TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.545 | Formula: C22H25N7O2S
H donors: 2 H acceptors: 6 LogP: 2.78 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: N#CCNC(=O)[C@@H](NC(=O)c1cc(nn1C)C(C)(C)C)Cc1cccc(c1)c1nncs1
InChi: 1S/C22H25N7O2S/c1-22(2,3)18-12-17(29(4)28-18)20(31)26-16(19(30)24-9-8-23)11-14-6-5-7-15(10-14)21-27-25-13-32-21/h5-7,10,12-13,16H,9,11H2,1-4H3,(H,24,30)(H,26,31)/t16-/m0/s1
InChiKey: ACGFKLACOBPYKQ-INIZCTEOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin V	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0977	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0077	0.168	0.325
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1382	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5167	0.5167
Entamoeba histolytica	hypothetical protein	0.0042	0.0541	0.1914
Echinococcus granulosus	histone acetyltransferase MYST2	0.0063	0.1223	0.1973
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0036	0.0346	0.067
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0112	0.2792	0.2792
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Echinococcus granulosus	polycomb protein SCMH1	0.0055	0.0977	0.1576
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0346	0.067
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0113	0.2825	1
Brugia malayi	CHE-14 protein	0.0047	0.0718	0.139
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2825	0.5467
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0494	0.0797
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0186	0.5167	1
Entamoeba histolytica	cysteine protease, putative	0.0113	0.2825	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0361	0.0698
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0494	0.1749
Brugia malayi	mbt repeat family protein	0.0055	0.0977	0.1891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2825	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5167	0.5167
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1145	0.4054
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0494	0.0956
Plasmodium vivax	vivapain-2	0.0113	0.2825	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0061	0.1145	0.4054
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0361	0.0698
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Onchocerca volvulus		0.0055	0.0977	0.346
Mycobacterium leprae	Probable lipase LipE	0.004	0.0494	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0077	0.168	0.168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0664	0.0664
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0036	0.0361	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0346	0.067
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2825	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.1145	0.2216
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.005	0.0794	0.1537
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0718	0.1159
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0113	0.2825	0.4555
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0571	0.1105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Plasmodium vivax	unspecified product	0.0061	0.1145	0.4054
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.0794	0.1537
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0977	0.0977
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0186	0.5167	0.5167
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0036	0.0361	0.0698
Leishmania major	cysteine peptidase A (CPA)	0.0113	0.2825	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0494	0.0956
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0718	0.139
Loa Loa (eye worm)	cathepsin B	0.0075	0.1598	0.3093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Schistosoma mansoni	hypothetical protein	0.0196	0.5512	0.5512
Schistosoma mansoni	lamin	0.003	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trypanosoma cruzi	cruzipain precursor, putative	0.0113	0.2825	0.5467
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0346	0.067
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0055	0.0977	0.1576
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2825	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1382	1
Trypanosoma cruzi	cysteine protease, putative	0.0061	0.1145	0.2216
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0718	0.2543
Schistosoma mansoni	hypothetical protein	0.0196	0.5512	0.5512
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1382	1
Brugia malayi	cathepsin L-like precursor	0.0077	0.168	0.325
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0113	0.2825	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Onchocerca volvulus	Cathepsin F homolog	0.0113	0.2825	1
Brugia malayi	hypothetical protein	0.0042	0.0541	0.1047
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0075	0.1598	0.3093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.2737	0.4414
Echinococcus multilocularis	protein patched	0.0047	0.0718	0.1159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1145	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0361	0.0698
Schistosoma mansoni	hypothetical protein	0.0046	0.0664	0.0664
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.005	0.0794	0.0794
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0061	0.1145	0.2216
Echinococcus granulosus	cathepsin b	0.0186	0.5167	0.8333
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0718	0.139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0346	0.067
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0036	0.0361	0.0698
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0063	0.1223	0.1973
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2825	0.5467
Brugia malayi	cathepsin B-like cysteine proteinase	0.0186	0.5167	1
Brugia malayi	Cathepsin L-like precursor	0.0077	0.168	0.325
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0036	0.0363	0.0703
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0061	0.1145	0.4054
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0063	0.1223	0.1223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Brugia malayi	intermediate filament protein	0.003	0.017	0.0328
Onchocerca volvulus		0.004	0.0494	0.1749
Echinococcus granulosus	serine protein kinase ATM	0.005	0.0794	0.1281
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0794	0.2811
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Brugia malayi	Cathepsin L-like precursor	0.0077	0.168	0.325
Loa Loa (eye worm)	hypothetical protein	0.0077	0.168	0.325
Brugia malayi	mbt repeat family protein	0.0055	0.0977	0.1891
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1145	0.2216
Onchocerca volvulus		0.0113	0.2825	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2825	0.2825
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1145	0.4054
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Echinococcus multilocularis	cysteine protease	0.0113	0.2825	0.4555
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0186	0.5167	0.5167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Echinococcus multilocularis	lamin	0.003	0.017	0.0273
Schistosoma mansoni	sex comb on midleg homolog	0.0055	0.0977	0.0977
Echinococcus granulosus	expressed conserved protein	0.0103	0.2523	0.4068
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.168	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0718	0.1159
Schistosoma mansoni	hypothetical protein	0.0046	0.0664	0.0664
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.017	0.0328
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0541	0.0872
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Loa Loa (eye worm)	hypothetical protein	0.003	0.0152	0.0294
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0036	0.0361	0.1278
Brugia malayi	beta-lactamase family protein	0.004	0.0494	0.0956
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2825	0.4555
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1145	0.2216
Echinococcus granulosus	SAM and MBT domain containing protein	0.0055	0.0977	0.1576
Onchocerca volvulus		0.004	0.0494	0.1749
Echinococcus multilocularis	lamin dm0	0.003	0.017	0.0273
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2825	0.4555
Echinococcus granulosus	cysteine protease	0.0061	0.1145	0.1847
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0113	0.2825	0.4555
Echinococcus granulosus	cathepsin l1	0.0113	0.2825	0.4555
Plasmodium vivax	vivapain-1	0.0061	0.1145	0.4054
Leishmania major	hypothetical protein, conserved	0.004	0.0494	0.0541
Onchocerca volvulus		0.0113	0.2825	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2825	0.5467
Onchocerca volvulus		0.0113	0.2825	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0113	0.2825	0.5467
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0494	0.0541
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0055	0.0977	0.0977
Echinococcus multilocularis	Niemann Pick C1 protein	0.0157	0.4255	0.6861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1145	0.3183
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0075	0.1598	0.5021
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.1382	0.1274
Loa Loa (eye worm)	hypothetical protein	0.0077	0.168	0.325
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.0361	0.1278
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0113	0.2825	0.4555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.005	0.0794	0.1758
Toxoplasma gondii	cathepsin CPL	0.0113	0.2825	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0218	0.6201	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0257	0.7463	1
Echinococcus multilocularis	serine protein kinase ATM	0.005	0.0794	0.1281
Trypanosoma cruzi	cysteine proteinase, putative	0.0061	0.1145	0.2216
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Schistosoma mansoni	hypothetical protein	0.0046	0.0664	0.0664
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.1382	0.2228
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0494	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0541	0.0541
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0494	0.0797
Giardia lamblia	Cathepsin B precursor	0.0075	0.1598	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0077	0.168	0.325
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0494	0.1749
Giardia lamblia	Cathepsin B precursor	0.0075	0.1598	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus multilocularis	polycomb protein SCMH1	0.0055	0.0977	0.1576
Schistosoma mansoni	intermediate filament proteins	0.003	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.1382	0.4892
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0036	0.0361	0.0582
Brugia malayi	Papain family cysteine protease containing protein	0.0113	0.2825	0.5467
Loa Loa (eye worm)	intermediate filament protein	0.003	0.017	0.0328
Plasmodium vivax	unspecified product	0.0036	0.0346	0.1225
Onchocerca volvulus		0.0113	0.2825	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0113	0.2825	0.4555
Loa Loa (eye worm)	ctsf protein	0.0113	0.2825	0.5467
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0494	0.0956
Echinococcus granulosus	cathepsin l1	0.0077	0.168	0.2708
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0541	0.0872
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Echinococcus granulosus	cathepsin b	0.0186	0.5167	0.8333
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.106	0.2051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus granulosus	intermediate filament protein	0.003	0.017	0.0273
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.017	0.0328
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.1382	0.4144
Giardia lamblia	Cathepsin B precursor	0.0075	0.1598	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0494	0.1749
Brugia malayi	Papain family cysteine protease containing protein	0.0061	0.1145	0.2216
Echinococcus granulosus	cathepsin L cysteine protease	0.0061	0.1145	0.1847
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.011	0.2737	0.969
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1223	0.2367
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.1145	0.3183
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1382	0.1382
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0494	0.1749
Onchocerca volvulus		0.0077	0.168	0.5946
Entamoeba histolytica	hypothetical protein	0.005	0.0794	0.2811
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.2737	0.4414
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Echinococcus multilocularis	cathepsin b	0.0186	0.5167	0.8333
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Toxoplasma gondii	cathepsin B	0.0075	0.1598	0.5658
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1145	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0061	0.1145	0.4054
Brugia malayi	beta-lactamase family protein	0.004	0.0494	0.0956
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0346	0.067
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0494	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0113	0.2825	0.5467
Entamoeba histolytica	hypothetical protein	0.0042	0.0541	0.1914
Loa Loa (eye worm)	fibroinase	0.0113	0.2825	0.5467
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0075	0.1598	0.5658
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Onchocerca volvulus		0.0113	0.2825	1
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0541	0.1914
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0036	0.0361	0.0698
Toxoplasma gondii	ABC1 family protein	0.004	0.0494	0.1749
Loa Loa (eye worm)	hypothetical protein	0.004	0.0494	0.0956
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1145	0.1145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0113	0.2825	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0541	0.1914
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0361	0.0698
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.1382	0.2228
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0036	0.0361	0.0582
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0036	0.0361	0.0361
Echinococcus granulosus	lamin	0.003	0.017	0.0273
Echinococcus multilocularis	geminin	0.0196	0.5512	0.8888
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1145	0.1145
Plasmodium vivax	vivapain-3	0.0061	0.1145	0.4054
Loa Loa (eye worm)	MBCTL1	0.0063	0.1223	0.2367
Schistosoma mansoni	cathepsin s	0.0036	0.0346	0.0346
Schistosoma mansoni	hypothetical protein	0.0042	0.0541	0.0541
Echinococcus multilocularis	cysteine protease	0.0113	0.2825	0.4555
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0061	0.1145	0.1145
Loa Loa (eye worm)	hypothetical protein	0.0186	0.5167	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.011	0.2737	0.5297
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0036	0.0361	0.0698
Echinococcus multilocularis	protein dispatched 1	0.0054	0.0933	0.1504
Onchocerca volvulus		0.003	0.017	0.06
Plasmodium vivax	vivapain-2	0.0113	0.2825	1
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0718	0.1159
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0113	0.2825	1
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0494	0.0494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0036	0.0361	0.0361
Schistosoma mansoni	patched 1	0.0047	0.0718	0.0718
Trichomonas vaginalis	esterase, putative	0.004	0.0494	0.1749
Onchocerca volvulus		0.003	0.017	0.06
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0043	0.0571	0.1105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0113	0.2825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0077	0.168	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0346	0.067
Entamoeba histolytica	cysteine proteinase 2	0.0061	0.1145	0.4054
Echinococcus multilocularis	musashi	0.003	0.017	0.0273
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Trypanosoma cruzi	cruzipain precursor, putative	0.0036	0.0346	0.067
Onchocerca volvulus		0.0113	0.2825	1
Schistosoma mansoni	lamin	0.003	0.017	0.017
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0063	0.1223	0.1973
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0077	0.168	0.325
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Giardia lamblia	GTOR	0.0036	0.0361	0.2258
Echinococcus multilocularis	expressed conserved protein	0.0103	0.2523	0.4068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1382	0.1382
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0113	0.2825	1
Echinococcus multilocularis	cathepsin L	0.0061	0.1145	0.1847
Leishmania major	cathepsin L-like protease	0.0113	0.2825	1
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0113	0.2825	0.2825
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Brugia malayi	beta-lactamase	0.004	0.0494	0.0956
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0063	0.1223	0.1973
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0036	0.0361	0.0698
Echinococcus granulosus	lamin dm0	0.003	0.017	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0113	0.2825	1
Onchocerca volvulus		0.004	0.0494	0.1749
Entamoeba histolytica	cysteine protease, putative	0.0061	0.1145	0.4054
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0063	0.1223	0.2367
Loa Loa (eye worm)	beta-lactamase	0.004	0.0494	0.0956
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0113	0.2825	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0036	0.0363	0.0009
Onchocerca volvulus		0.0113	0.2825	1
Loa Loa (eye worm)	mbt repeat family protein	0.0055	0.0977	0.1891
Entamoeba histolytica	cysteine proteinase, putative	0.0113	0.2825	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0075	0.1598	0.5021
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0494	0.1749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0061	0.1145	0.4054
Toxoplasma gondii	FATC domain-containing protein	0.005	0.0794	0.2811
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.017	0.0328
Entamoeba histolytica	cysteine proteinase, putative	0.0077	0.168	0.5946
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0055	0.0977	0.346
Echinococcus multilocularis	cathepsin b	0.0186	0.5167	0.8333
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0346	0.067
Echinococcus granulosus	Niemann Pick C1 protein	0.0157	0.4255	0.6861
Onchocerca volvulus	Cathepsin L homolog	0.0113	0.2825	1
Echinococcus granulosus	cathepsin L	0.0061	0.1145	0.1847
Loa Loa (eye worm)	hypothetical protein	0.011	0.2737	0.5297
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0036	0.0361	0.0582
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0494	0.1749
Loa Loa (eye worm)	cysteine protease	0.0113	0.2825	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Trypanosoma cruzi	cysteine peptidase, putative	0.0113	0.2825	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0113	0.2825	0.5467
Echinococcus granulosus	geminin	0.0196	0.5512	0.8888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0361	0.1278
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0494	0.0494
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0218	0.6201	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0075	0.1598	0.1598

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 5	Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 6.9	Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 7.8	Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 8.2	Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430
IC50 (binding)	= 8.3	Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage	ChEMBL.	19616430

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549378

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1043493