561 0.0653
Entamoeba histolytica hypothetical protein 0.0047 0.025 0.0403
Loa Loa (eye worm) hypothetical protein 0.0095 0.0773 0.1126
Brugia malayi translation initiation factor 4E 0.0036 0.013 0.0149
Trichomonas vaginalis set domain proteins, putative 0.0479 0.4991 0.581
Loa Loa (eye worm) CBP-B 0.0088 0.0695 0.1013
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0326 0.331 0.3848
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0781 0.078
Schistosoma mansoni thyroid hormone receptor 0.0041 0.018 0.0209
Trypanosoma cruzi metacaspase, putative 0.0054 0.0321 0.0372
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0309 0.3126 0.3125
Onchocerca volvulus 0.0306 0.3087 0.3556
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0781 0.1434
Giardia lamblia Fructose-bisphosphate aldolase 0.0591 0.6221 0.722
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0321 0.0372
Leishmania major fucose kinase, putative 0.0156 0.1449 0.1687
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0189 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.018 0.0208
Loa Loa (eye worm) hypothetical protein 0.0101 0.0841 0.1226
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0076 0.0561 0.0652
Echinococcus multilocularis RUN 0.0059 0.0379 0.0377
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0266 0.2651 0.7008
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.005 0.0275 0.0319
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0309 0.3126 0.3642
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.108 0.2851
Brugia malayi MH2 domain containing protein 0.0242 0.2382 0.2775
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0123
Plasmodium vivax heat shock protein 86, putative 0.0044 0.0219 0.0324
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.018 0.0208
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0219 0.0253
Loa Loa (eye worm) heat shock protein 90 0.0044 0.0219 0.0319
Toxoplasma gondii thioredoxin reductase 0.0096 0.0781 0.1524
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0218 0.2126 0.562
Echinococcus multilocularis galactokinase 0.0369 0.3782 0.3781
Echinococcus multilocularis heat shock protein 90 0.0038 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0032 0.0081 0.0119
Mycobacterium leprae conserved hypothetical protein 0.0047 0.025 0.0658
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0117 0.0072
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.018 0.0178
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.2145 0.3125
Trypanosoma brucei metacaspase MCA2 0.0054 0.0321 0.0372
Onchocerca volvulus 0.0168 0.1577 0.1785
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0117 0.017
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0076 0.0561 0.107
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0226 0.2213 0.2212
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.018 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.018 0.0262
Trypanosoma cruzi polo-like protein kinase, putative 0.0303 0.3052 0.3556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Schistosoma mansoni heat shock protein 0.0044 0.0219 0.0255
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.108 0.1258
Echinococcus multilocularis peregrin 0.008 0.0605 0.0604
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0379 0.0552
Mycobacterium ulcerans hypothetical protein 0.005 0.0275 0.0319
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0117 0.0134
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0055 0.0054
Schistosoma mansoni 6-phosphofructokinase 0.022 0.2145 0.25
Plasmodium falciparum endoplasmin, putative 0.0032 0.0085 0.0138
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0125 0.0097
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0632 0.063
Echinococcus granulosus 6 phosphofructokinase 0.022 0.2145 0.2144
Treponema pallidum galactokinase 0.0213 0.2065 0.3216
Mycobacterium ulcerans hypothetical protein 0.005 0.0275 0.0319
Trichomonas vaginalis galactokinase, putative 0.0156 0.1449 0.1674
Trypanosoma cruzi metacaspase, putative 0.0054 0.0321 0.0372
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0326 0.331 0.6467
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0095 0.0182
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0321 0.0623
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.025 0.029
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0258 0.0298
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0059 0.0383 0.0951
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0125 0.0215
Schistosoma mansoni heat shock protein 0.003 0.0055 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Trypanosoma cruzi ISWI complex protein 0.0031 0.0071 0.0081
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0129 0.1144 0.1332
Loa Loa (eye worm) hexokinase 0.0101 0.0841 0.1225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.018 0.0262
Plasmodium vivax hexokinase, putative 0.0161 0.15 0.2853
Echinococcus multilocularis caspase 3 0.0147 0.1346 0.1345
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0394 0.0392
Schistosoma mansoni hypothetical protein 0.0059 0.0379 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.018 0.0208
Schistosoma mansoni caspase-3 (C14 family) 0.0201 0.1935 0.2255
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0095 0.0182
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0258 0.0298
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.011 0.0108
Echinococcus multilocularis pyruvate kinase 0.0028 0.0035 0.0034
Echinococcus multilocularis citrate lyase subunit beta protein 0.005 0.0275 0.0273
Loa Loa (eye worm) hypothetical protein 0.0054 0.0321 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0182 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0508 0.0575
Entamoeba histolytica phosphofructokinase, putative 0.022 0.2145 0.3448
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0529 0.0527
Brugia malayi jmjC domain containing protein 0.0075 0.0557 0.0648
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0463 0.0675
Echinococcus granulosus hexokinase 0.0161 0.15 0.1498
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0321 0.0372
Echinococcus multilocularis neuropeptide receptor A26 0.0935 1 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.005 0.0275 0.0723
Trypanosoma cruzi hexokinase, putative 0.0161 0.15 0.1746
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0107 0.0909 0.2399
Leishmania major hypothetical protein, conserved 0.0275 0.2754 0.3208
Loa Loa (eye worm) translation initiation factor 4E 0.0036 0.013 0.0189
Loa Loa (eye worm) hypothetical protein 0.0156 0.1449 0.2111
Echinococcus multilocularis aspartyl aminopeptidase 0.0076 0.0561 0.0559
Trichomonas vaginalis galactokinase, putative 0.0213 0.2065 0.2394
Trypanosoma cruzi phosphomannose isomerase, putative 0.0491 0.5118 0.5964
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0076 0.0561 0.0653
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0508 0.059
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0095 0.0157
Brugia malayi hypothetical protein 0.0059 0.0379 0.044
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.018 0.0208
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0081 0.008
Echinococcus multilocularis caspase 2 0.0054 0.0321 0.0319
Onchocerca volvulus 0.0161 0.15 0.1695
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0182 0.0196
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0125 0.0325
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0219 0.0146
Echinococcus granulosus histone acetyltransferase KAT2B 0.0561 0.5887 0.5886
Giardia lamblia Grp94/Hsp90 0.0042 0.0189 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.053 0.0528
Entamoeba histolytica phosphofructokinase, putative 0.022 0.2145 0.3448
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0201 0.1935 0.1934
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0182 0.0149
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.025 0.0658
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.025 0.029
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.2145 0.2487
Schistosoma mansoni rab6-interacting 0.0059 0.0379 0.0441
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0149 0.0171
Brugia malayi steroid hormone receptor 0.0041 0.018 0.0208
Trypanosoma brucei homoserine kinase 0.0369 0.3782 0.4407
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.026 0.2581 0.258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.1197 0.1924
Echinococcus multilocularis 6 phosphofructokinase 0.022 0.2145 0.2144
Trypanosoma cruzi heat shock protein, putative 0.003 0.0055 0.0063
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0258 0.0414
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.0321 0.0372
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Plasmodium falciparum basic transcription factor 3b, putative 0.0071 0.0508 0.0966
Entamoeba histolytica hypothetical protein 0.0073 0.053 0.0852
Treponema pallidum hypothetical protein 0.0369 0.3782 0.6019
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0777 0.089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0258 0.0298
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0059 0.0383 0.0722
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0488 0.0567
Trypanosoma brucei hexokinase 0.0161 0.15 0.1746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0838 0.0975
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0117 0.0121
Brugia malayi Thioredoxin reductase 0.0096 0.0781 0.0909
Brugia malayi Cytochrome P450 family protein 0.0045 0.0225 0.026
Onchocerca volvulus Hexokinase homolog 0.0101 0.0841 0.0921
Schistosoma mansoni nuclear hormone receptor 0.0041 0.018 0.0209
Brugia malayi chromobox protein homolog 3 0.0041 0.0182 0.0211
Toxoplasma gondii phosphofructokinase PFKII 0.0059 0.0383 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.018 0.0208
Entamoeba histolytica phosphomannomutase, putative 0.0044 0.0219 0.0351
Brugia malayi acetyltransferase, GNAT family protein 0.0583 0.6136 0.7151
Brugia malayi Doublecortin family protein 0.0059 0.0379 0.044
Plasmodium vivax endoplasmin, putative 0.0044 0.0219 0.0324
Leishmania major pyruvate kinase 0.0035 0.0117 0.0134
Treponema pallidum heat shock protein 90 0.0042 0.0189 0.0154
Echinococcus granulosus pyruvate kinase 0.0035 0.0117 0.0115
Echinococcus multilocularis caspase 8 0.0054 0.0321 0.0319
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0085 0.0082
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0117 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.018 0.0208
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0181
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0156 0.1449 0.4466
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0095 0.0109
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0036 0.013 0.0128
Schistosoma mansoni transcription factor btf3 0.0071 0.0508 0.0591
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0781 0.0909
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0225 0.0328
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Trypanosoma cruzi galactokinase, putative 0.0213 0.2065 0.2405
Trypanosoma brucei transcription factor BTF3, putative 0.0071 0.0508 0.059
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.2382 0.3471
Brugia malayi RNA binding protein 0.0067 0.0463 0.0538
Echinococcus granulosus peregrin 0.008 0.0605 0.0604
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.018 0.0209
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0258 0.0298
Trypanosoma cruzi fucose kinase, putative 0.0213 0.2065 0.2405
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.018 0.0178
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0117 0.0134
Plasmodium vivax glutathione reductase, putative 0.0096 0.0781 0.1434
Onchocerca volvulus 0.0059 0.0379 0.038
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.2145 0.2487
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0806 0.858 1
Trypanosoma brucei Heat shock protein 83, putative 0.0044 0.0219 0.0253
Mycobacterium ulcerans phosphomevalonate kinase 0.0369 0.3782 0.4407
Brugia malayi hexokinase type II 0.0051 0.0293 0.034
Trypanosoma cruzi transcription factor btf3, putative 0.0071 0.0508 0.059
Schistosoma mansoni hypothetical protein 0.0032 0.0081 0.0094
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni jumonji domain containing protein 0.0153 0.1416 0.165
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0463 0.0462
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0379 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0051 0.0042
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0326 0.331 0.3789
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0055 0.0089
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.108 0.1258
Plasmodium vivax 6-phosphofructokinase, putative 0.0059 0.0383 0.0648
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0369 0.3782 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.018 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.053 0.0617
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0181
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0219 0.032
Schistosoma mansoni CREB-binding protein 2 0.0118 0.1028 0.1198
Plasmodium falciparum thioredoxin reductase 0.0096 0.0781 0.1502
Loa Loa (eye worm) hypothetical protein 0.0051 0.0293 0.0428
Brugia malayi hexokinase 0.0161 0.15 0.1746
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.018 0.0208
Brugia malayi Bromodomain containing protein 0.0168 0.1571 0.1829
Trypanosoma brucei polo-like protein kinase 0.0303 0.3052 0.3556
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.025 0.029
Schistosoma mansoni hypothetical protein 0.0032 0.0081 0.0094
Loa Loa (eye worm) hypothetical protein 0.011 0.0938 0.1366
Brugia malayi Pre-SET motif family protein 0.0421 0.4353 0.5072
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.025 0.029
Brugia malayi PHD-finger family protein 0.0066 0.0459 0.0533
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0218 0.2126 0.562
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0149 0.0156
Mycobacterium tuberculosis Probable reductase 0.0218 0.2126 0.562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.018 0.0262
Echinococcus granulosus chromobox protein 1 0.0073 0.0536 0.0535
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.018 0.0208
Loa Loa (eye worm) endoplasmin 0.0044 0.0219 0.0319
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0218 0.2126 0.562
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Echinococcus multilocularis microtubule associated protein 2 0.067 0.708 0.708
Trichomonas vaginalis phosphofructokinase, putative 0.0059 0.0383 0.043
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni hypothetical protein 0.0069 0.0488 0.0568
Trypanosoma brucei beta lactamase 0.0062 0.041 0.0475
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Leishmania major cytochrome p450-like protein 0.0045 0.0225 0.026
Trichomonas vaginalis galactokinase, putative 0.0369 0.3782 0.4399
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0189 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0974 0.142
Loa Loa (eye worm) hexokinase 0.0161 0.15 0.2186
Loa Loa (eye worm) hexokinase 0.005 0.0278 0.0406
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.108 0.1078
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.018 0.0209
Giardia lamblia Pyruvate kinase 0.0035 0.0117 0.0026
Schistosoma mansoni hypothetical protein 0.0059 0.0379 0.0441
Echinococcus multilocularis GPCR, family 2 0.0032 0.0081 0.008
Brugia malayi TAR-binding protein 0.0067 0.0463 0.0538
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0176 0.1665 0.3252
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0869 0.0867
Trypanosoma brucei hypothetical protein, conserved 0.043 0.4455 0.5192
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0225 0.2198 0.3532
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0379 0.0639
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.1068 0.1556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.018 0.0262
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0632 0.063
Toxoplasma gondii Hsp90 domain-containing protein 0.0168 0.1581 0.3086
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.018 0.0209
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0232 0.023
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0193 0.1852 0.185
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Echinococcus granulosus N acetylgalactosamine kinase 0.0369 0.3782 0.3781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0225 0.026
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0225 0.026
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0095 0.0078
Loa Loa (eye worm) heat shock protein 75 0.003 0.0055 0.0081
Giardia lamblia Histone acetyltransferase GCN5 0.0156 0.1438 0.1583
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.2145 0.2487
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.041 0.0475
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0095 0.0157
Leishmania major galactokinase-like protein 0.0369 0.3782 0.4407
Trypanosoma cruzi phosphomannose isomerase, putative 0.0491 0.5118 0.5964
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0275 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0258 0.0298
Leishmania major eukaryotic translation initiation factor-like protein 0.0036 0.013 0.0149
Echinococcus granulosus transcription factor Dp 1 0.0077 0.058 0.0578
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0258 0.0677
Schistosoma mansoni lipoxygenase 0.0226 0.2213 0.2579
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.025 0.0462
Loa Loa (eye worm) diphosphomevalonate decarboxylase 0.065 0.6863 1
Leishmania major fucose kinase, putative 0.0156 0.1449 0.1687
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0258 0.0298
Trypanosoma brucei metacaspase 5, putative 0.0054 0.0321 0.0372
Plasmodium falciparum metacaspase 1 0.0054 0.0321 0.0599
Loa Loa (eye worm) hypothetical protein 0.0041 0.0182 0.0266
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0124
Brugia malayi phosphomannomutase 2 0.0044 0.0219 0.0253
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0309 0.3126 0.3642
Toxoplasma gondii phosphomannose isomerase type I protein 0.0491 0.5118 1
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Loa Loa (eye worm) hypothetical protein 0.0051 0.0293 0.0428
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0217 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.018 0.0208
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.0806 0.858 0.858
Echinococcus multilocularis heat shock protein 0.0044 0.0219 0.0217
Giardia lamblia Mevalonate kinase 0.0369 0.3782 0.4346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0838 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.018 0.0208
Brugia malayi heat shock protein 90 0.0044 0.0219 0.0253
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.025 0.0385
Brugia malayi glutathione reductase 0.0096 0.0781 0.0909
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0095 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0103 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.043 0.4455 0.5192
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0869 0.1397
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0491 0.5118 0.5958
Schistosoma mansoni loxhd1 0.0059 0.0379 0.0441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0379 0.0377
Plasmodium vivax phosphomannomutase, putative 0.0044 0.0219 0.0323
Echinococcus granulosus phosphomannomutase 0.0044 0.0219 0.0217
Echinococcus multilocularis hexokinase 0.0161 0.15 0.1498
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0275 0.2754 0.3208
Toxoplasma gondii GHMP kinase, putative 0.0369 0.3782 0.739
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.0321 0.0373
Brugia malayi nuclear receptor NHR-88 0.0041 0.018 0.0208
Plasmodium falciparum phd finger protein, putative 0.0059 0.0379 0.0713
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0258 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.018 0.0208
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0095 0.0094
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.041 0.1079
Plasmodium falciparum phosphomannomutase, putative 0.0044 0.0219 0.0399
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.0806 0.858 1
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0369 0.3782 0.4407
Brugia malayi Pre-SET motif family protein 0.006 0.0394 0.0457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0081 0.0093
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0243 0.2394 0.6327
Echinococcus granulosus heat shock protein 90 0.0044 0.0219 0.0217
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.018 0.0178
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0217 0.0236
Loa Loa (eye worm) bromodomain containing protein 0.0052 0.0298 0.0434
Loa Loa (eye worm) hypothetical protein 0.065 0.6863 1
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.058 0.0578
Trypanosoma cruzi metacaspase, putative 0.0054 0.0321 0.0372
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0117 0.0225
Echinococcus multilocularis pyruvate kinase 0.0035 0.0117 0.0115
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0117 0.0134
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0218 0.2126 0.562
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0275 0.2754 0.3208
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.2145 0.3125
Schistosoma mansoni heat shock protein 0.0044 0.0219 0.0255
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0326 0.331 0.3848
Schistosoma mansoni zinc finger protein 0.0055 0.034 0.0396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.018 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0095 0.0109
Loa Loa (eye worm) phosphofructokinase 0.022 0.2145 0.3125
Brugia malayi Hexokinase family protein 0.0161 0.15 0.1746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0095 0.0109
Leishmania major ATP-dependent phosphofructokinase 0.022 0.2145 0.2498
Mycobacterium tuberculosis Conserved protein 0.005 0.0275 0.0723
Echinococcus multilocularis chromobox protein 1 0.0073 0.0536 0.0535
Leishmania major heat shock protein 83-1 0.0044 0.0219 0.0253
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.0806 0.858 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0321 0.0467
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0258 0.0677
Echinococcus granulosus CREB binding protein 0.008 0.0611 0.0609
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0059 0.0383 0.043
Echinococcus multilocularis CREB binding protein 0.0087 0.0686 0.0684
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0055 0.0105
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0369 0.3782 0.4407
Loa Loa (eye worm) hexokinase 0.0161 0.15 0.2186
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0591 0.6221 1
Entamoeba histolytica phosphomannose isomerase, putative 0.0491 0.5118 0.8226
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0275 0.0319
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.018 0.0178
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0149 0.0147
Trypanosoma brucei heat shock protein, putative 0.0044 0.0219 0.0253
Loa Loa (eye worm) hypothetical protein 0.0101 0.0838 0.1221
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0258 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0463 0.0539
Brugia malayi hypothetical protein 0.0059 0.0379 0.044
Toxoplasma gondii phosphomannomutase 0.0044 0.0219 0.0424
Leishmania major phosphomevalonate kinase protein, putative 0.0369 0.3782 0.4407
Brugia malayi Cell death protein 3 precursor 0.0054 0.0321 0.0372
Onchocerca volvulus Alhambra homolog 0.0059 0.0379 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0321 0.0357
Echinococcus granulosus expressed conserved protein 0.0097 0.08 0.0798
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0219 0.0218
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0076 0.0561 0.0638
Onchocerca volvulus 0.0101 0.0841 0.0921
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0321 0.0623
Mycobacterium tuberculosis Probable oxidoreductase 0.0243 0.2394 0.6327
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.005 0.0275 0.0319
Echinococcus multilocularis zinc finger protein 0.0055 0.034 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.1449 0.1674
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.108 0.1256
Schistosoma mansoni phosphomannomutase 0.0044 0.0219 0.0254
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0379 0.0377
Trichomonas vaginalis glutaminase, putative 0.0265 0.2642 0.3068
Echinococcus multilocularis Mevalonate galactokinase 0.0369 0.3782 0.3781
Echinococcus granulosus GPCR family 2 0.0032 0.0081 0.008
Echinococcus granulosus tar DNA binding protein 0.0067 0.0463 0.0462
Brugia malayi phosphofructokinase 0.022 0.2145 0.2498
Brugia malayi glucose-6-phosphate dehydrogenase 0.0309 0.3126 0.3642
Echinococcus granulosus caspase 2 0.0054 0.0321 0.0319
Brugia malayi diphosphomevalonate decarboxylase family protein 0.0806 0.858 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0561 0.0817
Schistosoma mansoni hypothetical protein 0.0043 0.0202 0.0235
Toxoplasma gondii heat shock protein HSP90 0.0044 0.0219 0.0425
Toxoplasma gondii 6-phosphofructokinase 0.0059 0.0383 0.0746
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0781 0.1138
Echinococcus granulosus RUN 0.0059 0.0379 0.0377
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.108 0.1078
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0036 0.013 0.0151
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0117 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Brugia malayi Heterochromatin protein 1 0.0073 0.0536 0.0623
Plasmodium falciparum hexokinase 0.0161 0.15 0.291
Echinococcus granulosus diphosphomevalonate decarboxylase 0.0806 0.858 0.858
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0463 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0526 0.0612
Loa Loa (eye worm) hypothetical protein 0.0048 0.0258 0.0375
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0262
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0095 0.0109
Schistosoma mansoni endoplasmin 0.0044 0.0219 0.0255
Loa Loa (eye worm) hypothetical protein 0.0098 0.081 0.118
Chlamydia trachomatis pyruvate kinase 0.0035 0.0117 0.0071
Loa Loa (eye worm) phosphomannomutase 2 0.0044 0.0219 0.0319
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0118 0.1028 0.1198
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0379 0.0737
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0463 0.0539
Loa Loa (eye worm) hypothetical protein 0.0069 0.0488 0.0711
Schistosoma mansoni hypothetical protein 0.0043 0.0202 0.0235
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0491 0.5118 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0463 0.0539
Loa Loa (eye worm) hypothetical protein 0.0059 0.0379 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.012 0.0123
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0219 0.0253
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.012 0.0123
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0379 0.0737
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0886 0.1033
Giardia lamblia Diphosphomevalonate decarboxylase 0.0806 0.858 1
Loa Loa (eye worm) RNA binding protein 0.0067 0.0463 0.0675
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.3052 0.3546
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0117 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0838 0.0975
Trypanosoma cruzi phosphomannomutase, putative 0.0044 0.0219 0.0253
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.0156 0.1449 0.3827
Mycobacterium ulcerans hypothetical protein 0.0048 0.0258 0.0298
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0321 0.0524
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.011 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.018 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0321 0.0357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.6221 0.7246
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.0806 0.858 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.018 0.0209
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0369 0.3782 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0095 0.0247

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 187.9 nM Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay ChEMBL. 20232824

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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