TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.52 | Formula: C24H20N6O2S
H donors: 3 H acceptors: 3 LogP: 4.24 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)Nc1ncnc2c1cc(cc2)NC(=S)Nc1cccc(c1)C#N
InChi: 1S/C24H20N6O2S/c1-31-21-9-7-18(12-22(21)32-2)28-23-19-11-17(6-8-20(19)26-14-27-23)30-24(33)29-16-5-3-4-15(10-16)13-25/h3-12,14H,1-2H3,(H,26,27,28)(H2,29,30,33)
InChiKey: NOKFYNQZQPZKTJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0824	0.2474
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0436	0.1012
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0219	0.314	1
Trypanosoma brucei	cytochrome P450, putative	0.0027	0.0201	0.0412
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0216	0.0442
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0017	0.0045	0.0073
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.287	0.9139
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0017	0.0045	0.0073
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0992	0.212
Brugia malayi	Pre-SET motif family protein	0.0201	0.287	0.9136
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0091	0.012
Echinococcus multilocularis	musashi	0.0028	0.0224	0.0224
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0436	0.0918
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0436	0.1012
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0992	0.212
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0115	0.1554	0.4931
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0436	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0108	0.0345
Echinococcus multilocularis	expressed conserved protein	0.0108	0.1447	0.1447
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0108	0.0345
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0131	0.1803	0.1803
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0436	1
Schistosoma mansoni	hypothetical protein	0.0198	0.2825	0.2819
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0108	0.5
Brugia malayi	beta-lactamase family protein	0.0042	0.0436	0.1358
Echinococcus granulosus	intermediate filament protein	0.0028	0.0224	0.0224
Echinococcus multilocularis	inositol monophosphatase 1	0.0078	0.0992	0.0992
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0233	0.0225
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0216	0.0553
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0091	0.012
Echinococcus multilocularis	expressed protein	0.0039	0.0383	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0216	0.0687
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0436	0.4762
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0591	0.1854
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0436	0.1388
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0269	0.391	1
Echinococcus granulosus	X box binding protein 1	0.0337	0.495	0.495
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0216	0.0553
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0044	0.0141
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0216	0.0553
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0316	0.4637	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0165	0.231	0.231
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0436	0.0428
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0044	0.0044
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0078	0.0992	0.2987
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0436	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0548	0.1744
Brugia malayi	cytochrome P450	0.0017	0.0045	0.0107
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0219	0.314	1
Leishmania major	cytochrome p450-like protein	0.0027	0.0201	0.0412
Loa Loa (eye worm)	inositol-1	0.0078	0.0992	0.3159
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0216	0.0687
Onchocerca volvulus		0.0219	0.314	0.9496
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0436	0.0918
Schistosoma mansoni	hypothetical protein	0.0036	0.0338	0.033
Schistosoma mansoni	inositol monophosphatase	0.0078	0.0992	0.0985
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0216	0.0442
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0219	0.314	0.9528
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0436	0.1264
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0473	0.0998
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0017	0.0045	0.0343
Echinococcus multilocularis		0.0014	0.0011	0.0011
Entamoeba histolytica	hypothetical protein	0.0036	0.0341	0.1055
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0436	0.1012
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0201	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0008	0.0026
Onchocerca volvulus		0.0151	0.2101	0.6121
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0011	0.0035
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0216	0.0443
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0383	0.1132
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0039	0.0383	0.122
Echinococcus multilocularis	geminin	0.0198	0.2825	0.2825
Schistosoma mansoni	hypothetical protein	0.0337	0.495	0.4945
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0824	0.2474
Entamoeba histolytica	hypothetical protein	0.0036	0.0341	0.1055
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0108	0.4205
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0201	0.0412
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0436	0.1012
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0242	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0217	0.0217
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0216	0.0654
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0436	0.4762
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0219	0.314	0.9528
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0014	0.0011	0.0011
Trichomonas vaginalis	rotamase, putative	0.0038	0.0369	0.109
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0078	0.0992	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.0548	0.0548
Toxoplasma gondii	ABC1 family protein	0.0042	0.0436	0.4331
Echinococcus granulosus	expressed conserved protein	0.0108	0.1447	0.1447
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0436	0.1293
Echinococcus granulosus	expressed protein	0.0039	0.0383	0.0383
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0233	0.2261
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.0548	0.0548
Schistosoma mansoni	hypothetical protein	0.0198	0.2825	0.2819
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.0369	0.0774
Toxoplasma gondii	peptidylprolyl isomerase	0.0038	0.0369	0.365
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0044	0.0044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0436	0.0428
Brugia malayi	hypothetical protein	0.0019	0.0083	0.0229
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0091	0.012
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0436	0.1293
Echinococcus multilocularis	Niemann Pick C1 protein	0.0165	0.231	0.231
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.3295	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0115	0.1554	0.1554
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0824	0.1756
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.007	0.0866	0.2125
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.007	0.0866	1
Schistosoma mansoni	hypothetical protein	0.0048	0.052	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2101	0.669
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0436	0.0436
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0216	0.0553
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0023	0.0073
Mycobacterium ulcerans	lipase LipD	0.0042	0.0436	0.1264
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0219	0.314	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0728	0.2318
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0718	0.2286
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.1803	0.1796
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0728	0.2291
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0044	0.0044
Echinococcus granulosus	GPCR family 2	0.0017	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0044	0.0141
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0216	0.2082
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0436	0.1388
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0242	0.5449
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0201	0.0642
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0436	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1554	0.4948
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0036
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0436	0.0918
Echinococcus multilocularis	protein dispatched 1	0.0056	0.0655	0.0655
Echinococcus granulosus	lamin	0.0028	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0338	0.1076
Trichomonas vaginalis	rotamase, putative	0.0039	0.0383	0.1132
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0233	0.0233
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0338	0.1045
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0044	0.0044
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0017	0.0045	0.0073
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0216	0.0443
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0216	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0108	0.0345
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0436	0.1012
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0014	0.0011	0.0003
Trichomonas vaginalis	esterase, putative	0.0042	0.0436	0.1293
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0038	0.0369	0.0774
Trypanosoma cruzi	hypothetical protein, conserved	0.0067	0.0824	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0224	0.0713
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0216	0.0654
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0233	0.0233
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0039	0.0383	0.1189
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0108	0.0345
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0473	0.0998
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0242	0.05
Entamoeba histolytica	hypothetical protein	0.0036	0.0341	0.1055
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0038	0.0369	0.1144
Echinococcus multilocularis	lamin	0.0028	0.0224	0.0224
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0216	0.0654
Onchocerca volvulus		0.0042	0.0436	0.0715
Schistosoma mansoni	hypothetical protein	0.0036	0.0341	0.0333
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0078	0.0992	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0216	0.0688
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.015	0.2085	0.4482
Echinococcus granulosus	inositol monophosphatase 1	0.0078	0.0992	0.0992
Brugia malayi	beta-lactamase	0.0042	0.0436	0.1358
Brugia malayi	hypothetical protein	0.0036	0.0341	0.1055
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0219	0.314	0.9528
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0992	0.212
Echinococcus multilocularis	lamin dm0	0.0028	0.0224	0.0224
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0233	0.0233
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0201	0.0412
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0216	0.0442
Echinococcus granulosus	lamin dm0	0.0028	0.0224	0.0224
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0216	0.0553
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0436	0.1012
Echinococcus multilocularis	protein patched	0.0049	0.0548	0.0548
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0014	0.0011	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0548	0.1634
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0054	0.0622	0.132
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0219	0.314	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0316	0.4637	1
Brugia malayi	CHE-14 protein	0.0049	0.0548	0.1715
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0341	0.0333
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0233	0.0225
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0038	0.0369	0.0774
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0067	0.0824	0.1756
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0224	0.0216
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.015	0.2085	0.4482
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0224	0.068
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0036
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0242	0.05
Schistosoma mansoni	hypothetical protein	0.0017	0.0045	0.0036
Onchocerca volvulus		0.0042	0.0436	0.0715
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0341	0.0341
Brugia malayi	Pre-SET motif family protein	0.0029	0.0233	0.0709
Brugia malayi	hypothetical protein	0.0151	0.2101	0.6678
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0473	0.0998
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0219	0.314	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Leishmania major	hypothetical protein, conserved	0.0067	0.0824	0.1756
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Leishmania major	hypothetical protein, conserved	0.0029	0.0242	0.05
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0436	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0233	0.0741
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.1654	0.1654
Echinococcus multilocularis	microtubule associated protein 2	0.0667	1	1
Schistosoma mansoni	rotamase	0.0039	0.0383	0.0375
Schistosoma mansoni	lamin	0.0028	0.0224	0.0216
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0216	0.0553
Schistosoma mansoni	hypothetical protein	0.0122	0.1654	0.1647
Schistosoma mansoni	hypothetical protein	0.0048	0.052	0.0513
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0108	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0219	0.314	0.9528
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0027	0.0201	0.0507
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0044	0.0106
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0436	0.1264
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0014	0.0011	0.0011
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0233	0.0225
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0436	0.1358
Schistosoma mansoni	lamin	0.0028	0.0224	0.0216
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0201	0.0642
Brugia malayi	intermediate filament protein	0.0028	0.0224	0.068
Brugia malayi	beta-lactamase family protein	0.0042	0.0436	0.1358
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0216	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Loa Loa (eye worm)	cytochrome P450	0.0017	0.0045	0.0142
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0473	0.0998
Brugia malayi	hypothetical protein	0.0029	0.0242	0.074
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0044	0.0106
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0224	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0242	0.0772
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0108	0.2291
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0108	0.0165
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.015	0.2085	0.4482
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0316	0.4637	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0591	0.1882
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0216	0.0654
Onchocerca volvulus		0.0042	0.0436	0.0715
Echinococcus granulosus	geminin	0.0198	0.2825	0.2825
Leishmania major	cytochrome p450-like protein	0.0017	0.0045	0.0073
Schistosoma mansoni	patched 1	0.0049	0.0548	0.054
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0224	0.0713
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0242	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0216	0.0687
Echinococcus granulosus	cytochrome P450 2K1	0.0017	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0591	0.1882
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0091	0.012
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0036
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0151	0.2108	0.5338
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0117	0.1581	0.1574
Onchocerca volvulus		0.0028	0.0224	0.0027
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0023	0.0038
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0036
Echinococcus multilocularis	X box binding protein 1	0.0337	0.495	0.495
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0233	0.0225
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0167	0.2344	0.5948
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0078	0.0992	0.3135
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0017	0.0045	0.0073
Schistosoma mansoni	cytochrome P450	0.0017	0.0045	0.0036
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0591	0.1854
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0436	0.1012
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0436	0.1264
Toxoplasma gondii	hypothetical protein	0.0051	0.0573	0.5727
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0436	0.1293
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0078	0.0992	0.212
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0216	0.0553
Onchocerca volvulus		0.0229	0.3295	1
Mycobacterium ulcerans	hypothetical protein	0.0167	0.2344	0.7427
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.1803	0.1796
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.0548	0.1744
Plasmodium vivax	SET domain protein, putative	0.0029	0.0233	0.522
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0078	0.0992	0.2987
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0017	0.0045	0.0073
Loa Loa (eye worm)	CYP4Cod1	0.0027	0.0201	0.0642
Leishmania major	cytochrome p450-like protein	0.0017	0.0045	0.0073
Schistosoma mansoni	inositol monophosphatase	0.0078	0.0992	0.0985
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0078	0.0992	0.306
Onchocerca volvulus		0.0029	0.0233	0.0056
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0242	0.236
Echinococcus granulosus	Niemann Pick C1 protein	0.0115	0.1554	0.1554
Schistosoma mansoni	microtubule-associated protein tau	0.0667	1	1
Leishmania major	mitochondrial DNA polymerase beta	0.0316	0.4637	1
Onchocerca volvulus		0.0028	0.0224	0.0027
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.0548	0.0548
Echinococcus multilocularis		0.0017	0.0045	0.0045
Entamoeba histolytica	hypothetical protein	0.0036	0.0341	0.1055
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0216	0.0654
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0341	0.0341
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0044	0.0044
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0216	0.0654
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0219	0.314	0.9528
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0436	0.1264
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0219	0.314	1
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0436	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0108	0.0345
Trichomonas vaginalis	inositol monophosphatase, putative	0.0078	0.0992	0.2987
Brugia malayi	Niemann-Pick C1 protein precursor	0.0115	0.1554	0.4931
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0242	0.05
Echinococcus granulosus	CTD small phosphatase protein like	0.0014	0.0011	0.0011
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0219	0.314	0.9528
Leishmania major	hypothetical protein, conserved	0.0042	0.0436	0.0918
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.1654	0.1654
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0201	0.0609
Schistosoma mansoni	hypothetical protein	0.0048	0.052	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0436	0.1388
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0436	0.1293
Schistosoma mansoni	hypothetical protein	0.0048	0.052	0.0513
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0045	0.0107
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0038	0.0369	0.0774
Brugia malayi	Inositol-1	0.0078	0.0992	0.3135

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 10 ug ml-1	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7	ChEMBL.	19586687

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL570502

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1066655