TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 469.538 | Formula: C26H27N7O2
H donors: 2 H acceptors: 4 LogP: 3.41 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCn1ncc2c1nc(nc2N1CC2CCC(C1)O2)c1ccc(cc1)NC(=O)Nc1ccccc1
InChi: 1S/C26H27N7O2/c1-2-33-25-22(14-27-33)24(32-15-20-12-13-21(16-32)35-20)30-23(31-25)17-8-10-19(11-9-17)29-26(34)28-18-6-4-3-5-7-18/h3-11,14,20-21H,2,12-13,15-16H2,1H3,(H2,28,29,34)
InChiKey: ADCADUHNSKXDGZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0113	0.122	0.8248
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.004	0.0302	0.0778
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0696	0.1793
Echinococcus granulosus	muscleblind protein	0.0149	0.1667	0.1966
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1667	0.4297
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0255	0.0658
Echinococcus granulosus	apoptotic protease activating factor 1	0.0124	0.1356	0.1599
Plasmodium vivax	replication factor C subunit 1, putative	0.002	0.0049	0.0071
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0021	0.0063	0.0154
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0145	0.1612	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0076	0.0753	0.4988
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0021	0.0063	0.017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0116	0.0298
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0696	0.4138
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0071	0.0696	0.4176
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0322	0.0831
Loa Loa (eye worm)	phosphatidylinositol 3	0.0076	0.0753	0.1942
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.038	0.1083
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Onchocerca volvulus		0.0029	0.0165	0.0388
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Plasmodium falciparum	replication factor C subunit 1, putative	0.002	0.0049	0.0071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.002	0.0049	0.0029
Entamoeba histolytica	hypothetical protein	0.0039	0.0288	0.0717
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0037	0.0263	0.1561
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0353	0.4217	0.4972
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0026	0.0132	0.0647
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0265	0.1437
Echinococcus multilocularis	caspase	0.0353	0.4217	0.4217
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1564	0.1845
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0001	0.0002
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0063	0.0231
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.1039	0.1225
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0063	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0263	0.0749
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0022	0.0081	0.0295
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0022	0.0081	0.0096
Echinococcus granulosus	cpg binding protein	0.0031	0.0186	0.0219
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0022	0.0081	0.0295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0614	0.1751
Echinococcus multilocularis	caspase 8	0.0133	0.1471	0.1471
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0036	0.0255	0.0728
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0022	0.0081	0.0232
Plasmodium falciparum	metacaspase-like protein	0.0133	0.1471	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0186	0.0219
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0001	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.004	0.0302	0.1834
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0265	0.0756
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0604	0.0712
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0049	0.0141
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0022	0.0081	0.0096
Schistosoma mansoni	topbp1	0.002	0.0049	0.0058
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0063	0.0231
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Brugia malayi	hypothetical protein	0.0025	0.0116	0.0298
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0145	0.1612	1
Brugia malayi	Cell death protein 3 precursor	0.0258	0.3026	0.78
Echinococcus multilocularis	microtubule associated protein 2	0.0693	0.848	0.848
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0614	0.1751
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.0384	0.0989
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0302	0.086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0164	0.185	0.4768
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3026	0.78
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0047	0.0384	0.1094
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0441	0.052
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0696	0.1793
Leishmania major	phosphatidylinositol 3-kinase, putative	0.004	0.0302	0.1834
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0047	0.0384	0.0994
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0125	0.1369	0.929
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0001	0.0001
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0263	0.1561
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0021	0.0063	0.0154
Schistosoma mansoni	patched 1	0.0042	0.0332	0.0392
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0063	0.017
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0265	0.0756
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0133	0.1471	1
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.0049	0.0071
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.2775	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0433	0.1116
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0102	0.0292
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0033	0.021	0.1193
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0039	0.0077
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.002	0.0049	0.0071
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0604	0.1557
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0604	0.1557
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0848	0.2185
Schistosoma mansoni	ap endonuclease	0.0019	0.0039	0.0046
Loa Loa (eye worm)	phosphatidylinositol 3	0.0205	0.2371	0.6111
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0696	0.1793
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1342	0.4341
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0255	0.151
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0021	0.0063	0.0075
Trypanosoma brucei	calpain, putative	0.0113	0.122	0.8248
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0433	0.2562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0476	0.1356
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0071	0.0696	0.4176
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0001
Onchocerca volvulus		0.0021	0.0063	0.0047
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0433	0.1116
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0255	0.0623
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0255	0.0255
Brugia malayi	hypothetical protein	0.002	0.0049	0.0127
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0696	0.4176
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0024	0.0102	0.0441
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0021	0.0063	0.007
Trypanosoma brucei	Metacaspase-4	0.0133	0.1471	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0753	0.2147
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0255	0.0728
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0255	0.0658
Brugia malayi	tumor suppressor.	0.0326	0.388	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0063	0.017
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0022	0.0081	0.021
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0165	0.0425
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0071	0.0696	0.4221
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0696	0.1793
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0039	0.0288	0.1738
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0039	0.0046
Onchocerca volvulus		0.0021	0.0063	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0022	0.0081	0.0232
Echinococcus multilocularis	cpg binding protein	0.0031	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0001
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0076	0.0753	0.4988
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.002	0.0049	0.0127
Leishmania major	metacaspase, putative	0.0133	0.1471	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0491	0.3154
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0001	0.0001
Echinococcus multilocularis	ubiquitin specific protease 41	0.0037	0.0263	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.121
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0604	0.0712
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0696	0.4176
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0116	0.0534
Onchocerca volvulus		0.0021	0.0063	0.0047
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0076	0.0753	0.1942
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0037	0.0263	0.031
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0022	0.0081	0.0081
Echinococcus granulosus	caspase 8	0.0133	0.1471	0.1734
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0113	0.122	0.8248
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.121
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.002	0.0049	0.0071
Entamoeba histolytica	hypothetical protein	0.0036	0.0257	0.0628
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0332	0.0392
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0063	0.0231
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0696	0.4176
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0022	0.0081	0.0096
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0076	0.0753	0.0888
Plasmodium falciparum	acyl-CoA synthetase	0.0053	0.0469	0.3006
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0039	0.0288	0.1738
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0696	0.1793
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0118	0.0552
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0233	0.06
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.121
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0024	0.0102	0.0121
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0037	0.0263	0.0644
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0039	0.0112
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0116	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0146	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0441	0.1256
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0113	0.122	0.8248
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0062	0.0579	0.3772
Brugia malayi	hypothetical protein	0.0124	0.1356	0.3495
Echinococcus multilocularis	caspase 2	0.0258	0.3026	0.3026
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Trypanosoma brucei	metacaspase	0.0133	0.1471	1
Plasmodium vivax	hypothetical protein, conserved	0.0133	0.1471	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0258	0.3026	0.3569
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0164	0.185	0.4768
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.1237	0.3454
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0255	0.0728
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0407	0.0407
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Brugia malayi	DKFZp564C0469 protein	0.002	0.0049	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.121
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.185	0.185
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0022	0.0081	0.021
Toxoplasma gondii	FATC domain-containing protein	0.0039	0.0288	0.1738
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0036	0.0255	0.0623
Schistosoma mansoni	hypothetical protein	0.0035	0.0233	0.0275
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0332	0.0856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.006	0.0554	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0332	0.0856
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0063	0.0231
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0133	0.1471	0.1734
Schistosoma mansoni	hypothetical protein	0.0041	0.0313	0.0369
Schistosoma mansoni	hypothetical protein	0.0028	0.0146	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Trypanosoma brucei	glucosidase, putative	0.0036	0.0255	0.151
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0263	0.031
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.004	0.0302	0.1834
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0255	0.0728
Entamoeba histolytica	hypothetical protein	0.0036	0.0257	0.0628
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.002	0.0049	0.0141
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0964	0.0964
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0024	0.0102	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0332	0.0947
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0076	0.0753	0.4988
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0039	0.0101
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0696	0.4586
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Loa Loa (eye worm)	inositol-1	0.0037	0.0265	0.0684
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0132	0.0376
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0113	0.122	0.8248
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0165	0.0425
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0071	0.0696	0.4176
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0217	0.107
Onchocerca volvulus		0.0124	0.1356	0.439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.044	0.1255
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Giardia lamblia	GTOR	0.0076	0.0753	0.2059
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0263	0.0749
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0265	0.0756
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0049	0.0141
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.002	0.0049	0.0065
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0146	0.0172
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0076	0.0753	0.0753
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0753	0.2147
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0022	0.0081	0.0295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0302	0.086
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.002	0.0049	0.0449
Echinococcus granulosus	protein quaking	0.0028	0.0146	0.0172
Trypanosoma cruzi	target of rapamycin kinase 3	0.0065	0.0615	0.4021
Echinococcus granulosus	serine protein kinase ATM	0.0039	0.0288	0.034
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0053	0.0469	0.2793
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0125	0.1369	0.929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0614	0.1751
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Brugia malayi	hypothetical protein	0.002	0.0049	0.0127
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0113	0.122	0.8248
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0001	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0071	0.0202
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0065	0.0615	0.4021
Plasmodium vivax	acyl-CoA synthetase, putative	0.0053	0.0469	0.3006
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0039	0.0112
Loa Loa (eye worm)	tumor suppressor	0.0326	0.388	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2775	0.7152
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0265	0.1579
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0049	0.0141
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0302	0.086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0444	0.1267
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0265	0.0313
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0088	0.0906	0.2581
Entamoeba histolytica	acyl-coA synthetase, putative	0.0071	0.0696	0.1893
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.004	0.0302	0.1834
Entamoeba histolytica	hypothetical protein	0.0036	0.0257	0.0628
Schistosoma mansoni	hypothetical protein	0.0041	0.0313	0.0369
Brugia malayi	TAR-binding protein	0.0064	0.0604	0.1557
Schistosoma mansoni	alpha glucosidase	0.0036	0.0255	0.0301
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0265	0.1579
Echinococcus multilocularis	nibrin	0.002	0.0049	0.0049
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0116	0.0534
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0063	0.0231
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0217	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0001	0.0002
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0353	0.4217	0.4217
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0113	0.122	0.8248
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0263	0.1561
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0265	0.0265
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0116	0.0534
Echinococcus multilocularis	Zinc finger, PHD finger	0.0022	0.0081	0.0081
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0047	0.0384	0.2408
Echinococcus granulosus	expressed conserved protein	0.0093	0.0964	0.1137
Toxoplasma gondii	ATPase, AAA family protein	0.002	0.0049	0.0071
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0252	0.1487
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0081	0.0295
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.1105	0.2848
Brugia malayi	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0022	0.0081	0.0122
Loa Loa (eye worm)	phosphatidylinositol 3	0.004	0.0302	0.0778
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0229	0.2673	0.3152
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1667	0.4297
Onchocerca volvulus		0.0051	0.0441	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1039	0.2678
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0039	0.0039
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.1039	0.1039
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0024	0.0102	0.0121
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0433	0.1116
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0604	0.1557
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0265	0.1579
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0433	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0452	0.1164
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0088	0.0906	0.2581
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0063	0.0231
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0022	0.0081	0.0096
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.157	0.1852
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0024	0.0102	0.0264
Brugia malayi	topoisomerase	0.002	0.0049	0.0127
Trypanosoma brucei	hypothetical protein	0.0113	0.122	0.8248
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0469	0.121
Schistosoma mansoni	hypothetical protein	0.0048	0.0407	0.048
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0296	0.3508	1
Echinococcus multilocularis	caspase 3	0.0219	0.2546	0.2546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0441	0.1256
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0022	0.0081	0.0295
Schistosoma mansoni	hypothetical protein	0.0342	0.4081	0.4813
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0063	0.0181
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0021	0.0063	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0441	0.1137
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0125	0.1369	0.3529
Schistosoma mansoni	hypothetical protein	0.0342	0.4081	0.4813
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0265	0.1579
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0037	0.0263	0.0263
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0288	0.0742
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0001	0.0001
Echinococcus multilocularis	protein patched	0.0042	0.0332	0.0332
Plasmodium falciparum	metacaspase 1	0.0133	0.1471	1
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0049	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1342	0.3458
Echinococcus granulosus	microtubule associated protein 2	0.0693	0.848	1
Brugia malayi	hypothetical protein	0.0036	0.0257	0.0662
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0164	0.185	0.185
Echinococcus granulosus	hypothetical protein	0.0028	0.0146	0.0172
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0021	0.0063	0.0154
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0133	0.1471	1
Onchocerca volvulus		0.0048	0.0407	0.1202
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0433	0.2562
Echinococcus granulosus	tumor protein p63	0.035	0.4177	0.4925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Brugia malayi	RNA binding protein	0.0064	0.0604	0.1557
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0696	0.1893
Brugia malayi	Inositol-1	0.0037	0.0265	0.0684
Toxoplasma gondii	propionate-CoA ligase	0.0021	0.0063	0.017
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0332	0.0332
Brugia malayi	Temporarily assigned gene name protein 44	0.0028	0.0146	0.0376
Brugia malayi	hypothetical protein	0.0028	0.0146	0.0376
Echinococcus multilocularis	serine protein kinase ATM	0.0039	0.0288	0.0288
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0229	0.2673	0.3152
Entamoeba histolytica	hypothetical protein	0.002	0.0049	0.0029
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.0156	0.0818
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0063	0.0164
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0604	0.0712
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0125	0.1369	0.3903
Trypanosoma brucei	metacaspase MCA2	0.0133	0.1471	1
Trypanosoma cruzi	metacaspase, putative	0.0133	0.1471	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0257	0.0257
Schistosoma mansoni	alpha-glucosidase	0.0141	0.1564	0.1845
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0001
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0021	0.0063	0.017
Schistosoma mansoni	hypothetical protein	0.0016	0.0001	0.0001
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0036	0.0255	0.0728
Entamoeba histolytica	hypothetical protein	0.0036	0.0257	0.0628
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.038	0.1083
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0604	0.1557
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0021	0.0063	0.009
Schistosoma mansoni	acetyl-CoA synthetase	0.0021	0.0063	0.0075
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0696	0.4586
Brugia malayi	Pax transcription activation domain interacting protein	0.002	0.0049	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0049	0.0141
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.002	0.0049	0.0141
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Trichomonas vaginalis	replication factor C large subunit, putative	0.002	0.0049	0.0141
Trichomonas vaginalis	antibiotic synthetase, putative	0.0021	0.0063	0.0181
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0255	0.151
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0047	0.0384	0.1094
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0407	0.105
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0263	0.0263
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0265	0.0313
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0036	0.0255	0.0728
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0255	0.0728
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0476	0.1356
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0407	0.048
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0696	0.4138
Onchocerca volvulus		0.0021	0.0063	0.0047
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0113	0.122	0.8248
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0022	0.0081	0.0122
Echinococcus granulosus	replication factor c subunit 1	0.002	0.0049	0.0058
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0604	0.0712
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.004	0.0302	0.0302
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0296	0.3508	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0063	0.017
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0604	0.0604
Schistosoma mansoni	caspase-3 (C14 family)	0.0353	0.4217	0.4972
Schistosoma mansoni	chromosome transmission fidelity factor	0.002	0.0049	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0441	0.1256
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0037	0.0263	0.031
Echinococcus granulosus	caspase 3	0.0219	0.2546	0.3003
Schistosoma mansoni	DNA ligase IV	0.002	0.0049	0.0058
Schistosoma mansoni	topbp1	0.002	0.0049	0.0058
Schistosoma mansoni	microtubule-associated protein tau	0.0693	0.848	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0255	0.0728
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0696	0.4586
Schistosoma mansoni	cpg binding protein	0.0029	0.0165	0.0194
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0021	0.0063	0.0154
Plasmodium vivax	metacaspase 1, putative	0.0133	0.1471	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0036	0.0255	0.0728
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0255	0.151
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.1058	0.1248
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0302	0.086
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0047	0.0384	0.2408
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0125	0.1369	0.3834
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0433	0.2562
Mycobacterium ulcerans	acyl-CoA synthetase	0.0021	0.0063	0.0154
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.002	0.0049	0.0141
Trypanosoma cruzi	FHA domain containing protein, putative	0.002	0.0049	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1471	0.3791
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.0753	0.2147
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0022	0.0081	0.0295
Echinococcus granulosus	geminin	0.0342	0.4081	0.4813
Schistosoma mansoni	caspase-7 (C14 family)	0.0353	0.4217	0.4972
Trichomonas vaginalis	conserved hypothetical protein	0.0133	0.1471	0.4193
Trypanosoma brucei	metacaspase MCA3	0.0133	0.1471	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0255	0.0301
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0125	0.1369	0.3903
Echinococcus granulosus	caspase 2	0.0258	0.3026	0.3569
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0263	0.0677
Echinococcus granulosus	nibrin	0.002	0.0049	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1342	0.3458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.038	0.1083
Onchocerca volvulus		0.0071	0.0696	0.2171
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0021	0.0063	0.017
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0604	0.0712
Brugia malayi	hypothetical protein	0.0238	0.2775	0.7152
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0332	0.0392
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0059	0.0545	0.1459
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0021	0.0063	0.0164
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0696	0.1893
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1356	0.3495
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0053	0.0469	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0076	0.0753	0.0888
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0022	0.0081	0.0295
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0037	0.0263	0.0644
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0302	0.086
Onchocerca volvulus		0.0095	0.0986	0.3146
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0469	0.2737
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0065	0.0615	0.4021
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.157	0.157
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.2775	0.2775
Trypanosoma cruzi	metacaspase, putative	0.0133	0.1471	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.0579	0.1651
Schistosoma mansoni	hypothetical protein	0.0041	0.0313	0.0369
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0696	0.4176
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0696	0.1793
Giardia lamblia	Replication factor C, subunit 1	0.002	0.0049	0.0029
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0848	0.2185
Schistosoma mansoni	ap endonuclease	0.0019	0.0039	0.0046
Trypanosoma brucei	metacaspase 5, putative	0.0133	0.1471	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.044	0.1255
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0076	0.0753	0.4988
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.004	0.0302	0.0356
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0124	0.1356	0.1356
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0039	0.0288	0.034
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Treponema pallidum	fructose-bisphosphate aldolase	0.0296	0.3508	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.004	0.0302	0.1834
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0133	0.1471	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Echinococcus granulosus	ubiquitin specific protease 41	0.0037	0.0263	0.031
Echinococcus granulosus	caspase	0.0353	0.4217	0.4972
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0265	0.0652
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.0415	0.1183
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0116	0.0534
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0076	0.0753	0.2059
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.1039	0.2882
Schistosoma mansoni	hypothetical protein	0.0041	0.0313	0.0369
Onchocerca volvulus	Huntingtin homolog	0.0123	0.1342	0.4341
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0433	0.1116
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0037	0.0263	0.031
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0071	0.0696	0.4221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0288	0.0821
Brugia malayi	hypothetical protein	0.0123	0.1342	0.3458
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0133	0.1471	0.4193
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0229	0.2673	0.2673
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.1667	0.1667
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0101	0.1067	0.2963
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0145	0.1612	1
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0049	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0102	0.0264
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0076	0.0753	0.4988
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0063	0.0164
Leishmania major	alpha glucosidase II subunit, putative	0.0036	0.0255	0.151
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0021	0.0063	0.0154
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0076	0.0753	0.2059
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0021	0.0063	0.009
Schistosoma mansoni	cpg binding protein	0.0031	0.0186	0.0219
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0037	0.0263	0.0677
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.004	0.0302	0.0356
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0084	0.0848	0.0999
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0022	0.0081	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0063	0.0164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0441	0.1256
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0116	0.0534
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0133	0.1471	0.3791
Schistosoma mansoni	hypothetical protein	0.0414	0.4989	0.5883
Entamoeba histolytica	protein kinase rad3, putative	0.0024	0.0102	0.0182
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0257	0.0303
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0039	0.0101
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0035	0.0235	0.0564
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0573	0.0676
Echinococcus multilocularis	tumor protein p63	0.035	0.4177	0.4177
Trypanosoma brucei	calpain-like protein, putative	0.0113	0.122	0.8248
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0021	0.0063	0.0154
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0063	0.0164
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0125	0.1369	0.3903
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0047	0.0384	0.0453
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0024	0.0102	0.0102
Trypanosoma cruzi	metacaspase 5, putative	0.0133	0.1471	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0076	0.0753	0.4988
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Treponema pallidum	DNA ligase (lig)	0.002	0.0049	0.0029
Echinococcus multilocularis	muscleblind protein	0.0149	0.1667	0.1667
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0037	0.0263	0.1561
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0021	0.0063	0.0063
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0252	0.065
Brugia malayi	CHE-14 protein	0.0042	0.0332	0.0856
Trypanosoma cruzi	metacaspase, putative	0.0133	0.1471	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.004	0.0302	0.1834
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0021	0.0063	0.009
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0116	0.0534
Echinococcus multilocularis	replication factor c subunit 1	0.002	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0016	0.0004	0.001
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0265	0.1579
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0265	1
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0049	0.0071
Echinococcus multilocularis	dnaJ subfamily B	0.0414	0.4989	0.4989
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0021	0.0063	0.0154
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0064	0.0603	0.1626
Echinococcus granulosus	dnaJ subfamily B	0.0414	0.4989	0.5883
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0102	0.0292
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0113	0.122	0.8248
Schistosoma mansoni	hypothetical protein	0.0124	0.1356	0.1599
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0038	0.0271	0.1618
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0265	0.0313
Brugia malayi	Muscleblind-like protein	0.0149	0.1667	0.4297
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0132	0.034
Echinococcus granulosus	GPCR family 2	0.0016	0.0001	0.0001
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0063	0.0231
Onchocerca volvulus	Cell death protein 3 homolog	0.0258	0.3026	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0116	0.0534
Echinococcus multilocularis	protein quaking	0.0028	0.0146	0.0146
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.002	0.0049	0.0141
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0025	0.0118	0.0552
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0022	0.0081	0.0295
Loa Loa (eye worm)	hypothetical protein	0.002	0.0049	0.0127
Giardia lamblia	Fructose-bisphosphate aldolase	0.0296	0.3508	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.044	0.1255
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0257	0.0303
Echinococcus granulosus	lysosomal alpha glucosidase	0.0164	0.185	0.2181
Trypanosoma cruzi	metacaspase, putative	0.0133	0.1471	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0156	0.0403
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0022	0.0081	0.0295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0614	0.1751
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0084	0.0848	0.0848
Schistosoma mansoni	hypothetical protein	0.0036	0.0257	0.0303
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0071	0.0696	0.4176
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0021	0.0063	0.0154
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0037	0.0263	0.0749
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0604	0.0712
Entamoeba histolytica	hypothetical protein	0.0101	0.1067	0.2963
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0001	0.0001
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0063	0.0231
Leishmania major	acetyl-CoA synthetase, putative	0.0021	0.0063	0.017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0614	0.1751
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0063	0.0231
Echinococcus multilocularis	geminin	0.0342	0.4081	0.4081
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0063	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0233	0.06
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.1039	0.2678
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0021	0.0063	0.0164
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0296	0.3508	1
Trypanosoma cruzi	metacaspase 5, putative	0.0133	0.1471	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0047	0.0384	0.0994
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0047	0.0384	0.1094

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.3 nM	Inhibition of human FLAG-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIA	ChEMBL.	19896845
IC50 (functional)	= 0.8 nM	Antiproliferative activity against PTEN deficient human LNCAP cells after 3 days by MTS assay	ChEMBL.	19896845
IC50 (binding)	= 66 nM	Binding affinity to PI3Kalpha by fluorescence polarization assay	ChEMBL.	19896845

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19896845

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL565787

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1064658