TDR Targets

Basic information

Technical information

TDR Targets ID: 103173
Name: 4-[[2-(sulfanylmethyl)-3,4-dihydro-1H-naphtha lene-2-carbonyl]amino]cyclohexane-1-carboxyli c acid
MW: 347.472 | Formula: C19H25NO3S
H donors: 2 H acceptors: 3 LogP: 2.77 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: SCC1(CCc2c(C1)cccc2)C(=O)NC1CCC(CC1)C(=O)O
InChi: 1S/C19H25NO3S/c21-17(22)14-5-7-16(8-6-14)20-18(23)19(12-24)10-9-13-3-1-2-4-15(13)11-19/h1-4,14,16,24H,5-12H2,(H,20,23)(H,21,22)
InChiKey: OXEYHOKDQONWDG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[[2-(sulfanylmethyl)tetralin-2-carbonyl]amino]cyclohexanecarboxylic acid
4-[[[2-(mercaptomethyl)-2-tetralinyl]-oxomethyl]amino]cyclohexanecarboxylic acid
4-[[2-(sulfanylmethyl)-3,4-dihydro-1H-naphthalen-2-yl]carbonylamino]cyclohexane-1-carboxylic acid
4-[[2-(mercaptomethyl)tetralin-2-carbonyl]amino]cyclohexanecarboxylic acid
4-[[2-(sulfanylmethyl)3,4-dihydro-1H-naphthalene-2-carbonyl]amino]cyclohexane-1-carboxylic acid
4-[[2-(sulfanylmethyl)tetralin-2-carbonyl]amino]cyclohexane-1-carboxylic acid
4-[[[2-(mercaptomethyl)-2-tetralinyl]-oxomethyl]amino]-1-cyclohexanecarboxylic acid
4-[[2-(mercaptomethyl)tetralin-2-carbonyl]amino]cyclohexane-1-carboxylic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neprilysin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Onchocerca volvulus		Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium leprae	probable zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus multilocularis	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Toxoplasma gondii	peptidase family M13 protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	IPR000718,Peptidase M13, neprilysin,domain-containing	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium ulcerans	zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus granulosus	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	Get druggable targets OG5_127344	All targets in OG5_127344
Neospora caninum	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Neprilysin	750 aa	682 aa	31.1 %
Onchocerca volvulus		Neprilysin	750 aa	713 aa	34.1 %
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	Neprilysin	750 aa	778 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	aspartyl protease, putative	0.016	0.1258	0.4488
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0037	0.005	0.0247
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0299	0.2609	0.2961
Entamoeba histolytica	P-glycoprotein 5, putative	0.0083	0.0507	0.0429
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0083	0.0507	0.1424
Plasmodium falciparum	plasmepsin VII	0.0079	0.0467	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Schistosoma mansoni	sterol O-acyltransferase 1	0.0935	0.881	0.9794
Loa Loa (eye worm)	hhat protein	0.0091	0.0583	0.0662
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0091	0.0583	0.1735
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0091	0.0583	0.0662
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0129	0.0948	0.4691
Echinococcus granulosus	endothelin converting enzyme 1	0.0114	0.0805	0.0913
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0091	0.0583	0.0523
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Echinococcus granulosus	tm gpcr rhodopsin	0.0515	0.4712	0.5348
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Brugia malayi	diacylglycerol acyltransferase	0.0091	0.0583	0.2885
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0083	0.0507	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0583	0.0662
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0091	0.0583	0.0662
Treponema pallidum	alginate O-acetylation protein (algI)	0.0091	0.0583	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.2021	0.2294
Toxoplasma gondii	aspartyl protease ASP3	0.016	0.1258	0.1118
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0048	0.0158	0.0781
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0091	0.0583	0.0432
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	abcb9, putative	0.0083	0.0507	0.1424
Toxoplasma gondii	peptidase family M13 protein	0.0114	0.0805	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0665	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0083	0.0507	0.1424
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0805	0.0913
Plasmodium falciparum	plasmepsin V	0.0079	0.0467	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0805	0.0913
Echinococcus multilocularis	multidrug resistance protein 1	0.0058	0.0261	0.0296
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0129	0.0948	0.1054
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0091	0.0583	0.0432
Trichomonas vaginalis	ABC transporter, putative	0.0083	0.0507	0.1424
Schistosoma mansoni	memapsin-2 (A01 family)	0.0079	0.0467	0.052
Schistosoma mansoni	cathepsin D (A01 family)	0.0954	0.8995	1
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.0514	0.0584
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0048	0.0158	0.0781
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0114	0.0805	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0091	0.0583	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Toxoplasma gondii	hypothetical protein	0.0091	0.0583	0.0432
Plasmodium vivax	multidrug resistance protein 1, putative	0.0083	0.0507	0.1424
Leishmania major	glycerol uptake protein, putative	0.0091	0.0583	0.0212
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0037	0.005	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Trichomonas vaginalis	abcb9, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0091	0.0583	0.1735
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0299	0.2609	0.249
Brugia malayi	Pepsin A precursor	0.0079	0.0467	0.2312
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0079	0.0467	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0583	0.0662
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.0583	0.1735
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Toxoplasma gondii	aspartyl protease ASP1	0.0299	0.2609	0.249
Brugia malayi	aspartic protease BmAsp-2, identical	0.0079	0.0467	0.2312
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Onchocerca volvulus		0.0056	0.0243	0.3632
Plasmodium vivax	aspartyl proteinase, putative	0.0299	0.2609	1
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0114	0.0805	0.3982
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Entamoeba histolytica	P-glycoprotein-2	0.0083	0.0507	0.0429
Schistosoma mansoni	smdr2	0.0083	0.0507	0.0563
Brugia malayi	aspartic protease BmAsp-1, identical	0.0079	0.0467	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0467	0.053
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0091	0.0583	0.0662
Toxoplasma gondii	aspartyl protease	0.0079	0.0467	0.0314
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0091	0.0583	0.0662
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0665	0.3289
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0058	0.0254	0.0282
Plasmodium falciparum	plasmepsin VIII, putative	0.0079	0.0467	0.1263
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0083	0.0507	0.0575
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0299	0.2609	0.2961
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0357	0.1767
Loa Loa (eye worm)	multidrug resistance protein 3	0.0083	0.0507	0.0575
Plasmodium falciparum	plasmepsin IV	0.0299	0.2609	1
Entamoeba histolytica	hypothetical protein	0.0091	0.0583	0.0523
Plasmodium falciparum	plasmepsin IX	0.016	0.1258	0.4488
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0091	0.0583	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0507	0.0575
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0091	0.0583	0.0662
Trichomonas vaginalis	abcb9, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0514	0.0584
Brugia malayi	MBOAT family protein	0.0091	0.0583	0.2885
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0299	0.2609	0.2961
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0452	0.4103	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0091	0.0583	0.0662
Leishmania major	glycerol uptake protein, putative	0.0091	0.0583	0.0212
Leishmania major	phosphatidylcholine:ceramide cholinephosphotransferase 2	0.0452	0.4103	1
Schistosoma mansoni	hypothetical protein	0.0091	0.0583	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0583	0.0662
Trichomonas vaginalis	ABC transporter, putative	0.0083	0.0507	0.1424
Brugia malayi	multidrug resistance protein 3	0.0083	0.0507	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0514	0.0584
Schistosoma mansoni	spingomyelin synthetase-related	0.0048	0.0158	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0467	0.053
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0037	0.005	0.0247
Echinococcus multilocularis	endothelin converting enzyme 1	0.0114	0.0805	0.0913
Echinococcus multilocularis	ATP binding cassette sub family B	0.0083	0.0498	0.0565
Leishmania major	hypothetical protein, conserved	0.0091	0.0583	0.0212
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0058	0.0261	0.042
Schistosoma mansoni	zinc finger protein	0.0091	0.0583	0.0648
Loa Loa (eye worm)	MBOAT family protein	0.0091	0.0583	0.0662
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0254	0.0282
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.0514	0.0584
Mycobacterium ulcerans	zinc metalloprotease	0.0114	0.0805	0.5
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0091	0.0583	0.0662
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0091	0.0583	0.0662
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0091	0.0583	0.0662
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0083	0.0507	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0514	0.0584
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 3	0.0048	0.0158	0.0781
Entamoeba histolytica	vacuolar protein sorting 26	0.0091	0.0583	0.0523
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0083	0.0507	0.0575
Plasmodium falciparum	plasmepsin I	0.0299	0.2609	1
Leishmania major	glycerol uptake protein, putative	0.0091	0.0583	0.0212
Schistosoma mansoni	multidrug resistance protein	0.0083	0.0507	0.0563
Plasmodium falciparum	plasmepsin III	0.0079	0.0467	0.1263
Trypanosoma brucei	glycerol uptake protein, putative	0.0091	0.0583	0.1078
Brugia malayi	Peptidase family M13 containing protein	0.0114	0.0805	0.3982
Entamoeba histolytica	hypothetical protein, conserved	0.0091	0.0583	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0037	0.005	0.0057
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0254	0.0282
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0091	0.0583	0.0662
Schistosoma mansoni	multidrug resistance protein	0.0083	0.0507	0.0563
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0091	0.0583	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0514	0.0584
Brugia malayi	MBOAT family protein	0.0091	0.0583	0.2885
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Loa Loa (eye worm)	aspartyl protease 6	0.0079	0.0467	0.053
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0299	0.2609	1
Entamoeba histolytica	P-glycoprotein-5	0.0083	0.0507	0.0429
Echinococcus multilocularis	multidrug resistance protein 1	0.0083	0.0507	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0299	0.2609	0.2961
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0091	0.0583	0.0648
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0129	0.0948	0.1076
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0048	0.0158	0.0179
Mycobacterium leprae	probable zinc metalloprotease	0.0114	0.0805	0.5
Plasmodium vivax	aspartyl proteinase, putative	0.0079	0.0467	0.1263
Brugia malayi	ABC transporter family protein	0.0083	0.0507	0.2507
Plasmodium vivax	aspartyl protease, putative	0.016	0.1258	0.4488
Trypanosoma cruzi	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0452	0.4103	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0083	0.0507	0.0575
Leishmania major	glycerol uptake protein, putative	0.0091	0.0583	0.0212
Leishmania major	glycerol uptake protein, putative	0.0091	0.0583	0.0212
Entamoeba histolytica	P-glyco protein 6, putative	0.0083	0.0507	0.0429
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0091	0.0583	0.0523
Trichomonas vaginalis	taga, putative	0.0083	0.0507	0.1424
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0083	0.0507	0.0575
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Loa Loa (eye worm)	hypothetical protein	0.01	0.0665	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0083	0.0507	0.0575
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0083	0.0507	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0507	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0935	0.881	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0083	0.0507	0.1424
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0129	0.0948	0.1076
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0091	0.0583	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0048	0.0158	0.0179
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0091	0.0583	0.0662
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0083	0.0507	0.0575
Schistosoma mansoni	hypothetical protein	0.0068	0.0357	0.0397
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0083	0.0507	0.0575
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0091	0.0583	0.0662
Brugia malayi	MH2 domain containing protein	0.0239	0.2021	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0091	0.0583	0.0662
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0058	0.0254	0.0282
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0091	0.0583	0.0662
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0091	0.0583	0.0648
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0079	0.0467	0.052
Echinococcus granulosus	multidrug resistance protein 1	0.0083	0.0507	0.0575
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0048	0.0158	0.0781
Plasmodium falciparum	multidrug resistance protein 1	0.0083	0.0507	0.1424
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0665	0.0754
Brugia malayi	MBOAT family protein	0.0091	0.0583	0.2885
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0091	0.0583	0.0662
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0452	0.4103	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0083	0.0507	0.1424
Brugia malayi	MBOAT family protein	0.0091	0.0583	0.2885
Brugia malayi	hypothetical protein	0.0079	0.0467	0.2312
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0083	0.0507	0.1424
Onchocerca volvulus		0.0079	0.0467	0.7831
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.0583	0.1735
Onchocerca volvulus		0.0091	0.0583	1
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0058	0.0254	0.0282
Trichomonas vaginalis	ABC transporter, putative	0.0083	0.0507	0.1424
Echinococcus granulosus	multidrug resistance protein 1	0.0058	0.0261	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Loa Loa (eye worm)	hhat protein	0.0091	0.0583	0.0662
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0083	0.0507	0.0575
Entamoeba histolytica	P-glycoprotein-2	0.0083	0.0507	0.0429
Schistosoma mansoni	multidrug resistance protein	0.0083	0.0507	0.0563
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.2021	0.2294
Onchocerca volvulus		0.0079	0.0467	0.7831
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0129	0.0948	0.1076
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0515	0.4712	0.5348
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0091	0.0583	0.0662
Plasmodium falciparum	plasmepsin X	0.016	0.1258	0.4488
Trichomonas vaginalis	conserved hypothetical protein	0.0091	0.0583	0.1735
Plasmodium vivax	plasmepsin V, putative	0.0079	0.0467	0.1263
Brugia malayi	Hhat protein	0.0091	0.0583	0.2885
Brugia malayi	Sphingomyelin synthase-related 1	0.0048	0.0158	0.0781
Brugia malayi	MBOAT family protein	0.0091	0.0583	0.2885
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0243	0.0276
Plasmodium vivax	plasmepsin IV, putative	0.0299	0.2609	1
Trypanosoma brucei	sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional	0.0452	0.4103	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0083	0.0507	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0129	0.0948	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0357	0.0405
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0083	0.0507	0.0355
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0091	0.0583	0.0648
Entamoeba histolytica	P-glycoprotein-1	0.0083	0.0507	0.0429
Onchocerca volvulus		0.0083	0.0507	0.857
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0079	0.0467	0.053
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0299	0.2609	0.29
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Echinococcus granulosus	multidrug resistance protein 1	0.0058	0.0261	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0179
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0083	0.0507	0.0575
Trichomonas vaginalis	ABC transporter, putative	0.0083	0.0507	0.1424
Trichomonas vaginalis	porcupine, putative	0.0091	0.0583	0.1735
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0091	0.0583	0.0648
Echinococcus multilocularis	multidrug resistance protein 1	0.0083	0.0507	0.0575
Loa Loa (eye worm)	MBOAT family protein	0.0091	0.0583	0.0662
Plasmodium vivax	aspartyl protease, putative	0.0079	0.0467	0.1263
Brugia malayi	Phosphatidylcholine:ceramide cholinephosphotransferase 1	0.0048	0.0158	0.0781
Trypanosoma brucei	glycerol uptake protein, putative	0.0091	0.0583	0.1078
Schistosoma mansoni	cathepsin D (A01 family)	0.0954	0.8995	1
Echinococcus granulosus	multidrug resistance protein 1	0.0083	0.0507	0.0575
Plasmodium falciparum	plasmepsin II	0.0299	0.2609	1
Loa Loa (eye worm)	MBOAT family protein	0.0091	0.0583	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Entamoeba histolytica	P-glycoprotein-2, putative	0.0083	0.0507	0.0429
Echinococcus granulosus	multidrug resistance protein 1	0.0083	0.0507	0.0575
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0083	0.0507	0.1424
Echinococcus multilocularis	sterol O acyltransferase 1	0.0935	0.881	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0805	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0534	0.0606
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0114	0.0805	0.0895
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0083	0.0498	0.0565
Entamoeba histolytica	hypothetical protein, conserved	0.0881	0.8287	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0083	0.0507	0.1424
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0079	0.0467	0.0314
Echinococcus granulosus	sterol O acyltransferase 1	0.0935	0.881	1
Plasmodium falciparum	plasmepsin VI	0.0299	0.2609	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0091	0.0583	0.1735
Brugia malayi	hypothetical protein	0.0079	0.0467	0.2312
Loa Loa (eye worm)	hypothetical protein	0.0843	0.792	0.8989
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0498	0.0565
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0037	0.005	0.0057
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0091	0.0583	0.0648
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0129	0.0948	0.1076

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.6 nM	Inhibition of neutral endopeptidase(NEP).	ChEMBL.	No reference
Ki (binding)	= 0.6 nM	Inhibition of neutral endopeptidase(NEP).	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 19789941

Bibliographic References

No literature references available for this target.

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Detailed information for compound 103173