TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 242.227 | Formula: C14H10O4
H donors: 1 H acceptors: 4 LogP: 1.78 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)/C(=C/C1=CC(=O)c2c(C1=O)cccc2)/C
InChi: 1S/C14H10O4/c1-8(14(17)18)6-9-7-12(15)10-4-2-3-5-11(10)13(9)16/h2-7H,1H3,(H,17,18)/b8-6+
InChiKey: RHWRWEWZESPYTH-SOFGYWHQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.0742	0.6782
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0071	0.0469	0.0649
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0029	0.0102
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0017	0.0013	0.0123
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0503	0.1222
Echinococcus granulosus	zinc finger protein	0.002	0.0039	0.0357
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0041	0.0214	0.0323
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0022	0.018
Mycobacterium ulcerans	beta-lactamase	0.0075	0.0503	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.1094	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0168	0.1539
Trypanosoma brucei	mitotic cyclin 6	0.0071	0.0469	0.1775
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0097	0.0134
Trypanosoma cruzi	cyclin 9, putative	0.0017	0.0013	0.0045
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0153	0.0211
Entamoeba histolytica	hypothetical protein	0.0035	0.0168	0.34
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0041	0.0214	0.0765
Schistosoma mansoni	zinc finger protein	0.0016	0.0002	0.0016
Echinococcus granulosus	Cyclin L1	0.0017	0.0013	0.0123
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0027	0.0041
Loa Loa (eye worm)	cyclin domain-containing protein	0.0071	0.0469	0.3784
Brugia malayi	hypothetical protein	0.0017	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0044	0.024	0.1935
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0071	0.0469	0.0649
Leishmania major	hypothetical protein, conserved	0.0027	0.0097	0.0363
Echinococcus granulosus	cyclin G2	0.0017	0.0013	0.0123
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0017	0.0013	0.002
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.0742	0.6782
Trypanosoma cruzi	mitotic cyclin, putative	0.0017	0.0013	0.0045
Echinococcus multilocularis	lamin dm0	0.0027	0.0097	0.0146
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0029	0.0231
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0027	0.0052
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0027	0.0041
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0103	0.0742	0.1119
Echinococcus granulosus	cyclins	0.0017	0.0013	0.0123
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0027	0.0096
Echinococcus granulosus	cyclins	0.0071	0.0469	0.4289
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus multilocularis	cyclin B3 1	0.0071	0.0469	0.0708
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0041	0.0214	0.5
Echinococcus multilocularis	cyclin	0.0017	0.0013	0.002
Brugia malayi	beta-lactamase family protein	0.0075	0.0503	0.0695
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0027	0.0052
Schistosoma mansoni	ap endonuclease	0.0041	0.0214	0.1956
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0284	0.2291
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0503	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0168	0.34
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0182	0.0274
Toxoplasma gondii	ABC1 family protein	0.0075	0.0503	0.1865
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Trichomonas vaginalis	cyclin B, putative	0.0071	0.0469	0.9322
Trypanosoma cruzi	mitotic cyclin, putative	0.0017	0.0013	0.0045
Leishmania major	mitotic cyclin, putative	0.0017	0.0013	0.0045
Trichomonas vaginalis	cyclin B, putative	0.0071	0.0469	0.9322
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0284	0.0393
Trichomonas vaginalis	cyclins, putative	0.0071	0.0469	0.9322
Trypanosoma brucei	telomerase reverse transcriptase	0.0327	0.2636	1
Trypanosoma brucei	mitotic cyclin	0.0017	0.0013	0.0045
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0478	0.392	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0029	0.0262
Echinococcus granulosus	cyclins	0.0071	0.0469	0.4289
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0017	0.0013	0.0045
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1094	1
Giardia lamblia	Hypothetical protein	0.0071	0.0469	0.1739
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0182	0.1659
Trichomonas vaginalis	cyclins, putative	0.0071	0.0469	0.9322
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0017	0.0156
Mycobacterium leprae	conserved hypothetical protein	0.0075	0.0503	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.0953	0.7678
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0029	0.0262
Echinococcus granulosus	cyclin B3 1	0.0071	0.0469	0.4289
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0503	0.1901
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Echinococcus multilocularis	cyclin B	0.0071	0.0469	0.0708
Onchocerca volvulus		0.0027	0.0097	0.0084
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0145	0.1094	0.8821
Echinococcus multilocularis	musashi	0.0027	0.0097	0.0146
Brugia malayi	MH2 domain containing protein	0.0128	0.0953	0.1317
Echinococcus multilocularis	cyclin b3	0.0071	0.0469	0.0708
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0029	0.0102
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0168	0.1539
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0065	0.0593
Schistosoma mansoni	bromodomain containing protein	0.0065	0.042	0.3836
Entamoeba histolytica	cyclin family protein	0.0071	0.0469	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0075	0.0503	0.1222
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0097	0.032
Echinococcus multilocularis	cyclin G2	0.0017	0.0013	0.002
Schistosoma mansoni	cyclin l	0.0017	0.0013	0.0123
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Echinococcus granulosus	cyclins	0.0071	0.0469	0.4289
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0075	0.0503	0.0695
Entamoeba histolytica	cyclin family protein	0.0071	0.0469	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0075	0.0503	0.1901
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0027	0.0052
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0071	0.0469	0.1775
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.0953	0.7678
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0029	0.0231
Giardia lamblia	Telomerase catalytic subunit	0.0327	0.2636	1
Schistosoma mansoni	cyclin B	0.0071	0.0469	0.4289
Schistosoma mansoni	hypothetical protein	0.0017	0.0013	0.0123
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0097	0.0886
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus multilocularis	Cyclin L1	0.0017	0.0013	0.002
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0389	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0017	0.0137
Leishmania major	mitotic cyclin, putative	0.0017	0.0013	0.0045
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.1094	0.1651
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Echinococcus granulosus	cyclin y	0.0017	0.0013	0.0123
Trypanosoma brucei	cyclin 3	0.0017	0.0013	0.0045
Brugia malayi	exodeoxyribonuclease III family protein	0.0041	0.0214	0.0296
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0065	0.0593
Trichomonas vaginalis	cyclins, putative	0.0071	0.0469	0.9322
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0503	0.4592
Onchocerca volvulus		0.0162	0.1241	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0013	0.0109
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Trichomonas vaginalis	cyclin D, putative	0.0071	0.0469	0.9322
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0041	0.0214	0.0806
Echinococcus multilocularis	cyclin y	0.0017	0.0013	0.002
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0041	0.0214	0.048
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0389	0.3551
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0029	0.0262
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0029	0.004
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0168	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0153	0.123
Brugia malayi	Bromodomain containing protein	0.0039	0.0202	0.0279
Schistosoma mansoni	cyclin G2	0.0017	0.0013	0.0123
Echinococcus multilocularis	cyclin k	0.0017	0.0013	0.002
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0027	0.0096
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0027	0.0247
Schistosoma mansoni	hypothetical protein	0.0034	0.0153	0.1395
Schistosoma mansoni	cyclin d	0.0017	0.0013	0.0123
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0029	0.004
Echinococcus granulosus	lamin dm0	0.0027	0.0097	0.0886
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0075	0.0503	1
Echinococcus multilocularis	G1:S specific cyclin D1	0.0017	0.0013	0.002
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0017	0.0156
Echinococcus multilocularis	lamin	0.0027	0.0097	0.0146
Giardia lamblia	G2/mitotic-specific cyclin B	0.0071	0.0469	0.1739
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0503	1
Echinococcus granulosus	intermediate filament protein	0.0027	0.0097	0.0886
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0029	0.0262
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Plasmodium vivax	hypothetical protein, conserved	0.0075	0.0503	0.1865
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0017	0.0156
Leishmania major	DNA polymerase eta, putative	0.0019	0.0029	0.0102
Schistosoma mansoni	cyclin k	0.0017	0.0013	0.0123
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0017	0.0013	0.0123
Brugia malayi	hypothetical protein	0.0017	0.0013	0.0019
Toxoplasma gondii	RNA-directed DNA polymerase	0.0327	0.2636	1
Trichomonas vaginalis	cyclin A, putative	0.0071	0.0469	0.9322
Echinococcus granulosus	cyclin A3 4	0.0017	0.0013	0.0123
Echinococcus granulosus	cyclin t1	0.0017	0.0013	0.0123
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0284	0.0393
Toxoplasma gondii	melibiase subfamily protein	0.0103	0.0742	0.2779
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0029	0.0262
Trypanosoma brucei	cyclin 9	0.0017	0.0013	0.0045
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0075	0.0503	0.1222
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0103	0.0742	0.6782
Brugia malayi	hypothetical protein	0.0162	0.1241	0.1715
Onchocerca volvulus		0.0075	0.0503	0.049
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0029	0.0334
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0071	0.0469	0.0708
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0071	0.0469	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0203	0.1634
Echinococcus granulosus	lamin	0.0027	0.0097	0.0886
Mycobacterium ulcerans	lipase LipD	0.0075	0.0503	1
Leishmania major	cyclin	0.0071	0.0469	0.1775
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0027	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0097	0.0363
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0027	0.0037
Brugia malayi	PHD-finger family protein	0.0026	0.0085	0.0118
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0097	0.0363
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0041	0.0214	0.1725
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0041	0.0214	0.4398
Trichomonas vaginalis	cyclin B, putative	0.0071	0.0469	0.9322
Loa Loa (eye worm)	cyclin domain-containing protein	0.0017	0.0013	0.0109
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0017	0.0013	0.002
Schistosoma mansoni	cyclin B3	0.0071	0.0469	0.4289
Leishmania major	hypothetical protein, conserved	0.0075	0.0503	0.1901
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0075	0.0503	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Trichomonas vaginalis	cyclin D, putative	0.0071	0.0469	0.9322
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0075	0.0503	0.1222
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0027	0.0096
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0097	0.032
Echinococcus granulosus	cyclins	0.0071	0.0469	0.4289
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0097	0.0363
Brugia malayi	beta-lactamase family protein	0.0075	0.0503	0.0695
Entamoeba histolytica	hypothetical protein	0.0035	0.0168	0.34
Mycobacterium leprae	Probable lipase LipE	0.0075	0.0503	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Mycobacterium ulcerans	esterase/lipase LipP	0.0075	0.0503	1
Onchocerca volvulus		0.0075	0.0503	0.049
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0027	0.0041
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0017	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0013	0.0109
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Brugia malayi	cyclin fold protein 1 variant b	0.0017	0.0013	0.0019
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0103	0.0742	0.1119
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0041	0.0214	0.0806
Onchocerca volvulus		0.0027	0.0097	0.0084
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0027	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0097	0.0782
Echinococcus multilocularis	cyclin t1	0.0017	0.0013	0.002
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0029	0.0311
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0469	0.9322
Entamoeba histolytica	cyclin, putative	0.0071	0.0469	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Echinococcus multilocularis	zinc finger protein	0.002	0.0039	0.0059
Brugia malayi	Cyclin C	0.0017	0.0013	0.0019
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0029	0.0043
Echinococcus granulosus	cyclins	0.0071	0.0469	0.4289
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0097	0.032
Mycobacterium tuberculosis	Probable hydrolase	0.0075	0.0503	0.1222
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0503	1
Echinococcus granulosus	cyclin y	0.0017	0.0013	0.0123
Brugia malayi	hypothetical protein	0.0027	0.0097	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0013	0.0045
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.0742	0.6782
Trypanosoma cruzi	cyclin, putative	0.0071	0.0469	0.1775
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1094	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0168	0.34
Trypanosoma cruzi	cyclin 6, putative	0.0071	0.0469	0.1775
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0451	0.4122
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0029	0.0102
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0071	0.0469	0.1775
Loa Loa (eye worm)	cyclin C	0.0017	0.0013	0.0109
Trichomonas vaginalis	ap endonuclease, putative	0.0041	0.0214	0.41
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0451	0.3637
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0027	0.0041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0029	0.0004
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0451	0.4122
Plasmodium falciparum	cyclin	0.0071	0.0469	0.1739
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0041	0.0214	0.0806
Schistosoma mansoni	ap endonuclease	0.0041	0.0214	0.1956
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0029	0.0043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0799	0.6631	1
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0017	0.0013	0.0109
Mycobacterium tuberculosis	Probable lipase LipE	0.0075	0.0503	0.1222
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0485	0.3906
Brugia malayi	Telomerase reverse transcriptase	0.087	0.7233	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0097	0.0782
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0027	0.0052
Plasmodium falciparum	telomerase reverse transcriptase	0.0327	0.2636	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0075	0.0503	0.4592
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0029	0.0058
Brugia malayi	Bromodomain containing protein	0.0077	0.0522	0.0722
Trichomonas vaginalis	cyclin B3, putative	0.0071	0.0469	0.9322
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0097	0.0782
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0503	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0041	0.0214	0.0765
Trichomonas vaginalis	penicillin-binding protein, putative	0.0075	0.0503	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Trypanosoma brucei	unspecified product	0.0019	0.0029	0.0102
Echinococcus granulosus	cyclin b3	0.0071	0.0469	0.4289
Echinococcus granulosus	cyclin	0.0017	0.0013	0.0123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0075	0.0503	0.4592
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0284	0.2291
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus granulosus	dna polymerase eta	0.0019	0.0029	0.0262
Echinococcus multilocularis	cyclins	0.0071	0.0469	0.0708
Schistosoma mansoni	lamin	0.0027	0.0097	0.0886
Trypanosoma brucei	hypothetical protein, conserved	0.0075	0.0503	0.1901
Trichomonas vaginalis	cyclins, putative	0.0071	0.0469	0.9322
Toxoplasma gondii	hypothetical protein	0.0054	0.0324	0.1186
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0145	0.1094	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0017	0.0026
Giardia lamblia	Cyclin A	0.0071	0.0469	0.1739
Echinococcus multilocularis	cyclin y	0.0017	0.0013	0.002
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0017	0.0013	0.0019
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0041	0.0214	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0093	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0027	0.0218
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0029	0.0102
Onchocerca volvulus		0.0075	0.0503	0.049
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0097	0.032
Schistosoma mansoni	Cyclin fold protein	0.0017	0.0013	0.0123
Echinococcus granulosus	cyclin B	0.0071	0.0469	0.4289
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0029	0.0102
Trypanosoma cruzi	cyclin, putative	0.0071	0.0469	0.1775
Trichomonas vaginalis	esterase, putative	0.0075	0.0503	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0041	0.0214	0.0806
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0027	0.0247
Schistosoma mansoni	lamin	0.0027	0.0097	0.0886
Trichomonas vaginalis	D-aminoacylase, putative	0.0075	0.0503	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0145	0.1094	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0469	0.3784
Loa Loa (eye worm)	hypothetical protein	0.0162	0.1241	1
Trichomonas vaginalis	ap endonuclease, putative	0.0041	0.0214	0.41
Echinococcus granulosus	cyclin G2	0.0017	0.0013	0.0123
Schistosoma mansoni	cyclin G	0.0017	0.0013	0.0123
Schistosoma mansoni	cyclins	0.0071	0.0469	0.4289
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0097	0.0785
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.0742	0.6782
Brugia malayi	Melibiase family protein	0.0069	0.0451	0.0624
Leishmania major	cyclin 9, putative	0.0017	0.0013	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Trichomonas vaginalis	cyclin B, putative	0.0071	0.0469	0.9322
Brugia malayi	hypothetical protein	0.0017	0.0016	0.0022
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0327	0.2636	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0075	0.0503	0.1222
Echinococcus multilocularis	cyclin G2	0.0017	0.0013	0.002
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0168	0.0254
Schistosoma mansoni	hypothetical protein	0.0021	0.0048	0.0441
Brugia malayi	intermediate filament protein	0.0027	0.0097	0.0134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0145	0.1094	0.1651
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0503	0.1222
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0017	0.0156
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0027	0.0096
Schistosoma mansoni	hypothetical protein	0.0017	0.0013	0.0123
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0029	0.0004
Entamoeba histolytica	cyclin, putative	0.0071	0.0469	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0075	0.0503	0.4051
Schistosoma mansoni	hypothetical protein	0.0016	0.0002	0.0016
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0041	0.0214	0.1956
Loa Loa (eye worm)	beta-lactamase	0.0075	0.0503	0.4051
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0029	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0503	0.4051
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0017	0.0156
Loa Loa (eye worm)	CYL-1 protein	0.0017	0.0013	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0223	0.18
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0029	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0469	0.3784
Trichomonas vaginalis	cyclins, putative	0.0071	0.0469	0.9322
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0327	0.2636	1
Echinococcus multilocularis	cyclin A3 4	0.0017	0.0013	0.002
Echinococcus granulosus	G1:S specific cyclin D1	0.0017	0.0013	0.0123
Brugia malayi	hypothetical protein	0.0035	0.0168	0.0233
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0041	0.0214	0.5
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0029	0.0043
Schistosoma mansoni	g1/s-specific cyclin C	0.0017	0.0013	0.0123
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0065	0.0098
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0041	0.0214	0.3911
Leishmania major	telomerase reverse transcriptase, putative	0.0327	0.2636	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0075	0.0503	0.1222
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0029	0.0102
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0017	0.0013	0.0123
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0145	0.1094	0.1513
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0503	0.1222
Trichomonas vaginalis	cyclin B, putative	0.0071	0.0469	0.9322
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0027	0.0041
Echinococcus granulosus	cyclin k	0.0017	0.0013	0.0123
Onchocerca volvulus		0.0071	0.0469	0.0457
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0017	0.0026
Schistosoma mansoni	zinc finger protein	0.002	0.0039	0.0357
Toxoplasma gondii	exonuclease III APE	0.0041	0.0214	0.0765
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0048	0.0389
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0327	0.2636	1
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0069	0.0451	0.8949
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0071	0.0469	0.0649
Brugia malayi	beta-lactamase	0.0075	0.0503	0.0695

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3 uM	Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA	ChEMBL.	20067291
Inhibition (binding)		Inhibition of Ape1/ref-1 endonuclease activity up to 100 uM	ChEMBL.	20067291

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL572065

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1065281