Detailed information for compound 1065212

Basic information

Technical information
  • TDR Targets ID: 1065212
  • Name: phenyl (2S)-1-(4-methylphenyl)sulfonylpyrroli dine-2-carboxylate
  • MW: 345.413 | Formula: C18H19NO4S
  • H donors: 0 H acceptors: 3 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H]1CCCN1S(=O)(=O)c1ccc(cc1)C)Oc1ccccc1
  • InChi: 1S/C18H19NO4S/c1-14-9-11-16(12-10-14)24(21,22)19-13-5-8-17(19)18(20)23-15-6-3-2-4-7-15/h2-4,6-7,9-12,17H,5,8,13H2,1H3/t17-/m0/s1
  • InChiKey: MDVWINCYNQZXQI-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-1-(4-methylphenyl)sulfonyl-2-pyrrolidinecarboxylic acid phenyl ester
  • (2S)-1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxylic acid phenyl ester
  • T5336241
  • ZINC03413765

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Brugia malayi beta-lactamase family protein 0.0037 0.0169 0.0168
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0137 0.0137
Echinococcus multilocularis phd:f box containing protein 0.0027 0.0094 0.0094
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.4898
Loa Loa (eye worm) jmjC domain-containing protein 0.0105 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Trichomonas vaginalis esterase, putative 0.0037 0.0169 0.0676
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0756 0.6315
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Brugia malayi jmjC domain containing protein 0.0171 0.1236 0.1236
Echinococcus multilocularis protein dispatched 1 0.0048 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0048 0.026 0.026
Leishmania major trypanothione reductase 0.0048 0.0261 0.556
Schistosoma mansoni jumonji domain containing protein 0.0149 0.106 0.106
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0169 0.3211
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0469 0.0468
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Schistosoma mansoni serine/threonine protein kinase 0.1272 1 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0052 0.0288 0.1307
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Echinococcus multilocularis geminin 0.0193 0.1411 0.1411
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0149 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0149 0.126
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0064 0.0481
Giardia lamblia PHD finger protein 15 0.0033 0.0137 0.0549
Echinococcus granulosus GPCR family 3 C terminal 0.0052 0.0288 0.0288
Brugia malayi hypothetical protein 0.0041 0.0201 0.02
Plasmodium vivax JmjC domain containing protein 0.0027 0.0094 0.3594
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0169 0.3211
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0137 0.526
Onchocerca volvulus Huntingtin homolog 0.0126 0.0875 0.427
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0149 0.0149
Onchocerca volvulus Poor gastrulation protein homolog 0.0052 0.0288 0.1307
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0394 0.3009 0.3009
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0001 0.0048
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0484 0.0484
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0052 0.0288 0.0288
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0009 0.0166
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0219 0.0219
Giardia lamblia Fructose-bisphosphate aldolase 0.033 0.2504 1
Onchocerca volvulus 0.003 0.0115 0.043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0287 0.0287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Echinococcus multilocularis expressed conserved protein 0.0093 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0082 0.0528 0.0527
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0071 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0287
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0169 0.0169
Onchocerca volvulus Alhambra homolog 0.0033 0.0137 0.0545
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.3214 0.3214
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0009 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0219 0.0219
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0997 0.0997
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0064 0.0257
Echinococcus granulosus JmjC domain containing protein 4 0.0027 0.0094 0.0094
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0115 0.043
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0027 0.0094 0.0795
Echinococcus multilocularis nmda type glutamate receptor 0.003 0.0115 0.0115
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.024 0.024
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0268 0.2008 0.2008
Loa Loa (eye worm) glutamate receptor 0.032 0.2421 0.242
Plasmodium falciparum thioredoxin reductase 0.0017 0.0009 0.0345
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0201 0.0201
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0261 0.1484
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0064 0.0481
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0708 0.0708
Echinococcus granulosus poly adp ribose polymerase 2 0.0082 0.0524 0.0524
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0073 0.0459 0.0458
Brugia malayi hypothetical protein 0.0126 0.0875 0.0874
Brugia malayi jmjC domain containing protein 0.0105 0.0708 0.0708
Onchocerca volvulus 0.0037 0.0169 0.0705
Echinococcus granulosus GPCR family 2 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0756 0.4307
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.023 0.1924
Brugia malayi hypothetical protein 0.0237 0.1761 0.176
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1493 0.5965
Loa Loa (eye worm) hypothetical protein 0.0153 0.1095 0.1094
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0169 0.0959
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0169 0.6475
Leishmania major extracellular receptor, putative 0.003 0.0115 0.2424
Echinococcus multilocularis JmjC domain containing protein 4 0.0027 0.0094 0.0094
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0854 0.4868
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0148
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0136
Brugia malayi glutathione reductase 0.0048 0.0261 0.026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0009 0.0148
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0854 0.4868
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0169 0.0959
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.023 0.023
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Onchocerca volvulus 0.0268 0.2011 1
Echinococcus granulosus tyrosine kinase 0.003 0.0115 0.0115
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0171 0.1236 0.1236
Onchocerca volvulus 0.0037 0.0169 0.0705
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0137 0.1163
Brugia malayi TAR-binding protein 0.0076 0.0484 0.0483
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Echinococcus multilocularis glutamate receptor 2 0.003 0.0115 0.0115
Brugia malayi Cytochrome P450 family protein 0.0027 0.0089 0.0088
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0064 0.0257
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0009 0.0166
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0029 0.054
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Schistosoma mansoni microtubule-associated protein tau 0.0741 0.5772 0.5772
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0469 0.0469
Trypanosoma brucei trypanothione reductase 0.0048 0.0261 0.4972
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Onchocerca volvulus Huntingtin homolog 0.0126 0.0875 0.427
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Plasmodium vivax SET domain protein, putative 0.0034 0.0149 0.5696
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Loa Loa (eye worm) glutamate receptor 0.0126 0.0877 0.0876
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0484 0.0483
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0137 0.0137
Schistosoma mansoni tyrosine kinase 0.003 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0153 0.1095 0.1094
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0082 0.0528 0.0527
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.023 0.195
Trypanosoma brucei poly(adp-ribose) polymerase 0.0082 0.0524 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0009 0.0008
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0064 0.036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0146
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0273 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.026 0.0259
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Onchocerca volvulus 0.0034 0.0149 0.0602
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0169 0.0676
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.066 0.066
Echinococcus multilocularis lysine specific demethylase 6a 0.0027 0.0094 0.0094
Schistosoma mansoni cpg binding protein 0.0031 0.0123 0.0123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0854 0.4868
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0027 0.0094 0.0094
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0009 0.0076
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0064 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0287 0.0287
Echinococcus multilocularis glutamate receptor 2 0.003 0.0115 0.0115
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0009 0.0076
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0469 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Treponema pallidum fructose-bisphosphate aldolase 0.033 0.2504 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0017 0.0633
Echinococcus granulosus jumonji domain containing protein 0.0046 0.024 0.024
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0169 0.1392
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Plasmodium falciparum thioredoxin reductase 0.0048 0.0261 1
Echinococcus multilocularis protein patched 0.0042 0.0212 0.0212
Schistosoma mansoni protein phosphatase 2C 0.0027 0.0094 0.0094
Echinococcus multilocularis jumonji domain containing 1A 0.0027 0.0094 0.0094
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0171 0.1236 0.1236
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0169 0.0959
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0261 1
Brugia malayi beta-lactamase 0.0037 0.0169 0.0168
Brugia malayi Bromodomain containing protein 0.0033 0.0137 0.0136
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0234
Echinococcus granulosus dnaJ subfamily B 0.0419 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.0126 0.0875 0.0874
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0164 0.1181 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0169 0.0169
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0034 0.0146 0.0146
Brugia malayi metabotropic glutamate receptor type 2 0.0156 0.1116 0.1115
Schistosoma mansoni survival motor neuron protein 0.0048 0.026 0.026
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0105 0.0708 0.0708
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.023 0.092
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0294 0.2215 0.2214
Echinococcus granulosus poly (ADP ribose) polymerase 0.0046 0.0242 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Mycobacterium ulcerans hypothetical protein 0.0024 0.0064 0.0481
Toxoplasma gondii thioredoxin reductase 0.0048 0.0261 0.2212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0169 0.0959
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0212 0.0212
Echinococcus granulosus tar DNA binding protein 0.0076 0.0484 0.0484
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0148 0.1056 0.1056
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0997 0.0997
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0469 0.8942
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.2504 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Loa Loa (eye worm) glutathione reductase 0.0048 0.0261 0.026
Leishmania major hypothetical protein, conserved 0.0037 0.0169 0.3591
Schistosoma mansoni hypothetical protein 0.0193 0.1411 0.1411
Entamoeba histolytica hypothetical protein 0.003 0.0115 0.0458
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.023 0.092
Brugia malayi Receptor family ligand binding region containing protein 0.0082 0.0528 0.0527
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0029 0.0029
Plasmodium falciparum JmjC domain-containing protein, putative 0.0027 0.0094 0.3594
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0082 0.0524 0.0524
Schistosoma mansoni jumonji domain containing protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Echinococcus granulosus geminin 0.0193 0.1411 0.1411
Loa Loa (eye worm) hypothetical protein 0.0082 0.0524 0.0523
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0484 0.0483
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1493 0.5965
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.2504 1
Plasmodium falciparum glutathione reductase 0.0017 0.0009 0.0345
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.1411 0.6972
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Echinococcus multilocularis GPCR, family 3, C terminal 0.0052 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1272 1 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.003 0.0115 0.0115
Schistosoma mansoni phd/f-box containing protein 0.0027 0.0094 0.0094
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Schistosoma mansoni hypothetical protein 0.0193 0.1411 0.1411
Mycobacterium ulcerans hypothetical protein 0.0037 0.0169 0.1392
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1753 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0193 0.1095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0064 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0261 0.026
Echinococcus granulosus poly ADP ribose polymerase 1 0.0148 0.1056 0.1056
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Loa Loa (eye worm) hypothetical protein 0.0237 0.1761 0.176
Echinococcus multilocularis muscleblind protein 0.0153 0.1095 0.1095
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0058 0.0341 0.034
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0052 0.0288 0.0287
Brugia malayi WGR domain containing protein 0.0082 0.0524 0.0523
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0484 0.0483
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0009
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Brugia malayi PHD-finger family protein 0.0033 0.0137 0.0136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0027 0.0094 0.0795
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0169 0.0169
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0261 0.4972
Schistosoma mansoni inositol monophosphatase 0.0045 0.023 0.023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0287 0.0286
Toxoplasma gondii ABC1 family protein 0.0037 0.0169 0.1432
Echinococcus multilocularis microtubule associated protein 2 0.0741 0.5772 0.5772
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0087
Schistosoma mansoni tyrosine kinase 0.003 0.0115 0.0115
Echinococcus granulosus glutamate receptor 2 0.003 0.0115 0.0115
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0089 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0147 0.0146
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0009 0.0148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.1752 0.1751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Echinococcus multilocularis cpg binding protein 0.0031 0.0123 0.0123
Echinococcus granulosus phd:f box containing protein 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0009 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0756 0.4307
Brugia malayi RNA binding protein 0.0076 0.0484 0.0483
Loa Loa (eye worm) hypothetical protein 0.0394 0.3009 0.3009
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Brugia malayi Pre-SET motif family protein 0.0236 0.1752 0.1751
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1761 0.1761
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Echinococcus multilocularis peregrin 0.0033 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Echinococcus granulosus peregrin 0.0033 0.0137 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0009 0.0345
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.0153 0.1095 0.1094
Loa Loa (eye worm) hypothetical protein 0.0113 0.0774 0.0773
Schistosoma mansoni protein kinase 0.003 0.0115 0.0115
Trypanosoma brucei DNA repair protein, putative 0.0019 0.0029 0.054
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0019 0.0029 0.054
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0169 0.0676
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0009 0.0345
Echinococcus granulosus metabotropic glutamate receptor 5 0.0394 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Brugia malayi Inositol-1 0.0045 0.023 0.0229
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0115 0.0115
Schistosoma mansoni cpg binding protein 0.0029 0.011 0.011
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0029 0.054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0149 0.0149
Brugia malayi Thioredoxin reductase 0.0048 0.0261 0.026
Mycobacterium ulcerans lipase LipD 0.0037 0.0169 0.1392
Mycobacterium ulcerans beta-lactamase 0.0037 0.0169 0.1392
Brugia malayi Metabotropic glutamate receptor precursor. 0.032 0.2421 0.242
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0756 0.4307
Brugia malayi WGR domain containing protein 0.0148 0.1056 0.1055
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0364 0.277 0.277
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0149 0.0149
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0201 0.0201
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.023 0.023
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0115 0.0115
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0017 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0273 0.0272
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0169 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0064 0.0063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0854 0.7213
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.029 0.2182 0.2181
Echinococcus multilocularis atrial natriuretic peptide receptor 0.003 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0114
Onchocerca volvulus 0.003 0.0115 0.043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0287 0.0286
Schistosoma mansoni patched 1 0.0042 0.0212 0.0212
Schistosoma mansoni metabotropic glutamate receptor 0.0268 0.2008 0.2008
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0082 0.0524 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0212 0.0211
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.066 0.0659
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0027 0.0094 0.1771
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.023 0.092
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0082 0.0528 0.0527
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0169 0.0959
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0166
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1159 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.011 0.0109
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0137 0.1163
Echinococcus multilocularis GPCR, family 2 0.0016 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0287 0.0287
Onchocerca volvulus 0.0037 0.0169 0.0705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Onchocerca volvulus 0.0029 0.011 0.0405
Echinococcus granulosus muscleblind protein 0.0153 0.1095 0.1095
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1272 1 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.003 0.0115 0.0114
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0148 0.1056 0.422
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0756 0.4307
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1159 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0009 0.0148
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.066 0.066
Mycobacterium leprae Probable lipase LipE 0.0037 0.0169 0.0958
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0017 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.023 0.023
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0169 0.0959
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0029 0.0107 0.0107
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0137 0.0136
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0169 0.0959
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1095 0.1095
Loa Loa (eye worm) beta-lactamase 0.0037 0.0169 0.0168
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0417 0.0416
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0137 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0287 0.0287
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0673 0.0673
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0001 0.0048
Loa Loa (eye worm) RNA binding protein 0.0076 0.0484 0.0483
Schistosoma mansoni phosphatidylserine receptor 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0469 0.0468
Brugia malayi CHE-14 protein 0.0042 0.0212 0.0211
Brugia malayi hypothetical protein 0.003 0.0115 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0009 0.0036
Echinococcus granulosus WGR domain containing protein 0.0046 0.0242 0.0242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0469 0.1873
Brugia malayi metabotropic GABA-B receptor subtype 2 0.003 0.0115 0.0114
Schistosoma mansoni metabotropic glutamate receptor 0.0156 0.1116 0.1116
Mycobacterium tuberculosis Probable reductase 0.0111 0.0756 0.4307
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2011 0.8031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0294 0.2215 0.2214
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0756 0.4307
Onchocerca volvulus 0.0024 0.0064 0.0176
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.011 0.0109
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1761 0.1761
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0261 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Echinococcus granulosus metabotropic glutamate receptor 2 0.0268 0.2008 0.2008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.023 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0137 0.526
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0148 0.1056 0.1056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0329 0.2788
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0212 0.0212
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.003 0.0115 0.0115
Echinococcus granulosus lysine specific demethylase 6a 0.0027 0.0094 0.0094
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1159 0.661
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0169 0.3211
Loa Loa (eye worm) hypothetical protein 0.0042 0.0212 0.0211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0169 0.0168
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0009 0.0345
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0115 0.0115
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0193 0.1176
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0009 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0048 0.026 0.1163
Mycobacterium tuberculosis Conserved protein 0.0037 0.0169 0.0959
Echinococcus granulosus nmda type glutamate receptor 0.003 0.0115 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0011
Echinococcus granulosus atrial natriuretic peptide receptor 0.003 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0419 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0064 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0105 0.0708 0.0708
Schistosoma mansoni hypothetical protein 0.0041 0.02 0.02
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.0695 0.0695
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0212 0.0848
Echinococcus multilocularis tyrosine kinase 0.003 0.0115 0.0115
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0115 0.0115
Leishmania major hypothetical protein, conserved 0.0019 0.0029 0.0603
Plasmodium falciparum glutathione reductase 0.0048 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0288 0.0287
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0029 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0126 0.0875 0.0874
Echinococcus granulosus glutamate receptor 2 0.003 0.0115 0.0115
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0115 0.0114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0009 0.0036
Leishmania major DNA repair protein, putative 0.0019 0.0029 0.0603
Plasmodium vivax glutathione reductase, putative 0.0048 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.066 0.0659
Loa Loa (eye worm) hypothetical protein 0.005 0.0273 0.0272
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0273 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0169 0.1392
Echinococcus granulosus cpg binding protein 0.0031 0.0123 0.0123
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.023 0.438
Schistosoma mansoni hypothetical protein 0.0034 0.0147 0.0147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0064 0.0481
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.2215 0.8849
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Trypanosoma cruzi extracellular receptor, putative 0.003 0.0115 0.2168
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0064 0.1349
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0009 0.0166
Brugia malayi Pre-SET motif family protein 0.0034 0.0149 0.0148
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0115 0.0114
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.066 0.2638
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0149 0.0149
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1272 1 1
Loa Loa (eye worm) inositol-1 0.0045 0.023 0.0229
Entamoeba histolytica hypothetical protein 0.0041 0.0201 0.0804
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0064 0.0481
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0201 0.0201
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0169 0.0169
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0169 0.0958
Loa Loa (eye worm) hypothetical protein 0.0027 0.0094 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0382 0.0382
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0042 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0149 0.0149
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.023 0.092
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0201
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0469 0.0469
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0134 0.0134
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0009 0.0345
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0261 0.0261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0469 0.0469
Brugia malayi jmjC domain containing protein 0.0027 0.0094 0.0093
Brugia malayi beta-lactamase family protein 0.0037 0.0169 0.0168
Echinococcus granulosus jumonji domain containing 1A 0.0027 0.0094 0.0094
Leishmania major hypothetical protein, conserved 0.0027 0.0094 0.1981
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0009 0.0043
Echinococcus granulosus poly (ADP ribose) polymerase 0.0023 0.0059 0.0059
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0524 0.0524
Echinococcus granulosus microtubule associated protein 2 0.0741 0.5772 0.5772
Loa Loa (eye worm) jmjC domain-containing protein 0.0027 0.0094 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.2504 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0484 0.0484
Echinococcus granulosus expressed conserved protein 0.0093 0.0613 0.0613
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0169 0.0676
Brugia malayi Guanylyl cyclase protein 23 0.003 0.0115 0.0114
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0017 0.0633
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0009 0.0148
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1411 0.5634
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0082 0.0524 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0287 0.0287
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.6342 0.6342
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0064 0.036

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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