Detailed information for compound 1371652

Basic information

Technical information
  • TDR Targets ID: 1371652
  • Name: N-[3-(1,3-benzoxazol-2-yl)phenyl]-2-methylpro panamide
  • MW: 280.321 | Formula: C17H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)C)Nc1cccc(c1)c1nc2c(o1)cccc2
  • InChi: 1S/C17H16N2O2/c1-11(2)16(20)18-13-7-5-6-12(10-13)17-19-14-8-3-4-9-15(14)21-17/h3-11H,1-2H3,(H,18,20)
  • InChiKey: QHWVPFFXFYFJEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(1,3-benzoxazol-2-yl)phenyl]-2-methyl-propanamide
  • N-[3-(1,3-benzoxazol-2-yl)phenyl]-2-methyl-propionamide
  • MLS000099088
  • SMR000070478
  • Oprea1_649182
  • Oprea1_369223
  • BAS 01170065
  • N-(3-Benzooxazol-2-yl-phenyl)-isobutyramide
  • BIM-0039121.P001
  • ZINC00237483
  • CBMicro_039050

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0899 0.2984
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0139 0.071
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0096 0.0238
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0496 0.0496
Entamoeba histolytica hypothetical protein 0.0072 0.0645 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0248 0.0754
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0343 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0659 0.1976
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0005
Brugia malayi glutathione reductase 0.0055 0.0441 0.0781
Echinococcus multilocularis dna polymerase eta 0.0019 0.0027 0.0027
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0027 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 0.1817
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0077 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.15 0.2655
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0027 0.0001
Brugia malayi steroid hormone receptor 0.0049 0.0379 0.067
Schistosoma mansoni ap endonuclease 0.0038 0.0248 0.0248
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0126 0.127 0.127
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0183 0.0299
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0077 0.0077
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0027 0.0012
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0027 0.0027
Brugia malayi beta-lactamase family protein 0.0074 0.0659 0.1166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.1812 0.6107
Loa Loa (eye worm) hypothetical protein 0.0097 0.0935 0.1655
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.0379 0.067
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0027 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.0379 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0077 0.0137
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0071 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0496 0.0496
Echinococcus multilocularis geminin 0.0341 0.3745 0.3745
Brugia malayi nuclear hormone receptor 0.0049 0.0379 0.067
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0077 0.0077
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0135 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0259 0.0458
Echinococcus granulosus dna polymerase kappa 0.0019 0.0027 0.0027
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0289 0.0819
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0272 0.295 0.295
Brugia malayi hypothetical protein 0.0026 0.011 0.0194
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0965 0.1708
Brugia malayi Heterochromatin protein 1 0.007 0.0612 0.1083
Schistosoma mansoni 23-cyclic-nucleotide 2-phosphodiesterase 0.0271 0.2941 0.2941
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0027 0.0002
Brugia malayi nuclear receptor RXR 0.0023 0.0077 0.0137
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0114 0.113 0.2001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0248 0.069
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0227 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0883 0.0883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0379 0.0379
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.036 0.1041
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0659 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0248 0.3493
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.1251 0.8735
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0246
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0027 0.0027
Brugia malayi nuclear receptor NHR-88 0.0023 0.0077 0.0137
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0139 0.1817
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1474 0.2609
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.071
Loa Loa (eye worm) hypothetical protein 0.0505 0.5649 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0027 0.0002
Schistosoma mansoni zinc finger protein 0.0023 0.0077 0.0077
Echinococcus granulosus tumor protein p63 0.0666 0.7505 0.7505
Plasmodium vivax glutathione reductase, putative 0.0055 0.0441 0.4745
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0194
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0659 0.4082
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0227 0.0625
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0077 0.0137
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0629 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0068 0.0658
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0248 0.0438
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.036 0.5268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0659 0.0659
Mycobacterium tuberculosis Probable reductase 0.0125 0.1251 0.2348
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0659 0.1212
Schistosoma mansoni hypothetical protein 0.0103 0.0999 0.0999
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0027 0.0048
Brugia malayi hypothetical protein 0.0026 0.011 0.0194
Brugia malayi hypothetical protein 0.0072 0.0645 0.1141
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0434 0.4827 0.8546
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0659 0.3997
Brugia malayi nuclear hormone receptor 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0077 0.0069
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.0379 0.067
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0131 0.0232
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 1
Echinococcus multilocularis survival motor neuron protein 1 0.0505 0.5649 0.5649
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0127 0.1589
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0248 0.3574
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0027 0.0047
Trypanosoma brucei trypanothione reductase 0.0055 0.0441 0.1295
Toxoplasma gondii hypothetical protein 0.0033 0.0184 0.0537
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0689 0.122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0379 0.0379
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 1
Brugia malayi jmjC domain containing protein 0.0071 0.0629 0.1113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0659 0.1212
Plasmodium falciparum glutathione reductase 0.0019 0.0027 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.036 0.5268
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.036 0.036
Toxoplasma gondii ABC1 family protein 0.0074 0.0659 0.2162
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Echinococcus multilocularis Protein lozenge 0.0054 0.0438 0.0438
Loa Loa (eye worm) runx1 0.0054 0.0438 0.0775
Echinococcus multilocularis thyroid hormone receptor alpha 0.0049 0.0379 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0042 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0645 0.0645
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 0.1817
Echinococcus multilocularis chromobox protein 1 0.007 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0899 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.0379 0.0379
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0248 0.3493
Leishmania major cathepsin L-like protease 0.0063 0.0531 0.1577
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.036 0.036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0659 0.1212
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1413 0.2657
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 0.2983
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0899 0.597
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0272 0.295 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Schistosoma mansoni cpg binding protein 0.0097 0.0926 0.0926
Echinococcus granulosus cpg binding protein 0.0097 0.0926 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0293 0.4211
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0343 0.0343
Onchocerca volvulus 0.0434 0.4827 1
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0227 0.3164
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0689 0.0689
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1426 0.4373
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0343 0.0608
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0027 0.0002
Onchocerca volvulus 0.0074 0.0659 0.1285
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0531 0.1577
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0379 0.0379
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0496 0.2969
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1413 0.2657
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0027 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0629 0.0629
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.011 0.011
Echinococcus granulosus geminin 0.0341 0.3745 0.3745
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.5243 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0883 0.0883
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0379 0.0379
Mycobacterium ulcerans hypothetical protein 0.0074 0.0659 0.3997
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0496 0.0496
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0999 0.1769
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1413 0.2657
Echinococcus multilocularis cpg binding protein 0.0097 0.0926 0.0926
Trichomonas vaginalis chromobox protein, putative 0.007 0.0612 0.9257
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Onchocerca volvulus 0.0074 0.0659 0.1285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.0379 0.067
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0645 0.0645
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0096 0.0796
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0248 0.2528
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0048 0.036 0.5268
Mycobacterium ulcerans hypothetical protein 0.0156 0.1608 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0027 0.0005
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0077 0.0137
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0441 0.0441
Brugia malayi hypothetical protein 0.0505 0.5649 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.0379 0.0379
Onchocerca volvulus 0.0049 0.0379 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.0379 0.067
Leishmania major cathepsin L-like protease 0.0063 0.0531 0.1577
Brugia malayi ecdysone receptor 0.0023 0.0077 0.0137
Mycobacterium leprae Probable lipase LipE 0.0074 0.0659 0.4082
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.011 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0468 0.1381
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0248 0.2528
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0441 0.0441
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0227 0.3164
Mycobacterium ulcerans lipase LipD 0.0074 0.0659 0.3997
Loa Loa (eye worm) hypothetical protein 0.0048 0.036 0.0637
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0659 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.0379 0.067
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.0379 0.067
Schistosoma mansoni nuclear receptor 0.0023 0.0077 0.0077
Treponema pallidum 5'-nucleotidase (ushA) 0.0272 0.295 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0248 0.0423
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0126 0.127 0.7858
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0047
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0055 0.0325
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0048
Schistosoma mansoni hypothetical protein 0.0882 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0184 0.1801
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Onchocerca volvulus 0.0031 0.0161 0.0244
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0899 0.0899
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0071 0.0071
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0227 0.2286
Schistosoma mansoni survival motor neuron protein 0.0103 0.0999 0.0999
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0027 0.0027
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0248 0.0248
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0027 0.0005
Schistosoma mansoni inositol monophosphatase 0.0036 0.0227 0.0227
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.036 0.036
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0126 0.127 0.2248
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0002
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.15 0.2655
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0139 0.071
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0077 0.0077
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0027 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0441 0.0781
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0071 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0659 0.1212
Loa Loa (eye worm) hypothetical protein 0.0094 0.0899 0.1592
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0659 0.7244
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0899 0.0899
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0227 0.1265
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.0379 0.0379
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.0379 0.0699
Schistosoma mansoni hypothetical protein 0.0046 0.0343 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0259 0.367
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0227 0.0683
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0027 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0227 0.3164
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.0379 0.067
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0077 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0077 0.0077
Leishmania major trypanothione reductase 0.0055 0.0441 0.1295
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0523 0.0952
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0055 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0042 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0248 0.2072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0343 0.0608
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.036 0.0637
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.0379 0.0379
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0092 0.0866 0.0866
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0042 0.0029
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0126 0.127 0.2383
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.0379 0.0379
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.011 0.0194
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Schistosoma mansoni hypothetical protein 0.0341 0.3745 0.3745
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0077 0.0077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.0379 0.0379
Brugia malayi jmjC domain containing protein 0.0076 0.0689 0.122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3226 1
Schistosoma mansoni hypothetical protein 0.0341 0.3745 0.3745
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0441 0.0794
Schistosoma mansoni chromobox protein 0.007 0.0612 0.0612
Loa Loa (eye worm) glutathione reductase 0.0055 0.0441 0.0781
Brugia malayi chromobox protein homolog 3 0.0039 0.0259 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0379 0.067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0139 0.071
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0351
Echinococcus multilocularis dnaJ subfamily B 0.0882 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0126 0.127 0.3885
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0248 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0246
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0077 0.0077
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0027 0.0047
Schistosoma mansoni cpg binding protein 0.0097 0.0926 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0379 0.067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.0379 0.0379
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0027 0.0048
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0659 0.1212
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0194
Plasmodium falciparum thioredoxin reductase 0.0019 0.0027 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.0379 0.067
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0496 0.0496
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0248 0.2524
Loa Loa (eye worm) hypothetical protein 0.01 0.0965 0.1708
Echinococcus granulosus FTZ F1 alpha 0.0049 0.0379 0.0379
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0184 0.0354
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.011 0.011
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0659 0.3997
Trichomonas vaginalis helicase, putative 0.0021 0.0048 0.0335
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.036 0.036
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0126 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0194
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.1251 0.2348
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.0379 0.067
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0659 1
Brugia malayi nuclear receptor RXR 0.0026 0.011 0.0194
Schistosoma mansoni hypothetical protein 0.01 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0194
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0027 0.0001
Mycobacterium ulcerans beta-lactamase 0.0074 0.0659 0.3997
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.0379 0.067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.2052 0.2052
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.0379 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0659 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0077 0.0077
Brugia malayi Probable ClpP-like protease 0.0094 0.0899 0.1592
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1426 0.4373
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0289 0.0819
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0047
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0055 0.0325
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0376 0.1093
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Echinococcus granulosus GPCR family 2 0.0046 0.0343 0.0343
Leishmania major hypothetical protein, conserved 0.0074 0.0659 0.1976
Echinococcus granulosus chromobox protein 1 0.007 0.0612 0.0612
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0048 0.036 0.1041
Schistosoma mansoni inositol monophosphatase 0.0036 0.0227 0.0227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0689 0.0689
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0027
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0496 0.2969
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0077 0.0077
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0027 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0659 0.0659
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0025 0.0096 0.0218
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0496 0.09
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0379 0.0379
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.3226 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.011 0.0194
Brugia malayi beta-lactamase 0.0074 0.0659 0.1166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.0379 0.067
Brugia malayi jmjC domain containing protein 0.0019 0.0027 0.0048
Plasmodium falciparum glutathione reductase 0.0055 0.0441 0.4745
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.0379 0.0379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0259 0.0448
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0248 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.071
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0183 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Brugia malayi hypothetical protein 0.0434 0.4827 0.8546
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0608
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0659 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0293 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0127 0.1589
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0659 0.1976
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0098
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0135 0.024
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.0379 0.0699
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0027 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0629 0.0629
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1608 0.3032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0883 0.1563
Schistosoma mansoni hypothetical protein 0.0046 0.0343 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0139 0.0215
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0659 0.1166
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0286
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0246
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0027 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0883 0.0883
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0027 0.0001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0227 0.3237
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0248 0.069
Brugia malayi Inositol-1 0.0036 0.0227 0.0401
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0048 0.036 0.3125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0227 0.0625
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0027 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.0379 0.0379
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0496 0.2969
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0246
Toxoplasma gondii hypothetical protein 0.0048 0.0359 0.1137
Schistosoma mansoni thyroid hormone receptor 0.0049 0.0379 0.0379
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.0379 0.0379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0659 0.1166
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0612 0.1083
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0343 0.0343
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0343 0.0608
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.15 0.2655
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0351
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0645 0.0645
Entamoeba histolytica hypothetical protein 0.0072 0.0645 1
Brugia malayi hypothetical protein 0.0023 0.0077 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0531 0.1577
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0096 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Schistosoma mansoni hypothetical protein 0.0072 0.0645 0.0645
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.036 0.1041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.0379 0.0379
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0077 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.0379 0.067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0289 0.0819
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.011 0.0194
Mycobacterium ulcerans hypothetical protein 0.0029 0.0139 0.071
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0139 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0379 0.067
Leishmania major hypothetical protein, conserved 0.0019 0.0027 0.0001
Schistosoma mansoni ap endonuclease 0.0038 0.0248 0.0248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0379 0.067
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0077 0.0137
Brugia malayi jmjC domain containing protein 0.0019 0.0027 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0379 0.0379
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.1251 0.2348
Brugia malayi hypothetical protein 0.0025 0.0096 0.0171
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.036 0.036
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0227 0.0227
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0179 0.2415
Brugia malayi ecdysteroid receptor 0.0049 0.0379 0.067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0394 0.1148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.0379 0.067
Loa Loa (eye worm) DR-78 0.0023 0.0077 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.0379 0.067
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 0.5517
Brugia malayi beta-lactamase family protein 0.0074 0.0659 0.1166
Trichomonas vaginalis esterase, putative 0.0074 0.0659 1
Toxoplasma gondii thioredoxin reductase 0.0055 0.0441 0.1416
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0027 0.0002
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1426 0.4373
Onchocerca volvulus 0.0092 0.0866 0.1718
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0899 0.5517
Brugia malayi MH2 domain containing protein 0.0144 0.1474 0.2609
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.1251 0.2348
Loa Loa (eye worm) beta-lactamase 0.0074 0.0659 0.1166
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0184 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.0379 0.067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0071 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0248 0.0248
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0248 0.0753
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.3226 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0077 0.0137
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0096 0.0796
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0139 0.071
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0531 0.1577
Echinococcus granulosus chromobox protein 1 0.007 0.0612 0.0612
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.036 0.036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0027 0.0005
Loa Loa (eye worm) inositol-1 0.0036 0.0227 0.0401
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0227 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0051 0.0381
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0531 0.1577
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0194
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0077 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0883 0.0883
Echinococcus multilocularis chromobox protein 1 0.007 0.0612 0.0612
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0883 0.0883
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.0379 0.0379
Echinococcus granulosus phd:f box containing protein 0.0019 0.0027 0.0027
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0496 0.1605
Schistosoma mansoni hypothetical protein 0.0046 0.0343 0.0343
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.0379 0.0379
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0135 0.0135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0248 0.069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0629 0.0629
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.3226 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0077 0.0077
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0659 0.0659
Onchocerca volvulus 0.0097 0.0935 0.1861
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0077 0.0077
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.0379 0.067
Onchocerca volvulus 0.0023 0.0077 0.0069
Schistosoma mansoni lozenge 0.0054 0.0438 0.0438
Schistosoma mansoni nuclear receptor 0.0023 0.0077 0.0077
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0087 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0027 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Schistosoma mansoni chromobox protein 0.007 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0098
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0659 0.0659
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.0379 0.0699
Brugia malayi hypothetical protein 0.0023 0.0077 0.0137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0343 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0899 0.0899
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1413 1
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0379 0.067
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.011 0.011
Leishmania major cathepsin L-like protease 0.0063 0.0531 0.1577
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0027 0.0012
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.036 0.539
Brugia malayi nuclear receptor NHR-88 0.0049 0.0379 0.067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0689 0.0689
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0027 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0293 0.4211
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0077 0.0077
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0659 0.1212
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.0379 0.067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.0379 0.067
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0523 0.0952
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0027 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0068 0.0658
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.0379 0.067
Mycobacterium tuberculosis Conserved protein 0.0074 0.0659 0.1212
Brugia malayi CXXC zinc finger family protein 0.0092 0.0866 0.1533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Brugia malayi jmjC domain containing protein 0.0019 0.0027 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0042 0.0029
Schistosoma mansoni DNA polymerase eta 0.0019 0.0027 0.0027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0496 0.1468
Plasmodium falciparum thioredoxin reductase 0.0055 0.0441 0.4745
Entamoeba histolytica hypothetical protein 0.0072 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0048
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0126 0.127 0.127
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0184 0.1801
Loa Loa (eye worm) hypothetical protein 0.0074 0.0659 0.1166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0659 0.1212
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Echinococcus multilocularis GPCR, family 2 0.0046 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0025 0.0096 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0096 0.0218
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0179 0.2415
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0096 0.0218
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0523 0.3018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0883 0.0883
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0227 0.0625
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0087 0.0087
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.0351
Schistosoma mansoni hypothetical protein 0.0046 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0434 0.4827 0.8546
Onchocerca volvulus 0.0103 0.0999 0.1997
Onchocerca volvulus 0.0023 0.0077 0.0069
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0027 0.0027
Brugia malayi nuclear receptor NHR-67 0.0023 0.0077 0.0137
Onchocerca volvulus 0.0074 0.0659 0.1285
Toxoplasma gondii 5'-nucleotidase, C-terminal domain-containing protein 0.0112 0.1101 0.3676
Loa Loa (eye worm) hypothetical protein 0.0146 0.15 0.2655
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0523 0.0523
Echinococcus multilocularis tumor protein p63 0.0666 0.7505 0.7505
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0379 0.0379
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0027 0.0049
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.0379 0.0379
Brugia malayi Thioredoxin reductase 0.0055 0.0441 0.0781
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0126 0.127 0.7858
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.0379 0.0379
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1474 0.2609
Schistosoma mansoni coup transcription factor 0.0049 0.0379 0.0379
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0899 0.2984
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0179 0.2415
Echinococcus granulosus dna polymerase eta 0.0019 0.0027 0.0027
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.036 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0259 0.367
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0441 0.1295
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0027 0.0001
Brugia malayi tailless protein 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0096 0.0218
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0077 0.0077
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0055 0.032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0883 0.0883
Onchocerca volvulus 0.0029 0.0139 0.0198
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0027 0.0001
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0077 0.0137
Giardia lamblia Hypothetical protein 0.0111 0.1093 1
Entamoeba histolytica hypothetical protein 0.0072 0.0645 1
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0246
Mycobacterium tuberculosis Conserved protein 0.0074 0.0659 0.1212
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0866 0.1533
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0074 0.0659 0.1212
Brugia malayi conserved hypotetical protein 0.0023 0.0077 0.0137
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.036 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.1251 0.2348
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.1251 0.2348
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0248 0.1396
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0027 0.0027
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0659 0.1976
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0027 0.0027
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0027 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.0379 0.067
Trichomonas vaginalis chromobox protein, putative 0.007 0.0612 0.9257
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.0335
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0441 0.4745
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0055 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0883 0.1563
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0048 0.036 0.1041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0098
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0289 0.0819
Echinococcus granulosus survival motor neuron protein 1 0.0505 0.5649 0.5649
Brugia malayi jmjC domain containing protein 0.0019 0.0027 0.0048
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0523 0.0523
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0531 0.1577
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.0935 0.0935
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0077 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.0379 0.0379

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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