Detailed information for compound 1031898

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.522 | Formula: C7H9BrClN3O2
  • H donors: 2 H acceptors: 4 LogP: 2.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(O)c(c(n1)N1CCC1)Br.Cl
  • InChi: 1S/C7H8BrN3O2.ClH/c8-4-5(11-2-1-3-11)9-7(13)10-6(4)12;/h1-3H2,(H2,9,10,12,13);1H
  • InChiKey: COPRCCHJEUKSCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0014 0.0037 0.5
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0037 0.0037
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0077 0.0464
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Giardia lamblia MRP-like ABC transporter 0.0014 0.0037 1
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Plasmodium falciparum multidrug resistance protein 1 0.0045 0.0239 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0089 0.0089
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0037 0.0037
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0037 0.8685
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0045 0.0239 1
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0014 0.0037 0.1111
Loa Loa (eye worm) hypothetical protein 0.0045 0.0238 0.1443
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2783 0.2756
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Echinococcus multilocularis multidrug resistance protein 1 0.0045 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.026 0.1651 1
Onchocerca volvulus 0.0111 0.0673 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0236 0.1429
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0037 0.1544
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 1
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Brugia malayi ABC transporter 0.0014 0.0037 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.1315
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1651 0.1651
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Brugia malayi multidrug resistance protein 3 0.0045 0.0239 0.1449
Loa Loa (eye worm) multidrug resistance protein 3 0.0045 0.0239 0.1449
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.1449
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0262 0.0262
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0047 0.0285
Schistosoma mansoni hypothetical protein 0.002 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0111 0.0673 0.4078
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.0073
Leishmania major p-glycoprotein 0.0045 0.0239 0.6842
Brugia malayi PHD-finger family protein 0.0024 0.0104 0.0629
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0045 0.0239 0.0203
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0333 0.0349
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0199 0.0199
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2783 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Giardia lamblia ABC transporter, putative 0.0014 0.0037 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0054 0.0054
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0045 0.0239 0.6842
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0037 0.0037
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Brugia malayi protein kinase C II. 0.0016 0.0047 0.0285
Echinococcus granulosus zinc finger protein 0.0019 0.007 0.007
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.015 0.015
Entamoeba histolytica P-glycoprotein-2 0.0045 0.0239 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Entamoeba histolytica P-glycoprotein 5, putative 0.0045 0.0239 1
Brugia malayi Protein kinase c protein 2 0.0046 0.0248 0.1499
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0293 0.1774
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0014 0.0037 0.8685
Echinococcus granulosus protein kinase c iota type 0.0014 0.0039 0.0039
Brugia malayi multidrug resistance related protein 1 0.0014 0.0037 0.0224
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0333 1
Echinococcus multilocularis zinc finger protein 0.0019 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Schistosoma mansoni multidrug resistance protein 0.0014 0.0034 0.0035
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0174 0.0174
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Entamoeba histolytica hypothetical protein 0.0014 0.0037 0.1544
Entamoeba histolytica ABC transporter, putative 0.0014 0.0037 0.1544
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0262 0.0262
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0089 0.0093
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Toxoplasma gondii ABC transporter family protein 0.0014 0.0037 0.1111
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0014 0.0037 0.8685
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0891 0.5795 0.5795
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Brugia malayi Bromodomain containing protein 0.0073 0.0424 0.2566
Brugia malayi ABC transporter family protein 0.0045 0.0239 0.1449
Onchocerca volvulus 0.0053 0.0293 0.1236
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1651 0.1651
Loa Loa (eye worm) hypothetical protein 0.0037 0.019 0.115
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0034 0.0204
Entamoeba histolytica P-glycoprotein-5 0.0045 0.0239 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0089 0.0089
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0034 0.141
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0014 0.0034 0.0035
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.015 0.015
Entamoeba histolytica P-glycoprotein-2, putative 0.0045 0.0239 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0174 0.0174
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0209 0.1263
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0014 0.0037 0.0224
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0325
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0333 0.0333
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0037 0.1544
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0037 0.8685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0326 0.0326
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0045 0.0239 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0034 0.141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0396 0.2401
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0045 0.0239 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.141
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0333 0.0333
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0037 0.1544
Trypanosoma brucei p-glycoprotein 0.0014 0.0037 0.8685
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.1241
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0204
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0037 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0056
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Entamoeba histolytica P-glycoprotein-2 0.0045 0.0239 1
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Entamoeba histolytica P-glyco protein 6, putative 0.0045 0.0239 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0045 0.0239 0.7192
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0056
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.015 0.015
Brugia malayi ABC transporter 0.0014 0.0034 0.0204
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0199 0.0199
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0044 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0204
Echinococcus granulosus microtubule associated protein 2 0.146 0.9535 0.9535
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0333 0.0349
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.0911 0.5515
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0911 0.0911
Schistosoma mansoni atypical protein kinase C 0.0014 0.0039 0.0041
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.015 0.6284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0326 0.0326
Trichomonas vaginalis taga, putative 0.0045 0.0239 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0056
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0911 0.0911
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0301 0.0316
Echinococcus multilocularis multidrug resistance protein 1 0.0045 0.0239 0.0239
Trypanosoma brucei ISWI complex protein 0.0015 0.0043 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.0301 0.0301
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.0911 0.5515
Schistosoma mansoni smdr1 0.0014 0.0037 0.0039
Toxoplasma gondii ABC transporter, putative 0.0014 0.0037 0.1111
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0047 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0911 0.0911
Brugia malayi Bromodomain containing protein 0.0037 0.0189 0.1147
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0037 0.0037
Schistosoma mansoni cellular tumor antigen P53 0.0111 0.0673 0.0706
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2783 0.2756
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0037 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Schistosoma mansoni survival motor neuron protein 0.0053 0.0293 0.0307
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0199 0.0199
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0911 0.0911
Leishmania major hypothetical protein, conserved 0.0015 0.0043 0.0189
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0045 0.0239 0.7192
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.0236 0.0236
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Brugia malayi P-glycoprotein-like protein 0.0014 0.0037 0.0224
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0037 0.8685
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0039 0.0039
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0034 0.141
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Echinococcus multilocularis 0.0014 0.0037 0.0037
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0037 0.0037
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Schistosoma mansoni hypothetical protein 0.0053 0.0293 0.0307
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0014 0.0037 0.0039
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0047 0.0047
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0058 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0034 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0047 0.0049
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Brugia malayi hypothetical protein 0.026 0.1651 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.1207
Schistosoma mansoni smdr2 0.0045 0.0239 0.0251
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Echinococcus multilocularis tumor protein p63 0.0758 0.4921 0.4921
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0037 0.0037
Plasmodium vivax multidrug resistance protein 1, putative 0.0045 0.0239 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Brugia malayi hypothetical protein 0.0014 0.0037 0.0224
Echinococcus granulosus tumor protein p63 0.0758 0.4921 0.4921
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0045
Echinococcus multilocularis microtubule associated protein 2 0.146 0.9535 0.9535
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0014 0.0037 0.5
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0333 0.0297
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.0301 0.0301
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0034 0.141
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0054 0.0054
Schistosoma mansoni zinc finger protein 0.0015 0.0043 0.0045
Schistosoma mansoni bromodomain containing protein 0.0062 0.0349 0.0366
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0045 0.0239 0.1449
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0037 0.1544
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0034 0.141
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Entamoeba histolytica P-glycoprotein-1 0.0045 0.0239 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0333 1
Schistosoma mansoni microtubule-associated protein tau 0.146 0.9535 1
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0301 0.0316
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.1449

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 uM Inhibition of Escherichia coli TP ChEMBL. 16337119
IC50 (binding) = 6.3 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 6.8 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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