Detailed information for compound 883892

Basic information

Technical information
  • TDR Targets ID: 883892
  • Name: ZINC05009601
  • MW: 244.272 | Formula: C11H8N4OS
  • H donors: 1 H acceptors: 5 LogP: 1.23 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)CSc1nncc(n1)O
  • InChi: 1S/C11H8N4OS/c12-5-8-1-3-9(4-2-8)7-17-11-14-10(16)6-13-15-11/h1-4,6H,7H2,(H,14,15,16)
  • InChiKey: PJJPJEVIXXQLDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ST5328519

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0056 0.1036 0.3625
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0413 0.1446
Brugia malayi Flap endonuclease-1 0.0029 0.0413 0.0742
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0047 0.0043
Echinococcus multilocularis chromobox protein 1 0.0077 0.1505 0.1485
Echinococcus multilocularis dnaJ subfamily B 0.0453 1 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0135 0.0135
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.021 0.1117
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.1297 0.1276
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0157 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0134 0.0599
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0491 0.1718
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0156 0.0252
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.007
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0491 0.0891
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0347 0.1213
Brugia malayi N-terminal motif family protein 0.02 0.428 0.8121
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0267 0.0464
Echinococcus granulosus p2X purinoceptor 4 0.0271 0.5875 0.5865
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0061 0.0214
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0047 0.0000000013246
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0777 0.0754
Schistosoma mansoni hypothetical protein 0.0023 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.02 0.428 0.8121
Schistosoma mansoni hypothetical protein 0.0017 0.0144 0.0144
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0727 0.0727
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0727 0.4667
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.1574 0.2957
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0203 0.0342
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0733 0.0733
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0727 1
Echinococcus multilocularis muscleblind protein 0.0166 0.35 0.3485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0157 0.0133
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0047 0.0043
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0413 0.27
Trichomonas vaginalis chromobox protein, putative 0.0077 0.1505 1
Trichomonas vaginalis chromobox protein, putative 0.0077 0.1505 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0491 0.0891
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0061 0.0214
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0156 0.0132
Leishmania major DNA polymerase eta, putative 0.0071 0.1365 1
Entamoeba histolytica hypothetical protein 0.0013 0.0047 0.0641
Brugia malayi polk-prov protein 0.0013 0.0061 0.007
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0727 0.1342
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0347 0.2189
Entamoeba histolytica recQ family helicase, putative 0.0027 0.0368 0.5054
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0047 0.0064
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0347 0.4239
Loa Loa (eye worm) hypothetical protein 0.0045 0.0781 0.1444
Loa Loa (eye worm) hypothetical protein 0.0017 0.0156 0.0252
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0727 0.511
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0157 0.0253
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0047 0.0163
Onchocerca volvulus 0.0092 0.1842 0.4242
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0047 0.0641
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0368 0.2351
Schistosoma mansoni P2X receptor subunit 0.0271 0.5875 0.5875
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0157 0.0548
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0157 0.0133
Echinococcus multilocularis dna polymerase eta 0.0071 0.1365 0.1344
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0157 0.0733
Echinococcus multilocularis chromobox protein 1 0.0077 0.1505 0.1485
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0157 0.0733
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0024
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.1842 0.347
Echinococcus multilocularis zinc finger protein 0.0024 0.0292 0.0269
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0156 0.0132
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0347 0.5
Echinococcus granulosus dna polymerase eta 0.0071 0.1365 0.1344
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.2151 0.2132
Schistosoma mansoni ets-related 0.0244 0.5265 0.5265
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0061 0.0061
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0047 0.0047
Brugia malayi Ets-domain containing protein 0.008 0.1574 0.2957
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0813 0.5254
Schistosoma mansoni hypothetical protein 0.0038 0.0614 0.0614
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0777 0.0754
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0727 0.0705
Trypanosoma brucei DNA polymerase eta, putative 0.0071 0.1365 1
Echinococcus granulosus chromobox protein 2 0.0013 0.0047 0.0023
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0366 0.0343
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0061 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0739 0.4746
Entamoeba histolytica hypothetical protein 0.0026 0.0347 0.4764
Loa Loa (eye worm) hypothetical protein 0.0078 0.1531 0.2876
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0047 0.0064
Loa Loa (eye worm) hypothetical protein 0.0055 0.1009 0.1879
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0413 0.2512
Leishmania major DNA polymerase kappa, putative 0.0043 0.0727 0.511
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0427 0.281
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0727 1
Schistosoma mansoni chromobox protein 0.0077 0.1505 0.1505
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0347 0.3327
Loa Loa (eye worm) hypothetical protein 0.0034 0.0528 0.0961
Schistosoma mansoni hypothetical protein 0.0453 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0368 0.22
Brugia malayi PHD-finger family protein 0.0014 0.0089 0.0123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.023 0.0804
Schistosoma mansoni ets 0.0012 0.0024 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0661 0.0638
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0733 0.1353
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0204 0.0204
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0278 0.0484
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0727 1
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0727 0.0705
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0188 0.0164
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0137 0.2848 0.2848
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0733 0.0733
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0157 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0413 0.27
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0156 0.0252
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0727 0.0727
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0157 0.0733
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.023 0.0206
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0413 0.5679
Schistosoma mansoni hypothetical protein 0.0013 0.0047 0.0047
Brugia malayi hypothetical protein 0.0013 0.0047 0.0043
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0739 0.1364
Schistosoma mansoni P2X receptor subunit 0.0134 0.2793 0.2793
Schistosoma mansoni hypothetical protein 0.0017 0.0156 0.0156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0086 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0157 0.0133
Brugia malayi isocitrate dehydrogenase 0.0018 0.0157 0.0253
Brugia malayi Ets-domain containing protein 0.008 0.1574 0.2957
Echinococcus multilocularis p2X purinoceptor 4 0.0271 0.5875 0.5865
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0047 0.0641
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0347 0.1213
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0813 0.181
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.023 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0739 0.4746
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.048 0.087
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0047 0.0163
Brugia malayi PHD-finger family protein 0.0032 0.0491 0.0891
Onchocerca volvulus 0.0032 0.048 0.1024
Schistosoma mansoni DNA helicase recq5 0.0021 0.023 0.023
Giardia lamblia PHD finger protein 15 0.0032 0.0491 0.4452
Schistosoma mansoni DNA polymerase eta 0.0071 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0166 0.35 0.6634
Echinococcus granulosus flap endonuclease 1 0.0029 0.0413 0.039
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0204 0.018
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0347 0.5
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0347 0.4285
Loa Loa (eye worm) hypothetical protein 0.0021 0.023 0.0392
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0061 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0204 0.018
Giardia lamblia DINP protein human, muc B family 0.0043 0.0727 0.69
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0135 0.0112
Echinococcus granulosus cpg binding protein 0.0036 0.0569 0.0546
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.023 0.0206
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1182 0.4139
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0699 0.2446
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.1574 0.1554
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1286 0.1286
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0055 0.1012 0.1886
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.0758 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.35 0.6634
Echinococcus multilocularis p2X purinoceptor 4 0.0271 0.5875 0.5865
Loa Loa (eye worm) hypothetical protein 0.0049 0.087 0.1614
Plasmodium falciparum flap endonuclease 1 0.0029 0.0413 0.5169
Schistosoma mansoni hypothetical protein 0.0032 0.0491 0.0491
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0727 0.511
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0047 0.0023
Brugia malayi Muscleblind-like protein 0.0166 0.35 0.6634
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.1842 0.1823
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0727 0.1342
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) helicase 0.0013 0.0047 0.0043
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.023 0.0392
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0156 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0347 0.2189
Schistosoma mansoni jumonji domain containing protein 0.0084 0.166 0.166
Brugia malayi CHD4 protein 0.0017 0.0135 0.0212
Trypanosoma brucei unspecified product 0.003 0.0427 0.281
Schistosoma mansoni chromobox protein 0.0013 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0453 0.2789
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Trypanosoma brucei unspecified product 0.003 0.0427 0.281
Loa Loa (eye worm) hypothetical protein 0.0092 0.1842 0.347
Giardia lamblia Hypothetical protein 0.0056 0.1027 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Schistosoma mansoni hypothetical protein 0.0017 0.0156 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus granulosus zinc finger protein 0.0024 0.0292 0.0269
Brugia malayi Bloom's syndrome protein homolog 0.005 0.0896 0.1664
Loa Loa (eye worm) hypothetical protein 0.0153 0.3212 0.6083
Brugia malayi jmjC domain containing protein 0.0043 0.0733 0.1353
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0157 0.1583
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.1842 0.1842
Loa Loa (eye worm) fli-1 protein 0.0244 0.5265 1
Entamoeba histolytica hypothetical protein 0.0013 0.0047 0.0641
Brugia malayi Heterochromatin protein 1 0.0077 0.1505 0.2826
Brugia malayi chromobox protein homolog 3 0.0043 0.0739 0.1364
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0157 0.2332
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1009 0.1879
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1009 0.1879
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0727 0.511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0047 0.0000000013246
Schistosoma mansoni hypothetical protein 0.0017 0.0156 0.0156
Schistosoma mansoni chromobox protein 0.0077 0.1505 0.1505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Loa Loa (eye worm) RecQ helicase 0.005 0.0896 0.1664
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0645 0.0622
Schistosoma mansoni cpg binding protein 0.0032 0.048 0.048
Trichomonas vaginalis DNA helicase recq1, putative 0.005 0.0896 0.5825
Echinococcus multilocularis GPCR, family 2 0.0017 0.0156 0.0132
Echinococcus granulosus GA binding protein alpha chain 0.008 0.1574 0.1554
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0896 0.5825
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.023 0.0392
Schistosoma mansoni hypothetical protein 0.0017 0.0156 0.0156
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0135 0.0112
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0727 0.4667
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0413 0.7617
Brugia malayi SET domain containing protein 0.0013 0.0062 0.0073
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0047 0.0023
Schistosoma mansoni zinc finger protein 0.0017 0.0144 0.0144
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.023 0.1747
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0047 0.0043
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.023 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0427 0.281
Echinococcus granulosus peregrin 0.0035 0.055 0.0527
Trypanosoma cruzi ISWI complex protein 0.0017 0.0144 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0427 0.281
Loa Loa (eye worm) hypothetical protein 0.002 0.0204 0.0343
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0047 0.0000000013246
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0491 0.1718
Echinococcus granulosus bloom syndrome protein 0.005 0.0896 0.0874
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0727 0.511
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.023 0.2605
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0034 0.0529 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0188 0.0164
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0047 0.0047
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0413 0.27
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0413 0.039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0188 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0047 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0722 0.1331
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0122 0.0518
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0047 0.0043
Echinococcus multilocularis bloom syndrome protein 0.005 0.0896 0.0874
Schistosoma mansoni P2X receptor subunit 0.0271 0.5875 0.5875
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0157 0.0548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0727 0.511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Echinococcus granulosus Chromo domain 0.0013 0.0047 0.0023
Brugia malayi CXXC zinc finger family protein 0.0032 0.048 0.087
Brugia malayi PHD-finger family protein 0.0029 0.0426 0.0766
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.023 0.0392
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0491 0.0468
Onchocerca volvulus 0.0034 0.0528 0.1136
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0047 0.0064
Brugia malayi jmjC domain containing protein 0.0106 0.2151 0.4059
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0699 0.489
Trypanosoma brucei ISWI complex protein 0.0017 0.0144 0.0637
Brugia malayi Fli-1 protein 0.0244 0.5265 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.023 0.0206
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0047 0.0047
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0366 0.0366
Trypanosoma cruzi DNA polymerase eta, putative 0.0071 0.1365 1
Echinococcus granulosus dna polymerase kappa 0.0043 0.0727 0.0705
Leishmania major DNA polymerase eta, putative 0.0042 0.0699 0.489
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.1505 0.2826
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Plasmodium falciparum phd finger protein, putative 0.0032 0.0491 0.6259
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Schistosoma mansoni P2X receptor subunit 0.0134 0.2793 0.2793
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0156 0.0132
Schistosoma mansoni cpg binding protein 0.0036 0.0569 0.0569
Onchocerca volvulus Alhambra homolog 0.0032 0.0491 0.105
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0491 0.9223
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0727 0.511
Echinococcus granulosus Chromobox protein 3 0.0013 0.0047 0.0023
Brugia malayi Bromodomain containing protein 0.0035 0.055 0.1004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0089 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0413 0.0742
Echinococcus multilocularis p2X purinoceptor 4 0.0271 0.5875 0.5865
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0347 0.1213
Schistosoma mansoni elf1 0.0012 0.0024 0.0024
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0047 0.0163
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0347 0.4285
Echinococcus granulosus p2X purinoceptor 4 0.0271 0.5875 0.5865
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0134 0.0599
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0733 0.0711
Echinococcus granulosus p2X purinoceptor 4 0.0271 0.5875 0.5865
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0727 0.0705
Onchocerca volvulus 0.0013 0.0062 0.0037
Echinococcus multilocularis cpg binding protein 0.0036 0.0569 0.0546
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0157 0.0157
Schistosoma mansoni bromodomain containing protein 0.0072 0.1386 0.1386
Echinococcus multilocularis chromobox protein 2 0.0013 0.0047 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0727 0.511
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0043
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.1842 0.1823
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0368 0.2351
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0491 0.0468
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0739 0.1635
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0137 0.2857 0.2857
Loa Loa (eye worm) hypothetical protein 0.0069 0.1311 0.2456
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0157 0.0733
Echinococcus granulosus muscleblind protein 0.0166 0.35 0.3485
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0727 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0368 0.2351
Trypanosoma cruzi ISWI complex protein 0.0017 0.0144 0.0637
Echinococcus multilocularis muscleblind protein 1 0.0166 0.35 0.3485
Trypanosoma brucei unspecified product 0.0043 0.0727 0.511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0204 0.0204
Brugia malayi Protein cec-1. 0.0013 0.0047 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.1365 0.2559
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0135 0.0212
Brugia malayi Bromodomain containing protein 0.0085 0.168 0.3159
Schistosoma mansoni chromobox protein 0.0013 0.0047 0.0047
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0156 0.0252
Echinococcus multilocularis Chromo domain 0.0013 0.0047 0.0023
Leishmania major hypothetical protein, conserved 0.0017 0.0144 0.0637
Schistosoma mansoni cpg binding protein 0.0036 0.0569 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0453 0.2789
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.021 0.1117
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0047 0.0043
Entamoeba histolytica hypothetical protein 0.0013 0.0047 0.0641
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.428 1
Echinococcus multilocularis peregrin 0.0035 0.055 0.0527
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0366 0.0343
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1009 0.1879
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0614 0.1126
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0727 0.511
Brugia malayi ImpB/MucB/SamB family protein 0.0071 0.1365 0.2559
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0137 0.2857 1
Echinococcus granulosus GPCR family 2 0.0017 0.0156 0.0132
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0157 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1268 0.2374
Schistosoma mansoni DNA helicase recq1 0.0021 0.023 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0178 0.0178
Treponema pallidum 5'-nucleotidase (ushA) 0.0137 0.2857 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0157 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0614 0.1126
Echinococcus granulosus chromobox protein 1 0.0077 0.1505 0.1485
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0062 0.0062
Echinococcus granulosus chromobox protein 1 0.0077 0.1505 0.1485
Schistosoma mansoni gabp alpha 0.008 0.1574 0.1574
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0086 0.0062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.021 0.1117
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.2151 0.2132
Brugia malayi Bromodomain containing protein 0.0042 0.072 0.1328
Schistosoma mansoni flap endonuclease-1 0.0026 0.035 0.035
Schistosoma mansoni ets-related 0.0012 0.0024 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.052 0.1819
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0661 0.0638
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0813 0.5254
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0657 0.0657
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0188 0.0188
Schistosoma mansoni zinc finger protein 0.0024 0.0292 0.0292
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0347 0.6246
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0413 0.3645
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0047 0.0641
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.1297 0.1276
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0047 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0157 0.0133

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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