Detailed information for compound 921310

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.3 | Formula: C16H17F3O2
  • H donors: 2 H acceptors: 2 LogP: 3.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(C2=CC[C@]3([C@H](C2)CC[C@@H]3O)C)c(c(c1O)F)F
  • InChi: 1S/C16H17F3O2/c1-16-5-4-8(6-9(16)2-3-12(16)20)10-7-11(17)15(21)14(19)13(10)18/h4,7,9,12,20-21H,2-3,5-6H2,1H3/t9-,12-,16-/m0/s1
  • InChiKey: UHZCHDLPWKPBBC-HCYDYPBKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0007 0.0069 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0112 0.1211
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.0192 0.2236
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Echinococcus multilocularis smad 0.0007 0.0069 0.0069
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0041 0.1049 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0118 0.0161
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0005 0.0016 0.0107
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0055 0.1437 0.183
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0759 0.0759
Schistosoma mansoni troponin I 0.0093 0.2513 0.2513
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0008 0.0106 0.0145
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0011 0.0192 0.1529
Loa Loa (eye worm) troponin I 0.0093 0.2513 0.3354
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0115 0.3149 0.3149
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0346 0.0346
Leishmania major DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Brugia malayi hypothetical protein 0.0022 0.0492 0.0669
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0005 0.0016 0.0107
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0163 0.4524 0.4524
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0118 0.0118
Treponema pallidum fructose-bisphosphate aldolase 0.0254 0.7108 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0009 0.0112 0.0153
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0118 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0346 0.418
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0115 0.0115
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0192 0.241
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0118 0.0161
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0118 0.0161
Mycobacterium leprae conserved hypothetical protein 0.002 0.0447 0.1018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0118 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0258 0.0258
Plasmodium vivax importin-beta 2, putative 0.0025 0.0582 0.7222
Onchocerca volvulus 0.0262 0.7354 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0118 0.0161
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0011 0.0192 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0118 0.0118
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0069 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0192 0.2365
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.002 0.0447 0.1272
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0492 0.6036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0118 0.0161
Schistosoma mansoni ran 0.0018 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Schistosoma mansoni hypothetical protein 0.0014 0.0258 0.0258
Brugia malayi MH2 domain containing protein 0.0007 0.0069 0.0094
Trichomonas vaginalis replication factor C large subunit, putative 0.0009 0.0112 0.0153
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0192 0.2236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0118 0.0161
Entamoeba histolytica hypothetical protein 0.0031 0.0759 0.1064
Mycobacterium tuberculosis Probable reductase 0.0075 0.2005 0.5644
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0254 0.7108 1
Loa Loa (eye worm) mbt repeat family protein 0.0041 0.1049 0.14
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0069 0.0069
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0009 0.0112 0.0153
Brugia malayi glutathione reductase 0.0033 0.0805 0.1094
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0346 0.0973
Echinococcus granulosus troponin i 0.0093 0.2513 0.2513
Trypanosoma brucei unspecified product 0.0012 0.0197 0.2426
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0115 0.0154
Schistosoma mansoni hypothetical protein 0.0014 0.0258 0.0258
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0258 0.0258
Brugia malayi Troponin T 0.0055 0.1437 0.1954
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0118 0.0118
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0011 0.0192 0.241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.1001 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Echinococcus granulosus dna polymerase eta 0.0017 0.0346 0.0346
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0072 0.1927 0.1927
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.1049 0.1049
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0018 0.0393 0.4871
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0118 0.0158
Plasmodium vivax SET domain protein, putative 0.0026 0.0623 0.773
Leishmania major phosphopantetheinyl transferase-like protein 0.002 0.0447 0.5538
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.2825 0.377
Onchocerca volvulus 0.0041 0.1049 0.1295
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0163 0.4524 0.4524
Brugia malayi RNA, U transporter 1 0.0071 0.1899 0.2582
Echinococcus multilocularis importin subunit beta 1 0.0025 0.0582 0.0582
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0011 0.0192 0.2365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.1001 0.1001
Echinococcus multilocularis cpg binding protein 0.0026 0.062 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Trypanosoma cruzi FHA domain containing protein, putative 0.0009 0.0112 0.1211
Schistosoma mansoni ran 0.0018 0.0393 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0623 0.0623
Giardia lamblia Fructose-bisphosphate aldolase 0.0254 0.7108 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0029 0.0037
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0003 0.0004
Brugia malayi MH1 domain containing protein 0.0007 0.0069 0.0094
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Entamoeba histolytica hypothetical protein 0.0031 0.0759 0.1064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0118 0.0009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.001 0.0148 0.0148
Schistosoma mansoni sex comb on midleg homolog 0.0041 0.1049 0.1049
Brugia malayi topoisomerase 0.0009 0.0112 0.0152
Echinococcus granulosus oncosphere protein Tso22e 0.0115 0.3149 0.3149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.1001 0.1361
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0018 0.0393 0.0532
Echinococcus granulosus GTP binding nuclear protein Ran 0.0018 0.0393 0.0393
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.2825 0.377
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.058 0.058
Toxoplasma gondii thioredoxin reductase 0.0033 0.0805 0.6468
Echinococcus granulosus transportin 1 0.0005 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.002 0.0447 0.0625
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.0346 0.0483
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0011 0.0192 0.2365
Brugia malayi mbt repeat family protein 0.0041 0.1049 0.1427
Loa Loa (eye worm) MBCTL1 0.0047 0.1213 0.1619
Schistosoma mansoni topbp1 0.0009 0.0112 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0346 0.047
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0118 0.0118
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0023 0.0513 0.6298
Trypanosoma brucei unspecified product 0.0012 0.0197 0.2426
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0009 0.0112 0.0282
Echinococcus granulosus GPCR family 2 0.0014 0.0258 0.0258
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0023 0.0513 0.6359
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.1404 0.1404
Loa Loa (eye worm) hypothetical protein 0.0093 0.2513 0.3354
Loa Loa (eye worm) troponin T 0.0055 0.1437 0.1918
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0267 0.7493 1
Brugia malayi hypothetical protein 0.0009 0.0112 0.0152
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0075 0.2005 0.5644
Leishmania major DNA polymerase kappa, putative 0.0005 0.0016 0.0166
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0018 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0072 0.1927 0.2621
Brugia malayi Smad1 0.0007 0.0069 0.0094
Trypanosoma brucei hypothetical protein, conserved 0.0005 0.0016 0.0166
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0192 0.2236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0118 0.0161
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0805 0.1074
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.002 0.0447 0.1272
Brugia malayi Importin beta-1 subunit 0.0025 0.0582 0.0791
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0346 0.0346
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0346 0.4277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0346 0.4277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1001 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0112 0.0153
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0041 0.1049 0.1295
Brugia malayi MH1 domain containing protein 0.0007 0.0069 0.0094
Schistosoma mansoni hypothetical protein 0.001 0.0148 0.0148
Plasmodium falciparum DNA repair protein REV1, putative 0.0005 0.0016 0.0166
Schistosoma mansoni hypothetical protein 0.0014 0.0258 0.0258
Leishmania major hypothetical protein, conserved 0.0022 0.0492 0.6101
Echinococcus multilocularis geminin 0.0147 0.4065 0.4065
Trypanosoma brucei hypothetical protein, conserved 0.0005 0.0016 0.0166
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0112 0.0153
Brugia malayi ecdysteroid receptor 0.0009 0.0118 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.1103 0.1499
Trichomonas vaginalis helicase, putative 0.0006 0.0029 0.0037
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0069 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0492 0.6036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0112 0.1211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0118 0.0158
Onchocerca volvulus 0.0009 0.0118 0.0009
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0018 0.0393 0.315
Echinococcus multilocularis translational activator gcn1 0.0005 0.0003 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.001 0.0148 0.0148
Onchocerca volvulus 0.0025 0.0579 0.0646
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0118 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0492 0.6101
Trypanosoma cruzi importin beta-1 subunit, putative 0.002 0.0447 0.5462
Trichomonas vaginalis mercuric reductase, putative 0.0011 0.0192 0.0267
Schistosoma mansoni hypothetical protein 0.0093 0.2513 0.2513
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0023 0.0513 0.4113
Schistosoma mansoni troponin I 0.0093 0.2513 0.2513
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0047 0.1213 0.1213
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0083 0.2244 0.6386
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0011 0.0192 0.2365
Echinococcus multilocularis SAM and MBT domain containing protein 0.0041 0.1049 0.1049
Schistosoma mansoni hypothetical protein 0.0147 0.4065 0.4065
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0118 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0118 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0118 0.0118
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0118 0.0118
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0011 0.0192 0.0262
Leishmania major GTP-binding protein, putative 0.0018 0.0393 0.4871
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0258 0.0351
Echinococcus granulosus Smad4 0.0007 0.0069 0.0069
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0346 0.0346
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0346 0.418
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0069 0.0069
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0623 0.0623
Onchocerca volvulus 0.0072 0.1927 0.2507
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0118 0.0158
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0393 0.4784
Schistosoma mansoni smad1 5 8 and 0.0007 0.0069 0.0069
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0009 0.0112 0.0153
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0346 0.0346
Brugia malayi nuclear receptor NHR-88 0.0009 0.0118 0.0161
Brugia malayi hypothetical protein 0.0262 0.7354 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0009 0.0112 0.0877
Brugia malayi Thioredoxin reductase 0.0033 0.0805 0.1094
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0011 0.0192 0.2365
Schistosoma mansoni smad 0.0007 0.0069 0.0069
Toxoplasma gondii ATPase, AAA family protein 0.0009 0.0112 0.0877
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0623 0.0623
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.002 0.0447 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0346 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0197 0.2426
Trichomonas vaginalis importin beta-1, putative 0.002 0.0447 0.0625
Echinococcus multilocularis replication factor c subunit 1 0.0009 0.0112 0.0112
Echinococcus granulosus cpg binding protein 0.0026 0.062 0.062
Plasmodium vivax glutathione reductase, putative 0.0033 0.0805 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0258 0.0345
Echinococcus granulosus importin 5 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0083 0.2244 0.6386
Echinococcus multilocularis snurportin 1 0.0267 0.7493 0.7493
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0118 0.0118
Brugia malayi polk-prov protein 0.0005 0.0016 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0582 0.7222
Echinococcus granulosus dna polymerase kappa 0.0017 0.0346 0.0346
Leishmania major trypanothione reductase 0.0033 0.0805 1
Trichomonas vaginalis set domain proteins, putative 0.0206 0.5751 0.809
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Schistosoma mansoni hypothetical protein 0.003 0.0712 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0118 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0118 0.0158
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0072 0.0072
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0011 0.0192 0.2365
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.0346 0.0483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Schistosoma mansoni topbp1 0.0009 0.0112 0.0112
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0003 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0447 0.0625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.1001 0.1001
Schistosoma mansoni hypothetical protein 0.0252 0.7051 0.7051
Echinococcus multilocularis flap endonuclease 1 0.0023 0.0513 0.0513
Trichomonas vaginalis flap endonuclease-1, putative 0.0023 0.0513 0.0718
Echinococcus granulosus translational activator gcn1 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0346 0.0477
Brugia malayi nuclear hormone receptor 0.0009 0.0118 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Brugia malayi Pre-SET motif family protein 0.0026 0.0623 0.0847
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Schistosoma mansoni DNA ligase IV 0.0009 0.0112 0.0112
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0005 0.0016 0.0107
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0254 0.7108 1
Schistosoma mansoni smad1 5 8 and 0.0007 0.0069 0.0069
Schistosoma mansoni troponin t invertebrate 0.0115 0.3149 0.3149
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Schistosoma mansoni importin-beta 2 0.0005 0.0003 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0355 1 1
Schistosoma mansoni flap endonuclease-1 0.002 0.0451 0.0451
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0011 0.0192 0.052
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0009 0.0112 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0118 0.0161
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0011 0.0192 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1001 0.1001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Entamoeba histolytica Ran family GTPase 0.0018 0.0393 0.055
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0112 0.0153
Brugia malayi steroid hormone receptor 0.0009 0.0118 0.0161
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0069 0.0069
Entamoeba histolytica Flap nuclease, putative 0.0023 0.0513 0.0718
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0047 0.1213 0.1649
Plasmodium falciparum importin beta, putative 0.0025 0.0582 0.7222
Entamoeba histolytica hypothetical protein 0.0031 0.0759 0.1064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Echinococcus multilocularis transportin 1 0.0005 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0192 0.241
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0011 0.0192 0.052
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0118 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Brugia malayi CXXC zinc finger family protein 0.0025 0.0579 0.0788
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0118 0.0118
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0011 0.0192 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0047 0.1213 0.1619
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0018 0.0393 0.4871
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Leishmania major importin beta-1 subunit, putative 0.002 0.0447 0.5538
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0118 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0258 0.0351
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0623 0.0623
Plasmodium falciparum thioredoxin reductase 0.0033 0.0805 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.0817 0.0817
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0118 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0579 0.0773
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0011 0.0192 0.2365
Loa Loa (eye worm) hypothetical protein 0.0262 0.7354 0.9815
Echinococcus multilocularis polycomb protein SCMH1 0.0041 0.1049 0.1049
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0346 0.418
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0492 0.6101
Brugia malayi Troponin T 0.0055 0.1437 0.1954
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0492 0.6101
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0118 0.0118
Brugia malayi Flap endonuclease-1 0.0023 0.0513 0.0697
Mycobacterium tuberculosis Probable dehydrogenase 0.0075 0.2005 0.5644
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0011 0.0192 0.2365
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0112 0.0153
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0258 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0041 0.1049 0.14
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.002 0.0447 0.5538
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0118 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0118 0.0161
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0192 0.2365
Loa Loa (eye worm) hypothetical protein 0.0025 0.0582 0.0777
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0118 0.0118
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0018 0.0393 0.4784
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0197 0.2426
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0008 0.0106 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Brugia malayi hypothetical protein 0.0014 0.0271 0.0368
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0346 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0112 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0623 0.0623
Echinococcus multilocularis dna polymerase eta 0.0017 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0355 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0258 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0118 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0075 0.2005 0.5644
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0623 0.5
Schistosoma mansoni cpg binding protein 0.0025 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Schistosoma mansoni chromosome transmission fidelity factor 0.0009 0.0112 0.0112
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0759 0.0759
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0118 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0029 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0118 0.0158
Schistosoma mansoni coup transcription factor 0.0009 0.0118 0.0118
Trichomonas vaginalis Importin beta-1 subunit, putative 0.002 0.0447 0.0625
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0258 0.0258
Echinococcus granulosus SAM and MBT domain containing protein 0.0041 0.1049 0.1049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2365
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0115 0.3149 0.4194
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0112 0.0153
Schistosoma mansoni hypothetical protein 0.0014 0.0258 0.0258
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0075 0.2005 0.5644
Plasmodium falciparum replication factor C subunit 1, putative 0.0009 0.0112 0.1357
Brugia malayi kap beta 3 protein 0.0005 0.0003 0.0004
Echinococcus granulosus histone acetyltransferase MYST2 0.0047 0.1213 0.1213
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0005 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Entamoeba histolytica hypothetical protein 0.0009 0.0112 0.0153
Trichomonas vaginalis glutathione reductase, putative 0.0011 0.0192 0.0267
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0009 0.0112 0.1211
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0118 0.0118
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0023 0.0513 0.6359
Onchocerca volvulus 0.0026 0.0623 0.0706
Loa Loa (eye worm) hypothetical protein 0.0009 0.0112 0.0149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0083 0.2244 0.6475
Entamoeba histolytica hypothetical protein 0.0031 0.0759 0.1064
Schistosoma mansoni hypothetical protein 0.0267 0.7493 0.7493
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.1001 0.1336
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0197 0.2426
Loa Loa (eye worm) hypothetical protein 0.0026 0.0623 0.0831
Echinococcus multilocularis nibrin 0.0009 0.0112 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.1103 0.1472
Echinococcus granulosus polycomb protein SCMH1 0.0041 0.1049 0.1049
Echinococcus multilocularis troponin i 0.0093 0.2513 0.2513
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.002 0.0447 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0005 0.0016 0.0166
Schistosoma mansoni hypothetical protein 0.0147 0.4065 0.4065
Brugia malayi MH2 domain containing protein 0.0104 0.2825 0.3842
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0118 0.0118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0346 0.4277
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0346 0.4277
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.002 0.0447 0.5538
Plasmodium falciparum glutathione reductase 0.0033 0.0805 1
Brugia malayi mbt repeat family protein 0.0041 0.1049 0.1427
Schistosoma mansoni smad1 5 8 and 0.0007 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0118 0.0161
Loa Loa (eye worm) hypothetical protein 0.0043 0.1103 0.1472
Plasmodium vivax DNA repair protein REV1, putative 0.0005 0.0016 0.0166
Toxoplasma gondii NADPH-glutathione reductase 0.0011 0.0192 0.1529
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Plasmodium vivax flap endonuclease 1, putative 0.0023 0.0513 0.6359
Trichomonas vaginalis ran, putative 0.0018 0.0393 0.055
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0069 0.0069
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0346 0.0477
Brugia malayi hypothetical protein 0.0055 0.1437 0.1954
Schistosoma mansoni troponin I 0.0093 0.2513 0.2513
Leishmania major DNA polymerase eta, putative 0.0017 0.0346 0.4277
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0118 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Echinococcus granulosus L aminoadipate semialdehyde 0.0072 0.1927 0.1927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0118 0.0118
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0018 0.0393 0.0535
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0118 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0447 0.5538
Schistosoma mansoni DNA polymerase eta 0.0017 0.0346 0.0346
Giardia lamblia NADH oxidase lateral transfer candidate 0.0011 0.0192 0.0249
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0492 0.6101
Echinococcus multilocularis Smad4 0.0007 0.0069 0.0069
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0346 0.0346
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0181 0.5039 0.6725
Trypanosoma brucei importin beta-1 subunit, putative 0.0025 0.0582 0.7222
Plasmodium vivax replication factor C subunit 1, putative 0.0009 0.0112 0.1357
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0118 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0623 0.0623
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.003 0.0712 0.095
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0072 0.0072
Leishmania major DNA damage repair protein, putative 0.0005 0.0016 0.0166
Plasmodium falciparum flap endonuclease 1 0.0023 0.0513 0.6359
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0346 0.418
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.002 0.0447 0.0792
Echinococcus granulosus geminin 0.0147 0.4065 0.4065
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.002 0.0447 0.3582
Treponema pallidum 4'-phosphopantetheinyl transferase 0.002 0.0447 0.0479
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0124 0.3405 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0124 0.3405 1
Echinococcus granulosus replication factor c subunit 1 0.0009 0.0112 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Echinococcus multilocularis L aminoadipate semialdehyde 0.0072 0.1927 0.1927
Echinococcus multilocularis importin 5 0.0005 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.1001 0.1001
Echinococcus granulosus flap endonuclease 1 0.0023 0.0513 0.0513
Trypanosoma brucei chrX additional, unordered contigs 0.0005 0.0016 0.0166
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0047 0.1213 0.1213
Echinococcus multilocularis GPCR, family 2 0.0014 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0072 0.1927 0.2572
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2236
Onchocerca volvulus 0.0206 0.5751 0.7787
Loa Loa (eye worm) flap endonuclease-1 0.0023 0.0513 0.0684
Schistosoma mansoni Smad4 0.0007 0.0069 0.0069
Giardia lamblia Flap structure-specific endonuclease 0.0023 0.0513 0.07
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0118 0.0118
Plasmodium falciparum thioredoxin reductase 0.0011 0.0192 0.2365
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0011 0.0192 0.052
Schistosoma mansoni hypothetical protein 0.0031 0.0759 0.0759
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0011 0.0192 0.2365
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0192 0.2365
Schistosoma mansoni myelin transcription factor 1 myt1 0.0047 0.1213 0.1213
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.0817 0.0817
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0346 0.0973
Trypanosoma brucei trypanothione reductase 0.0033 0.0805 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0018 0.0393 0.4871
Loa Loa (eye worm) troponin 0.0055 0.1437 0.1918
Echinococcus granulosus smad 0.0007 0.0069 0.0069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0118 0.0118
Echinococcus granulosus importin subunit beta 1 0.0025 0.0582 0.0582
Leishmania major DNA polymerase eta, putative 0.0005 0.0016 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0346 0.0461
Trypanosoma brucei DNA polymerase kappa, putative 0.0005 0.0016 0.0166
Plasmodium falciparum glutathione reductase 0.0011 0.0192 0.2365
Treponema pallidum NADH oxidase 0.0011 0.0192 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0118 0.0161
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.1103 0.1499
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0009 0.0112 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.1001 0.1001
Echinococcus granulosus nibrin 0.0009 0.0112 0.0112
Brugia malayi hypothetical protein 0.0009 0.0112 0.0152
Loa Loa (eye worm) hypothetical protein 0.0009 0.0118 0.0158
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0009 0.0112 0.0153
Echinococcus granulosus snurportin 1 0.0267 0.7493 0.7493
Brugia malayi DKFZp564C0469 protein 0.0009 0.0112 0.0152
Trypanosoma brucei unspecified product 0.0017 0.0346 0.4277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0346 0.418
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0072 0.0072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0083 0.2244 0.6386
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0075 0.2005 0.5644
Schistosoma mansoni importin beta-1 0.0025 0.0582 0.0582
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0124 0.3405 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0029 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0069 0.0069
Brugia malayi Troponin I 0.0093 0.2513 0.3417
Loa Loa (eye worm) hypothetical protein 0.0055 0.1437 0.1918
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0492 0.3946
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0759 0.0759
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0805 1
Toxoplasma gondii HEAT repeat-containing protein 0.0025 0.0582 0.4671
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0009 0.0112 0.1357
Schistosoma mansoni cpg binding protein 0.0026 0.062 0.062
Brugia malayi Troponin T 0.0055 0.1437 0.1954
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0346 0.0461
Onchocerca volvulus Troponin I homolog 0.0093 0.2513 0.3316
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Giardia lamblia Replication factor C, subunit 1 0.0009 0.0112 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0254 0.7108 1
Trypanosoma brucei DNA damage repair protein, putative 0.0005 0.0016 0.0166
Brugia malayi Pax transcription activation domain interacting protein 0.0009 0.0112 0.0152
Schistosoma mansoni cpg binding protein 0.0026 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0492 0.0657
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0346 0.4277
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0018 0.0393 0.0525
Brugia malayi hypothetical protein 0.0031 0.0759 0.1032
Entamoeba histolytica hypothetical protein 0.002 0.0447 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0346 0.4277
Echinococcus multilocularis histone acetyltransferase MYST2 0.0047 0.1213 0.1213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.1243 1
Brugia malayi Troponin family protein 0.0093 0.2513 0.3417
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0712 0.0968
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0033 0.0805 0.1906
Schistosoma mansoni troponin I 0.0093 0.2513 0.2513
Schistosoma mansoni DNA polymerase IV / kappa 0.0005 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0029 0.0037
Brugia malayi Pre-SET motif family protein 0.0181 0.5039 0.6852
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0075 0.2005 0.5751
Loa Loa (eye worm) Smad1 0.0007 0.0069 0.0092
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0118 0.0161
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0805 1
Loa Loa (eye worm) glutathione reductase 0.0033 0.0805 0.1074
Trypanosoma brucei DNA damage repair protein, putative 0.0005 0.0016 0.0166
Loa Loa (eye worm) hypothetical protein 0.0093 0.2513 0.3354
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0118 0.0118
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.002 0.0447 0.3582
Giardia lamblia DINP protein human, muc B family 0.0017 0.0346 0.0465
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0118 0.0118

Activities

Activity type Activity value Assay description Source Reference
RBA (binding) = 0.076 Binding affinity to ERbeta (unknown origin) relative to estradiol ChEMBL. 25027938
RBA (binding) = 0.099 Binding affinity to ERalpha (unknown origin) relative to estradiol ChEMBL. 25027938

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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