Detailed information for compound 1029663

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.248 | Formula: C16H20Cl2N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1CO[C@](O1)(CCc1ccc(cc1)Cl)Cn1cncc1.Cl
  • InChi: 1S/C16H19ClN2O2.ClH/c1-13-10-20-16(21-13,11-19-9-8-18-12-19)7-6-14-2-4-15(17)5-3-14;/h2-5,8-9,12-13H,6-7,10-11H2,1H3;1H/t13-,16-;/m0./s1
  • InChiKey: UWYBMGBXHNOTPP-LINSIKMZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Heme oxygenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans heme oxygenase induced when hemin is sole source of iron Heme oxygenase 1   289 aa 232 aa 24.6 %
Candida albicans heme oxygenase induced when hemin is sole source of iron Heme oxygenase 1   289 aa 232 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0112043 0.0122466 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0131396 0.0206278 0.0206278
Echinococcus multilocularis 5' AMP activated protein kinase subunit beta 1 0.0438451 0.153601 0.239296
Schistosoma mansoni ephrin receptor 0.0289106 0.0889252 0.138538
Plasmodium vivax unspecified product 0.0186759 0.0446031 0.120178
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.022624 0.0617004 0.0722363
Leishmania major cathepsin L-like protease 0.0592069 0.220126 0.292638
Loa Loa (eye worm) TK/KIN16 protein kinase 0.239292 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0318156 0.101505 0.405405
Loa Loa (eye worm) hypothetical protein 0.0186759 0.0446031 0.0446031
Brugia malayi Immunoglobulin I-set domain containing protein 0.239292 1 1
Echinococcus multilocularis serine:threonine kinase SAD 1 0.022624 0.0617004 0.0961239
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0112043 0.0122466 0.0190791
Plasmodium vivax vivapain-1 0.0318156 0.101505 0.405405
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0103874 0.00870889 0.00870889
Giardia lamblia Cathepsin B precursor 0.0402853 0.138184 0.272688
Giardia lamblia Cathepsin B precursor 0.0131396 0.0206278 0.0181474
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.156597 0.641884 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0186759 0.0446031 0.0446031
Mycobacterium tuberculosis Conserved protein 0.0112043 0.0122466 0.5
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Echinococcus granulosus c src tyrosine kinase 0.00867417 0.00128967 0.00200919
Leishmania major cathepsin L-like protease 0.0592069 0.220126 0.292638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0592069 0.220126 0.342937
Loa Loa (eye worm) chloride channel protein 7 0.0112043 0.0122466 0.0122466
Echinococcus multilocularis protein kinase shaggy 0.0398469 0.136286 0.212321
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.11785 0.474084 0.738583
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0592069 0.220126 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0791633 0.306549 0.477577
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.106646 0.425563 0.662991
Onchocerca volvulus 0.0592069 0.220126 0.240308
Leishmania major cathepsin L-like protease 0.0592069 0.220126 0.292638
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0112043 0.0122466 0.0122466
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.00937006 0.00430327 0.00670412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus multilocularis cathepsin L 0.0131396 0.0206278 0.0321363
Toxoplasma gondii histone kinase SNF1, putative 0.022624 0.0617004 0.246845
Loa Loa (eye worm) hypothetical protein 0.010634 0.00977674 0.00977674
Echinococcus granulosus cysteine protease 0.0318156 0.101505 0.158137
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0112043 0.0122466 0.5
Brugia malayi protein-tyrosine kinase 0.0177219 0.0404717 0.0404717
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.022624 0.0617004 0.0722363
Echinococcus multilocularis neuroglian 0.022055 0.0592364 0.0922852
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0791633 0.306549 0.477577
Echinococcus granulosus H:Cl exchange transporter 4 0.0112043 0.0122466 0.0190791
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0183756 0.0433025 0.0674615
Echinococcus granulosus tyrosine protein kinase Src42A 0.0152143 0.0296121 0.0461331
Giardia lamblia Kinase, CAMK CAMKL 0.022624 0.0617004 0.10708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0592069 0.220126 0.342937
Entamoeba histolytica cysteine proteinase, putative 0.0318156 0.101505 0.405405
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Trypanosoma cruzi major cysteine proteinase, putative 0.13055 0.529081 0.722458
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0112043 0.0122466 0.00343605
Giardia lamblia Cathepsin B precursor 0.0131396 0.0206278 0.0181474
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0592069 0.220126 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0112043 0.0122466 0.0190791
Brugia malayi cathepsin L-like precursor 0.040531 0.139248 0.139248
Loa Loa (eye worm) cysteine protease 0.0592069 0.220126 0.220126
Echinococcus granulosus cathepsin L 0.0318156 0.101505 0.158137
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Schistosoma mansoni neuroglian 0.00937006 0.00430327 0.00670412
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0318156 0.101505 0.158137
Echinococcus granulosus defective proboscis extension response 0.0183756 0.0433025 0.0674615
Trichomonas vaginalis CMGC family protein kinase 0.0398469 0.136286 0.579744
Giardia lamblia Cathepsin B precursor 0.0402853 0.138184 0.272688
Schistosoma mansoni cathepsin s 0.0186759 0.0446031 0.0694878
Entamoeba histolytica protein kinase domain containing protein 0.0398469 0.136286 0.579744
Entamoeba histolytica cysteine proteinase 2 0.0318156 0.101505 0.405405
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.181865 0.75131 0.75131
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0131396 0.0206278 0.0321363
Mycobacterium ulcerans transcriptional regulator 0.0112043 0.0122466 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0186759 0.0446031 0.0446031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Loa Loa (eye worm) hypothetical protein 0.040531 0.139248 0.139248
Echinococcus multilocularis cysteine protease 0.0592069 0.220126 0.342937
Loa Loa (eye worm) hypothetical protein 0.181865 0.75131 0.75131
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Loa Loa (eye worm) hypothetical protein 0.0186759 0.0446031 0.0446031
Entamoeba histolytica cysteine proteinase, putative 0.0592069 0.220126 1
Loa Loa (eye worm) hypothetical protein 0.0134364 0.0219131 0.0219131
Echinococcus granulosus cathepsin b 0.0791633 0.306549 0.477577
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Echinococcus multilocularis tyrosine protein kinase Blk 0.0177219 0.0404717 0.0630515
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Onchocerca volvulus 0.213712 0.889223 0.97075
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.00937006 0.00430327 0.00430327
Echinococcus granulosus 5' AMP activated protein kinase subunit beta 1 0.0438451 0.153601 0.239296
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.156597 0.641884 0.641884
Echinococcus multilocularis contactin neuroglian septate junction protein 0.00937006 0.00430327 0.00670412
Brugia malayi Immunoglobulin I-set domain containing protein 0.0193693 0.0476057 0.0476057
Giardia lamblia Cysteine protease 0.0131396 0.0206278 0.0181474
Echinococcus granulosus ephrin type A receptor 4 A 0.0289106 0.0889252 0.138538
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) bone morphogenic protein 6 0.0140973 0.0247751 0.0247751
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Echinococcus multilocularis AMPK beta subunit 0.0809898 0.314459 0.4899
Loa Loa (eye worm) hypothetical protein 0.0791633 0.306549 0.306549
Echinococcus granulosus twitchin 0.0230723 0.063642 0.0991488
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0152143 0.0296121 0.0461331
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0318156 0.101505 0.158137
Trypanosoma cruzi chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Trypanosoma cruzi SNF1-related protein kinases, putative 0.022624 0.0617004 0.0722363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0318156 0.101505 0.405405
Giardia lamblia Cathepsin L-like protease 0.0131396 0.0206278 0.0181474
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0112043 0.0122466 0.0117416
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Brugia malayi ephrin receptor 1 precursor 0.0149504 0.0284695 0.0284695
Loa Loa (eye worm) cathepsin B 0.0402853 0.138184 0.138184
Onchocerca volvulus Cathepsin L homolog 0.0592069 0.220126 0.240308
Echinococcus granulosus tyrosine protein kinase HCK 0.0145999 0.0269516 0.0419883
Entamoeba histolytica cysteine proteinase, putative 0.0318156 0.101505 0.405405
Giardia lamblia Cathepsin B precursor 0.0402853 0.138184 0.272688
Brugia malayi ancient conserved domain protein 4 0.0112043 0.0122466 0.0122466
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Toxoplasma gondii CBS domain-containing protein 0.0112043 0.0122466 0.0117416
Trypanosoma cruzi cysteine peptidase, putative 0.176617 0.72858 1
Schistosoma mansoni nephrin 0.0230487 0.0635397 0.0989894
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0398469 0.136286 0.176
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0183756 0.0433025 0.0674615
Brugia malayi Papain family cysteine protease containing protein 0.0318156 0.101505 0.101505
Echinococcus multilocularis roundabout 2 0.00937006 0.00430327 0.00670412
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0112043 0.0122466 0.00343605
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.11785 0.474084 1
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Schistosoma mansoni chloride channel protein 0.0112043 0.0122466 0.0190791
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0112043 0.0122466 0.5
Loa Loa (eye worm) hypothetical protein 0.040531 0.139248 0.139248
Trypanosoma cruzi chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Onchocerca volvulus Cathepsin F homolog 0.0592069 0.220126 0.240308
Mycobacterium tuberculosis Conserved protein 0.0112043 0.0122466 0.5
Onchocerca volvulus 0.0264029 0.0780655 0.0852228
Schistosoma mansoni serine/threonine protein kinase 0.022624 0.0617004 0.0961239
Loa Loa (eye worm) hypothetical protein 0.0216066 0.0572948 0.0572948
Brugia malayi Immunoglobulin I-set domain containing protein 0.00937006 0.00430327 0.00430327
Onchocerca volvulus 0.0592069 0.220126 0.240308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0827246 0.321971 0.501604
Toxoplasma gondii preprocathepsin c precursor, putative 0.0131396 0.0206278 0.0515857
Leishmania major cathepsin L-like protease 0.0592069 0.220126 0.292638
Onchocerca volvulus Tyrosine kinase homolog 0.219899 0.916016 1
Giardia lamblia Encystation-specific protease 0.0131396 0.0206278 0.0181474
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0398469 0.136286 0.136286
Trypanosoma brucei SNF1-related protein kinases, putative 0.022624 0.0617004 0.0722363
Leishmania major cathepsin L-like protease 0.0592069 0.220126 0.292638
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Brugia malayi ancient conserved domain protein 2 0.0112043 0.0122466 0.0122466
Echinococcus granulosus tyrosine kinase 0.0177219 0.0404717 0.0630515
Plasmodium falciparum serine repeat antigen 2 0.0131396 0.0206278 0.0403174
Onchocerca volvulus 0.040531 0.139248 0.152015
Echinococcus granulosus tyrosine protein kinase Blk 0.0177219 0.0404717 0.0630515
Onchocerca volvulus 0.0592069 0.220126 0.240308
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0112043 0.0122466 0.5
Plasmodium falciparum serine repeat antigen 9 0.0131396 0.0206278 0.0403174
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0112043 0.0122466 0.00343605
Echinococcus granulosus serine:threonine kinase SAD 1 0.022624 0.0617004 0.0961239
Loa Loa (eye worm) hypothetical protein 0.040531 0.139248 0.139248
Plasmodium falciparum cysteine proteinase falcipain 3 0.0592069 0.220126 1
Mycobacterium ulcerans hypothetical protein 0.0112043 0.0122466 0.5
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0112043 0.0122466 0.00343605
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0827246 0.321971 0.501604
Leishmania major chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Toxoplasma gondii cathepsin CPL 0.0592069 0.220126 1
Plasmodium falciparum serine/threonine protein kinase KIN 0.022624 0.0617004 0.237897
Loa Loa (eye worm) hypothetical protein 0.0193693 0.0476057 0.0476057
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0112043 0.0122466 0.5
Onchocerca volvulus 0.0398469 0.136286 0.148781
Plasmodium falciparum serine repeat antigen 5 0.0131396 0.0206278 0.0403174
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0207664 0.0536562 0.0835918
Trypanosoma cruzi chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0112043 0.0122466 0.00343605
Giardia lamblia Cathepsin B precursor 0.0131396 0.0206278 0.0181474
Echinococcus multilocularis Immunoglobulin 0.0183756 0.0433025 0.0674615
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0131396 0.0206278 0.0181474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Onchocerca volvulus 0.0168005 0.0364815 0.0398263
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.00937006 0.00430327 0.00670412
Brugia malayi Papain family cysteine protease containing protein 0.0318156 0.101505 0.101505
Brugia malayi cathepsin F-like cysteine proteinase 0.0186759 0.0446031 0.0446031
Echinococcus granulosus tyrosine protein kinase Btk29A 0.00867417 0.00128967 0.00200919
Echinococcus multilocularis tyrosine protein kinase Abl 0.00867417 0.00128967 0.00200919
Brugia malayi Papain family cysteine protease containing protein 0.0131396 0.0206278 0.0206278
Schistosoma mansoni vesicular amine transporter 0.0183756 0.0433025 0.0674615
Echinococcus multilocularis c src tyrosine kinase 0.00867417 0.00128967 0.00200919
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.022624 0.0617004 0.0722363
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00867417 0.00128967 0.00200919
Loa Loa (eye worm) hypothetical protein 0.0168005 0.0364815 0.0364815
Echinococcus granulosus tyrosine protein kinase Src42A 0.0207664 0.0536562 0.0835918
Trypanosoma cruzi GMP reductase 0.0112043 0.0122466 0.00343605
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0112043 0.0122466 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0402853 0.138184 0.589261
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Echinococcus multilocularis tyrosine protein kinase Srms 0.0177219 0.0404717 0.0630515
Schistosoma mansoni protein kinase subunit beta 0.010634 0.00977674 0.0152313
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.00867417 0.00128967 0.00200919
Loa Loa (eye worm) hypothetical protein 0.022624 0.0617004 0.0617004
Brugia malayi Fibronectin type III domain containing protein 0.0193693 0.0476057 0.0476057
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0112043 0.0122466 0.5
Trypanosoma brucei GMP reductase 0.0112043 0.0122466 0.00343605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.040531 0.139248 0.594595
Echinococcus granulosus roundabout 2 0.00937006 0.00430327 0.00670412
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0398469 0.136286 0.176
Brugia malayi intracellular kinase 0.0398469 0.136286 0.136286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Mycobacterium leprae conserved hypothetical protein 0.0112043 0.0122466 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0207664 0.0536562 0.0835918
Brugia malayi Cathepsin L-like precursor 0.0186759 0.0446031 0.0446031
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.040531 0.139248 0.594595
Brugia malayi Immunoglobulin I-set domain containing protein 0.00937006 0.00430327 0.00430327
Loa Loa (eye worm) hypothetical protein 0.0183756 0.0433025 0.0433025
Loa Loa (eye worm) IMP dehydrogenase 1 0.0112043 0.0122466 0.0122466
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0183756 0.0433025 0.0674615
Plasmodium falciparum serine repeat antigen 8 0.0131396 0.0206278 0.0403174
Echinococcus granulosus H:Cl exchange transporter 7 0.0112043 0.0122466 0.0190791
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0112043 0.0122466 0.0190791
Brugia malayi Dopamine receptor protein 1 0.130164 0.52741 0.52741
Giardia lamblia Hypothetical protein 0.0131396 0.0206278 0.0181474
Giardia lamblia Kinase, AGC AKT 0.0357062 0.118354 0.229751
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) hypothetical protein 0.0267519 0.079577 0.079577
Loa Loa (eye worm) hypothetical protein 0.0156399 0.0314554 0.0314554
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0131396 0.0206278 0.0403174
Schistosoma mansoni serine/threonine protein kinase 0.022624 0.0617004 0.0961239
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0207664 0.0536562 0.0835918
Schistosoma mansoni serine/threonine protein kinase 0.022624 0.0617004 0.0961239
Schistosoma mansoni protein kinase subunit beta 0.0809898 0.314459 0.4899
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Brugia malayi putative serine/threonine kinase SADA gamma 0.022624 0.0617004 0.0617004
Toxoplasma gondii cathepsin CPC2 0.0131396 0.0206278 0.0515857
Schistosoma mansoni cell adhesion molecule 0.0240662 0.0679463 0.105854
Trypanosoma cruzi GMP reductase 0.0112043 0.0122466 0.00343605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus granulosus neuroglian 0.00937006 0.00430327 0.00670412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Trypanosoma cruzi cysteine protease, putative 0.0318156 0.101505 0.127613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Brugia malayi Voltage gated chloride channel family protein 0.0112043 0.0122466 0.0122466
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0112043 0.0122466 0.0190791
Schistosoma mansoni tyrosine kinase 0.0207664 0.0536562 0.0835918
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0112043 0.0122466 0.5
Toxoplasma gondii IMP dehydrogenas 0.0112043 0.0122466 0.0117416
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0398469 0.136286 0.212321
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0112043 0.0122466 0.5
Echinococcus multilocularis tyrosine protein kinase HCK 0.0145999 0.0269516 0.0419883
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0398469 0.136286 0.601423
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.022624 0.0617004 0.20588
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Echinococcus granulosus tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Trypanosoma brucei cysteine peptidase C (CPC) 0.0402853 0.138184 0.178641
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0414877 0.143391 0.223392
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0112043 0.0122466 0.5
Echinococcus granulosus cathepsin l1 0.040531 0.139248 0.216937
Trypanosoma cruzi cruzipain precursor, putative 0.0186759 0.0446031 0.0484505
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0168005 0.0364815 0.0568351
Brugia malayi fibroinase precursor 0.0131396 0.0206278 0.0206278
Onchocerca volvulus 0.0168005 0.0364815 0.0398263
Schistosoma mansoni tyrosine kinase 0.00867417 0.00128967 0.00200919
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0112043 0.0122466 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0791633 0.306549 0.477577
Schistosoma mansoni nephrin 0.00937006 0.00430327 0.00670412
Schistosoma mansoni cathepsin S (C01 family) 0.0131396 0.0206278 0.0321363
Mycobacterium ulcerans hypothetical protein 0.0112043 0.0122466 0.5
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0140973 0.0247751 0.0385975
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus granulosus Immunoglobulin 0.0183756 0.0433025 0.0674615
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0207664 0.0536562 0.0835918
Leishmania major cathepsin L-like protease 0.176617 0.72858 1
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Echinococcus multilocularis ephrin type A receptor 4 A 0.0289106 0.0889252 0.138538
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Plasmodium falciparum serine repeat antigen 6 0.0131396 0.0206278 0.0403174
Plasmodium vivax vivapain-2 0.0592069 0.220126 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus multilocularis neuroglian 0.00937006 0.00430327 0.00670412
Loa Loa (eye worm) LjBmp2/4b 0.114625 0.460117 0.460117
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Brugia malayi Immunoglobulin I-set domain containing protein 0.00937006 0.00430327 0.00430327
Echinococcus multilocularis cathepsin L cysteine protease 0.0592069 0.220126 0.342937
Toxoplasma gondii 5'-AMP-activated protein kinase subunit beta-1 family protein, putative 0.0477787 0.170635 0.76472
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0112043 0.0122466 0.5
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0131396 0.0206278 0.0206278
Brugia malayi Cathepsin L-like cysteine proteinase 0.040531 0.139248 0.139248
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Leishmania major hypothetical protein, conserved 0.0112043 0.0122466 0.00343605
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0131396 0.0206278 0.0403174
Loa Loa (eye worm) hypothetical protein 0.0592069 0.220126 0.220126
Loa Loa (eye worm) fibroinase 0.0592069 0.220126 0.220126
Onchocerca volvulus 0.0131396 0.0206278 0.022519
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0398469 0.136286 0.212321
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0112043 0.0122466 0.5
Schistosoma mansoni tyrosine kinase 0.0207664 0.0536562 0.0835918
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Trypanosoma brucei 5'-AMP-activated protein kinase subunit beta 0.0809898 0.314459 0.423874
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Toxoplasma gondii CBS domain-containing protein 0.0112043 0.0122466 0.0117416
Mycobacterium ulcerans hypothetical protein 0.0112043 0.0122466 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0592069 0.220126 0.342937
Brugia malayi cathepsin L precursor 0.0131396 0.0206278 0.0206278
Trichomonas vaginalis CMGC family protein kinase 0.0398469 0.136286 0.579744
Schistosoma mansoni protein kinase subunit beta 0.0438451 0.153601 0.239296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0112043 0.0122466 0.0190791
Leishmania major hypothetical protein, conserved 0.0809898 0.314459 0.423874
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0112043 0.0122466 0.0190791
Schistosoma mansoni protein kinase subunit gamma 0.11785 0.474084 0.738583
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0357062 0.118354 0.151053
Schistosoma mansoni cathepsin F (C01 family) 0.0592069 0.220126 0.342937
Echinococcus granulosus cathepsin l1 0.0592069 0.220126 0.342937
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0318156 0.101505 0.127613
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0318156 0.101505 0.405405
Loa Loa (eye worm) TK protein kinase 0.0177219 0.0404717 0.0404717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Entamoeba histolytica cysteine proteinase, putative 0.0318156 0.101505 0.405405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0318156 0.101505 0.405405
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0168005 0.0364815 0.0568351
Giardia lamblia Cysteine protease 0.0131396 0.0206278 0.0181474
Schistosoma mansoni cell adhesion molecule 0.00937006 0.00430327 0.00670412
Entamoeba histolytica serine/threonine protein kinase, putative 0.022624 0.0617004 0.20588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.156597 0.641884 1
Echinococcus granulosus protein kinase shaggy 0.0398469 0.136286 0.212321
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0112043 0.0122466 0.0190791
Echinococcus multilocularis roundabout 2 0.0277456 0.0838803 0.130678
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0112043 0.0122466 0.0190791
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.11785 0.474084 0.738583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0357062 0.118354 0.118354
Onchocerca volvulus Cathepsin L homolog 0.0131396 0.0206278 0.022519
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0112043 0.0122466 0.0190791
Schistosoma mansoni serine/threonine protein kinase 0.022624 0.0617004 0.0961239
Leishmania major chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Giardia lamblia Kinase, CMGC GSK 0.0398469 0.136286 0.268577
Onchocerca volvulus 0.0112043 0.0122466 0.0133694
Giardia lamblia 5-AMP-activated protein kinase, beta-1 subunit 0.0809898 0.314459 0.654369
Brugia malayi Tyrosine-protein kinase abl-1 0.00867417 0.00128967 0.00128967
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0112043 0.0122466 0.00343605
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0791633 0.306549 0.477577
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0177219 0.0404717 0.0630515
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0402853 0.138184 0.178641
Trypanosoma cruzi cysteine peptidase, putative 0.0186759 0.0446031 0.0484505
Leishmania major CBS domain protein, conserved 0.0112043 0.0122466 0.00343605
Brugia malayi chloride channel protein 7 0.0112043 0.0122466 0.0122466
Echinococcus multilocularis cathepsin b 0.0791633 0.306549 0.477577
Echinococcus granulosus contactin 0.00937006 0.00430327 0.00670412
Loa Loa (eye worm) TK protein kinase 0.0145999 0.0269516 0.0269516
Mycobacterium ulcerans cystathionine beta-synthase 0.0112043 0.0122466 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318156 0.101505 0.127613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Treponema pallidum hemolysin (tlyC) 0.0112043 0.0122466 1
Mycobacterium tuberculosis Conserved protein 0.0112043 0.0122466 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0207664 0.0536562 0.0835918
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Schistosoma mansoni serine/threonine protein kinase 0.0414877 0.143391 0.223392
Echinococcus multilocularis cathepsin b 0.0791633 0.306549 0.477577
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0112043 0.0122466 0.5
Schistosoma mansoni chloride channel protein 0.0112043 0.0122466 0.0190791
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0402853 0.138184 0.178641
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Echinococcus granulosus H:Cl exchange transporter 3 0.0112043 0.0122466 0.0190791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Echinococcus granulosus roundabout 2 0.0277456 0.0838803 0.130678
Loa Loa (eye worm) hypothetical protein 0.0193693 0.0476057 0.0476057
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.00937006 0.00430327 0.00670412
Loa Loa (eye worm) 5'-AMP-activated protein kinase 0.0809898 0.314459 0.314459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Plasmodium falciparum serine repeat antigen 1 0.0131396 0.0206278 0.0403174
Plasmodium falciparum serine repeat antigen 3 0.0131396 0.0206278 0.0403174
Brugia malayi CLC chloride channel protein 0.0112043 0.0122466 0.0122466
Onchocerca volvulus 0.0592069 0.220126 0.240308
Loa Loa (eye worm) hypothetical protein 0.0183756 0.0433025 0.0433025
Schistosoma mansoni cell adhesion molecule 0.00937006 0.00430327 0.00670412
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.00937006 0.00430327 0.00670412
Trypanosoma cruzi cysteine peptidase, putative 0.0318156 0.101505 0.127613
Trypanosoma cruzi cysteine peptidase, putative 0.0592069 0.220126 0.292638
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0592069 0.220126 0.342937
Brugia malayi Cathepsin L-like precursor 0.040531 0.139248 0.139248
Echinococcus granulosus roundabout 2 0.00937006 0.00430327 0.00670412
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0112043 0.0122466 0.00343605
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0207664 0.0536562 0.0835918
Leishmania major cysteine peptidase A (CPA) 0.0592069 0.220126 0.292638
Echinococcus multilocularis cathepsin L 0.0318156 0.101505 0.158137
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0131396 0.0206278 0.0181474
Trypanosoma brucei protein kinase, putative 0.0398469 0.136286 0.176
Trypanosoma cruzi cruzipain precursor, putative 0.176617 0.72858 1
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0112043 0.0122466 0.0190791
Giardia lamblia Cysteine protease 0.0131396 0.0206278 0.0181474
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0592069 0.220126 0.220126
Brugia malayi hypothetical protein 0.0193693 0.0476057 0.0476057
Onchocerca volvulus Alicorn homolog 0.0703559 0.268408 0.293016
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Plasmodium falciparum cysteine proteinase falcipain 1 0.0318156 0.101505 0.429378
Echinococcus granulosus tyrosine protein kinase Lyn 0.0217838 0.0580618 0.0904553
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Trypanosoma cruzi cysteine proteinase, putative 0.0318156 0.101505 0.127613
Echinococcus multilocularis cysteine protease 0.0592069 0.220126 0.342937
Echinococcus granulosus AMPK beta subunit 0.0809898 0.314459 0.4899
Loa Loa (eye worm) hypothetical protein 0.0112043 0.0122466 0.0122466
Toxoplasma gondii cathepsin B 0.0402853 0.138184 0.61045
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0791633 0.306549 0.41287
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0592069 0.220126 1
Trypanosoma cruzi 5'-AMP-activated protein kinase subunit beta, putative 0.0809898 0.314459 0.423874
Giardia lamblia Cathepsin L-like protease 0.0131396 0.0206278 0.0181474
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0592069 0.220126 0.220126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0112043 0.0122466 0.0190791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0318156 0.101505 0.127613
Giardia lamblia Kinase, CAMK CAMKL 0.022624 0.0617004 0.10708
Loa Loa (eye worm) hypothetical protein 0.130164 0.52741 0.52741
Schistosoma mansoni cathepsin C 0.0131396 0.0206278 0.0321363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Giardia lamblia Cathepsin L precursor 0.0131396 0.0206278 0.0181474
Loa Loa (eye worm) chloride channel 3 0.0112043 0.0122466 0.0122466
Brugia malayi Transforming growth factor beta like domain containing protein 0.0140973 0.0247751 0.0247751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0592069 0.220126 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0791633 0.306549 0.306549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Loa Loa (eye worm) hypothetical protein 0.0112043 0.0122466 0.0122466
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Entamoeba histolytica cysteine proteinase, putative 0.040531 0.139248 0.594595
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0112043 0.0122466 0.0190791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0398469 0.136286 0.212321
Loa Loa (eye worm) loechrig isoform VII 0.11785 0.474084 0.474084
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.022624 0.0617004 0.0617004
Echinococcus granulosus cathepsin L 0.0131396 0.0206278 0.0321363
Echinococcus granulosus tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Trypanosoma cruzi cysteine peptidase, putative 0.176617 0.72858 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Entamoeba histolytica cysteine proteinase, putative 0.0592069 0.220126 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0230725 0.0636431 0.0991504
Brugia malayi Protein kinase domain containing protein 0.215655 0.897637 0.897637
Treponema pallidum Mg2+ transport protein (mgtE) 0.0112043 0.0122466 1
Loa Loa (eye worm) hypothetical protein 0.00937006 0.00430327 0.00430327
Brugia malayi SRC-1 0.0207664 0.0536562 0.0536562
Echinococcus granulosus cathepsin L cysteine protease 0.0318156 0.101505 0.158137
Plasmodium falciparum serine repeat antigen 4 0.0131396 0.0206278 0.0403174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.176617 0.72858 1
Leishmania major cathepsin L-like protease 0.176617 0.72858 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0318156 0.101505 0.158137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Loa Loa (eye worm) hypothetical protein 0.0112043 0.0122466 0.0122466
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0402853 0.138184 0.215279
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0131396 0.0206278 0.0403174
Brugia malayi Cathepsin L-like precursor 0.040531 0.139248 0.139248
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0207664 0.0536562 0.0835918
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0112043 0.0122466 0.5
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Brugia malayi loechrig isoform VII 0.11785 0.474084 0.474084
Echinococcus multilocularis roundabout 2 0.00937006 0.00430327 0.00670412
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Loa Loa (eye worm) hypothetical protein 0.0230725 0.0636431 0.0636431
Giardia lamblia Cysteine protease 0.0131396 0.0206278 0.0181474
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0207664 0.0536562 0.0835918
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0112043 0.0122466 0.00343605
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0207664 0.0536562 0.0835918
Plasmodium falciparum glycogen synthase kinase 3 0.0398469 0.136286 0.596688
Giardia lamblia Hypothetical protein 0.0131396 0.0206278 0.0181474
Echinococcus granulosus cathepsin b 0.0791633 0.306549 0.477577
Brugia malayi Papain family cysteine protease containing protein 0.0131396 0.0206278 0.0206278
Echinococcus granulosus cathepsin l cysteine peptidase 0.0592069 0.220126 0.342937
Trypanosoma cruzi cysteine proteinase, putative 0.0318156 0.101505 0.127613
Schistosoma mansoni cathepsin F (C01 family) 0.040531 0.139248 0.216937
Brugia malayi cathepsin L-like cysteine proteinase 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.156597 0.641884 0.641884
Plasmodium vivax vivapain-3 0.0318156 0.101505 0.405405
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0131396 0.0206278 0.0321363
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0112043 0.0122466 0.5
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.157941 0.647702 0.887483
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0809898 0.314459 0.314459
Echinococcus granulosus neuroglian 0.022055 0.0592364 0.0922852
Plasmodium falciparum serine repeat antigen 7 0.0131396 0.0206278 0.0403174
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0131396 0.0206278 0.0181474
Plasmodium vivax vivapain-2 0.0592069 0.220126 1
Brugia malayi Papain family cysteine protease containing protein 0.0592069 0.220126 0.220126
Schistosoma mansoni serine/threonine protein kinase 0.156597 0.641884 1
Leishmania major guanosine monophosphate reductase 0.0112043 0.0122466 0.00343605
Loa Loa (eye worm) hypothetical protein 0.0267519 0.079577 0.079577
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0140973 0.0247751 0.0385975
Loa Loa (eye worm) hypothetical protein 0.0183756 0.0433025 0.0433025
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0112043 0.0122466 0.00343605
Trypanosoma cruzi chloride channel protein, putative 0.0112043 0.0122466 0.00343605
Onchocerca volvulus 0.0168005 0.0364815 0.0398263
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0398469 0.136286 0.136286
Brugia malayi 5'-AMP-activated protein kinase, beta subunit, complex-interacting region containing protein 0.0809898 0.314459 0.314459
Entamoeba histolytica cysteine protease, putative 0.0318156 0.101505 0.405405
Onchocerca volvulus 0.0592069 0.220126 0.240308
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0592069 0.220126 1
Loa Loa (eye worm) hypothetical protein 0.0168005 0.0364815 0.0364815
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.215655 0.897637 0.897637
Loa Loa (eye worm) hypothetical protein 0.0186759 0.0446031 0.0446031
Schistosoma mansoni chloride channel protein 0.0112043 0.0122466 0.0190791
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0131396 0.0206278 0.0321363
Chlamydia trachomatis Mg++ transporter 0.0112043 0.0122466 0.5
Loa Loa (eye worm) SRC-1 0.0207664 0.0536562 0.0536562
Chlamydia trachomatis CBS domain-containing protein 0.0112043 0.0122466 0.5
Loa Loa (eye worm) hypothetical protein 0.0264029 0.0780655 0.0780655
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0112043 0.0122466 0.00343605
Plasmodium vivax glycogen synthase kinase 3, putative 0.0398469 0.136286 0.579744
Toxoplasma gondii CBS family protein 0.0112043 0.0122466 0.0117416
Brugia malayi hypothetical protein 0.0216066 0.0572948 0.0572948
Loa Loa (eye worm) hypothetical protein 0.0112043 0.0122466 0.0122466
Entamoeba histolytica protein kinase domain containing protein 0.0398469 0.136286 0.579744
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Brugia malayi CBS domain containing protein 0.0112043 0.0122466 0.0122466
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0207664 0.0536562 0.0835918
Brugia malayi cathepsin Z-like cysteine proteinase 0.0131396 0.0206278 0.0206278
Onchocerca volvulus 0.0592069 0.220126 0.240308
Brugia malayi Papain family cysteine protease containing protein 0.0131396 0.0206278 0.0206278
Schistosoma mansoni cathepsin F (C01 family) 0.0592069 0.220126 0.342937
Trypanosoma cruzi major cysteine proteinase, putative 0.0131396 0.0206278 0.015096
Loa Loa (eye worm) TK/EPH protein kinase 0.0361492 0.120273 0.120273
Entamoeba histolytica cysteine protease, putative 0.0592069 0.220126 1
Brugia malayi Transforming growth factor beta like domain containing protein 0.114625 0.460117 0.460117
Loa Loa (eye worm) hypothetical protein 0.0193693 0.0476057 0.0476057
Echinococcus multilocularis Immunoglobulin 0.0183756 0.0433025 0.0674615
Leishmania major cathepsin L-like protease 0.176617 0.72858 1
Loa Loa (eye worm) ctsf protein 0.0592069 0.220126 0.220126
Onchocerca volvulus 0.0592069 0.220126 0.240308
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.00937006 0.00430327 0.00670412
Schistosoma mansoni cathepsin B (C01 family) 0.0131396 0.0206278 0.0321363
Giardia lamblia Cathepsin B precursor 0.0131396 0.0206278 0.0181474
Leishmania major inosine-5-monophosphate dehydrogenase 0.0112043 0.0122466 0.00343605
Giardia lamblia Cathepsin B precursor 0.0131396 0.0206278 0.0181474
Giardia lamblia Kinase, CMGC GSK 0.0398469 0.136286 0.268577
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0112043 0.0122466 0.5
Entamoeba histolytica protein kinase, putative 0.0398469 0.136286 0.579744
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.022624 0.0617004 0.0722363
Onchocerca volvulus Cathepsin L homolog 0.0592069 0.220126 0.240308
Brugia malayi Cathepsin L-like precursor 0.0592069 0.220126 0.220126
Toxoplasma gondii cathepsin CPC1 0.0131396 0.0206278 0.0515857
Plasmodium vivax unspecified product 0.0318156 0.101505 0.405405
Schistosoma mansoni tyrosine kinase 0.010884 0.0108596 0.0169184
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0414877 0.143391 0.223392
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) hypothetical protein 0.0131396 0.0206278 0.0206278
Brugia malayi cathepsin F-like cysteine proteinase 0.0131396 0.0206278 0.0206278
Loa Loa (eye worm) hypothetical protein 0.0216066 0.0572948 0.0572948
Brugia malayi Cation transporter family protein 0.0168005 0.0364815 0.0364815
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0131396 0.0206278 0.0181474
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0414877 0.143391 0.143391
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0177219 0.0404717 0.0630515
Trichomonas vaginalis CAMK family protein kinase 0.022624 0.0617004 0.20588
Trypanosoma cruzi cysteine peptidase, putative 0.176617 0.72858 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0131396 0.0206278 0.0206278
Entamoeba histolytica protein kinase, putative 0.0145999 0.0269516 0.0316989
Trypanosoma cruzi SNF1-related protein kinase regulatory subunit beta, putative 0.0809898 0.314459 0.423874
Schistosoma mansoni tyrosine kinase 0.00867417 0.00128967 0.00200919

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12 uM Inhibition of Sprague-Dawley rat spleen HO1 ChEMBL. 16821802
IC50 (functional) = 18 uM Antimalarial activity against Plasmodium falciparum ChEMBL. 16495054
IC50 (ADMET) = 20 uM Inhibition of rat liver CYP2E1 ChEMBL. 16821802
IC50 (binding) > 100 uM Inhibition of Sprague-Dawley rat brain HO2 ChEMBL. 16821802
IC50 (binding) > 500 uM Inhibition of rat lung sGC ChEMBL. 16821802
IC50 (binding) > 500 uM Inhibition of rat brain nNOS ChEMBL. 16821802

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 16495054

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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