Detailed information for compound 735895

Basic information

Technical information
  • TDR Targets ID: 735895
  • Name: [2-[(1,1-dioxo-1,2-benzothiazol-3-yl)amino]ph enyl] 3,4,5-trimethoxybenzoate
  • MW: 468.479 | Formula: C23H20N2O7S
  • H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)Oc1ccccc1NC1=NS(=O)(=O)c2c1cccc2
  • InChi: 1S/C23H20N2O7S/c1-29-18-12-14(13-19(30-2)21(18)31-3)23(26)32-17-10-6-5-9-16(17)24-22-15-8-4-7-11-20(15)33(27,28)25-22/h4-13H,1-3H3,(H,24,25)
  • InChiKey: HGVAOSREPNHOPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4,5-trimethoxybenzoic acid [2-[(1,1-dioxo-1,2-benzothiazol-3-yl)amino]phenyl] ester
  • 3,4,5-trimethoxybenzoic acid [2-[(1,1-diketo-1,2-benzothiazol-3-yl)amino]phenyl] ester
  • CBKinase1_005118
  • ZINC02843221
  • TULIP011566
  • CBKinase1_017518

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1438 0.132
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Loa Loa (eye worm) glutathione reductase 0.0037 0.1072 0.0979
Leishmania major DNA polymerase eta, putative 0.0031 0.0831 0.0763
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0167 0.0231
Loa Loa (eye worm) hypothetical protein 0.0136 0.4864 0.481
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0281 0.0182
Echinococcus multilocularis sodium leak channel non selective protein 0.0017 0.0281 0.0182
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0017 0.0281 0.0278
Schistosoma mansoni hypothetical protein 0.0033 0.091 0.091
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0227 0.0224
Loa Loa (eye worm) hypothetical protein 0.0104 0.3623 0.3557
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0135 0.0028
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0286 0.0187
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0281 0.018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0557 0.0473
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0281 0.0281
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0281 0.0278
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.1335 0.4016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0983 0.2797
Echinococcus multilocularis bloom syndrome protein 0.0045 0.1357 0.1318
Leishmania major hypothetical protein, unknown function 0.0017 0.0281 0.0182
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0557 0.1466
Echinococcus granulosus GPCR family 2 0.0015 0.0227 0.0125
Schistosoma mansoni voltage-gated ion channel 0.0017 0.0281 0.0281
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0135 0.0027
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0259 0.9579 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0135 0.0255
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0281 0.0182
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.1438 0.132
Schistosoma mansoni two-pore calcium channel 0.0017 0.0281 0.0281
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0351 1
Echinococcus granulosus oncosphere protein Tso22e 0.0129 0.4582 0.4724
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0348 0.0253
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0017 0.0281 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0135 0.0087
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0167 0.0032
Onchocerca volvulus 0.0017 0.0281 0.026
Echinococcus granulosus hypothetical protein 0.0017 0.0281 0.0182
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1003 0.0945
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0017 0.0281 0.0278
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0017 0.0281 0.0278
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0348 0.0253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.1393
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0281 0.0281
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.1438 0.409
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0017 0.0282 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0143 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.1438 0.4545
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.037 0.0855
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0351 0.0245
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0281 0.0281
Schistosoma mansoni DNA helicase recq1 0.0019 0.0348 0.0348
Brugia malayi Troponin T 0.0062 0.2002 0.2
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0983 0.0859
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Loa Loa (eye worm) glutaminase 2 0.027 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0281 0.0278
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0281 0.0182
Trypanosoma brucei unspecified product 0.0013 0.0143 0.0112
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0167 0.0558
Brugia malayi Bromodomain containing protein 0.0074 0.2488 0.2485
Plasmodium falciparum thioredoxin reductase 0.0037 0.1072 0.9267
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0787 0.7338
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0831 0.2364
Echinococcus granulosus shaker cognate 0.0017 0.0281 0.0182
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.037 0.0855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0281 0.018
Echinococcus multilocularis transient receptor potential gamma protein 0.0017 0.0281 0.0182
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0281 0.2625
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0351 0.111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0286 0.0286
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.1438 0.409
Echinococcus multilocularis two pore calcium channel protein 2 0.0017 0.0281 0.0182
Plasmodium falciparum thioredoxin reductase 0.0013 0.0135 0.0255
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3163 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0281 0.0281
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0281 0.0182
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0017 0.0281 0.0278
Loa Loa (eye worm) troponin T 0.0062 0.2002 0.1919
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0167 0.019
Echinococcus granulosus potassium large conductance calcium activated 0.0017 0.0281 0.0182
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0038 0.1096 0.1003
Echinococcus multilocularis shaker cognate 0.0017 0.0281 0.0182
Schistosoma mansoni zinc finger protein 0.0015 0.022 0.022
Echinococcus granulosus TRP transient receptor potential channel 0.0017 0.0281 0.0182
Schistosoma mansoni transient receptor potential channel 0.0017 0.0281 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0351 0.0256
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0983 0.8408
Echinococcus granulosus calcium activated potassium channel 0.0017 0.0293 0.0195
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.2909 0.8853
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.1072 0.3078
Echinococcus multilocularis sodium channel protein 0.0259 0.9579 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1438 0.1403
Leishmania major hypothetical protein, conserved 0.0017 0.0281 0.0182
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0167 0.1554
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0281 0.0182
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0281 0.0182
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0109 0.1014
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0017 0.0281 0.0566
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0104 0.3623 0.3557
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.3163 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0281 0.018
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Giardia lamblia DINP protein human, muc B family 0.0019 0.037 0.0855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0351 0.0794
Echinococcus multilocularis dna polymerase eta 0.0044 0.1335 0.1295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.1393
Leishmania major hypothetical protein, conserved 0.0015 0.022 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1383 0.1289
Loa Loa (eye worm) voltage-dependent calcium channel 0.0017 0.0281 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0983 0.0889
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0286 0.0286
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.1438 0.132
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.1438 0.132
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.3163 0.3161
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0351 0.0219
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0167 0.0231
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0348 0.23
Loa Loa (eye worm) hypothetical protein 0.0047 0.1438 0.1349
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0167 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0017 0.0281 0.0566
Schistosoma mansoni hypothetical protein 0.0012 0.0103 0.0103
Echinococcus multilocularis potassium large conductance calcium activated 0.0017 0.0281 0.0182
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0135 0.0028
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0281 0.0281
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.1438 0.132
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0167 0.0061
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0281 0.0182
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0135 0.0087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0227 0.0125
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0348 0.0253
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0351 0.2333
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0281 0.0182
Schistosoma mansoni troponin I 0.0104 0.3623 0.3623
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.091 0.0907
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0135 0.0028
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0281 0.0281
Schistosoma mansoni hypothetical protein 0.0015 0.0227 0.0227
Leishmania major trypanothione reductase 0.0037 0.1072 0.1017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0983 0.0889
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0281 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0167 0.0163
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0422 0.0323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Echinococcus multilocularis dna polymerase kappa 0.0019 0.037 0.0276
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.3274 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0167 0.0231
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0062 0.2002 0.4157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0028
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0281 0.0281
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.037 0.037
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0286 0.0286
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.037 0.0276
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.037 0.0367
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Echinococcus granulosus zinc finger protein 0.0019 0.0382 0.0289
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.7221 0.722
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0135 0.0132
Loa Loa (eye worm) hypothetical protein 0.0062 0.2002 0.1919
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1383 0.1289
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0167 0.0231
Schistosoma mansoni hypothetical protein 0.002 0.0422 0.0422
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Mycobacterium ulcerans hypothetical protein 0.0047 0.1438 0.132
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Brugia malayi Troponin T 0.0062 0.2002 0.2
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0017 0.0281 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Echinococcus granulosus dna polymerase kappa 0.0019 0.037 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.3274 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.3274 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.037 0.0276
Schistosoma mansoni calcium-activated potassium channel 0.0017 0.0281 0.0281
Plasmodium vivax glutathione reductase, putative 0.0037 0.1072 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0017 0.0281 0.0182
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0281 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.1438 0.4227
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.1335 0.4016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0351 0.0256
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0135 0.1261
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.1335 0.1333
Loa Loa (eye worm) hypothetical protein 0.0019 0.0348 0.0248
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1438 0.1435
Loa Loa (eye worm) troponin I 0.0104 0.3623 0.3557
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0028
Echinococcus multilocularis zinc finger protein 0.0019 0.0382 0.0289
Echinococcus granulosus two pore calcium channel protein 2 0.0017 0.0281 0.0182
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0281 0.0182
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0557 0.1466
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0281 0.0182
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0351 0.0348
Brugia malayi hypothetical protein 0.0017 0.0281 0.0278
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0167 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0143 0.0112
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0281 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0135 0.0276
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0281 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1438 0.1403
Loa Loa (eye worm) RecQ helicase 0.0045 0.1357 0.1267
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0281 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0281 0.2625
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0167 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.091 0.0816
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0167 0.1554
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0167 0.0167
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0017 0.0281 0.0566
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.2909 0.8825
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0909 0.2566
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.3274 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0167 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0017 0.0281 0.0281
Echinococcus granulosus ryanodine receptor 44f 0.0017 0.0282 0.0183
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0135 0.0087
Schistosoma mansoni glutaminase 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0135 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0351 0.2517
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.2909 0.8853
Echinococcus granulosus transient receptor potential gamma protein 0.0017 0.0281 0.0182
Toxoplasma gondii exonuclease III APE 0.0019 0.0351 0.3276
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.3163 0.6787
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0135 0.0087
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.1438 0.4545
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.1072 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0909 0.2566
Loa Loa (eye worm) hypothetical protein 0.0042 0.1259 0.1168
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0017 0.0281 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0995 0.0995
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1499 0.1496
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.037 0.0855
Brugia malayi Thioredoxin reductase 0.0037 0.1072 0.1069
Trypanosoma brucei unspecified product 0.0019 0.037 0.0855
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0167 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.1438 0.4227
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1438 0.1435
Schistosoma mansoni troponin I 0.0104 0.3623 0.3623
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0167 0.0231
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Plasmodium falciparum glutathione reductase 0.0037 0.1072 0.9267
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.037 0.087
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0017 0.0281 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0167 0.0032
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0281 0.0182
Schistosoma mansoni ryanodine receptor related 0.0017 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.004 0.1186 0.1094
Echinococcus granulosus dna polymerase eta 0.0044 0.1335 0.1295
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0167 0.0163
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0135 0.0028
Loa Loa (eye worm) ion channel NompC 0.0017 0.0281 0.018
Mycobacterium tuberculosis Probable reductase 0.0085 0.2909 0.8853
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0348 0.0783
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0012 0.0109 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.1072 0.3154
Schistosoma mansoni DNA polymerase eta 0.0044 0.1335 0.1335
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.3163 0.3092
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0167 0.0527
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0143 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0227 0.0125
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0135 0.0132
Schistosoma mansoni troponin I 0.0104 0.3623 0.3623
Schistosoma mansoni hypothetical protein 0.0015 0.0227 0.0227
Schistosoma mansoni bromodomain containing protein 0.0063 0.2042 0.2042
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.1091 0.1038
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.3163 0.3226
Schistosoma mansoni transient receptor potential channel 0.0017 0.0281 0.0281
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0167 0.0032
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0281 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.3163 0.3163
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0167 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0227 0.0125
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0017 0.0281 0.0281
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0047 0.1438 0.1349
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0167 0.1554
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1499 0.141
Trypanosoma cruzi ISWI complex protein 0.0015 0.022 0.0363
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0165 0.595 0.6168
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0281 0.0182
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0017 0.0281 0.2625
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0351 0.0811
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0167 0.0231
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0017 0.0281 0.2625
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0281 0.0182
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0017 0.0281 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0351 0.0251
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0286 0.0185
Loa Loa (eye worm) ryanodine receptor 0.0017 0.0281 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0135 0.1261
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0351 0.0245
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0167 0.0231
Brugia malayi Troponin family protein 0.0104 0.3623 0.3621
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0167 0.019
Schistosoma mansoni hypothetical protein 0.0015 0.022 0.022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0351 0.0794
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0281 0.0182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0351 1
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0281 0.0182
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0281 0.0182
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0017 0.0281 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0167 0.0163
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0017 0.0281 0.0278
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0909 0.2566
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0017 0.0281 0.0278
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0259 0.9579 1
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0281 0.0182
Trypanosoma brucei ISWI complex protein 0.0015 0.022 0.0363
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0281 0.0175
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi Bromodomain containing protein 0.0038 0.1093 0.109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0227 0.0125
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0281 0.0182
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0109 0.0344
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0281 0.0182
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0281 0.0182
Brugia malayi glutathione reductase 0.0037 0.1072 0.1069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0135 0.0087
Loa Loa (eye worm) hypothetical protein 0.007 0.2325 0.2245
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0165 0.595 0.6168
Onchocerca volvulus 0.0047 0.1438 0.2879
Trichomonas vaginalis DNA helicase recq1, putative 0.0045 0.1357 0.1262
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0167 0.0061
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0348 0.0345
Brugia malayi hypothetical protein 0.0062 0.2002 0.2
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1393 0.1356
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0281 0.0281
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.037 0.0855
Brugia malayi olfactory channel protein osm-9 0.0017 0.0281 0.0278
Loa Loa (eye worm) voltage-gated calcium channel 0.0017 0.0281 0.018
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0281 0.0182
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0281 0.0278
Brugia malayi Transient-receptor-potential like protein 0.0017 0.0281 0.0278
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.1906 0.1898
Toxoplasma gondii hypothetical protein 0.0017 0.0281 0.2625
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0281 0.026
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0831 0.775
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0286 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1393 0.1393
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0983 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0167 0.019
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0281 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Toxoplasma gondii thioredoxin reductase 0.0037 0.1072 1
Schistosoma mansoni hypothetical protein 0.0015 0.0227 0.0227
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0129 0.4582 0.4724
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0167 0.0059
Schistosoma mansoni voltage-dependent calcium channel 0.0017 0.0281 0.0281
Trypanosoma brucei trypanothione reductase 0.0037 0.1072 0.3154
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0017 0.0281 0.0281
Schistosoma mansoni transient receptor potential channel 4 0.0017 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0983 0.0889
Echinococcus granulosus troponin i 0.0104 0.3623 0.3712
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.037 0.0238
Onchocerca volvulus Troponin I homolog 0.0104 0.3623 0.7829
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1438 0.1403
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.3163 0.3226
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.1906 0.1898
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0348 0.0253
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0348 0.3244
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Schistosoma mansoni troponin t invertebrate 0.0129 0.4582 0.4582
Echinococcus multilocularis two pore calcium channel protein 1 0.0017 0.0281 0.0182
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1393 0.1356
Schistosoma mansoni kinase 0.0047 0.143 0.143
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0281 0.0182
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.037 0.087
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0017 0.0281 0.0278
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0495 0.0495
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0017 0.0281 0.0182
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0047 0.1438 0.1349
Echinococcus granulosus sodium leak channel non selective protein 0.0017 0.0281 0.0182
Giardia lamblia Kinase, PLK 0.0092 0.3163 1
Brugia malayi Bloom's syndrome protein homolog 0.0045 0.1357 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0167 0.0032
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0167 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Trypanosoma brucei polo-like protein kinase 0.0092 0.3163 1
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0557 0.1759
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.1091 0.1038
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0167 0.0231
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0167 0.0064
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.2909 0.8853
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi Troponin T 0.0062 0.2002 0.2
Trypanosoma cruzi ISWI complex protein 0.0015 0.022 0.0363
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0167 0.019
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0281 0.0182
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0286 0.0187
Loa Loa (eye worm) hypothetical protein 0.0044 0.1335 0.1245
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0351 0.0256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0909 0.2566
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0348 0.0345
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.037 0.0855
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Echinococcus granulosus two pore calcium channel protein 1 0.0017 0.0281 0.0182
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0281 0.0175
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0557 0.0453
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.1438 0.4545
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1438 0.1435
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0135 0.0027
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0135 0.0276
Trichomonas vaginalis glutaminase, putative 0.027 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0281 0.0182
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0167 0.019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0227 0.0224
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0017 0.0281 0.0182
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0167 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Schistosoma mansoni ap endonuclease 0.0019 0.0351 0.0351
Schistosoma mansoni hypothetical protein 0.0104 0.3623 0.3623
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0167 0.0602
Loa Loa (eye worm) hypothetical protein 0.0198 0.7221 0.7193
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0281 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0351 0.0794
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1393 0.1303
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1393 0.139
Echinococcus multilocularis calcium activated potassium channel 0.0017 0.0293 0.0195
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0017 0.0281 0.0182
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0351 0.0794
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0167 0.0064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0286 0.0187
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0167 0.0061
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0801 0.718
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.037 0.0264
Schistosoma mansoni transient receptor potential channel 0.0017 0.0281 0.0281
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0281 0.0182
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1438 0.132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0064
Schistosoma mansoni hypothetical protein 0.0015 0.0227 0.0227
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.037 0.0264
Schistosoma mansoni vesicular amine transporter 0.0017 0.0281 0.0281
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0167 0.0032
Toxoplasma gondii hypothetical protein 0.0017 0.0281 0.2625
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1393 0.1356
Schistosoma mansoni troponin I 0.0104 0.3623 0.3623
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0017 0.0281 0.0182
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0281 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0286 0.0286
Leishmania major DNA polymerase kappa, putative 0.0019 0.037 0.0276
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.3163 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.037 0.027
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0281 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.3163 0.3088
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1438 0.132
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.2909 0.8853
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0135 0.0087
Echinococcus multilocularis transfer RNA-Gly 0.0017 0.0281 0.0182
Trypanosoma brucei unspecified product 0.0013 0.0143 0.0112
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0109 0.0109
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0281 0.2625
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0983 0.9072
Loa Loa (eye worm) troponin 0.0062 0.2002 0.1919
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0281 0.0182
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0017 0.0281 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0281 0.0278
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Brugia malayi cation channel family protein 0.0017 0.0281 0.0278
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0135 0.0087
Schistosoma mansoni ap endonuclease 0.0019 0.0351 0.0351
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi voltage-dependent calcium channel 0.0017 0.0281 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.037 0.0855
Echinococcus multilocularis ryanodine receptor 44f 0.0017 0.0282 0.0183
Echinococcus granulosus voltage gated hydrogen channel 1 0.0017 0.0281 0.0182
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0983 0.0889
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.037 0.0276
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0167 0.0061
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.037 0.1169
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0109 0.0105
Loa Loa (eye worm) calcium channel 0.0017 0.0281 0.018
Schistosoma mansoni DNA helicase recq5 0.0019 0.0348 0.0348
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0281 0.0182
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1003 0.0945
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0281 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.037 0.0855
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0281 0.0182
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0109 0.0109
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0281 0.0281
Echinococcus granulosus sodium channel protein 0.0259 0.9579 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0281 0.0281
Leishmania major DNA polymerase eta, putative 0.0044 0.1335 0.1295
Schistosoma mansoni zinc finger protein 0.0019 0.0382 0.0382
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.1357 0.1262
Echinococcus multilocularis troponin i 0.0104 0.3623 0.3712
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0167 0.0231
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0017 0.0281 0.0281
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.1072 0.0979
Brugia malayi cation channel family protein 0.0017 0.0281 0.0278
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0281 0.0182
Schistosoma mansoni voltage-gated cation channel 0.0017 0.0281 0.0281
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.1148 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0017 0.0281 0.0278
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.2909 0.8853
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0167 0.019
Loa Loa (eye worm) glutaminase 0.027 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0167 0.0163
Brugia malayi PHD-finger family protein 0.0025 0.0585 0.0582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1393 0.1356
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0167 0.0032
Plasmodium falciparum glutathione reductase 0.0013 0.0135 0.0255
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0135 0.0135
Brugia malayi Troponin I 0.0104 0.3623 0.3621
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0495 0.0408
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0495 0.0408
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0281 0.0182
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0281 0.0281
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0167 0.0231
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0348 0.0248
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0281 0.0182
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0017 0.0281 0.0281
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0129 0.4582 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0167 0.0064
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0135 0.0255
Echinococcus multilocularis GPCR, family 2 0.0015 0.0227 0.0125
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.3163 0.3226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.037 0.0855
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0167 0.0163
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.037 0.0238
Mycobacterium ulcerans glutaminase 0.027 1 1
Brugia malayi ion channel NompC 0.0017 0.0281 0.0278
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0281 0.018
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0281 0.018
Echinococcus granulosus bloom syndrome protein 0.0045 0.1357 0.1318
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0017 0.0281 0.0278
Loa Loa (eye worm) oxidoreductase 0.0014 0.0167 0.0064
Schistosoma mansoni hypothetical protein 0.0017 0.0281 0.0281
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0309 0.0209
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0348 0.3244
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0135 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0983 0.0889

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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