Detailed information for compound 1034338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.411 | Formula: C18H25N3O
  • H donors: 0 H acceptors: 1 LogP: 3.11 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nccc1c1ccc(cc1)OCCCN1CCCCC1
  • InChi: 1S/C18H25N3O/c1-20-18(10-11-19-20)16-6-8-17(9-7-16)22-15-5-14-21-12-3-2-4-13-21/h6-11H,2-5,12-15H2,1H3
  • InChiKey: XBIDNEGDXXMQIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0171 0.2592
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0352 0.1756
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0117 0.0132
Onchocerca volvulus 0.0048 0.0223 0.0339
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.045 0.8042
Echinococcus multilocularis expressed conserved protein 0.009 0.0472 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Plasmodium falciparum calcium-dependent protein kinase 5 0.0105 0.0564 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0039 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0019 0.005 0.0249
Plasmodium vivax calcium-dependent protein kinase, putative 0.0105 0.0564 0.0648
Brugia malayi hypothetical protein 0.0135 0.0742 0.3721
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0048 0.0223 0.1107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0835
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0171 0.3769
Leishmania major threonyl-tRNA synthetase, putative 0.0019 0.005 0.0715
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0117 0.0575
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.0006 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0171 0.0862
Brugia malayi glycyl-tRNA synthetase 0.0019 0.005 0.0234
Schistosoma mansoni transient receptor potential channel 0.0097 0.0516 0.2581
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0103 0.0551 0.2756
Treponema pallidum prolyl-tRNA synthetase 0.0036 0.0152 0.3328
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0171 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0048 0.0223 0.3415
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0036 0.0152 0.3328
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.0561
Loa Loa (eye worm) hypothetical protein 0.0097 0.0516 0.2593
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0019 0.005 0.0249
Plasmodium falciparum calcium-dependent protein kinase 3 0.0105 0.0564 0.0648
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0506 0.2534
Mycobacterium tuberculosis Conserved protein 0.004 0.0171 0.0956
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0039 0.0196
Plasmodium falciparum calcium-dependent protein kinase 2 0.0105 0.0564 0.0648
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0036 0.0508
Schistosoma mansoni hypothetical protein 0.004 0.0171 0.0844
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0078 0.0379
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0516 0.0513
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.045 0.2249
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0272 0.1667
Entamoeba histolytica hypothetical protein 0.007 0.0352 0.6225
Loa Loa (eye worm) hypothetical protein 0.0105 0.0563 0.2832
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.012 0.0653 1
Onchocerca volvulus Huntingtin homolog 0.0135 0.0742 0.3755
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0039 0.0181
Loa Loa (eye worm) hypothetical protein 0.0028 0.0102 0.0511
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0272 0.4587
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Leishmania major hypothetical protein, conserved 0.0017 0.0036 0.0508
Echinococcus granulosus glycyl tRNA synthetase 0.0019 0.005 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Onchocerca volvulus 0.0048 0.0223 0.0339
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0103 0.0551 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0057 0.0054
Trichomonas vaginalis sugar transport protein, putative 0.0048 0.0223 0.1121
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0005 0.0075
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0048 0.0223 0.4921
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0171 0.2626
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Onchocerca volvulus 0.0048 0.0223 0.0339
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Leishmania major glycyl tRNA synthetase, putative 0.0012 0.0003 0.0005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0223 0.1121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0117 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Mycobacterium leprae conserved hypothetical protein 0.004 0.0171 0.2631
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0039 0.0554
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0103 0.0551 0.2756
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0065 0.0324 0.2031
Trichomonas vaginalis sugar transporter, putative 0.0106 0.0571 0.2872
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0325 0.0322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0058 0.0847
Chlamydia trachomatis lysine--tRNA ligase 0.0077 0.0393 0.8722
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0263 0.1321
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0048 0.0223 0.132
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0019 0.005 0.104
Toxoplasma gondii ABC1 family protein 0.004 0.0171 0.0299
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0171 0.3769
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0105 0.0564 0.0648
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.018 0.0903
Schistosoma mansoni hypothetical protein 0.004 0.0171 0.0844
Echinococcus granulosus GPCR family 2 0.0017 0.0038 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0038 0.0176
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.0006 0.0012
Plasmodium falciparum calcium-dependent protein kinase 4 0.0105 0.0564 0.0648
Echinococcus granulosus Threonyl tRNA synthetase C 0.0019 0.005 0.0234
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.0561
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Treponema pallidum threonyl-tRNA synthetase 0.0019 0.005 0.104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0176
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Echinococcus granulosus lysyl tRNA synthetase 0.0077 0.0393 0.1962
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0039 0.0196
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.0561
Trypanosoma cruzi histidyl-tRNA synthetase 0.0012 0.0003 0.0005
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0343 0.199 0.1987
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Brugia malayi Sugar transporter family protein 0.0343 0.199 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0171 0.0862
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.003 0.0027
Trypanosoma cruzi glucose transporter, putative 0.0048 0.0223 0.3384
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0171 0.0956
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0039 0.0554
Schistosoma mansoni protein kinase 0.0105 0.0563 0.2821
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0103 0.0551 0.2768
Brugia malayi beta-lactamase family protein 0.004 0.0171 0.0848
Schistosoma mansoni hypothetical protein 0.0343 0.199 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0506 0.2534
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0171 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0039 0.0643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0171 0.0848
Leishmania major glucose transporter, lmgt3 0.0106 0.0571 0.8747
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0563 0.2821
Echinococcus multilocularis glycyl tRNA synthetase 0.0019 0.005 0.0047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0039 0.0557
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.022 0.109
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0008 0.0005
Trypanosoma cruzi hexose transporter 0.0106 0.0571 0.8747
Schistosoma mansoni glucose transport protein 0.0343 0.199 1
Giardia lamblia GTOR 0.0018 0.0039 0.0657
Onchocerca volvulus 0.0048 0.0223 0.0339
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.0561
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Leishmania major protein kinase, putative 0.0012 0.0008 0.0083
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0039 0.0599
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.045 0.0783
Leishmania major hypothetical protein, conserved 0.004 0.0171 0.2592
Trichomonas vaginalis glucose transporter, putative 0.0106 0.0571 0.2872
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0752 0.0749
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.022 0.1104
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0343 0.199 1
Loa Loa (eye worm) sugar transporter 0.0343 0.199 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus granulosus importin subunit beta 1 0.0028 0.0102 0.0496
Echinococcus granulosus solute carrier family 22 0.0048 0.0223 0.1107
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0102 0.0099
Chlamydia trachomatis proline--tRNA ligase 0.0036 0.0152 0.3328
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Schistosoma mansoni transient receptor potential channel 0.0065 0.0325 0.1619
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0223 0.1107
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0039 0.0181
Schistosoma mansoni glucose transport protein 0.0343 0.199 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0171 0.0862
Echinococcus multilocularis synaptic vesicle 2 protein 0.0048 0.0223 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0102 0.0177
Schistosoma mansoni patched 1 0.0041 0.018 0.0889
Onchocerca volvulus 0.0293 0.1691 1
Giardia lamblia Hexose transporter 0.0048 0.0223 0.4016
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.0006 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Schistosoma mansoni ran 0.0021 0.0057 0.0273
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0006 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0117 0.0114
Schistosoma mansoni lysyl-tRNA synthetase 0.0077 0.0393 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trypanosoma cruzi hexose transporter, putative 0.0106 0.0571 0.8747
Onchocerca volvulus 0.0048 0.0223 0.0339
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0078 0.0136
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0077 0.0393 0.1974
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0012 0.0003 0.0007
Brugia malayi major facilitator superfamily protein 0.0048 0.0223 0.1107
Onchocerca volvulus 0.0048 0.0223 0.0339
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0506 0.8983
Brugia malayi isocitrate dehydrogenase 0.0031 0.0117 0.0576
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0171 0.0848
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.012 0.0653 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0077 0.0393 0.5997
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.003 0.0136
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0171 0.0956
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0038 0.0176
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0352 0.0349
Echinococcus granulosus expressed conserved protein 0.009 0.0472 0.2359
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0067 0.0336 0.169
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0171 0.0862
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0117 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0811
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0038 0.0191
Brugia malayi lysyl-tRNA synthetase 0.0077 0.0393 0.1962
Leishmania major lysyl-tRNA synthetase, putative 0.0077 0.0393 0.5997
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0006 0.0012
Schistosoma mansoni survival motor neuron protein 0.0053 0.0252 0.1254
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0012 0.0003 0.0015
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.018 0.0903
Schistosoma mansoni protein kinase 0.0105 0.0563 0.2821
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0039 0.0181
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0039 0.0554
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0077 0.0393 0.8722
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0105 0.0563 0.2832
Onchocerca volvulus 0.0053 0.0252 0.0531
Trypanosoma brucei histidyl-tRNA synthetase 0.0012 0.0003 0.0052
Schistosoma mansoni lysyl-tRNA synthetase 0.0077 0.0393 0.1962
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0036 0.0181
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0343 0.199 0.1987
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0019 0.005 0.0047
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.022 0.109
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0019 0.005 0.104
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0012 0.0003 0.0007
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Toxoplasma gondii sugar transporter ST2 0.0048 0.0223 0.0388
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0078 0.1159
Loa Loa (eye worm) hypothetical protein 0.0096 0.0506 0.2545
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0006 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0117 0.0114
Giardia lamblia Sugar-proton symporter 0.0048 0.0223 0.4016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0927
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0252 0.1254
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 0.0516
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0117 0.176
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0176
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0112 0.0125
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0103 0.0551 0.0548
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0048 0.0223 0.132
Toxoplasma gondii transporter, major facilitator family protein 0.0048 0.0223 0.0388
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.003 0.0136
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.022 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0112 0.1469
Echinococcus granulosus solute carrier family 22 0.0048 0.0223 0.1107
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0325 0.0322
Toxoplasma gondii facilitative glucose transporter GT1 0.0343 0.199 0.3465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Echinococcus multilocularis solute carrier family 22 0.0048 0.0223 0.022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0343 0.199 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0171 0.0848
Toxoplasma gondii lysine-tRNA ligase 0.0077 0.0393 0.0684
Entamoeba histolytica Ran family GTPase 0.0021 0.0057 0.0968
Plasmodium falciparum protein kinase 6 0.1456 0.8659 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.0293 0.1691 0.8501
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.003 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0183 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Schistosoma mansoni hypothetical protein 0.004 0.0171 0.0844
Entamoeba histolytica hypothetical protein 0.0077 0.0393 0.6955
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0117 0.1799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus survival motor neuron protein 1 0.026 0.1494 0.7506
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0571 0.2872
Schistosoma mansoni threonyl-tRNA synthetase 0.0012 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0249
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0161 0.0797
Loa Loa (eye worm) hypothetical protein 0.0103 0.0551 0.2768
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0012 0.0003 0.0015
Trypanosoma brucei glucose transporter 2A 0.0106 0.0571 0.8753
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.007 0.0351
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0117 0.176
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0006 0.0028
Echinococcus granulosus solute carrier family 22 0.0048 0.0223 0.1107
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0042 0.0187 0.094
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0039 0.0643
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0008 0.0027
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0012 0.0003 0.0047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0035
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.012 0.0653 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0039 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0263 0.1308
Toxoplasma gondii protein kinase, putative 0.0969 0.5742 1
Brugia malayi beta-lactamase 0.004 0.0171 0.0848
Trypanosoma brucei THT1 - hexose transporter, putative 0.0106 0.0571 0.8753
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0077 0.0393 0.6016
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0019 0.005 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0036 0.0508
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0516 0.2581
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0039 0.0554
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Plasmodium vivax importin-beta 2, putative 0.0028 0.0102 0.0114
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0223 0.1107
Schistosoma mansoni histidyl-tRNA synthetase 0.0012 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0036 0.0181
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0006 0.0012
Loa Loa (eye worm) 63kd antigen 0.0012 0.0003 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0171 0.0956
Leishmania major protein kinase, putative 0.0012 0.0008 0.0083
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0019 0.005 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0078 0.0379
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0012 0.0008 0.0015
Toxoplasma gondii sugar transporter ST3 0.0048 0.0223 0.0388
Echinococcus granulosus histidyl tRNA synthetase 0.0012 0.0003 0.0002
Schistosoma mansoni sugar transporter 0.0048 0.0223 0.1107
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.048 0.0477
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.007 0.1028
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0039 0.0554
Plasmodium falciparum threonine--tRNA ligase 0.0019 0.005 0.0054
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0012 0.0003 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0117 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0343 0.199 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Entamoeba histolytica hypothetical protein 0.007 0.0352 0.6225
Mycobacterium ulcerans sugar transporter 0.0048 0.0223 0.4921
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0554 0.3256 0.567
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0105 0.0564 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0223 0.1121
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0039 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0171 0.0848
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.018 0.0177
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0171 0.0956
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.005 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trypanosoma cruzi hexose transporter, putative 0.0058 0.0282 0.4299
Mycobacterium tuberculosis Conserved protein 0.004 0.0171 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0272 0.0269
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0171 0.0862
Giardia lamblia Prolyl-tRNA synthetase 0.0103 0.0551 1
Entamoeba histolytica hypothetical protein 0.0023 0.007 0.1192
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0065 0.0324 0.2031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0057 0.0063
Plasmodium vivax hypothetical protein, conserved 0.004 0.0171 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0223 0.1121
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.0006 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0343 0.199 0.1987
Trypanosoma brucei THT1 - hexose transporter, putative 0.0106 0.0571 0.8753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0078 0.0394
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0077 0.0393 0.6932
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Trichomonas vaginalis glucose transporter, putative 0.0106 0.0571 0.2872
Brugia malayi major facilitator superfamily protein 0.0048 0.0223 0.1107
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.045 0.2249
Leishmania major protein kinase, putative 0.0105 0.0563 0.8623
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0019 0.005 0.104
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0017 0.0036 0.0063
Schistosoma mansoni hypothetical protein 0.0053 0.0252 0.1254
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0019 0.005 0.0759
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0065 0.0324 0.5587
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.018 0.0889
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0039 0.0554
Echinococcus multilocularis GPCR, family 2 0.0017 0.0038 0.0035
Plasmodium falciparum cGMP-dependent protein kinase 0.0012 0.0008 0.0006
Echinococcus multilocularis solute carrier family 22 0.0048 0.0223 0.022
Onchocerca volvulus Putative transporter 0.0048 0.0223 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0176
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0161 0.0158
Mycobacterium ulcerans hypothetical protein 0.004 0.0171 0.3769
Trichomonas vaginalis ran, putative 0.0021 0.0057 0.0288
Echinococcus granulosus calcium activated potassium channel 0.0013 0.001 0.0033
Mycobacterium ulcerans integral membrane transport protein 0.0048 0.0223 0.4921
Brugia malayi Cam kinase protein 1 0.0105 0.0563 0.2821
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0117 0.0114
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0077 0.0393 0.8722
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0019 0.005 0.0095
Brugia malayi RNA, U transporter 1 0.008 0.0411 0.2052
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Schistosoma mansoni sugar transporter 0.0048 0.0223 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Onchocerca volvulus 0.0048 0.0223 0.0339
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0102 0.1556
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.012 0.0653 1
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0012 0.0003 0.0006
Brugia malayi CHE-14 protein 0.0041 0.018 0.0889
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0343 0.199 1
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0012 0.0003 0.0017
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0057 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0628 0.3157
Echinococcus granulosus Sugar transporter ERD6 protein 0.0048 0.0223 0.1107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0117 0.0576
Loa Loa (eye worm) hypothetical protein 0.0077 0.0393 0.1974
Echinococcus multilocularis expressed conserved protein 0.0012 0.0008 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0008 0.0027
Plasmodium vivax proline--tRNA ligase, putative 0.012 0.0653 0.0751
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0039 0.0599
Plasmodium vivax glycine--tRNA ligase, putative 0.0019 0.005 0.0054
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0223 0.1121
Echinococcus multilocularis lysyl tRNA synthetase 0.0077 0.0393 0.039
Entamoeba histolytica hypothetical protein 0.0024 0.0078 0.1344
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0008 0.0027
Trypanosoma cruzi sugar transporter, putative 0.0048 0.0223 0.3384
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0103 0.0551 0.2756
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0102 0.1556
Plasmodium vivax threonine--tRNA ligase, putative 0.0019 0.005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0103 0.0551 0.2768
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0039 0.0068
Brugia malayi hypothetical protein 0.026 0.1494 0.7506
Echinococcus granulosus solute carrier family 22 0.0048 0.0223 0.1107
Brugia malayi hypothetical protein 0.0048 0.0223 0.1107
Onchocerca volvulus 0.0048 0.0223 0.0339
Loa Loa (eye worm) hypothetical protein 0.0135 0.0742 0.3731
Schistosoma mansoni hypothetical protein 0.007 0.0352 0.1756
Leishmania major glucose transporter, lmgt2 0.0106 0.0571 0.8747
Schistosoma mansoni protein kinase 0.0105 0.0563 0.2821
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0506 0.0504
Echinococcus multilocularis protein dispatched 1 0.0047 0.0214 0.0211
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0117 0.059
Onchocerca volvulus 0.0048 0.0223 0.0339
Brugia malayi hypothetical protein 0.0293 0.1691 0.8498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0105 0.0564 0.0982
Echinococcus granulosus synaptic vesicle 2 protein 0.0048 0.0223 0.1107
Trypanosoma cruzi hexose transporter, putative 0.0106 0.0571 0.8747
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0223 0.1107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0343 0.199 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0105 0.0563 0.2821
Toxoplasma gondii anticodon binding domain-containing protein 0.0012 0.0003 0.0006
Leishmania major histidyl-tRNA synthetase, putative 0.0012 0.0003 0.0005
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0006 0.0012
Brugia malayi beta-lactamase family protein 0.004 0.0171 0.0848
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.2821
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0117 0.0576
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0112 0.0125
Plasmodium falciparum calcium-dependent protein kinase 1 0.0105 0.0564 0.0648
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0039 0.0181
Leishmania major glucose transporter, lmgt1 0.0106 0.0571 0.8747
Echinococcus granulosus General substrate transporter 0.0295 0.1701 0.8545
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0028
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0191
Echinococcus multilocularis solute carrier family 22 0.0048 0.0223 0.022
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0019 0.005 0.0715
Plasmodium falciparum mitogen-activated protein kinase 2 0.0554 0.3256 0.3758
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0012 0.0003 0.0047
Onchocerca volvulus Huntingtin homolog 0.0135 0.0742 0.3755
Schistosoma mansoni sugar transporter 0.0048 0.0223 0.1107
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0878
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0012 0.0003 0.0047
Schistosoma mansoni sugar transporter 0.0048 0.0223 0.1107
Loa Loa (eye worm) sugar transporter 0.0048 0.0223 0.1121
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.045 0.0447
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.012 0.0653 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0105 0.0564 0.0982
Brugia malayi hypothetical protein 0.0048 0.0223 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0176
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0039 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Giardia lamblia Lysyl-tRNA synthetase 0.0077 0.0393 0.7117
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0159 0.0798
Echinococcus multilocularis solute carrier family 22 0.0048 0.0223 0.022
Echinococcus granulosus calcium dependent protein kinase 0.0099 0.0524 0.2625
Leishmania major GTP-binding protein, putative 0.0021 0.0057 0.0835
Trypanosoma cruzi hexose transporter, putative 0.0106 0.0571 0.8747
Brugia malayi hypothetical protein 0.007 0.0352 0.1756
Onchocerca volvulus 0.0048 0.0223 0.0339
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0039 0.0554
Giardia lamblia Threonyl-tRNA synthetase 0.0019 0.005 0.0849
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0159 0.0784
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0078 0.12
Loa Loa (eye worm) hypothetical protein 0.0086 0.045 0.2261
Loa Loa (eye worm) hypothetical protein 0.0032 0.0125 0.0628
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0117 0.176
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0039 0.0557
Mycobacterium ulcerans lipase LipD 0.004 0.0171 0.3769
Trypanosoma brucei glucose transporter 1E 0.0106 0.0571 0.8753
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.045 0.0783
Onchocerca volvulus 0.0048 0.0223 0.0339
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0006 0.0002
Trypanosoma brucei THT1 - hexose transporter, putative 0.0106 0.0571 0.8753
Giardia lamblia Glycyl-tRNA synthetase 0.0019 0.005 0.0849
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0263 0.1321
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0019 0.005 0.083
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.1494 0.1492
Trichomonas vaginalis myo-inositol transporter, putative 0.0048 0.0223 0.1121
Entamoeba histolytica hypothetical protein 0.007 0.0352 0.6225
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0223 0.1121
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0048 0.0223 0.0254
Plasmodium vivax hexose transporter 0.0343 0.199 0.2295
Plasmodium vivax CDK-related protein kinase 6, putative 0.1456 0.8659 1
Plasmodium falciparum proline--tRNA ligase 0.012 0.0653 0.0751
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0628 0.3157
Schistosoma mansoni importin beta-1 0.0028 0.0102 0.0496
Loa Loa (eye worm) hypothetical protein 0.0135 0.0742 0.3731
Leishmania major hypothetical protein, conserved 0.0048 0.0223 0.3384
Loa Loa (eye worm) hypothetical protein 0.0059 0.0288 0.145
Trichomonas vaginalis sugar transporter, putative 0.0106 0.0571 0.2872
Entamoeba histolytica protein kinase, putative 0.0105 0.0563 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.007 0.0351
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0006 0.0002
Leishmania major hypothetical protein, conserved 0.0017 0.0036 0.0508
Treponema pallidum glycyl-tRNA synthetase 0.0012 0.0003 0.0007
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0516 0.2581
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0006 0.0012
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0039 0.0554
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0057 0.0835
Brugia malayi Sugar transporter family protein 0.0048 0.0223 0.1107
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0103 0.0551 0.9773
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0117 0.0205
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0161 0.0797
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0019 0.005 0.083
Mycobacterium ulcerans beta-lactamase 0.004 0.0171 0.3769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Schistosoma mansoni transient receptor potential channel 0.0065 0.0325 0.1619
Mycobacterium leprae Probable lipase LipE 0.004 0.0171 0.2631
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0048 0.0223 0.4921
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.2821
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0006 0.0012
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0105 0.0563 0.2832
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0012 0.0003 0.0005
Entamoeba histolytica protein kinase, putative 0.0105 0.0563 1
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0325 0.1619
Brugia malayi Sugar transporter family protein 0.0048 0.0223 0.1107
Echinococcus multilocularis calcium activated potassium channel 0.0013 0.001 0.0007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0112 0.2431
Echinococcus multilocularis protein patched 0.0041 0.018 0.0177
Toxoplasma gondii sugar transporter ST1 0.0048 0.0223 0.0388
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.0006 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.012 0.0653 0.1137
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0571 0.2872
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0039 0.0554
Echinococcus granulosus snurportin 1 0.0299 0.1724 0.8662
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0515 0.2578
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0117 0.0205
Onchocerca volvulus 0.0048 0.0223 0.0339
Echinococcus multilocularis snurportin 1 0.0299 0.1724 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0105 0.0563 0.863
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0352 0.1756
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0563 0.2832
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0105 0.0563 0.2821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0012 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0862
Mycobacterium ulcerans hypothetical protein 0.0017 0.0036 0.0739
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0057 0.0273
Loa Loa (eye worm) AGC/PKG protein kinase 0.0012 0.0008 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0048 0.0223 0.022
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0019 0.005 0.0234
Loa Loa (eye worm) hypothetical protein 0.0084 0.0435 0.2186
Trichomonas vaginalis glucose transporter, putative 0.0048 0.0223 0.1121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1121
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0105 0.0564 0.0982
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0036 0.0508
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0171 0.0168
Trichomonas vaginalis sugar transporter, putative 0.0106 0.0571 0.2872
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0171 0.2592
Onchocerca volvulus 0.0048 0.0223 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Toxoplasma gondii hypothetical protein 0.003 0.0112 0.0194
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0183 0.0921
Chlamydia trachomatis threonine--tRNA ligase 0.0019 0.005 0.104
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0006 0.0002
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0554 0.3256 0.3758
Onchocerca volvulus 0.0048 0.0223 0.0339
Schistosoma mansoni hypothetical protein 0.004 0.0171 0.0844
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.018 0.0903
Schistosoma mansoni glucose transporter 0.0048 0.0223 0.1107
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.0176
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0325 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0171 0.0956
Toxoplasma gondii aspartate-tRNA ligase 0.0012 0.0003 0.0005
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0078 0.0379
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0105 0.0563 0.2821
Leishmania major importin beta-1 subunit, putative 0.0023 0.007 0.1028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0039 0.0599
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0006 0.0028
Mycobacterium tuberculosis Conserved protein 0.004 0.0171 0.0956
Schistosoma mansoni glucose transport protein 0.0343 0.199 1
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0008 0.0027
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0272 0.1667
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0006 0.0012
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0078 0.0075
Chlamydia trachomatis histidine--tRNA ligase 0.0012 0.0003 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0171 0.0956
Brugia malayi MH2 domain containing protein 0.0116 0.0628 0.3146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0292
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0012 0.0006 0.0028
Onchocerca volvulus 0.0048 0.0223 0.0339
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1724 0.8664
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0272 0.1354
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0244 0.1214
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0019 0.005 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0105 0.0564 0.0648
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0036 0.0508
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0171 0.0862
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0019 0.005 0.0234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0263 0.1308
Toxoplasma gondii glycyl-tRNA synthetase 0.0019 0.005 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0223 0.1121
Echinococcus multilocularis calcium dependent protein kinase 0.0099 0.0524 0.0522
Loa Loa (eye worm) hypothetical protein 0.026 0.1494 0.751
Schistosoma mansoni ran 0.0021 0.0057 0.0273
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0048 0.0223 0.4921
Echinococcus granulosus Protein patched homolog 1 0.0041 0.018 0.0889
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0103 0.0551 0.2756
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.003 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0036 0.0181
Loa Loa (eye worm) hypothetical protein 0.005 0.0235 0.1181
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0151
Plasmodium falciparum importin beta, putative 0.0028 0.0102 0.0114
Trichomonas vaginalis importin beta-1, putative 0.0023 0.007 0.0351
Trypanosoma cruzi hexose transporter, putative 0.0048 0.0223 0.3384
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.045 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0343 0.199 0.1987
Leishmania major glucose transporter/membrane transporter D2, putative 0.0106 0.0571 0.8747
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0752 0.377
Leishmania major myo-inositol/proton symporter (MIT) 0.0048 0.0223 0.3384
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus voltage gated potassium channel 0.0016 0.003 0.0136
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0039 0.0554
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0273
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0012 0.0003 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Plasmodium vivax lysine--tRNA ligase, putative 0.0077 0.0393 0.045
Brugia malayi Egg laying defective protein 4 0.0012 0.0008 0.0027
Plasmodium vivax sugar transporter, putative 0.0048 0.0223 0.0254
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0223 0.1121
Schistosoma mansoni glycyl-tRNA synthetase 0.0019 0.005 0.0234
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0057 0.0063
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0017 0.0036 0.0553
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0008 0.0005
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0012 0.0003 0.0017
Plasmodium falciparum protein kinase 7 0.0969 0.5742 0.663
Schistosoma mansoni histidyl-tRNA synthetase 0.0012 0.0003 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0117 0.0114
Onchocerca volvulus 0.0048 0.0223 0.0339
Entamoeba histolytica hypothetical protein 0.007 0.0352 0.6225
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0117 0.0576
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1452 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0039 0.0599
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0019 0.005 0.0759
Plasmodium falciparum lysine--tRNA ligase 0.0077 0.0393 0.045
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0039 0.0599
Brugia malayi hypothetical protein 0.0048 0.0223 0.1107
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0019 0.005 0.104
Brugia malayi Probable ClpP-like protease 0.0086 0.045 0.2249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Schistosoma mansoni hypothetical protein 0.0299 0.1724 0.8662
Trypanosoma brucei sugar transporter, putative 0.0048 0.0223 0.3415
Echinococcus multilocularis General substrate transporter 0.0295 0.1701 0.1698
Trypanosoma brucei glucose transporter, putative 0.0106 0.0571 0.8753
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0012 0.0003 0.0005
Trichomonas vaginalis esterase, putative 0.004 0.0171 0.0862
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0244 0.1214
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.048 0.2398
Plasmodium falciparum hexose transporter 0.0343 0.199 0.2295
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.003 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0039 0.0196
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0103 0.0551 0.2756
Schistosoma mansoni hypothetical protein 0.0038 0.0159 0.0784
Brugia malayi Importin beta-1 subunit 0.0028 0.0102 0.0496
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0006 0.0012
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.045 0.0516

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.8 nM Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay ChEMBL. 21802950
Ki (binding) = 190 nM Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay ChEMBL. 21802950

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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