Detailed information for compound 1054304

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 375.42 | Formula: C22H21N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Oc1nccc(c1)/C(=N/O)/N1Cc2c(C1)cccc2
  • InChi: 1S/C22H21N3O3/c1-2-27-19-7-9-20(10-8-19)28-21-13-16(11-12-23-21)22(24-26)25-14-17-5-3-4-6-18(17)15-25/h3-13,26H,2,14-15H2,1H3/b24-22-
  • InChiKey: APNVTIWVOJRCKA-GYHWCHFESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans heat shock protein 90 0.0055 0.0308 0.3109
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0292 0.0336
Brugia malayi beta-lactamase 0.0036 0.0088 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0388 0.0388
Leishmania major hypothetical protein, conserved 0.0028 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0493 0.0681
Schistosoma mansoni coup transcription factor 0.0053 0.0292 0.0292
Mycobacterium tuberculosis Probable reductase 0.0636 0.7051 0.8943
Plasmodium vivax importin-beta 2, putative 0.0061 0.0382 0.1314
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0165 0.0098
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0053 0.0073
Schistosoma mansoni heat shock protein 0.0069 0.047 0.047
Schistosoma mansoni heat shock protein 0.0069 0.047 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Leishmania major trypanothione reductase 0.0279 0.2908 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.009 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.031
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0258 0.0297
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0872 0.1205
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.009 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0707 0.7874 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0292 0.0336
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0292 0.0336
Plasmodium falciparum endoplasmin, putative 0.0042 0.0162 0.0558
Giardia lamblia NADH oxidase lateral transfer candidate 0.0097 0.0794 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0258 0.0258
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Echinococcus granulosus GPCR family 2 0.0033 0.0053 0.0061
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0097 0.0794 0.0907
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0165 0.0353
Brugia malayi mbt repeat family protein 0.005 0.0258 0.0552
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0088 0.0304
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0292 0.0292
Treponema pallidum NADH oxidase 0.0097 0.0794 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.0388 0.0536
Loa Loa (eye worm) hypothetical protein 0.0028 0 0.0001
Trichomonas vaginalis ran, putative 0.0045 0.0195 0.0363
Loa Loa (eye worm) thioredoxin reductase 0.0279 0.2908 0.4018
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0165 0.3508
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0292 0.0404
Echinococcus granulosus heat shock protein 0.0069 0.047 0.054
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0165 0.1083
Brugia malayi hypothetical protein 0.0028 0.0003 0.0007
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.047 0.1617
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0165 0.0307
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0165 0.0567
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0292 0.0292
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0195 0.0224
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0088 0.0165
Trypanosoma brucei unspecified product 0.0042 0.0165 0.0567
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Trypanosoma brucei hypothetical protein 0.0118 0.1045 0.3594
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0097 0.0794 1
Brugia malayi MH2 domain containing protein 0.0122 0.1088 0.2326
Schistosoma mansoni alpha glucosidase 0.0036 0.009 0.009
Toxoplasma gondii heat shock protein HSP90 0.0069 0.047 0.1617
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0292 0.0292
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0053 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0812 0.1737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0812 0.0812
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.2025 0.2327
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0339 0.039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0292 0.0336
Brugia malayi steroid hormone receptor 0.0053 0.0292 0.0625
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0097 0.0794 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0195 0.0224
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0165 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Brugia malayi nuclear hormone receptor 0.0053 0.0292 0.0625
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0097 0.0794 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.009 0.031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0292 0.0336
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0055 0.0308 0.0354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0292 0.0404
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1551 0.1783
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0308 0.0574
Loa Loa (eye worm) heat shock protein 90 0.0069 0.047 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0812 0.0934
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0088 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0292 0.0404
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.1551 0.1783
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0279 0.2908 0.3621
Onchocerca volvulus 0.005 0.0258 0.0481
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0636 0.7051 0.8943
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0162 0.0302
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0097 0.0794 0.2732
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0195 0.0671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0872 0.1865
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Toxoplasma gondii thioredoxin reductase 0.0279 0.2908 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0292 0.0292
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0097 0.0794 0.2732
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0382 0.1314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0812 0.0934
Trichomonas vaginalis mercuric reductase, putative 0.0097 0.0794 0.148
Brugia malayi tumor suppressor. 0.034 0.3615 0.7728
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0097 0.0794 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0292 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0292 0.0404
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0097 0.0794 0.2732
Onchocerca volvulus 0.0036 0.0088 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0292 0.0292
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0248 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0088 0.0304
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0055 0.0308 0.1059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0812 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0088 0.0088
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0162 0.0302
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0097 0.0794 0.2732
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0308 0.1059
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0088 0.0304
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0391 0.0391
Brugia malayi nuclear receptor NHR-88 0.0053 0.0292 0.0625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0292 0.0404
Brugia malayi Endoplasmin precursor 0.0069 0.047 0.1005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0088 0.0304
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0003 0.0011
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Brugia malayi ecdysteroid receptor 0.0053 0.0292 0.0625
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0292 0.0336
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0165 0.0567
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0339 0.039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0365 0.0419
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Echinococcus multilocularis thioredoxin glutathione reductase 0.028 0.292 0.3356
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0292 0.0625
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.1045 0.3594
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0292 0.0336
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0308 0.0574
Echinococcus granulosus thioredoxin glutathione reductase 0.028 0.292 0.3356
Giardia lamblia Heat shock protein HSP 90-alpha 0.0069 0.047 0.485
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0071 0.0497 0.1062
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.009 0.1918
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0003 0.0011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0165 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.009 0.0168
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Loa Loa (eye worm) hypothetical protein 0.0103 0.0872 0.1205
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Loa Loa (eye worm) hypothetical protein 0.0028 0 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0636 0.7051 0.8943
Loa Loa (eye worm) hypothetical protein 0.0028 0 0.0001
Giardia lamblia Grp94/Hsp90 0.0055 0.0308 0.2272
Brugia malayi hypothetical protein 0.0028 0 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0391 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0292 0.0625
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0382 0.1314
Echinococcus multilocularis heat shock protein 90 0.0069 0.047 0.054
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0388 0.0446
Trypanosoma brucei unspecified product 0.0029 0.0012 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0391 0.1345
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0195 0.0417
Loa Loa (eye worm) hypothetical protein 0.005 0.0258 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0292 0.0625
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0388 0.0388
Trichomonas vaginalis heat shock protein, putative 0.0069 0.047 0.0876
Echinococcus multilocularis dna polymerase eta 0.0042 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Loa Loa (eye worm) endoplasmin 0.0069 0.047 0.065
Brugia malayi beta-lactamase family protein 0.0036 0.0088 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0812 0.0934
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0292 0.0336
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.047 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.1551 0.2143
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0165 0.0567
Schistosoma mansoni alpha-glucosidase 0.0139 0.129 0.129
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0292 0.0404
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.009 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0292 0.0625
Schistosoma mansoni hypothetical protein 0.0185 0.1817 0.1817
Brugia malayi glutathione reductase 0.0279 0.2908 0.6217
Echinococcus multilocularis heat shock protein 0.0069 0.047 0.054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0053 0.0061
Leishmania major hypothetical protein, conserved 0.0036 0.0088 0.0304
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.009 0.0168
Leishmania major DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.009 0.0193
Plasmodium falciparum thioredoxin reductase 0.0279 0.2908 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0088 0.0088
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0003 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0292 0.0625
Toxoplasma gondii heat shock protein 90, putative 0.0069 0.047 0.1617
Trichomonas vaginalis esterase, putative 0.0036 0.0088 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0088 0.0165
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1088 0.1503
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0097 0.0794 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0195 0.0671
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.009 0.1918
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0097 0.0794 0.0794
Schistosoma mansoni hypothetical protein 0.0652 0.7236 0.7236
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0692 0.0796
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0258 0.0297
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0195 0.0671
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0707 0.7874 1
Plasmodium falciparum importin beta, putative 0.0061 0.0382 0.1314
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.009 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0003 0.0011
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.009 0.031
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0292 0.0292
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0382 0.0528
Entamoeba histolytica Ran family GTPase 0.0045 0.0195 0.4147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0707 0.7874 1
Leishmania major importin beta-1 subunit, putative 0.0049 0.0248 0.0853
Leishmania major DNA polymerase eta, putative 0.0042 0.0165 0.0567
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0292 0.0292
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.047 0.1617
Echinococcus multilocularis heat shock protein 90 0.0055 0.0308 0.0354
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0195 0.0671
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0248 0.0462
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Trypanosoma cruzi trypanothione reductase, putative 0.0279 0.2908 1
Entamoeba histolytica hypothetical protein 0.0049 0.0248 0.5275
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.009 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0292 0.0292
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Trichomonas vaginalis set domain proteins, putative 0.0491 0.5368 1
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0292 0.0545
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0165 0.0165
Echinococcus granulosus endoplasmin 0.0055 0.0308 0.0354
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0118 0.1045 0.3594
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0195 0.0671
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Brugia malayi RNA binding protein 0.0062 0.0388 0.0829
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0071 0.0497 0.1062
Schistosoma mansoni hypothetical protein 0.031 0.3275 0.3275
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0088 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0118 0.1045 0.3594
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0292 0.0545
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0097 0.0794 0.0913
Brugia malayi Pre-SET motif family protein 0.0431 0.4677 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0097 0.0794 0.2732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.1551 0.1783
Brugia malayi Thioredoxin reductase 0.0279 0.2908 0.6217
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0292 0.0625
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0382 0.0439
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0165 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0292 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0292 0.0625
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0195 0.0477
Plasmodium falciparum glutathione reductase 0.0279 0.2908 1
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0258 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0388 0.0388
Echinococcus granulosus microtubule associated protein 2 0.0778 0.8701 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0292 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0292 0.0625
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.1045 0.3594
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0165 0.1083
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0097 0.0794 0.2732
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0088 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0053 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0053 0.0061
Schistosoma mansoni ran 0.0045 0.0195 0.0195
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0388 0.0536
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0391 0.045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0292 0.0336
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0165 0.0567
Schistosoma mansoni importin beta-1 0.0061 0.0382 0.0382
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0097 0.0794 0.2732
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0292 0.0545
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Echinococcus granulosus dna polymerase eta 0.0042 0.0165 0.019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0165 0.019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0391 0.0541
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0165 0.0228
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0097 0.0794 0.1698
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.009 0.0125
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0165 0.0567
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0258 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.009 0.0168
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0088 0.0102
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0812 0.0934
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0097 0.0794 0.2732
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0097 0.0794 0.2732
Brugia malayi hypothetical protein 0.0028 0 0.0001
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0097 0.0794 0.0913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0391 0.045
Trypanosoma brucei calpain, putative 0.0118 0.1045 0.3594
Schistosoma mansoni hypothetical protein 0.0029 0.0007 0.0007
Echinococcus multilocularis protein quaking 0.0029 0.0007 0.0008
Plasmodium vivax glutathione reductase, putative 0.0279 0.2908 1
Echinococcus granulosus snurportin 1 0.0652 0.7236 0.8317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0088 0.0189
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0292 0.0336
Brugia malayi mbt repeat family protein 0.005 0.0258 0.0552
Brugia malayi beta-lactamase family protein 0.0036 0.0088 0.0189
Echinococcus granulosus geminin 0.0185 0.1817 0.2089
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0707 0.7874 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0248 0.0853
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0292 0.0625
Onchocerca volvulus 0.0036 0.0088 0.0165
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0382 0.1314
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0088 0.0122
Onchocerca volvulus 0.0036 0.0088 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0292 0.0404
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Onchocerca volvulus 0.0053 0.0292 0.0545
Plasmodium vivax SET domain protein, putative 0.0062 0.0391 0.1345
Schistosoma mansoni ran 0.0045 0.0195 0.0195
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0636 0.7051 0.8943
Echinococcus granulosus importin subunit beta 1 0.0061 0.0382 0.0439
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0 0.0001
Echinococcus multilocularis endoplasmin 0.0055 0.0308 0.0354
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0292 0.0336
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0118 0.1045 0.3594
Trypanosoma brucei glucosidase, putative 0.0036 0.009 0.031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0391 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0012 0.0043
Plasmodium falciparum heat shock protein 90 0.0069 0.047 0.1617
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.1551 0.3316
Echinococcus multilocularis microtubule associated protein 2 0.0778 0.8701 1
Onchocerca volvulus 0.0088 0.0692 0.129
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0097 0.0794 0.2732
Toxoplasma gondii ABC1 family protein 0.0036 0.0088 0.0304
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0097 0.0794 0.2732
Schistosoma mansoni endoplasmin 0.0069 0.047 0.047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0292 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0292 0.0625
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Echinococcus granulosus protein quaking 0.0029 0.0007 0.0008
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0258 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Trichomonas vaginalis glutathione reductase, putative 0.0097 0.0794 0.148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0636 0.7051 0.8943
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0292 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.047 0.1617
Schistosoma mansoni alpha-glucosidase 0.0139 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0007 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1088 0.1503
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0003 0.0011
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.009 0.0168
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0636 0.7051 0.8943
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0012 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0292 0.0336
Schistosoma mansoni hypothetical protein 0.0071 0.0493 0.0493
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Echinococcus multilocularis geminin 0.0185 0.1817 0.2089
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0055 0.0308 0.0282
Echinococcus granulosus heat shock protein 90 0.0055 0.0308 0.0354
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0118 0.1045 0.3594
Plasmodium vivax heat shock protein 86, putative 0.0069 0.047 0.1617
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0118 0.1045 0.3594
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2324 0.2872
Echinococcus multilocularis GPCR, family 2 0.0033 0.0053 0.0061
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.4677 0.6463
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0118 0.1045 0.3594
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0195 0.0269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0053 0.0113
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0308 0.1059
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Loa Loa (eye worm) beta-lactamase 0.0036 0.0088 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0388 0.0388
Echinococcus granulosus tar DNA binding protein 0.0062 0.0388 0.0446
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0308 0.0574
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0258 0.0297
Loa Loa (eye worm) MBCTL1 0.0057 0.0339 0.0469
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0292 0.0292
Toxoplasma gondii NADPH-glutathione reductase 0.0097 0.0794 0.2732
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.047 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0195 0.0671
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.009 0.0104
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.047 0.1617
Schistosoma mansoni endoplasmin 0.0069 0.047 0.047
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0339 0.039
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0165 0.0567
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0012 0.0043
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0053
Plasmodium falciparum thioredoxin reductase 0.0097 0.0794 0.2732
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.047 0.1617
Loa Loa (eye worm) hypothetical protein 0.0057 0.0339 0.0469
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0388 0.0829
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0292 0.0336
Plasmodium vivax thioredoxin reductase, putative 0.0279 0.2908 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0003 0.0011
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0292 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0292 0.0625
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Brugia malayi heat shock protein 90 0.0069 0.047 0.1005
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0144 0.0494
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0258 0.0481
Plasmodium falciparum glutathione reductase 0.0097 0.0794 0.2732
Onchocerca volvulus 0.0491 0.5368 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0 0.0001
Trypanosoma brucei trypanothione reductase 0.0279 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0692 0.1481
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0165 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0097 0.0794 0.2732
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0636 0.7051 0.8943
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0652 0.7236 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0812 0.0812
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0388 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0088 0.0122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0097 0.0794 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.009 0.0168
Trypanosoma cruzi Heat shock protein 83, putative 0.0069 0.047 0.1617
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Echinococcus granulosus heat shock protein 90 0.0069 0.047 0.054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0872 0.1865
Echinococcus granulosus dna polymerase kappa 0.0042 0.0165 0.019
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0794 0.2732
Brugia malayi hypothetical protein 0.0029 0.0007 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0 0.0001
Loa Loa (eye worm) tumor suppressor 0.034 0.3615 0.4995
Loa Loa (eye worm) hypothetical protein 0.0088 0.0692 0.0957
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0292 0.0625
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0308 0.2272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0391 0.0391
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0228
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0339 0.0725
Plasmodium vivax endoplasmin, putative 0.0069 0.047 0.1617
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0493 0.1054
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.0007 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0055 0.0308 0.0282
Brugia malayi Importin beta-1 subunit 0.0061 0.0382 0.0817
Trypanosoma brucei calpain-like protein, putative 0.0118 0.1045 0.3594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0053 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Leishmania major heat shock protein 83-1 0.0069 0.047 0.1617
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0097 0.0794 0.2732
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0692 0.0692
Schistosoma mansoni DNA polymerase eta 0.0042 0.0165 0.0165
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0165 0.0307
Brugia malayi RNA, U transporter 1 0.0174 0.1688 0.361
Brugia malayi TAR-binding protein 0.0062 0.0388 0.0829
Trypanosoma brucei heat shock protein, putative 0.0069 0.047 0.1617
Schistosoma mansoni microtubule-associated protein tau 0.0778 0.8701 0.8701
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0388 0.0536
Leishmania major GTP-binding protein, putative 0.0045 0.0195 0.0671
Schistosoma mansoni hypothetical protein 0.0185 0.1817 0.1817
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0165 0.0567
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0088 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0292 0.0404
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0292 0.0292
Echinococcus multilocularis snurportin 1 0.0652 0.7236 0.8317
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.2025 0.2327
Brugia malayi Pre-SET motif family protein 0.0062 0.0391 0.0837
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0258 0.0297
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0812 0.1123
Brugia malayi nuclear receptor RXR 0.0028 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0 0.0001
Loa Loa (eye worm) glutathione reductase 0.0279 0.2908 0.4018
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0692 0.0796
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0292 0.0625
Loa Loa (eye worm) hypothetical protein 0.0053 0.0292 0.0404
Trypanosoma brucei unspecified product 0.0029 0.0012 0.0043
Onchocerca volvulus 0.0062 0.0391 0.0729
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0248 0.0462
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.009 0.0168
Onchocerca volvulus 0.0094 0.076 0.1415
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0 0.0001
Echinococcus granulosus hypothetical protein 0.0029 0.0007 0.0008
Trypanosoma brucei Heat shock protein 83, putative 0.0069 0.047 0.1617
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0097 0.0794 0.2732
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0292 0.0625
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0292 0.0336
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0339 0.039
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.047 0.1617
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0292 0.0336

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 3 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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