Detailed information for compound 105592

Basic information

Technical information
  • TDR Targets ID: 105592
  • Name: 2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)- 2H-chromene-3-carboxylic acid
  • MW: 402.396 | Formula: C24H18O6
  • H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=C(C(=O)O)C(Oc2c1cccc2)c1ccc2c(c1)OCO2
  • InChi: 1S/C24H18O6/c1-27-16-9-6-14(7-10-16)21-17-4-2-3-5-18(17)30-23(22(21)24(25)26)15-8-11-19-20(12-15)29-13-28-19/h2-12,23H,13H2,1H3,(H,25,26)
  • InChiKey: CFNXHTFSBOPIFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-2H-1-benzopyran-3-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Endothelin receptor ET-B Starlite/ChEMBL References
Rattus norvegicus Endothelin receptor ET-A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Endothelin receptor ET-B   443 aa 392 aa 23.5 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 20.1 %
Onchocerca volvulus Endothelin receptor ET-B   443 aa 371 aa 20.5 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Endothelin receptor ET-A   426 aa 412 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium large conductance calcium activated 0.0046 0.0034 0.003
Brugia malayi cytochrome P450 0.0052 0.0045 0.004
Echinococcus granulosus roundabout 2 0.0068 0.0073 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0052 0.0045 0.5
Echinococcus granulosus twitchin 0.0085 0.0101 0.0096
Leishmania major cytochrome p450-like protein 0.0052 0.0045 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0041 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0052 0.0045 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0202 0.02
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0043 0.0029 0.0029
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0019 0.0014
Schistosoma mansoni titin 0.0029 0.0005 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0202 0.0183
Trypanosoma cruzi aurora B kinase, putative 0.0144 0.0202 0.0197
Brugia malayi Cytochrome P450 family protein 0.0164 0.0237 0.0232
Giardia lamblia Kinase, CMGC MAPK 0.0074 0.0082 0.0063
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0056 0.0052 0.0051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0082 0.0077
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0014 0.0009
Mycobacterium leprae putative cytochrome p450 0.0052 0.0045 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0379 0.0605 0.06
Giardia lamblia Kinase, PLK 0.5873 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.5873 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Echinococcus granulosus calcium activated potassium channel 0.0069 0.0075 0.007
Schistosoma mansoni nephrin 0.0061 0.0061 0.006
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0063 0.0059
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0089 0.0084
Echinococcus granulosus aurora kinase A 0.0144 0.0202 0.0197
Entamoeba histolytica protein kinase, putative 0.0144 0.0202 0.0197
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0019 0.0014
Brugia malayi TAR-binding protein 0.0063 0.0063 0.0058
Schistosoma mansoni cytochrome P450 0.0052 0.0045 0.0044
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0359 0.0359
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0144 0.0202 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0082 0.0063
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0019 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.2458 0.4159 0.4148
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0041 0.0041
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0144 0.0202 0.5
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0052 0.0045 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0052 0.0045 0.5
Echinococcus multilocularis aurora kinase A 0.0144 0.0202 0.0197
Echinococcus granulosus Immunoglobulin 0.0056 0.0052 0.0047
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0202 0.0202
Schistosoma mansoni cell adhesion molecule 0.0063 0.0063 0.0062
Onchocerca volvulus 0.0311 0.0489 0.0484
Loa Loa (eye worm) RNA binding protein 0.0063 0.0063 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0202 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0005 0.0004
Brugia malayi Cytochrome P450 family protein 0.0078 0.0089 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Schistosoma mansoni protein kinase 0.0029 0.0005 0.0004
Echinococcus granulosus mitogen activated protein kinase 3 0.0074 0.0082 0.0077
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0089 0.0084
Loa Loa (eye worm) hypothetical protein 0.0034 0.0014 0.0014
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0379 0.0605 0.0605
Loa Loa (eye worm) cytochrome P450 family protein 0.0164 0.0237 0.0237
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0144 0.0202 0.0197
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.2159 0.3648 0.3645
Echinococcus multilocularis Immunoglobulin 0.0056 0.0052 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0082 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0052 0.0045 0.5
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0008 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0052 0.0045 0.5
Schistosoma mansoni calcium-activated potassium channel 0.0046 0.0034 0.0033
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.1127 0.1126
Loa Loa (eye worm) hypothetical protein 0.0063 0.0063 0.0063
Brugia malayi MAP kinase sur-1 0.0074 0.0082 0.0077
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0202 0.0183
Brugia malayi Cytochrome P450 family protein 0.0052 0.0045 0.004
Echinococcus granulosus calcium activated potassium channel variant 0.0043 0.0029 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.005 0.0045
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0074 0.0082 0.0082
Schistosoma mansoni kinase 0.5574 0.9488 0.9488
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0052 0.0045 0.004
Mycobacterium leprae Conserved hypothetical protein 0.0052 0.0045 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0322 0.0507 0.0502
Brugia malayi serine/threonine protein kinase 6 0.0144 0.0202 0.0196
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0144 0.0202 0.0197
Echinococcus multilocularis mitogen activated protein kinase 3 0.0074 0.0082 0.0077
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0019 0.0014
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0052 0.0045 0.004
Loa Loa (eye worm) CAMK protein kinase 0.0029 0.0005 0.0005
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.005 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Echinococcus granulosus potassium large conductance calcium activated 0.0046 0.0034 0.003
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0144 0.0202 0.0197
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0052 0.0045 0.004
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0029 0.0028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0045 0.004
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Echinococcus granulosus defective proboscis extension response 0.0056 0.0052 0.0047
Entamoeba histolytica serine/threonine protein kinase, putative 0.5873 1 1
Schistosoma mansoni protein kinase 0.0029 0.0005 0.0004
Trypanosoma brucei protein kinase, putative 0.0074 0.0082 0.0077
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0063 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.5873 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0063 0.0062
Echinococcus granulosus cytochrome P450 2K1 0.0052 0.0045 0.004
Brugia malayi serine/threonine kinase 12 0.0144 0.0202 0.0196
Echinococcus multilocularis Immunoglobulin 0.0056 0.0052 0.0047
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.2159 0.3648 0.3645
Onchocerca volvulus Serine\/threonine kinase homolog 0.5873 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0074 0.0082 0.0077
Echinococcus granulosus serine:threonine protein kinase PLK1 0.5873 1 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0052 0.0045 0.2039
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0052 0.0045 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0041 0.0035
Echinococcus granulosus tar DNA binding protein 0.0063 0.0063 0.0059
Trypanosoma cruzi polo-like protein kinase, putative 0.5873 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.1127 0.1123
Leishmania major cytochrome p450-like protein 0.0052 0.0045 0.004
Schistosoma mansoni lipoxygenase 0.0055 0.005 0.0049
Entamoeba histolytica protein kinase , putative 0.0144 0.0202 0.0197
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0052 0.0045 0.5
Schistosoma mansoni vesicular amine transporter 0.0059 0.0057 0.0056
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0078 0.0089 1
Brugia malayi serine/threonine-protein kinase 6 0.0144 0.0202 0.0196
Trichomonas vaginalis AGC family protein kinase 0.0144 0.0202 0.0183
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0029 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0144 0.0202 0.02
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0074 0.0082 0.3914
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0052 0.0045 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0074 0.0082 0.0077
Echinococcus multilocularis mitogen activated protein kinase 0.0074 0.0082 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0082 0.0063
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0068 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.5873 1 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0052 0.0045 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0014 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0052 0.0047
Schistosoma mansoni protein kinase 0.0029 0.0005 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.2458 0.4159 0.4148
Entamoeba histolytica protein kinase domain containing protein 0.0144 0.0202 0.0197
Trypanosoma brucei aurora B kinase 0.0144 0.0202 0.0197
Echinococcus granulosus neuroglian 0.0061 0.0061 0.0056
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0019 0.0014
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.1332 0.1328
Echinococcus granulosus microtubule associated protein 2 0.0685 0.1127 0.1123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0063 0.0063
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.5873 1 1
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0202 0.0202
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0074 0.0082 0.0077
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.0008 0.0008
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0074 0.0082 0.0077
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0052 0.0045 0.5
Echinococcus multilocularis neuroglian 0.0061 0.0061 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0052 0.0045 0.5
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0089 0.0089
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0056 0.0052 0.0047
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0041 0.0041
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0052 0.0045 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0008
Echinococcus multilocularis calcium activated potassium channel 0.0069 0.0075 0.007
Toxoplasma gondii aurora kinase 0.0144 0.0202 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.5873 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0082 0.0063
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0052 0.0045 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0073 0.0073
Echinococcus multilocularis roundabout 2 0.0068 0.0073 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0052 0.0045 0.5
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0052 0.0045 0.5
Brugia malayi hypothetical protein 0.0056 0.0052 0.0047
Giardia lamblia Aurora kinase 0.0144 0.0202 0.0183
Loa Loa (eye worm) hypothetical protein 0.0056 0.0052 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0063 0.0063
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0019 0.0014
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0144 0.0202 0.0197
Schistosoma mansoni hypothetical protein 0.0052 0.0045 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0089 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0005 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0052 0.0045 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0056 0.0052 0.0047
Plasmodium falciparum serine/threonine protein kinase, putative 0.0144 0.0202 1
Loa Loa (eye worm) cytochrome P450 0.0052 0.0045 0.0045
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0019 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0082 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.5873 1 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0056 0.0052 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0063 0.0062
Entamoeba histolytica protein kinase, putative 0.0144 0.0202 0.0197
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0074 0.0082 0.0077
Brugia malayi RNA binding protein 0.0063 0.0063 0.0058
Echinococcus multilocularis 0.0052 0.0045 0.004
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0052 0.0045 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0019 0.0014
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0036 0.0017 0.0017
Echinococcus granulosus mitogen activated protein kinase 0.0074 0.0082 0.0077
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0089 0.0084
Echinococcus multilocularis calcium activated potassium channel variant 0.0043 0.0029 0.0024
Trypanosoma brucei polo-like protein kinase 0.5873 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0089 0.0089
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0019 0.0018
Leishmania major protein kinase, putative 0.0144 0.0202 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0052 0.0045 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0052 0.0045 0.5
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0359 0.0354
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0063 0.0062
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0019 0.0014
Brugia malayi Cytochrome P450 family protein 0.0078 0.0089 0.0084
Leishmania major cytochrome p450-like protein 0.0078 0.0089 0.0084
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0019 0.0014
Loa Loa (eye worm) AUR protein kinase 0.0144 0.0202 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0052 0.0045 0.5
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0074 0.0082 0.0077

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 86 nM Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells ChEMBL. 11985472
IC50 (binding) = 86 nM Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells. ChEMBL. 15139753
IC50 (binding) = 86 nM Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cells ChEMBL. 11985472
IC50 (binding) = 86 nM Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells. ChEMBL. 15139753
IC50 (binding) = 1400 nM Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells ChEMBL. 11985472
IC50 (binding) = 1400 nM Binding affinity to endothelin B receptor measured by inhibition of [125I]-ET-3 binding recombinant pig ET-B receptor expressed in COS-7 cells ChEMBL. 11985472
Ratio (binding) = 16 Ratio of inhibitory concentrations at ET-B receptor relative to that of ET-A receptor ChEMBL. 11985472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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