Detailed information for compound 105852

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.614 | Formula: C28H38N2O2
  • H donors: 1 H acceptors: 1 LogP: 7.37 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCN(C(=O)Cc1c(oc2c1cccc2)c1ccc(cc1)N)CCCCCC
  • InChi: 1S/C28H38N2O2/c1-3-5-7-11-19-30(20-12-8-6-4-2)27(31)21-25-24-13-9-10-14-26(24)32-28(25)22-15-17-23(29)18-16-22/h9-10,13-18H,3-8,11-12,19-21,29H2,1-2H3
  • InChiKey: FNDCWVIXTOXTHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0708 0.0702
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0049 0.032
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.053 0.3444 1
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0155 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0527 0.3421 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Echinococcus multilocularis pyruvate kinase 0.0029 0.0104 0.0097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.079 0.216
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0032 0.018
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0127 0.2379
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0155 0.3006
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.043
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.015 0.1893
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2379
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2379
Chlamydia trachomatis transglycolase/transpeptidase 0.0752 0.4922 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0019 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.0071
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0299 0.028
Treponema pallidum penicillin-binding protein (pbp-3) 0.0925 0.6075 1
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0032 0.018
Loa Loa (eye worm) hypothetical protein 0.0084 0.0471 0.3265
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.079 0.2265
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0127 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0888
Echinococcus granulosus dna polymerase eta 0.0086 0.0485 0.0478
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0056 0.005
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0482 0.3122 0.9121
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0655
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0032 0.018
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0056 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0032 0.0274
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0049 0.0087
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0197 0.0426
Echinococcus multilocularis neuropeptide s receptor 0.0509 0.3303 0.3298
Brugia malayi SET domain containing protein 0.0014 0.0003 0.0022
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0188 0.1163 0.3361
Schistosoma mansoni lamin 0.003 0.0109 0.0089
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0056 0.0537
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0037 0.0383
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0708 1
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0439 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0114 0.0226
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.033 0.0636
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.013 0.2458
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0032 0.0036
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0393 0.5433
Leishmania major trypanothione reductase 0.0052 0.0258 0.3467
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0439 0.1008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0032 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.033 0.0636
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0032 0.0183
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0439 0.9294
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0059 0.0081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0032 0.018
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0708 0.1593
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0527 0.3421 0.9932
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0156 0.1063
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0155 0.1972
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0258 0.1779
Brugia malayi Thioredoxin reductase 0.0052 0.0258 0.1798
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0439 0.1123
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus granulosus chromobox protein 1 0.0076 0.042 0.0414
Trichomonas vaginalis chromobox protein, putative 0.0076 0.042 0.0962
Loa Loa (eye worm) hypothetical protein 0.0037 0.0155 0.1061
Trypanosoma brucei unspecified product 0.004 0.0179 0.2316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0493 0.688
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0708 0.1917
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Echinococcus multilocularis dna polymerase eta 0.0086 0.0485 0.0478
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0921
Schistosoma mansoni transcription factor btf3 0.0034 0.0138 0.0119
Toxoplasma gondii endonuclease IV APN 0.0084 0.0471 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0017 0.0098
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.053 0.3444 0.7003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0702 0.1899
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0708 0.1653
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.015 0.1893
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0702 0.2006
Echinococcus multilocularis pyruvate kinase 0.0037 0.0155 0.0149
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0127 0.2379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0439 0.1008
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0708 0.2024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0049 0.006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0439 0.0858
Onchocerca volvulus 0.0045 0.0214 0.1194
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.0485 0.6761
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.015 0.1893
Leishmania major DNA polymerase eta, putative 0.0086 0.0485 0.6761
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0138 0.1728
Brugia malayi intermediate filament protein 0.003 0.0109 0.0756
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0393 0.5433
Mycobacterium tuberculosis Probable reductase 0.0119 0.0702 0.2006
Schistosoma mansoni hypothetical protein 0.035 0.2246 0.2231
Treponema pallidum hypothetical protein 0.0175 0.1078 0.1731
Toxoplasma gondii ABC1 family protein 0.0079 0.0439 0.9294
Brugia malayi 6-phosphofructokinase 0.0119 0.0708 0.493
Brugia malayi beta-lactamase family protein 0.0079 0.0439 0.3058
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0049 0.0042
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0439 0.6097
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.1207
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0032 0.0274
Loa Loa (eye worm) intermediate filament protein 0.003 0.0109 0.0736
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0056 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0138 0.0286
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0032 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0439 0.6097
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0032 0.0183
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0752 0.4922 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0049 0.043
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0708 0.1408
Brugia malayi chromobox protein homolog 3 0.0043 0.0197 0.137
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0109 0.0756
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0049 0.043
Brugia malayi glutathione reductase 0.0052 0.0258 0.1798
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0056 0.005
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0439 0.1008
Treponema pallidum fructose-bisphosphate aldolase 0.0641 0.4185 0.6871
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0032 0.0278
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0155 0.0285
Loa Loa (eye worm) hypothetical protein 0.0047 0.0226 0.1555
Plasmodium falciparum glutathione reductase 0.0018 0.0032 0.0274
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0393 0.0387
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0037 0.0383
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0471 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0299 0.0822
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0113
Echinococcus granulosus neuropeptide s receptor 0.0509 0.3303 0.3298
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0138 0.0286
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0032 0.0025
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.075 0.4909 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0299 0.0604
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0155 0.0834
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0019 0.0013
Trichomonas vaginalis set domain proteins, putative 0.026 0.1647 0.3906
Echinococcus granulosus lamin dm0 0.003 0.0109 0.0102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0082 0.0547
Schistosoma mansoni microtubule-associated protein tau 0.1514 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0702 0.2006
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0032 0.0183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0056 0.0819
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.042 0.291
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0439 0.1234
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0103 0.0096
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0258 0.0251
Onchocerca volvulus 0.003 0.0109 0.0548
Entamoeba histolytica hypothetical protein 0.0034 0.0138 0.0216
Leishmania major DNA polymerase eta, putative 0.0046 0.0218 0.2882
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0493 0.688
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0155 0.0834
Treponema pallidum penicillin-binding protein (pbp-2) 0.053 0.3444 0.5646
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0032 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0708 0.1653
Mycobacterium leprae Probable lipase LipE 0.0079 0.0439 0.1123
Echinococcus granulosus pyruvate kinase 0.0019 0.0037 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0702 0.2006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0373 0.2395 0.6902
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0493 0.688
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.1207
Onchocerca volvulus 0.0079 0.0439 0.258
Brugia malayi Pre-SET motif family protein 0.0033 0.013 0.0909
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0471 0.3281
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0258 0.0702
Echinococcus multilocularis geminin 0.035 0.2246 0.2241
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.033 0.0324
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0155 0.0278
Schistosoma mansoni rotamase 0.0037 0.0156 0.0136
Echinococcus multilocularis chromobox protein 1 0.0076 0.042 0.0414
Leishmania major DNA damage repair protein, putative 0.0018 0.0032 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Trichomonas vaginalis esterase, putative 0.0079 0.0439 0.1008
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0226 0.3001
Schistosoma mansoni intermediate filament proteins 0.003 0.0109 0.0089
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0439 0.1234
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.015 0.2886
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0708 0.4918
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.033 0.4517
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0218 0.0478
Echinococcus granulosus geminin 0.035 0.2246 0.2241
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0708 0.1593
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0313 0.1999 0.4049
Loa Loa (eye worm) hypothetical protein 0.0043 0.0197 0.1351
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0032 0.0013
Echinococcus granulosus pyruvate kinase 0.0019 0.0037 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Echinococcus multilocularis expressed protein 0.0037 0.0156 0.0149
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0032 0.018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0641 0.4185 1
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0493 0.0969
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2379
Echinococcus multilocularis lamin dm0 0.003 0.0109 0.0102
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0156 0.1083
Echinococcus multilocularis transcription factor btf3 0.0034 0.0138 0.0132
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Loa Loa (eye worm) hypothetical protein 0.0086 0.0485 0.3362
Brugia malayi Pre-SET motif family protein 0.0229 0.1436 1
Echinococcus granulosus lamin 0.003 0.0109 0.0102
Echinococcus multilocularis microtubule associated protein 2 0.1514 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0708 0.069
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0056 0.0819
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0032 0.018
Plasmodium falciparum pyruvate kinase 0.0037 0.0155 0.3006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0197 0.109
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0127 0.0188
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0299 0.2083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Loa Loa (eye worm) glutathione reductase 0.0052 0.0258 0.1779
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0056 0.0089
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0155 0.1061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0056 0.0393
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0056 0.0537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0506 0.3281 0.9588
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0313 0.1999 0.582
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0138 0.1728
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0032 0.003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0299 0.028
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0032 0.0274
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0471 0.1218
Brugia malayi 6-phosphofructokinase 0.0119 0.0708 0.493
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0708 0.069
Brugia malayi phosphofructokinase 0.0119 0.0708 0.493
Schistosoma mansoni flap endonuclease-1 0.0026 0.0084 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0114 0.0226
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0103 0.184
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0113
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0113
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0299 0.2065
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0155 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0347 0.4761
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0032 0.0183
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0113
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0155 0.1061
Chlamydia trachomatis pyruvate kinase 0.0037 0.0155 0.0252
Brugia malayi Flap endonuclease-1 0.0029 0.0103 0.0714
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0127 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Echinococcus granulosus flap endonuclease 1 0.0029 0.0103 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0711
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Leishmania major DNA polymerase kappa, putative 0.0065 0.0347 0.4761
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0493 0.688
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.033 0.0324
Echinococcus multilocularis pyruvate kinase 0.0019 0.0037 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0439 0.3058
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0046 0.0218 0.4394
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0641 0.4185 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Chlamydia trachomatis transglycolase/transpeptidase 0.0371 0.2382 0.4807
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.015 0.1893
Loa Loa (eye worm) beta-lactamase 0.0079 0.0439 0.3043
Mycobacterium tuberculosis Conserved protein 0.0079 0.0439 0.1234
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0197 0.0426
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0138 0.0944
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0103 0.0129
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0122 0.0116
Toxoplasma gondii thioredoxin reductase 0.0052 0.0258 0.5285
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0155 0.1081
Schistosoma mansoni lamin 0.003 0.0109 0.0089
Mycobacterium ulcerans hypothetical protein 0.0018 0.0032 0.0026
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0056 0.0537
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0389
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0017 0.012
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.013 0.0124
Brugia malayi beta-lactamase family protein 0.0079 0.0439 0.3058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0049 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0156 0.0327
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0439 0.1234
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus multilocularis pyruvate kinase 0.0019 0.0037 0.003
Mycobacterium ulcerans hypothetical protein 0.0022 0.0059 0.0081
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0313 0.1999 0.5732
Giardia lamblia Pyruvate kinase 0.0019 0.0037 0.0042
Leishmania major basic transcription factor 3a, putative 0.0034 0.0138 0.1728
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0439 0.1008
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Leishmania major pyruvate kinase 0.0037 0.0155 0.1972
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0439 0.1234
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0175 0.1078 0.3011
Onchocerca volvulus 0.0079 0.0439 0.258
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0049 0.0342
Echinococcus granulosus intermediate filament protein 0.003 0.0109 0.0102
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0708 0.0702
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0302 0.2087
Giardia lamblia Pyruvate kinase 0.0037 0.0155 0.0326
Trypanosoma brucei unspecified product 0.004 0.0179 0.2316
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0218 0.2882
Mycobacterium tuberculosis Conserved protein 0.0079 0.0439 0.1234
Leishmania major DNA polymerase kappa, putative 0.0018 0.0032 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0708 0.1653
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0708 0.1593
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0049 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0439 0.0421
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Schistosoma mansoni ap endonuclease 0.0021 0.0049 0.003
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0155 0.1972
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0227 0.3015
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0527 0.3421 0.6956
Echinococcus multilocularis musashi 0.003 0.0109 0.0102
Echinococcus multilocularis pyruvate kinase 0.0037 0.0155 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0025
Leishmania major hypothetical protein, conserved 0.0079 0.0439 0.6097
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0138 0.0286
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0393 0.2724
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0226 0.3001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0056 0.005
Echinococcus granulosus pyruvate kinase 0.0019 0.0037 0.003
Echinococcus granulosus chromobox protein 1 0.0076 0.042 0.0414
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0056 0.005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0049 0.043
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0218 0.1223
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2379
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0056 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0191 0.0184
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0056 0.0819
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0471 1
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0493 0.0969
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0025
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0373 0.2395 0.4858
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0258 0.3467
Schistosoma mansoni DNA polymerase eta 0.0086 0.0485 0.0466
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0708 0.1653
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0155 0.0399
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0032 0.0183
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0082 0.0079
Mycobacterium ulcerans endonuclease IV 0.0084 0.0471 0.0924
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0482 0.3122 0.9049
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0178 0.1101 0.3179
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0218 0.0478
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0138 0.2635
Schistosoma mansoni pyruvate kinase 0.0019 0.0037 0.0017
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0188 0.1163 0.3261
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0103 0.0693
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0056 0.0393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0032 0.018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0702 0.2006
Schistosoma mansoni pyruvate kinase 0.0037 0.0155 0.0136
Trypanosoma brucei trypanothione reductase 0.0052 0.0258 0.3467
Schistosoma mansoni pyruvate kinase 0.0037 0.0155 0.0136
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0155 0.1972
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0056 0.0089
Echinococcus granulosus dna polymerase kappa 0.0087 0.0493 0.0487
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0103 0.02
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0138 0.2635
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0103 0.02
Plasmodium falciparum flap endonuclease 1 0.0029 0.0103 0.184
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Brugia malayi beta-lactamase 0.0079 0.0439 0.3058
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0049 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0439 0.1008
Echinococcus granulosus pyruvate kinase 0.0037 0.0155 0.0149
Echinococcus granulosus neuropeptide receptor A26 0.0509 0.3303 0.3298
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0493 0.0487
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0393 0.0387
Schistosoma mansoni DNA helicase recq1 0.0022 0.0056 0.0037
Chlamydia trachomatis endonuclease IV 0.0084 0.0471 0.0898
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0056 0.005
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.013 0.0124
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0393 0.5433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0111
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0439 0.1234
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Leishmania major pyruvate kinase 0.0037 0.0155 0.1972
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.0485 0.6761
Echinococcus granulosus bloom syndrome protein 0.0022 0.0056 0.005
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0056 0.0089
Echinococcus multilocularis neuropeptide receptor A26 0.0509 0.3303 0.3298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0439 0.0433
Mycobacterium ulcerans hypothetical protein 0.0079 0.0439 0.0858
Trichomonas vaginalis rotamase, putative 0.0036 0.015 0.0313
Onchocerca volvulus 0.0034 0.0135 0.0712
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0059 0.0116
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.033 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0227 0.3015
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0138 0.2635
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0393 0.0833
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0493 0.688
Echinococcus granulosus expressed protein 0.0037 0.0156 0.0149
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0032 0.0278
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0127 0.2379
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0032 0.0183
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0155 0.1061
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0032 0.0183
Schistosoma mansoni hypothetical protein 0.035 0.2246 0.2231
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0702 0.2006
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.013 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0049 0.0071
Trichomonas vaginalis rotamase, putative 0.0037 0.0156 0.0327
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0059 0.041
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.033 0.2301
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Onchocerca volvulus 0.026 0.1647 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0299 0.0292
Mycobacterium ulcerans lipase LipD 0.0079 0.0439 0.0858
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0445 0.618
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0393 0.5433
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.008 0.1344
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0471 0.1328
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0258 0.5285
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0214 0.0195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0439 0.3043
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0032 0.0278
Giardia lamblia DINP protein human, muc B family 0.0065 0.0347 0.0787
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Trypanosoma brucei unspecified product 0.008 0.0445 0.618
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0191 0.0184
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0032 0.0222
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0103 0.184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0547
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0493 0.1137
Mycobacterium tuberculosis Conserved protein 0.0079 0.0439 0.1234
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0049 0.0655
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0032 0.018
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0393 0.274
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0037 0.0383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0641 0.4185 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0025
Onchocerca volvulus 0.003 0.0109 0.0548
Echinococcus multilocularis lamin 0.003 0.0109 0.0102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0056 0.0819
Echinococcus multilocularis chromobox protein 1 0.0076 0.042 0.0414
Schistosoma mansoni chromobox protein 0.0076 0.042 0.0401
Echinococcus granulosus transcription factor btf3 0.0034 0.0138 0.0132
Loa Loa (eye worm) RecQ helicase 0.0022 0.0056 0.0372
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0032 0.0025
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0032 0.0183
Plasmodium falciparum thioredoxin reductase 0.0018 0.0032 0.0274
Plasmodium falciparum glutathione reductase 0.0052 0.0258 0.5285
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Mycobacterium ulcerans beta-lactamase 0.0079 0.0439 0.0858
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.033 0.0914
Plasmodium falciparum thioredoxin reductase 0.0052 0.0258 0.5285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0227 0.3015
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0439 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.053 0.3444 0.8221
Loa Loa (eye worm) hypothetical protein 0.003 0.0109 0.0736
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Schistosoma mansoni chromobox protein 0.0076 0.042 0.0401
Toxoplasma gondii exonuclease III APE 0.0021 0.0049 0.0655
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0439 0.6097
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0708 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0032 0.0025
Brugia malayi polk-prov protein 0.0047 0.0226 0.1574
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0493 0.688
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0138 0.0216
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0032 0.0274
Onchocerca volvulus 0.0079 0.0439 0.258
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0109 0.0736
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0175 0.1078 0.2165
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0175 0.1078 0.3112
Brugia malayi Heterochromatin protein 1 0.0076 0.042 0.2926
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.0485 0.3377
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0032 0.003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0439 0.0433
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.079 0.2265
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0049 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0439 0.0858
Trichomonas vaginalis chromobox protein, putative 0.0076 0.042 0.0962
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0393 0.0375
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0708 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0032 0.003
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0155 0.3006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0439 0.3043
Echinococcus granulosus pyruvate kinase 0.0037 0.0155 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0258 0.0251
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0708 0.4918
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Schistosoma mansoni DNA helicase recq5 0.0022 0.0056 0.0037
Treponema pallidum penicillin-binding protein (pbp-1) 0.0752 0.4922 0.8091
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0258
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0019 0.0013
Brugia malayi beta-NAC-like protein 0.0034 0.0138 0.0964
Giardia lamblia Fructose-bisphosphate aldolase 0.0641 0.4185 1
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0059 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0111
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0708 0.1119
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0032 0.0274
Giardia lamblia DNA damage repair protein 0.0018 0.0032 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0439 0.0421
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Mycobacterium ulcerans epimerase 0.0022 0.0059 0.0081
Echinococcus multilocularis pyruvate kinase 0.0019 0.0037 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Plasmodium vivax SET domain protein, putative 0.0033 0.013 0.2458
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0493 0.1137
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0347 0.4761
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0103 0.1207
Loa Loa (eye worm) hypothetical protein 0.0022 0.0056 0.0372
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0708 0.4918
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0299 0.0292
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0127 0.0157
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0138 0.1728
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0032 0.018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0056 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0493 0.688
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0019 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.079 0.2265
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0155 0.0326
Echinococcus granulosus Solute carrier family 22 5 0.1138 0.7492 0.749
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0347 0.0963
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0482 0.3122 0.6345
Plasmodium vivax glutathione reductase, putative 0.0052 0.0258 0.5285
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.015 0.0244
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0155 0.1972
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0373 0.2395 0.6984
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0155 0.0834
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.1436 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 35 nM Binding affinity was determined as the ability to displace [3H]-4''CD from the (mDRC) mitochondrial DBI receptorcomplex using primary cultures of glial cells ChEMBL. 9873493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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