TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 423.394 | Formula: C17H15F2N5O4S
H donors: 3 H acceptors: 5 LogP: 1.68 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1n[nH]c2c1cc(cn2)NC(=O)c1c(F)ccc(c1F)NS(=O)(=O)C1CC1
InChi: 1S/C17H15F2N5O4S/c1-28-17-10-6-8(7-20-15(10)22-23-17)21-16(25)13-11(18)4-5-12(14(13)19)24-29(26,27)9-2-3-9/h4-7,9,24H,2-3H2,1H3,(H,21,25)(H,20,22,23)
InChiKey: DJNDCPFUDBEFKM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cpg binding protein	0.0032	0.0388	0.0422
Brugia malayi	glutathione reductase	0.0038	0.0518	0.0518
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0027	0.0262	0.0285
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0018	0.0058	0.0063
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0058	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0018	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.0166	0.3545	0.3851
Brugia malayi	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0018	0.0058	0.0063
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0262	0.0285
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Leishmania major	ATP-dependent phosphofructokinase	0.0108	0.2177	0.3248
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0019	0.0083	0.009
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.1096	0.1096
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.027	0.6001	1
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.2177	0.2365
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0027	0.0262	0.0285
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.027	0.6001	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1096	0.119
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1096	0.119
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.032	0.0441
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.027	0.6001	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0586	0.0586
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0508	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Onchocerca volvulus		0.0236	0.5192	0.5164
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	MH2 domain containing protein	0.0117	0.2393	0.2393
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0058	0.0063
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Loa Loa (eye worm)	RNA binding protein	0.0062	0.1096	0.1096
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0518	1
Onchocerca volvulus	Bile acid receptor homolog	0.0027	0.0262	0.0205
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0018	0.0058	0.0058
Toxoplasma gondii	hypothetical protein	0.0048	0.0773	0.7828
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Leishmania major	tyrosine specific protein phosphatase, putative	0.0018	0.0058	0.0087
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0058	0.0063
Echinococcus granulosus	histone lysine methyltransferase setb	0.0047	0.0745	0.081
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0375	0.8464	0.9194
Brugia malayi	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0027	0.0262	0.0262
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.9206	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0262	0.0262
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.9206	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0018	0.0058	0.0063
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.2177	0.3565
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441
Echinococcus granulosus	FTZ F1 alpha	0.0027	0.0262	0.0285
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0027	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0531	0.0531
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0027	0.0262	0.0285
Brugia malayi	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0518	0.0518
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.1653	0.2084
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0508	0.0757
Onchocerca volvulus		0.0029	0.0305	0.0249
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0018	0.0058	0.0058
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.2978	0.4444
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0027	0.0262	0.0205
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.027	0.6001	0.6001
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.053	0.0576
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.013	0.2704	0.4452
Onchocerca volvulus		0.0027	0.0262	0.0205
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0518	0.0773
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.2704	0.4035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0108	0.2177	0.3038
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.027	0.6001	0.6001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0262	0.0285
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0262	0.0262
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.027	0.6001	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0027	0.0262	0.0285
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0027	0.0262	0.0285
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0108	0.2177	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0627	0.0935
Brugia malayi	Thioredoxin reductase	0.0038	0.0518	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0032	0.0035
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.2177	0.2365
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0027	0.0262	0.0262
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.032	0.6179
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.03	0.6702	1
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0518	0.0518
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1096	0.119
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0027	0.0262	0.0285
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0018	0.0058	0.0058
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0844	0.126
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0018	0.0058	0.0063
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0027	0.0262	0.0285
Schistosoma mansoni	cpg binding protein	0.0029	0.0305	0.0331
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0508	0.9798
Brugia malayi	RNA binding protein	0.0062	0.1096	0.1096
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0346	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.2177	0.3565
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0508	0.0757
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0032	0.0035
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0027	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0508	0.0758
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0346	0.0376
Echinococcus granulosus	cpg binding protein	0.0032	0.0388	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0027	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	ecdysteroid receptor	0.0027	0.0262	0.0262
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0018	0.0058	0.0087
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0058	0.1009	0.1096
Echinococcus multilocularis		0.0018	0.0058	0.0063
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0018	0.0058	0.0063
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0306	0.0332
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.2978	0.4444
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.1878	0.2494
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.1878	0.2494
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Schistosoma mansoni	hypothetical protein	0.002	0.0116	0.0126
Echinococcus granulosus	zinc finger protein	0.0021	0.0129	0.0141
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0027	0.0262	0.0262
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.1878	0.4297
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.053	0.0576
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0027	0.0262	0.0285
Toxoplasma gondii	exonuclease III APE	0.0037	0.0508	0.5143
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0027	0.0262	0.0262
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Brugia malayi	jmjC domain containing protein	0.0058	0.1009	0.1009
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.2704	0.4035
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Mycobacterium ulcerans	6-phosphofructokinase	0.0108	0.2177	0.3038
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0018	0.0058	0.0087
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.2177	0.3248
Schistosoma mansoni	RAR-like nuclear receptor	0.0027	0.0262	0.0285
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0988	1
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0018	0.0058	0.0063
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0027	0.0262	0.0285
Brugia malayi	Pre-SET motif family protein	0.0207	0.4519	0.4519
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0329	0.7401	0.7401
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.013	0.2704	0.4035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	runx1	0.0055	0.0933	0.0933
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.027	0.6001	1
Brugia malayi	6-phosphofructokinase	0.0108	0.2177	0.2177
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.1093	0.1187
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.2177	0.3565
Schistosoma mansoni	hypothetical protein	0.0166	0.3545	0.3851
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0262	0.0262
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.1069	0.1161
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Schistosoma mansoni	bromodomain containing protein	0.0064	0.1152	0.1252
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.032	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Schistosoma mansoni	lozenge	0.0055	0.0933	0.1014
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0518	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Protein-tyrosine phosphatase 1	0.0018	0.0058	0.0058
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0508	0.0758
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0508	0.0757
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0018	0.0058	0.0063
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0199	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0518	0.5248
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.027	0.6001	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0508	0.0508
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Echinococcus multilocularis	hypothetical protein	0.0018	0.0058	0.0063
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0018	0.0058	0.0063
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0058	0.0063
Brugia malayi	Bromodomain containing protein	0.0038	0.0529	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2393	0.2393
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.2177	0.2177
Brugia malayi	jmjC domain containing protein	0.0062	0.1093	0.1093
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441
Brugia malayi	nuclear receptor NHR-88	0.0027	0.0262	0.0262
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0518	1
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0329	0.7401	0.7401
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0058	0.0063
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0018	0.0058	0.0058
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0046	0.0046
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.027	0.6001	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Brugia malayi	photoreceptor-specific nuclear receptor	0.0027	0.0262	0.0262
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0508	0.0552
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0508	0.5
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.032	0.6179
Schistosoma mansoni	hypothetical protein	0.0406	0.9206	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.2177	0.3565
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0058	0.0063
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0058	0.0087
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0474	0.0515
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0027	0.0262	0.0285
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus granulosus	ecdysone induced protein 78C	0.0027	0.0262	0.0285
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.1069	0.1161
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0158	0.3356	0.5185
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0375	0.8464	0.8464
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.1653	0.2084
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0262	0.0262
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0058	0.0087
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0032	0.0035
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0027	0.0262	0.0285
Schistosoma mansoni	coup transcription factor	0.0027	0.0262	0.0285
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.027	0.6001	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0627	0.0935
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0047	0.0745	0.081
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0027	0.0262	0.0262
Schistosoma mansoni	thyroid hormone receptor	0.0027	0.0262	0.0285
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0018	0.0058	0.0063
Brugia malayi	steroid hormone receptor	0.0027	0.0262	0.0262
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.032	0.5
Echinococcus granulosus	tar DNA binding protein	0.0062	0.1096	0.119
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0027	0.0262	0.0285
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.032	0.3243
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.1096	0.1096
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0027	0.0262	0.0285
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1096	0.119
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0027	0.0262	0.0285
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.027	0.6001	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0745	0.081
Leishmania major	trypanothione reductase	0.0038	0.0518	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0058	0.0063
Loa Loa (eye worm)	steroid hormone receptor	0.0027	0.0262	0.0262
Brugia malayi	nuclear hormone receptor	0.0027	0.0262	0.0262
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0058	0.0063
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0627	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.013	0.2704	0.2937
Loa Loa (eye worm)	hypothetical protein	0.044	1	1
Schistosoma mansoni	ap endonuclease	0.0037	0.0508	0.0552
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0027	0.0262	0.0262
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0108	0.2177	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0745	0.0745
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0058	0.1009	0.1096
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.032	0.5
Onchocerca volvulus		0.003	0.0346	0.029
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.013	0.2704	0.2704
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0058	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0027	0.0262	0.0262
Echinococcus multilocularis	lysine specific demethylase 5A	0.0058	0.1009	0.1096
Schistosoma mansoni	cpg binding protein	0.0032	0.0388	0.0422
Plasmodium vivax	SET domain protein, putative	0.003	0.0346	0.6681
Echinococcus granulosus	geminin	0.0166	0.3545	0.3851
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0116	0.0116
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0199	0.0216
Brugia malayi	Pre-SET motif family protein	0.003	0.0346	0.0346
Echinococcus multilocularis	geminin	0.0166	0.3545	0.3851
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.027	0.6001	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.1093	0.1187
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0058	0.0063
Schistosoma mansoni	pcd6 interacting protein-related	0.0018	0.0058	0.0063
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0669	0.0669
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0508	0.0552
Brugia malayi	TAR-binding protein	0.0062	0.1096	0.1096
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0032	0.0035
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.032	0.6179
Brugia malayi	Bromodomain containing protein	0.0076	0.1427	0.1427
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.1878	0.2494
Leishmania major	mitochondrial DNA polymerase beta	0.03	0.6702	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0375	0.8464	0.9194
Echinococcus multilocularis	6 phosphofructokinase	0.0108	0.2177	0.2365
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0058	0.0063
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0508	0.9798
Brugia malayi	6-phosphofructokinase	0.0108	0.2177	0.2177
Plasmodium falciparum	glutathione reductase	0.0038	0.0518	1
Mycobacterium ulcerans	hypothetical protein	0.0158	0.3356	0.5185
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.2177	0.3565
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0027	0.0262	0.0262
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.032	0.6179
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0027	0.0262	0.0262
Echinococcus multilocularis	ecdysone induced protein 78C	0.0027	0.0262	0.0285
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0518	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Echinococcus granulosus	transcription factor Dp 1	0.0075	0.1411	0.1532
Schistosoma mansoni	ap endonuclease	0.0037	0.0508	0.0552
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.2177	0.2177
Onchocerca volvulus		0.027	0.6001	0.5978
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0305	0.0305
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0027	0.0262	0.0262
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0346	0.0376
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0508	0.0757
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0027	0.0262	0.0285
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0508	0.101
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.1096	0.1096
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0474	0.0515
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0027	0.0262	0.0262
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.1093	0.1093
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0047	0.0745	0.081
Schistosoma mansoni	jumonji domain containing protein	0.0058	0.1009	0.1096
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Schistosoma mansoni	zinc finger protein	0.0021	0.0129	0.0141
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0508	0.0758
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.2177	0.3248
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Schistosoma mansoni	thyroid hormone receptor	0.0027	0.0262	0.0285
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.013	0.2704	0.2937
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2393	0.2393
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.1096	0.119
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.03	0.6702	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.1096	0.119
Echinococcus multilocularis	FTZ F1 alpha	0.0027	0.0262	0.0285
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.013	0.2704	0.2937
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1084	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.03	0.6702	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0627	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.1653	0.2084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0375	0.8464	0.8464
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0058	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	cpg binding protein	0.0032	0.0388	0.0422
Brugia malayi	Steroid receptor seven-up type 2	0.0027	0.0262	0.0262
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0508	0.0508
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0199	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0329	0.7401	0.7401
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0019	0.0083	0.009
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0027	0.0262	0.0285
Loa Loa (eye worm)	phosphofructokinase	0.0108	0.2177	0.2177
Echinococcus multilocularis	zinc finger protein	0.0021	0.0129	0.0141
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0027	0.0262	0.0285
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.013	0.2704	0.2704
Onchocerca volvulus		0.044	1	1
Echinococcus granulosus	6 phosphofructokinase	0.0108	0.2177	0.2365
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0346	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0058	0.0058
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.032	0.3243
Brugia malayi	hypothetical protein	0.0018	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.007	0.1288	0.1288
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.032	0.0441
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0058	0.0063
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0018	0.0058	0.0063
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.2177	0.3565
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0058	0.0058
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0018	0.0058	0.0063
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	Protein lozenge	0.0055	0.0933	0.1014
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.1653	0.2084
Trypanosoma brucei	trypanothione reductase	0.0038	0.0518	0.0773
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.1093	0.1187
Mycobacterium tuberculosis	Probable reductase	0.0086	0.1653	0.2084
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0018	0.0058	0.0058
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0375	0.8464	0.9194
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.027	0.6001	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0142	0.2978	0.4444
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0018	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0058	0.0063
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0058	0.0063
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.2177	0.3565
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0027	0.0262	0.0262
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0027	0.0262	0.0262
Brugia malayi	hypothetical protein	0.0018	0.0058	0.0058
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0027	0.0262	0.0285
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0027	0.0262	0.0285
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0058	0.0063
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.4519	0.4519
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.013	0.2704	0.4035
Brugia malayi	phosphofructokinase	0.0108	0.2177	0.2177
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0262	0.0285
Onchocerca volvulus	Protein ultraspiracle homolog	0.0027	0.0262	0.0205
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0058	0.0063
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0058	0.0063
Schistosoma mansoni	nuclear hormone receptor	0.0027	0.0262	0.0285
Loa Loa (eye worm)	hypothetical protein	0.044	1	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.032	0.3243
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0058	0.0087
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.5192	0.8638
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	transcription factor Dp 1	0.0075	0.1411	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Brugia malayi	PHD-finger family protein	0.0026	0.0254	0.0254
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.1653	0.2084
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0027	0.0262	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0058	0.0058
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0058	0.0063
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.032	0.0441

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1822092

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1041198