Detailed information for compound 1051287

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.478 | Formula: C23H27N3O4
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1ccnc(c1)Oc1ccc(c2c1CCC2)C)\N1CCC(CC1)C(=O)OC
  • InChi: 1S/C23H27N3O4/c1-15-6-7-20(19-5-3-4-18(15)19)30-21-14-17(8-11-24-21)22(25-28)26-12-9-16(10-13-26)23(27)29-2/h6-8,11,14,16,28H,3-5,9-10,12-13H2,1-2H3/b25-22-
  • InChiKey: FPHZQSKZRDIFFY-LVWGJNHUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.001
Echinococcus multilocularis snurportin 1 0.0348 0.496 0.4944
Onchocerca volvulus 0.0058 0.059 0.0822
Loa Loa (eye worm) hypothetical protein 0.0047 0.0411 0.0632
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0063 0.0033
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0058 0.0589 0.2031
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0201 0.2612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0462 0.0432
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.03 0.027
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0589 0.0847
Echinococcus multilocularis long chain fatty acid transport protein 4 0.02 0.2719 0.2696
Echinococcus granulosus intermediate filament protein 0.0058 0.059 0.056
Entamoeba histolytica acyl-coA synthetase, putative 0.0058 0.0589 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0042 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0468
Schistosoma mansoni FFA transport protein 0.02 0.2719 0.2696
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.031
Entamoeba histolytica hypothetical protein 0.0037 0.0271 0.3947
Schistosoma mansoni lamin 0.0058 0.059 0.056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 0.496 0.7636
Loa Loa (eye worm) hypothetical protein 0.0258 0.3601 0.5544
Echinococcus multilocularis lamin 0.0058 0.059 0.056
Echinococcus multilocularis tumor protein p63 0.0334 0.4748 0.4732
Loa Loa (eye worm) hypothetical protein 0.0058 0.0589 0.0906
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0219 0.3003 1
Echinococcus granulosus lamin 0.0058 0.059 0.056
Schistosoma mansoni hypothetical protein 0.0143 0.187 0.1844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0042 0.0064
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0134 0.0103
Entamoeba histolytica hypothetical protein 0.0037 0.0271 0.3947
Echinococcus granulosus snurportin 1 0.0348 0.496 0.4944
Brugia malayi intermediate filament protein 0.0058 0.059 0.085
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0201 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0271 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0235 0.0664
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0108 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0042 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0304 0.0819
Entamoeba histolytica hypothetical protein 0.0037 0.0271 0.3947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0042 0.0064
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.059 0.085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.001
Echinococcus granulosus GPCR family 2 0.0066 0.0709 0.068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.056 0.053
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0271 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0709 0.068
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0589 0.0847
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0108 0.0068
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0271 0.024
Brugia malayi MH2 domain containing protein 0.0256 0.3563 0.5456
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.0908
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0462 0.0711
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0058 0.0589 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0042 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0058 0.0589 0.2031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0207
Schistosoma mansoni hypothetical protein 0.0175 0.2352 0.2328
Leishmania major importin beta-1 subunit, putative 0.0026 0.0108 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0709 0.1034
Trichomonas vaginalis ran, putative 0.0024 0.0071 0.0012
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0462 0.0432
Schistosoma mansoni hypothetical protein 0.0053 0.0503 0.0473
Schistosoma mansoni importin beta-1 0.0033 0.0201 0.017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0709 0.1092
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0304 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0873 0.0844
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.3737 0.5726
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2494 0.3656
Schistosoma mansoni hypothetical protein 0.0023 0.0049 0.0017
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0042 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0071 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0042 0.001
Schistosoma mansoni microtubule-associated protein tau 0.0683 1 1
Brugia malayi Bromodomain containing protein 0.0042 0.0339 0.0461
Loa Loa (eye worm) hypothetical protein 0.0044 0.0379 0.0584
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0235 0.0664
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0042 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0042 0.0064
Leishmania major 4-coumarate:coa ligase-like protein 0.0058 0.0589 0.2031
Onchocerca volvulus 0.0058 0.0589 0.082
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0071 0.004
Loa Loa (eye worm) hypothetical protein 0.0077 0.0873 0.1343
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0058 0.0589 0.1787
Brugia malayi PHD-finger family protein 0.0027 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0033
Schistosoma mansoni hypothetical protein 0.0066 0.0709 0.068
Onchocerca volvulus 0.0023 0.0063 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0873 0.0844
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0304 0.4554
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0058 0.0589 0.1787
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0058 0.0589 0.1787
Loa Loa (eye worm) hypothetical protein 0.0058 0.0589 0.0906
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0709 0.068
Loa Loa (eye worm) intermediate filament protein 0.0058 0.059 0.0908
Onchocerca volvulus 0.0023 0.0063 0.0032
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0181 0.0216
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0709 0.068
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0195 0.265 1
Plasmodium falciparum importin beta, putative 0.0033 0.0201 0.5734
Brugia malayi RNA, U transporter 1 0.0093 0.1108 0.1652
Echinococcus multilocularis lamin dm0 0.0058 0.059 0.056
Plasmodium vivax SET domain protein, putative 0.0059 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0691 0.0662
Schistosoma mansoni hypothetical protein 0.0037 0.0271 0.024
Onchocerca volvulus 0.0049 0.0447 0.0607
Mycobacterium ulcerans hypothetical protein 0.0058 0.0589 0.1787
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.008 0.0049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.03 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0042 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0042 0.001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0071 0.0157
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0042 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0589 0.1787
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0042 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0592 0.0563
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0304 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0468
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.2352 0.3463
Entamoeba histolytica Ran family GTPase 0.0024 0.0071 0.0158
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.3601 0.3581
Echinococcus granulosus importin subunit beta 1 0.0033 0.0201 0.017
Brugia malayi Importin beta-1 subunit 0.0033 0.0201 0.0247
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0182
Loa Loa (eye worm) hypothetical protein 0.0058 0.0589 0.0906
Schistosoma mansoni hypothetical protein 0.0175 0.2352 0.2328
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.3737 0.5753
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0042 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0108 0.0068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0574 0.0884
Schistosoma mansoni hypothetical protein 0.0348 0.496 0.4944
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0063 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.059 0.0908
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0589 0.1787
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0134 0.0103
Echinococcus multilocularis GPCR, family 2 0.0066 0.0709 0.068
Schistosoma mansoni ran 0.0024 0.0071 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Schistosoma mansoni hypothetical protein 0.0066 0.0709 0.068
Brugia malayi hypothetical protein 0.0258 0.3601 0.5515
Loa Loa (eye worm) hypothetical protein 0.0049 0.0447 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0462 0.0432
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0709 0.1092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0058 0.0589 0.2031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0063 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0589 0.1787
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.008 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0709 0.068
Brugia malayi Pre-SET motif family protein 0.0059 0.0592 0.0853
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0592 0.0563
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0042 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0235 0.0664
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0063 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0042 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0462 0.0432
Entamoeba histolytica hypothetical protein 0.0026 0.0108 0.0859
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0462 0.0432
Schistosoma mansoni hypothetical protein 0.0066 0.0709 0.068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.2869 0.4381
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0592 0.0563
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0042 0.001
Plasmodium vivax importin-beta 2, putative 0.0033 0.0201 0.2612
Schistosoma mansoni survival motor neuron protein 0.0053 0.0503 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0873 0.0844
Schistosoma mansoni intermediate filament proteins 0.0058 0.059 0.056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0462 0.0432
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0201 0.017
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0058 0.0589 0.2031
Echinococcus granulosus tumor protein p63 0.0334 0.4748 0.4732
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0063 0.0032
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0235 0.0664
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0108 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Loa Loa (eye worm) hypothetical protein 0.045 0.6496 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.06
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.2352 0.3442
Schistosoma mansoni bromodomain containing protein 0.0069 0.075 0.0721
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0049 0.0075
Loa Loa (eye worm) oxidoreductase 0.0023 0.0063 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0219 0.3003 0.4589
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0589 0.0847
Onchocerca volvulus 0.0053 0.0503 0.0692
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.02 0.2719 1
Echinococcus granulosus lamin dm0 0.0058 0.059 0.056
Schistosoma mansoni hypothetical protein 0.0066 0.0709 0.068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0462 0.0651
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0592 1
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0031
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0447 0.0417
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.2494 0.3656
Loa Loa (eye worm) hypothetical protein 0.0077 0.0873 0.1343
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0873 0.0844
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.02 0.2719 1
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0462 0.0432
Schistosoma mansoni ran 0.0024 0.0071 0.004
Echinococcus granulosus long chain fatty acid transport protein 4 0.02 0.2719 0.2696
Echinococcus granulosus geminin 0.0175 0.2352 0.2328
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0042 0.001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0063 0.0033
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0503 0.0715
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0042 0.001
Onchocerca volvulus 0.045 0.6496 0.9673
Onchocerca volvulus 0.0023 0.0063 0.0032
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.187 0.2832
Brugia malayi Bromodomain containing protein 0.0082 0.0943 0.1396
Echinococcus multilocularis geminin 0.0175 0.2352 0.2328
Schistosoma mansoni lamin 0.0058 0.059 0.056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0042 0.001
Leishmania major GTP-binding protein, putative 0.0024 0.0071 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.2869 0.4417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0042 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0589 0.1787
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.3563 0.5485
Entamoeba histolytica hypothetical protein 0.0037 0.0271 0.3947
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0031
Echinococcus multilocularis musashi 0.0058 0.059 0.056
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0201 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0063 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0195 0.265 1
Brugia malayi hypothetical protein 0.045 0.6496 1
Loa Loa (eye worm) hypothetical protein 0.021 0.2869 0.4417
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0691 0.0662
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.3601 0.3581
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.2869 0.4381
Onchocerca volvulus 0.0465 0.6714 1
Leishmania major fatty acid transporter protein-like protein 0.0195 0.265 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0468
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0219 0.3003 0.4624
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.008 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.001
Echinococcus multilocularis microtubule associated protein 2 0.0683 1 1
Brugia malayi Pre-SET motif family protein 0.0408 0.5863 0.902
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0042 0.001
Trichomonas vaginalis set domain proteins, putative 0.0465 0.6714 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.001
Loa Loa (eye worm) hypothetical protein 0.0143 0.187 0.2878
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0304 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.3737 0.5524
Onchocerca volvulus 0.0058 0.059 0.0822
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0042 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0058 0.0589 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.5863 0.9027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0042 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0063 0.0033
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0181 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0589 0.2031
Brugia malayi hypothetical protein 0.0037 0.0271 0.0354
Leishmania major 4-coumarate:coa ligase-like protein 0.0058 0.0589 0.2031
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0071 0.004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0064
Schistosoma mansoni coup transcription factor 0.0022 0.0042 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0042 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0042 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0709 0.1034
Onchocerca volvulus 0.0059 0.0592 0.0825
Loa Loa (eye worm) hypothetical protein 0.0042 0.034 0.0524
Onchocerca volvulus 0.0023 0.0063 0.0032
Loa Loa (eye worm) hypothetical protein 0.0039 0.0304 0.0468
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0042 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.3563 0.5485

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 11 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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