Detailed information for compound 1001975

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 172.226 | Formula: C11H12N2
  • H donors: 1 H acceptors: 0 LogP: 2.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCN/N=C/Cc1ccccc1
  • InChi: 1S/C11H12N2/c1-2-9-12-13-10-8-11-6-4-3-5-7-11/h1,3-7,10,12H,8-9H2/b13-10+
  • InChiKey: LPULHSIMSHZCDG-JLHYYAGUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0245 0.2457
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0039 0.0031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0038 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0485 0.0477
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0793 1
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Mycobacterium ulcerans lipoprotein LpqF 0.0062 0.0578 0.0914
Brugia malayi Pre-SET motif family protein 0.0034 0.0292 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Trypanosoma brucei beta lactamase 0.0062 0.0578 0.6924
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0008 0.0016
Schistosoma mansoni ets-related 0.0012 0.0054 0.0117
Brugia malayi Pre-SET motif family protein 0.0236 0.2408 0.9669
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0094 0.3702
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0124
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0292 0.0501
Echinococcus granulosus geminin 0.039 0.4025 0.7091
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0596 0.1403
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0793 0.1471
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0062 0.0578 0.0906
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0039 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0793 0.1471
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0039 0.0031
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0596 0.0588
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0495 0.1775
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0344
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0039 0.0124
Leishmania major hypothetical protein, conserved 0.0082 0.0793 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0239 0.208
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0039 0.0124
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0239 0.0231
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0292 0.1141
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0074 0.0708 0.2818
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0292 0.3349
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0573 0.0565
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0054 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.002 0.002
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0495 0.1162
Onchocerca volvulus 0.0054 0.0495 0.1775
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0292 0.3611
Onchocerca volvulus Putative hydrolase PNKD 0.0015 0.0094 0.0312
Loa Loa (eye worm) beta-lactamase 0.0082 0.0793 0.3161
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0292 0.05
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0116 0.0108
Schistosoma mansoni zinc phosphodiesterase 0.0015 0.0094 0.0211
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0793 0.1309
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0128 0.1278 0.2235
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0495 0.0487
Brugia malayi Ets-domain containing protein 0.008 0.0774 0.3087
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0054 0.0046
Onchocerca volvulus 0.0082 0.0793 0.2862
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0116 0.0434
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0074 0.0708 0.1159
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0573 0.1347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0292 0.0284
Leishmania major hypothetical protein, conserved 0.003 0.0245 0.2159
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0793 0.1384
Brugia malayi TAR-binding protein 0.0063 0.0596 0.2369
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0015 0.0094 0.0344
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0015 0.0094 0.1089
Schistosoma mansoni hypothetical protein 0.0018 0.0116 0.0264
Echinococcus multilocularis zinc phosphodiesterase 0.0015 0.0094 0.0086
Trypanosoma cruzi glyoxalase II 0.0015 0.0094 0.1089
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0074 0.0708 0.115
Loa Loa (eye worm) hypothetical protein 0.0061 0.0573 0.2275
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0008 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0515 0.204
Mycobacterium ulcerans acetylornithine aminotransferase 0.0074 0.0708 0.1159
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0515 0.204
Echinococcus granulosus tar DNA binding protein 0.0063 0.0596 0.1038
Plasmodium vivax ornithine aminotransferase, putative 0.0074 0.0708 0.8785
Brugia malayi Ets-domain containing protein 0.0012 0.0054 0.0184
Plasmodium falciparum ornithine aminotransferase 0.0074 0.0708 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0774 0.3087
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0015 0.0094 0.0151
Leishmania major hypothetical protein, conserved 0.0034 0.0292 0.283
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0245 0.2159
Schistosoma mansoni hypothetical protein 0.0018 0.0116 0.0264
Schistosoma mansoni cpg binding protein 0.0029 0.0233 0.0541
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0793 0.1309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0793 0.1868
Toxoplasma gondii ABC1 family protein 0.0082 0.0793 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0015 0.0094 0.0086
Echinococcus multilocularis ETHE1 protein 0.0015 0.0094 0.0086
Schistosoma mansoni hypothetical protein 0.039 0.4025 0.9532
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0072 0.0064
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0054 0.0046
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0094 0.0174
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0062 0.0578 0.0914
Brugia malayi hypothetical protein 0.0015 0.0094 0.0344
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0124
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0054 0.0184
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0793 0.1319
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0015 0.0094 0.1089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0793 0.3161
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.0211
Schistosoma mansoni regulator of G protein signaling 0.001 0.0039 0.0082
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0054 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0547 0.5673 0.567
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0039 0.0124
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0039 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0485 0.114
Echinococcus granulosus neuropeptide receptor A26 0.0547 0.5673 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0074 0.0708 0.1159
Brugia malayi beta-lactamase family protein 0.0082 0.0793 0.3161
Schistosoma mansoni flap endonuclease-1 0.0026 0.021 0.0486
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0495 0.0487
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0793 0.1471
Echinococcus granulosus flap endonuclease 1 0.0029 0.0239 0.0407
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0015 0.0094 0.1089
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0495 0.1961
Loa Loa (eye worm) hypothetical protein 0.0038 0.033 0.1297
Plasmodium vivax SET domain protein, putative 0.0034 0.0292 0.2842
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0292 0.3611
Schistosoma mansoni dep domain containing protein 0.001 0.0039 0.0082
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0039 0.0055
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0074 0.0708 1
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0793 1
Brugia malayi Flap endonuclease-1 0.0029 0.0239 0.093
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0793 0.1471
Brugia malayi Augmenter of liver regeneration 0.0034 0.0292 0.1141
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0573 0.0996
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0292 0.3611
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0233 0.0905
Onchocerca volvulus 0.001 0.0039 0.0113
Schistosoma mansoni cpg binding protein 0.003 0.025 0.0582
Entamoeba histolytica alkyl sulfatase, putative 0.0015 0.0094 0.3702
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0015 0.0094 0.0151
Schistosoma mansoni hypothetical protein 0.0038 0.033 0.0772
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0516 0.6322
Schistosoma mansoni zinc phosphodiesterase 0.0015 0.0094 0.0211
Mycobacterium ulcerans lipase LipD 0.0082 0.0793 0.1319
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0074 0.0708 0.8873
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0015 0.0094 0.0344
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0015 0.0094 0.0344
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0485 0.114
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0054 0.008
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0015 0.0094 0.1089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0116 0.0108
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0008 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0485 0.0477
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0239 0.208
Echinococcus granulosus ETHE1 protein 0.0015 0.0094 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0596 0.1403
Schistosoma mansoni hypothetical protein 0.0012 0.0054 0.0117
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0485 0.1923
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0596 0.2369
Brugia malayi mbt repeat family protein 0.0054 0.0495 0.1961
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0573 0.0565
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0292 0.0682
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0015 0.0094 0.0312
Trichomonas vaginalis A-type flavoprotein 0.0015 0.0094 0.0174
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.052 0.539 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0652 0.2594
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0015 0.0094 0.0724
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0015 0.0094 0.1089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.002 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0793 0.0785
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.002 0.0011
Entamoeba histolytica type A flavoprotein, putative 0.0015 0.0094 0.3702
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0239 0.093
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0015 0.0094 0.0211
Schistosoma mansoni ets 0.0012 0.0054 0.0117
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0074 0.0708 0.1159
Brugia malayi mbt repeat family protein 0.0054 0.0495 0.1961
Brugia malayi beta-lactamase family protein 0.0082 0.0793 0.3161
Brugia malayi ethe1-prov protein 0.0015 0.0094 0.0344
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0793 0.1309
Echinococcus granulosus neuropeptide s receptor 0.0547 0.5673 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0015 0.0094 0.3702
Mycobacterium ulcerans beta-lactamase 0.0082 0.0793 0.1319
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0015 0.0094 0.0344
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0292 0.3361
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Brugia malayi hypothetical protein 0.001 0.0039 0.0124
Echinococcus granulosus cpg binding protein 0.003 0.025 0.0427
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0774 0.1352
Brugia malayi Fli-1 protein 0.0244 0.249 1
Treponema pallidum ribonuclease Z 0.0015 0.0094 0.5
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0116 0.0434
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0239 0.208
Brugia malayi hypothetical protein 0.001 0.0039 0.0124
Echinococcus multilocularis protein C ets 2 0.0012 0.0054 0.0046
Echinococcus granulosus GPCR family 2 0.0018 0.0116 0.019
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0039 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0485 0.0842
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0292 0.283
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0292 0.0283
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0793 0.1309
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0793 0.1319
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0116 0.019
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0054 0.008
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0054 0.0046
Onchocerca volvulus 0.0082 0.0793 0.2862
Brugia malayi hypothetical protein 0.0019 0.0134 0.0505
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0038 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0292 0.0284
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0039 0.0031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0233 0.0905
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0485 0.1923
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.052 0.539 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0573 0.2275
Entamoeba histolytica alkyl sulfatase, putative 0.0015 0.0094 0.3702
Echinococcus multilocularis Aminotransferase class III 0.0074 0.0708 0.07
Mycobacterium tuberculosis Conserved protein 0.0082 0.0793 0.1309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0434
Mycobacterium tuberculosis Probable aminotransferase 0.052 0.539 0.9921
Plasmodium falciparum flap endonuclease 1 0.0029 0.0239 0.2367
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0037 0.0114
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0015 0.0094 0.3702
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0793 0.3161
Schistosoma mansoni hypothetical protein 0.039 0.4025 0.9532
Loa Loa (eye worm) RNA binding protein 0.0063 0.0596 0.2369
Brugia malayi RNA binding protein 0.0063 0.0596 0.2369
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0054 0.008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0596 0.1403
Onchocerca volvulus 0.0034 0.0292 0.1037
Trichomonas vaginalis apoptosis inducing factor, putative 0.0015 0.0094 0.0174
Onchocerca volvulus 0.0268 0.2749 1
Trichomonas vaginalis esterase, putative 0.0082 0.0793 0.1471
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.002 0.002
Brugia malayi transcription factor E74 isoform 0.0012 0.0054 0.0184
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0039 0.0055
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.1145
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0239 0.0444
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0008 0.0016
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0015 0.0094 0.1089
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0074 0.0708 0.1159
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0239 0.2653
Echinococcus granulosus Aminotransferase class III 0.0074 0.0708 0.1234
Loa Loa (eye worm) hypothetical protein 0.0054 0.0495 0.1961
Mycobacterium ulcerans L-lysine aminotransferase 0.0074 0.0708 0.1159
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0074 0.0708 0.1159
Onchocerca volvulus 0.0015 0.0094 0.0312
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0074 0.0708 0.115
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0596 0.1403
Loa Loa (eye worm) hypothetical protein 0.003 0.0245 0.0952
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.4223 0.4218
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0009
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0596 0.2369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.0682
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.002 0.0035
Onchocerca volvulus 0.0029 0.0233 0.082
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0039 0.0055
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0292 0.3221
Brugia malayi N-terminal motif family protein 0.0208 0.2117 0.8498
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0344
Schistosoma mansoni hypothetical protein 0.0012 0.0054 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0344
Schistosoma mansoni ets-related 0.0244 0.249 0.5892
Mycobacterium tuberculosis Conserved protein 0.0082 0.0793 0.1309
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0074 0.0708 0.115
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0074 0.0708 1
Trypanosoma cruzi glyoxalase II 0.0015 0.0094 0.1089
Echinococcus multilocularis cpg binding protein 0.003 0.025 0.0242
Brugia malayi hypothetical protein 0.003 0.0245 0.0952
Echinococcus multilocularis geminin 0.039 0.4025 0.402
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0008 0.0016
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0054 0.0184
Schistosoma mansoni cpg binding protein 0.003 0.025 0.0582
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0039 0.0082
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0793 0.1309
Schistosoma mansoni hypothetical protein 0.0018 0.0116 0.0264
Loa Loa (eye worm) hypothetical protein 0.0056 0.0515 0.204
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0239 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0054 0.008
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0015 0.0094 0.0086
Schistosoma mansoni hypothetical protein 0.0013 0.0072 0.016
Schistosoma mansoni hypothetical protein 0.0326 0.3355 0.7943
Loa Loa (eye worm) MBCTL1 0.0061 0.0573 0.2275
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.052 0.539 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0015 0.0094 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0793 1
Schistosoma mansoni dishevelled 0.001 0.0039 0.0082
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0054 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0515 0.204
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0074 0.0708 0.115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.0682
Echinococcus multilocularis ets variant gene 4 0.0012 0.0054 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0584 0.1373
Schistosoma mansoni hypothetical protein 0.0409 0.4223 1
Echinococcus granulosus ornithine aminotransferase 0.0074 0.0708 0.1234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0485 0.114
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0074 0.0708 0.1159
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0094 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0124
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Brugia malayi metallo-beta-lactamase superfamily protein 0.0015 0.0094 0.0344
Echinococcus multilocularis ornithine aminotransferase 0.0074 0.0708 0.07
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0495 0.0859
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.033 0.1297
Entamoeba histolytica type A flavoprotein, putative 0.0015 0.0094 0.3702
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0039 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0547 0.5673 0.567
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0054 0.0117
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0074 0.0708 0.1159
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0008 0.0009
Schistosoma mansoni gabp alpha 0.008 0.0774 0.1825
Brugia malayi beta-lactamase 0.0082 0.0793 0.3161
Onchocerca volvulus 0.0082 0.0793 0.2862
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0485 0.0842
Brugia malayi Ets-domain containing protein 0.008 0.0774 0.3087
Loa Loa (eye worm) fli-1 protein 0.0244 0.249 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0116 0.0434
Echinococcus granulosus dnaJ subfamily B 0.0409 0.4223 0.7439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0793 0.1868
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0072 0.0112
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0793 0.1309
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0208 0.2117 0.7695
Echinococcus granulosus zinc phosphodiesterase 0.0015 0.0094 0.0151
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0039 0.0082
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0344
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0524 0.5432 1
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0495 0.0859
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0245 0.2457
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0054 0.008
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0128 0.1278 0.2217
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0184
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0054 0.0184
Mycobacterium ulcerans hypothetical protein 0.0082 0.0793 0.1319
Trypanosoma cruzi glyoxalase II 0.0015 0.0094 0.1089
Onchocerca volvulus 0.0015 0.0094 0.0312
Loa Loa (eye worm) histone methyltransferase 0.001 0.0038 0.0119
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0039 0.0113
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0054 0.0184
Schistosoma mansoni hypothetical protein 0.0018 0.0116 0.0264
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2749 0.5099
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0008 0.0016
Echinococcus multilocularis ornithine aminotransferase 0.0074 0.0708 0.07
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0245 0.2159
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0292 0.283
Trichomonas vaginalis beta lactamase domain, putative 0.0015 0.0094 0.0174
Echinococcus multilocularis GPCR, family 2 0.0018 0.0116 0.0108
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.052 0.539 0.9921
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0211 0.2151 0.2144
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0495 0.1162
Entamoeba histolytica metallo-beta-lactamase family protein 0.0015 0.0094 0.3702
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0239 0.2943
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0793 0.1309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0292 0.0682
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2408 0.9669
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0074 0.0708 0.1667
Entamoeba histolytica metallo-beta-lactamase family protein 0.0015 0.0094 0.3702
Echinococcus granulosus protein C ets 2 0.0012 0.0054 0.008
Mycobacterium tuberculosis Conserved protein 0.0082 0.0793 0.1309
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0793 0.1319
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0054 0.008
Brugia malayi DIX domain containing protein 0.001 0.0039 0.0124
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0015 0.0094 0.0086
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0015 0.0094 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0184
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0211 0.2151 0.3782
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0596 0.1403
Schistosoma mansoni elf1 0.0012 0.0054 0.0117
Loa Loa (eye worm) hypothetical protein 0.0208 0.2117 0.8498
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Entamoeba histolytica metallo-beta-lactamase family protein 0.0015 0.0094 0.3702
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0292 0.3349
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0774 0.0767
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0039 0.0031
Schistosoma mansoni dishevelled 0.001 0.0039 0.0082
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.0211
Mycobacterium ulcerans hypothetical protein 0.052 0.539 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0245 0.3013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0116 0.019
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0015 0.0094 0.0724
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0273 0.0467
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0573 0.0996
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0245 0.3013
Mycobacterium leprae Probable lipase LipE 0.0082 0.0793 0.1319
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0596 0.2369
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0039 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0793 0.1471
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0245 0.2727
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0495 0.1162
Loa Loa (eye worm) hypothetical protein 0.0082 0.0793 0.3161
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0054 0.0184
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0793 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of GABA-transaminase at 10 uM ChEMBL. 18693021
Activity (binding) Inhibition of GABA-transaminase at 100 uM ChEMBL. 18693021

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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