Detailed information for compound 1031898

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.522 | Formula: C7H9BrClN3O2
  • H donors: 2 H acceptors: 4 LogP: 2.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(O)c(c(n1)N1CCC1)Br.Cl
  • InChi: 1S/C7H8BrN3O2.ClH/c8-4-5(11-2-1-3-11)9-7(13)10-6(4)12;/h1-3H2,(H2,9,10,12,13);1H
  • InChiKey: COPRCCHJEUKSCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0014 0.0037 0.1111
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0045 0.0239 0.1449
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0037 0.8685
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0069 0.0396 0.2401
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Loa Loa (eye worm) hypothetical protein 0.0111 0.0673 0.4078
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0301 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0056
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0034 0.0204
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0333 0.0297
Mycobacterium ulcerans thymidine phosphorylase 0.1531 1 1
Entamoeba histolytica P-glycoprotein-5 0.0045 0.0239 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0045 0.0239 1
Schistosoma mansoni hypothetical protein 0.0053 0.0293 0.0307
Plasmodium vivax multidrug resistance protein 1, putative 0.0045 0.0239 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0045 0.0239 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0037 0.0037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0054 0.0054
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Brugia malayi Bromodomain containing protein 0.0037 0.0189 0.1147
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0037 0.8685
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0034 0.141
Trypanosoma brucei p-glycoprotein 0.0014 0.0037 0.8685
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0891 0.5795 0.5795
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0293 0.1774
Schistosoma mansoni atypical protein kinase C 0.0014 0.0039 0.0041
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0034 0.141
Schistosoma mansoni cellular tumor antigen P53 0.0111 0.0673 0.0706
Echinococcus multilocularis tumor protein p63 0.0758 0.4921 0.4921
Schistosoma mansoni smdr1 0.0014 0.0037 0.0039
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0058 0.0349
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0911 0.0911
Brugia malayi ABC transporter family protein 0.0045 0.0239 0.1449
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2783 1
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0262 0.0262
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0037 0.1544
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0199 0.0199
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.0073
Leishmania major p-glycoprotein 0.0045 0.0239 0.6842
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Entamoeba histolytica hypothetical protein 0.0014 0.0037 0.1544
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0056
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0037 0.0037
Echinococcus granulosus zinc finger protein 0.0019 0.007 0.007
Schistosoma mansoni microtubule-associated protein tau 0.146 0.9535 1
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.015 0.015
Trypanosoma brucei ISWI complex protein 0.0015 0.0043 1
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Echinococcus multilocularis protein kinase c iota type 0.0014 0.0039 0.0039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Schistosoma mansoni bromodomain containing protein 0.0062 0.0349 0.0366
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1651 0.1651
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0911 0.0911
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0014 0.0037 0.0224
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0037 0.8685
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.1449
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0047 0.0049
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0333 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0333 0.0349
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.0301 0.0301
Brugia malayi hypothetical protein 0.0014 0.0037 0.0224
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0047 0.0285
Brugia malayi multidrug resistance protein 3 0.0045 0.0239 0.1449
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.1315
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.026 0.1651 1
Schistosoma mansoni hypothetical protein 0.002 0.0077 0.008
Echinococcus multilocularis multidrug resistance protein 1 0.0045 0.0239 0.0239
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0037 0.1544
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.015 0.6284
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0262 0.0262
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Echinococcus multilocularis thymidine phosphorylase 0.1531 1 1
Brugia malayi protein kinase C II. 0.0016 0.0047 0.0285
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Echinococcus multilocularis microtubule associated protein 2 0.146 0.9535 0.9535
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Echinococcus granulosus tumor protein p63 0.0758 0.4921 0.4921
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0037 0.019 0.115
Entamoeba histolytica ABC transporter, putative 0.0014 0.0037 0.1544
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0326 0.0326
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0333 0.0349
Entamoeba histolytica P-glycoprotein-2 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0239 0.1449
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0077 0.0464
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0043 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0045 0.0239 0.0203
Brugia malayi ABC transporter 0.0014 0.0034 0.0204
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0045
Echinococcus multilocularis zinc finger protein 0.0019 0.007 0.007
Echinococcus granulosus ATP binding cassette sub family B 0.0014 0.0037 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Echinococcus multilocularis 0.0014 0.0037 0.0037
Leishmania major hypothetical protein, conserved 0.0015 0.0043 0.0189
Echinococcus granulosus protein kinase c iota type 0.0014 0.0039 0.0039
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0045 0.0239 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0045 0.0239 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0911 0.0911
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0044 0.0236 0.1429
Brugia malayi PHD-finger family protein 0.0024 0.0104 0.0629
Brugia malayi Bromodomain containing protein 0.0073 0.0424 0.2566
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0199 0.0199
Brugia malayi Protein kinase c protein 2 0.0046 0.0248 0.1499
Schistosoma mansoni survival motor neuron protein 0.0053 0.0293 0.0307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.0911 0.5515
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.1241
Giardia lamblia MRP-like ABC transporter 0.0014 0.0037 1
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.015 0.015
Entamoeba histolytica P-glycoprotein-1 0.0045 0.0239 1
Brugia malayi hypothetical protein 0.026 0.1651 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0333 0.0333
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0014 0.0037 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0326 0.0326
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0037 1
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Schistosoma mansoni multidrug resistance protein 0.0014 0.0034 0.0035
Onchocerca volvulus 0.0053 0.0293 0.1236
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0014 0.0037 0.8685
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.015 0.015
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0224
Echinococcus multilocularis ATP binding cassette sub family B 0.0014 0.0037 0.0037
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Trichomonas vaginalis taga, putative 0.0045 0.0239 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0045 0.0239 0.1449
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0056
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0333 1
Schistosoma mansoni zinc finger protein 0.0015 0.0043 0.0045
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0089 0.0089
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0174 0.0174
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0037 0.1544
Echinococcus multilocularis multidrug resistance protein 1 0.0045 0.0239 0.0239
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0045 0.0239 0.6842
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2783 0.2756
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0014 0.0037 0.8685
Giardia lamblia ABC transporter, putative 0.0014 0.0037 1
Schistosoma mansoni smdr2 0.0045 0.0239 0.0251
Trichomonas vaginalis ABC transporter, putative 0.0045 0.0239 1
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0045 0.0239 1
Plasmodium falciparum multidrug resistance protein 1 0.0045 0.0239 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0089 0.0093
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0089 0.0089
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1651 0.1651
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0045 0.0239 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.1207
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0034 0.141
Echinococcus granulosus microtubule associated protein 2 0.146 0.9535 0.9535
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0034 0.141
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0014 0.0034 0.0035
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0037 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0045 0.0238 0.1443
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0014 0.0037 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0174 0.0174
Brugia malayi P-glycoprotein-like protein 0.0014 0.0037 0.0224
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2783 0.2756
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0045 0.0239 0.0239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Echinococcus granulosus multidrug resistance protein 1 0.0045 0.0239 0.0239
Brugia malayi multidrug resistance related protein 1 0.0014 0.0037 0.0224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.0911 0.5515
Brugia malayi ABC transporter 0.0014 0.0037 0.0224
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Echinococcus multilocularis ATP binding cassette sub family B 0.0044 0.0236 0.0236
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0333 0.0297
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0045 0.0239 0.7192
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0034 0.141
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0054
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0045 0.0239 0.7192
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0204
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0199 0.0199
Toxoplasma gondii ABC transporter family protein 0.0014 0.0037 0.1111
Brugia malayi ABC transporter family protein 0.0014 0.0037 0.0224
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0044 0.0236 0.0236
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0301 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0911 0.0955
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0037 0.0037
Entamoeba histolytica P-glycoprotein 6, putative 0.0014 0.0037 0.1544
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0047 0.0047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0045 0.0239 1
Loa Loa (eye worm) ABC transporter 0.0014 0.0037 0.0224
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0056
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0037 0.1111
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0045 0.0239 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.141
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0037 0.0224
Entamoeba histolytica P-glyco protein 6, putative 0.0045 0.0239 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0045 0.0239 0.0239
Schistosoma mansoni multidrug resistance protein 0.0014 0.0037 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0911 0.0911
Entamoeba histolytica P-glycoprotein-2 0.0045 0.0239 1
Schistosoma mansoni multidrug resistance protein 0.0045 0.0239 0.0251
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0209 0.1263
Toxoplasma gondii ABC transporter, putative 0.0014 0.0037 0.1111
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0037 0.0037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0333 0.0333
Trichomonas vaginalis abcb9, putative 0.0045 0.0239 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0037 0.1544
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0014 0.0037 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0325
Onchocerca volvulus 0.0111 0.0673 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 uM Inhibition of Escherichia coli TP ChEMBL. 16337119
IC50 (binding) = 6.3 uM Inhibition of human TP purified from placenta ChEMBL. 16337119
IC50 (binding) = 6.8 uM Inhibition of human TP expressed in V79 cells ChEMBL. 16337119

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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