Detailed information for compound 1065331

Basic information

Technical information
  • TDR Targets ID: 1065331
  • Name: 3-phenylsulfonyl-N-[4-(1,3-thiazol-2-ylsulfam oyl)phenyl]propanamide
  • MW: 451.54 | Formula: C18H17N3O5S3
  • H donors: 2 H acceptors: 6 LogP: 1.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)S(=O)(=O)Nc1nccs1)CCS(=O)(=O)c1ccccc1
  • InChi: 1S/C18H17N3O5S3/c22-17(10-13-28(23,24)15-4-2-1-3-5-15)20-14-6-8-16(9-7-14)29(25,26)21-18-19-11-12-27-18/h1-9,11-12H,10,13H2,(H,19,21)(H,20,22)
  • InChiKey: FSAJBAHXYBTEKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-phenylsulfonyl-N-[4-(thiazol-2-ylsulfamoyl)phenyl]propanamide
  • 3-phenylsulfonyl-N-[4-(2-thiazolylsulfamoyl)phenyl]propanamide
  • 3-phenylsulfonyl-N-[4-(thiazol-2-ylsulfamoyl)phenyl]propionamide
  • T0519-0688
  • ZINC02732405

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.075 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0062 0.1852 0.1852
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0647 0.0647
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Schistosoma mansoni DNA helicase recq1 0.0012 0.0189 0.0189
Schistosoma mansoni smad1 5 8 and 0.0009 0.0108 0.0108
Schistosoma mansoni tyrosine kinase 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0029 0.075 0.075
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0431 0.374
Echinococcus multilocularis NMDA receptor 0.0016 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0115 0.3589 0.3589
Brugia malayi Carboxylesterase family protein 0.0019 0.0435 0.0499
Onchocerca volvulus Matrilysin homolog 0.0038 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.036 0.036
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0189 0.0189
Entamoeba histolytica Ran family GTPase 0.0021 0.0498 0.7524
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0019 0.0431 0.0431
Loa Loa (eye worm) oxidoreductase 0.0008 0.0045 0.0045
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0019 0.0435 0.3776
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0305 0.4332
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0045 0.0309
Brugia malayi Smad1 0.0009 0.0108 0.0124
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0008 0.0045 0.0045
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0471 0.0539
Schistosoma mansoni ran 0.0021 0.0498 0.0498
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0431 0.5482
Brugia malayi MH2 domain containing protein 0.0009 0.0108 0.0124
Schistosoma mansoni metabotropic glutamate receptor 0.0008 0.0063 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0184 0.1386
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0008 0.0063 0.0063
Echinococcus multilocularis acetylcholinesterase 0.0115 0.3589 0.3589
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0498 0.6423
Echinococcus granulosus metabotropic glutamate receptor 5 0.0008 0.0063 0.0063
Onchocerca volvulus 0.0012 0.0184 0.1386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0431 0.0431
Schistosoma mansoni ATP-binding cassette transporter 0.0016 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Echinococcus granulosus Smad4 0.0009 0.0108 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0045 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0189 0.0189
Echinococcus granulosus glutamate receptor subunit protein glur 0.0016 0.0318 0.0318
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0045 0.0309
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0211
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0062 0.1852 0.1852
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0647 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0211
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0184 0.0184
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0569 0.7426
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0189 0.0189
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0431 0.5482
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0184 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1311 0.1311
Echinococcus granulosus smad 0.0009 0.0108 0.0108
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0019 0.0435 0.3776
Toxoplasma gondii exonuclease III APE 0.002 0.0471 0.6038
Brugia malayi hypothetical protein 0.0008 0.0063 0.0072
Echinococcus multilocularis BC026374 protein (S09 family) 0.0019 0.0435 0.0435
Echinococcus multilocularis importin subunit beta 1 0.0029 0.075 0.075
Schistosoma mansoni BC026374 protein (S09 family) 0.0019 0.0435 0.0435
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0041 0.1137 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0647 0.5652
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0184 0.0184
Brugia malayi ecdysteroid receptor 0.0012 0.0184 0.0211
Mycobacterium ulcerans hydrolase 0.0021 0.0484 0.4019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0471 0.6038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0647 0.5652
Brugia malayi follicle stimulating hormone receptor 0.027 0.8724 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0045 0.0045
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Loa Loa (eye worm) RGC/RGC protein kinase 0.0008 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0309 1 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0021 0.0484 0.7289
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0211
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0045 0.0309
Brugia malayi Hemopexin family protein 0.0024 0.0597 0.0684
Brugia malayi Carboxylesterase family protein 0.0115 0.3589 0.4114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Brugia malayi Carboxylesterase family protein 0.0019 0.0435 0.0499
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0569 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1311 0.1311
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.1139 0.1139
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0647 0.0742
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0184 0.0211
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0115 0.3589 0.3589
Leishmania major GTP-binding protein, putative 0.0021 0.0498 0.7524
Brugia malayi Matrixin family protein 0.0017 0.036 0.0413
Schistosoma mansoni Smad4 0.0009 0.0108 0.0108
Brugia malayi MH2 domain containing protein 0.0139 0.4397 0.504
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0435 0.0435
Echinococcus granulosus acetylcholinesterase 0.0115 0.3589 0.3589
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0471 0.6029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0189 0.0217
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0016 0.0318 0.0318
Entamoeba histolytica hypothetical protein 0.0008 0.0063 0.0302
Schistosoma mansoni ap endonuclease 0.002 0.0471 0.0471
Schistosoma mansoni ap endonuclease 0.002 0.0471 0.0471
Echinococcus granulosus tyrosine kinase 0.0008 0.0063 0.0063
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0045 0.0309
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0008 0.0063 0.0072
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0435 0.0435
Loa Loa (eye worm) RecQ helicase 0.0029 0.0751 0.0751
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0045 0.0309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0647 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0045 0.0045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0023 0.0569 0.8712
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0041 0.1137 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1311 0.1311
Echinococcus granulosus carboxylesterase 5A 0.0115 0.3589 0.3589
Echinococcus granulosus glutamate NMDA receptor subunit 0.0016 0.0318 0.0318
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0498 0.0498
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0184 0.0184
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0008 0.0063 0.0063
Brugia malayi metabotropic glutamate receptor type 2 0.0008 0.0063 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0647 1
Echinococcus multilocularis glutamate receptor NMDA 0.0169 0.5357 0.5357
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0017 0.036 0.036
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0471 0.7073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0184
Schistosoma mansoni smad 0.0009 0.0108 0.0108
Schistosoma mansoni metabotropic glutamate receptor 0.0008 0.0063 0.0063
Onchocerca volvulus 0.0008 0.0063 0.0181
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0189 0.0189
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0108 0.0108
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0045 0.0045
Echinococcus multilocularis carboxylesterase 5A 0.0115 0.3589 0.3589
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0184 0.0211
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0184 0.0184
Echinococcus granulosus para nitrobenzyl esterase 0.0019 0.0435 0.0435
Trypanosoma cruzi extracellular receptor, putative 0.0008 0.0063 0.0347
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0008 0.0063 0.0063
Loa Loa (eye worm) glutamate receptor 1 0.0016 0.0318 0.0318
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0498 0.0498
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0647 0.0742
Leishmania major importin beta-1 subunit, putative 0.0023 0.0569 0.8712
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0146 0.4612 0.4612
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0471 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0498 0.8636
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0184 0.0184
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0184 0.0184
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0471 0.6038
Echinococcus multilocularis para nitrobenzyl esterase 0.0019 0.0435 0.0435
Schistosoma mansoni neuroligin 3 (S09 family) 0.0019 0.0435 0.0435
Mycobacterium tuberculosis Carboxylesterase LipT 0.0019 0.0435 0.3776
Loa Loa (eye worm) hypothetical protein 0.0012 0.0189 0.0189
Brugia malayi Guanylyl cyclase protein 23 0.0008 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Echinococcus granulosus atrial natriuretic peptide receptor 0.0008 0.0063 0.0063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0184 0.1386
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0211
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0019 0.0435 0.0435
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0305 0.3698
Loa Loa (eye worm) RGC/RGC protein kinase 0.0008 0.0063 0.0063
Mycobacterium ulcerans carboxylesterase, LipT 0.0019 0.0435 0.3578
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0045 0.0051
Brugia malayi Matrixin family protein 0.0041 0.1163 0.1333
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0498 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0211
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0045 0.0309
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0587 0.0587
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0647 0.5514
Brugia malayi Receptor family ligand binding region containing protein 0.0008 0.0063 0.0072
Loa Loa (eye worm) hypothetical protein 0.0008 0.0045 0.0045
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.055 0.055
Brugia malayi Carboxylesterase family protein 0.0019 0.0435 0.0499
Loa Loa (eye worm) hypothetical protein 0.0019 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0211
Loa Loa (eye worm) matrixin family protein 0.0041 0.1163 0.1163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0184 0.0184
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0184 0.0184
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0045 0.0051
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0184 0.0184
Schistosoma mansoni coup transcription factor 0.0012 0.0184 0.0184
Loa Loa (eye worm) RGC/RGC protein kinase 0.0008 0.0063 0.0063
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0108 0.0108
Echinococcus multilocularis tyrosine kinase 0.0008 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.8724 0.8724
Onchocerca volvulus 0.0024 0.0597 0.5494
Brugia malayi MH2 domain containing protein 0.0009 0.0108 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0184 0.0211
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0441 0.5623
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1311 0.1502
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0305 0.3692
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0045 0.0309
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0024 0.0587 0.0587
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.075 1
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.4397 0.4397
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0057 0.1661 0.1661
Loa Loa (eye worm) matrixin family protein 0.0038 0.105 0.105
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0498 0.0571
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0498 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0008 0.0063 0.0063
Schistosoma mansoni acetylcholinesterase 0.0019 0.0435 0.0435
Brugia malayi Matrixin family protein 0.0017 0.036 0.0413
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0008 0.0063 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0569 0.7426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0431 0.0431
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0045 0.0051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0184 0.0184
Onchocerca volvulus 0.0017 0.036 0.3141
Brugia malayi Matrixin family protein 0.0017 0.036 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Echinococcus granulosus neuroligin 0.0019 0.0435 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0184 0.0211
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0647 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0024 0.0597 0.0597
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0647 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0041 0.1137 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0647 0.0742
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0587 0.0587
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0397 0.3431
Schistosoma mansoni importin beta-1 0.0029 0.075 0.075
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0189 0.2051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0434 0.5514
Loa Loa (eye worm) hypothetical protein 0.0026 0.0647 0.0647
Brugia malayi Carboxylesterase family protein 0.0019 0.0435 0.0499
Brugia malayi nuclear hormone receptor 0.0012 0.0184 0.0211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1311 0.1311
Onchocerca volvulus Matrix metalloproteinase homolog 0.0038 0.105 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1311 0.1311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0305 0.4972
Brugia malayi Importin beta-1 subunit 0.0029 0.075 0.086
Loa Loa (eye worm) Smad1 0.0009 0.0108 0.0108
Brugia malayi RNA, U transporter 1 0.0082 0.2513 0.288
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0184 0.0184
Schistosoma mansoni smad1 5 8 and 0.0009 0.0108 0.0108
Onchocerca volvulus Matrilysin homolog 0.0017 0.036 0.3141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0045 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.036 0.036
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0008 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0498 0.8636
Schistosoma mansoni ran 0.0021 0.0498 0.0498
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0318 0.0318
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0647 0.5514
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0024 0.0587 0.0587
Brugia malayi Glutamate receptor 2 precursor 0.0016 0.0318 0.0365
Schistosoma mansoni smad1 5 8 and 0.0009 0.0108 0.0108
Brugia malayi Matrixin family protein 0.0017 0.036 0.0413
Leishmania major extracellular receptor, putative 0.0008 0.0063 0.0302
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0045 0.0045
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0751 0.0861
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0647 0.5514
Echinococcus multilocularis smad 0.0009 0.0108 0.0108
Echinococcus multilocularis neuroligin 0.0019 0.0435 0.0435
Loa Loa (eye worm) acetylcholinesterase 1 0.0115 0.3589 0.3589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0184 0.0184
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0021 0.0484 0.0554
Schistosoma mansoni protein kinase 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0115 0.3589 0.3589
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0431 0.3541
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0471 0.7073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0471 0.0471
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0184 0.0184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0471 0.8119
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0108 0.0108
Echinococcus granulosus receptor type guanylyl cyclase 0.0008 0.0063 0.0063
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0019 0.0435 0.0435
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0471 0.6038
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0318 0.0318
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0189 0.2051
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0045 0.0045
Brugia malayi steroid hormone receptor 0.0012 0.0184 0.0211
Echinococcus multilocularis glutamate receptor 2 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0484 0.0484
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0471 0.0471
Trichomonas vaginalis spcc417.12 protein, putative 0.0019 0.0435 0.5531
Onchocerca volvulus 0.0019 0.0435 0.3889
Loa Loa (eye worm) glutamate receptor 0.0008 0.0063 0.0063
Schistosoma mansoni glutamate receptor NMDA 0.0016 0.0318 0.0318
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0045 0.0309
Schistosoma mansoni DNA helicase recq5 0.0012 0.0189 0.0189
Echinococcus multilocularis snurportin 1 0.0309 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0184 0.0211
Onchocerca volvulus 0.0026 0.0647 0.5993
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0647 0.5514
Loa Loa (eye worm) hypothetical protein 0.0017 0.036 0.036
Brugia malayi Receptor family ligand binding region containing protein 0.0008 0.0063 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0184 0.0211
Echinococcus granulosus nmda type glutamate receptor 0.0177 0.5626 0.5626
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0184 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1311 0.1311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1311 0.1311
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0587 0.0587
Brugia malayi hypothetical protein 0.0019 0.0435 0.0499
Brugia malayi Glutamate receptor 1 precursor 0.0016 0.0318 0.0365
Brugia malayi nuclear receptor NHR-88 0.0012 0.0184 0.0211
Brugia malayi MH1 domain containing protein 0.0009 0.0108 0.0124
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0751 0.0751
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0019 0.0435 0.5531
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0647 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0041 0.1137 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0647 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0471 0.6029
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0305 0.4332
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0184 0.0211
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0569 0.7426
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0397 0.3431
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0045 0.0309
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0484 0.4204
Plasmodium vivax importin-beta 2, putative 0.0029 0.075 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.4397 0.4397
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0471 0.912
Schistosoma mansoni hypothetical protein 0.0016 0.0318 0.0318
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0184 0.0184
Onchocerca volvulus 0.0019 0.0435 0.3889
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0587 0.0587
Echinococcus granulosus glutamate receptor 2 0.0008 0.0063 0.0063
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0184 0.0184
Echinococcus granulosus bloom syndrome protein 0.0029 0.0751 0.0751
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0318 0.0318
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0016 0.0318 0.0318
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0397 0.3431
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0647 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0189 0.2051
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0184 0.0211
Trichomonas vaginalis ran, putative 0.0021 0.0498 0.6413
Echinococcus granulosus glutamate receptor 2 0.0024 0.0587 0.0587
Onchocerca volvulus 0.0008 0.0063 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0184 0.0211
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0041 0.1137 1
Onchocerca volvulus 0.0019 0.0435 0.3889
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0189 0.0189
Brugia malayi Carboxylesterase family protein 0.0115 0.3589 0.4114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0647 0.5514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0397 0.3431
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0647 0.5514
Echinococcus granulosus glutamate receptor NMDA 0.0169 0.5357 0.5357
Loa Loa (eye worm) carboxylesterase 0.0019 0.0435 0.0435
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0635 0.8368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Brugia malayi MH1 domain containing protein 0.0009 0.0108 0.0124
Loa Loa (eye worm) matrix metalloproteinase 0.0017 0.036 0.036
Brugia malayi Metabotropic glutamate receptor precursor. 0.0008 0.0063 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0471 0.8119
Echinococcus multilocularis acetylcholinesterase 0.0115 0.3589 0.3589
Mycobacterium ulcerans hypothetical protein 0.0026 0.0647 0.5514
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0008 0.0063 0.0181
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0587 0.0587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0184 0.0184
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0108 0.0108
Echinococcus multilocularis nmda type glutamate receptor 0.0225 0.7224 0.7224
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0189 0.0217
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0184 0.0184
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0751 1
Loa Loa (eye worm) glutamate receptor 2 0.0016 0.0318 0.0318
Loa Loa (eye worm) carboxylesterase 0.0019 0.0435 0.0435
Echinococcus multilocularis receptor type guanylyl cyclase 0.0008 0.0063 0.0063
Loa Loa (eye worm) carboxylesterase 0.0115 0.3589 0.3589
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0019 0.0435 0.0435
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Echinococcus granulosus importin subunit beta 1 0.0029 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0471 0.4088
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0016 0.0318 0.0318
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0431 0.0431
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0045 0.0309
Chlamydia trachomatis glutamine binding protein 0.0041 0.1137 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0016 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0026 0.0647 0.0647
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0045 0.0051
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0647 0.5514
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0184 0.0184
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0435 0.0435
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0498 0.6423
Schistosoma mansoni glutamate receptor NMDA 0.0193 0.615 0.615
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0184 0.1386
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0045 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0184 0.0184
Schistosoma mansoni gliotactin 0.0019 0.0435 0.0435
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0016 0.0318 0.0318
Echinococcus granulosus BC026374 protein S09 family 0.0019 0.0435 0.0435
Echinococcus multilocularis nmda type glutamate receptor 0.0177 0.5626 0.5626
Onchocerca volvulus 0.0019 0.0435 0.3889
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0318 0.0318
Plasmodium falciparum importin beta, putative 0.0029 0.075 1
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0318 0.0318
Echinococcus multilocularis Smad4 0.0009 0.0108 0.0108
Echinococcus granulosus acetylcholinesterase 0.0115 0.3589 0.3589
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0471 0.0471
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0318 0.0318
Echinococcus granulosus metabotropic glutamate receptor 2 0.0008 0.0063 0.0063
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0751 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0184 0.0184
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0498 0.6423
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0184 0.0184
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0016 0.0318 0.0318
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0016 0.0318 0.0318
Echinococcus granulosus nmda type glutamate receptor 0.0225 0.7224 0.7224
Onchocerca volvulus 0.0019 0.0435 0.3889
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0471 0.39
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.075 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0498 0.6423

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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