Detailed information for compound 1066878

Basic information

Technical information
  • TDR Targets ID: 1066878
  • Name: ethyl 2-[[2-(2-amino-4-oxo-1,3-thiazol-5-yl)a cetyl]amino]-5-bromo-4-methylthiophene-3-carb oxylate
  • MW: 420.302 | Formula: C13H14BrN3O4S2
  • H donors: 2 H acceptors: 3 LogP: 3.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)CC2SC(=N)NC2=O)sc(c1C)Br
  • InChi: 1S/C13H14BrN3O4S2/c1-3-21-12(20)8-5(2)9(14)23-11(8)16-7(18)4-6-10(19)17-13(15)22-6/h6H,3-4H2,1-2H3,(H,16,18)(H2,15,17,19)
  • InChiKey: PGANPXIBGNBLGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[[2-(2-amino-4-oxo-thiazol-5-yl)acetyl]amino]-5-bromo-4-methyl-thiophene-3-carboxylate
  • 2-[[2-(2-amino-4-oxo-5-thiazolyl)-1-oxoethyl]amino]-5-bromo-4-methyl-3-thiophenecarboxylic acid ethyl ester
  • 2-[[2-(2-amino-4-keto-thiazol-5-yl)acetyl]amino]-5-bromo-4-methyl-thiophene-3-carboxylic acid ethyl ester
  • ethyl 2-[2-(2-amino-4-oxo-1,3-thiazol-5-yl)ethanoylamino]-5-bromo-4-methyl-thiophene-3-carboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0258 0.36
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1148 0.1424
Onchocerca volvulus 0.0011 0.0042 0.023
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.024 0.0238
Schistosoma mansoni hypothetical protein 0.0025 0.0307 0.0357
Onchocerca volvulus 0.0011 0.0042 0.023
Onchocerca volvulus 0.0011 0.0042 0.023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0025 0.029 0.0588
Echinococcus granulosus importin subunit beta 1 0.0028 0.0359 0.0357
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0249 0.0834
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0042 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0249 0.0834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0084 0.0081
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0733 0.0898
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.1148 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.004 0.0037
Brugia malayi RNA binding protein 0.012 0.2096 0.7033
Brugia malayi mbt repeat family protein 0.0048 0.0733 0.246
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.1148 0.3827
Schistosoma mansoni tar DNA-binding protein 0.012 0.2096 0.2628
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0359 0.0648
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.029 0.4118
Mycobacterium tuberculosis Probable lipase LipE 0.0025 0.029 0.0588
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0011 0.004 0.0068
Trichomonas vaginalis esterase, putative 0.0025 0.029 0.3477
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0315 0.0568
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0527 0.1767
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0754 1
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.004 0.0017
Schistosoma mansoni pyruvate kinase 0.0019 0.0186 0.0203
Onchocerca volvulus 0.0048 0.0733 1
Onchocerca volvulus 0.0011 0.004 0.0194
Schistosoma mansoni glutamate receptor NMDA 0.0266 0.4861 0.6138
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.2301 0.23
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0085 0.0754
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.004 0.0576 0.8828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0359 0.0423
Echinococcus granulosus glutamate receptor subunit protein glur 0.0022 0.0242 0.024
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.024 0.0238
Schistosoma mansoni hypothetical protein 0.0025 0.0307 0.0357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0454 0.0452
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0218 0.0393
Loa Loa (eye worm) glutamate receptor 0.0011 0.004 0.0068
Mycobacterium ulcerans lipase LipD 0.0025 0.029 0.1923
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.004 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0249 0.0247
Echinococcus multilocularis neuropeptide s receptor 0.0538 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0284 0.2185
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0026 0.0024
Onchocerca volvulus Cathepsin F homolog 0.0011 0.0042 0.023
Echinococcus granulosus neuropeptide receptor A26 0.0538 1 1
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0315 0.432
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0043 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0025 0.029 0.0588
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0527 0.0953
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0249 0.0247
Echinococcus granulosus pyruvate kinase 0.0037 0.0527 0.0525
Loa Loa (eye worm) hypothetical protein 0.0025 0.0307 0.0554
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0086
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.024 0.3125
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0026 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.3461 0.3459
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0042 0.0072
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0527 0.7859
Loa Loa (eye worm) hypothetical protein 0.0026 0.0315 0.0568
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0249 0.0247
Brugia malayi hypothetical protein 0.0012 0.005 0.0167
Echinococcus granulosus geminin 0.0151 0.2677 0.2675
Echinococcus multilocularis beta LACTamase domain containing family member 0.0025 0.029 0.0287
Echinococcus granulosus cpg binding protein 0.0032 0.0426 0.0424
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0134 0.085
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0284 0.3806
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.298 0.375
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.004 0.0037
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0454 0.0452
Echinococcus multilocularis cpg binding protein 0.0032 0.0426 0.0424
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0733 0.1328
Brugia malayi ecdysteroid receptor 0.0022 0.0249 0.0834
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0218 0.2944
Brugia malayi intermediate filament protein 0.0028 0.0359 0.1204
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0026 0.0087
Leishmania major hypothetical protein, conserved 0.0024 0.0284 0.2203
Schistosoma mansoni coup transcription factor 0.0022 0.0249 0.0283
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0025 0.029 0.0588
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0733 0.0731
Mycobacterium ulcerans hypothetical protein 0.0025 0.029 0.1923
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0284 0.3532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0074 0.013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.005 0.0047
Leishmania major cysteine peptidase A (CPA) 0.0011 0.0042 0.0023
Plasmodium falciparum pyruvate kinase 0.0037 0.0527 0.7634
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0307 0.0554
Onchocerca volvulus 0.0011 0.0042 0.023
Brugia malayi RNA recognition motif domain containing protein 0.012 0.2096 0.7033
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0085 0.0754
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0249 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0527 0.7859
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1148 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0249 0.0834
Trypanosoma cruzi cruzipain precursor, putative 0.0043 0.0647 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0258 0.1973
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.0007
Onchocerca volvulus 0.0022 0.0249 0.3151
Brugia malayi hypothetical protein 0.0011 0.004 0.0133
Echinococcus multilocularis nmda type glutamate receptor 0.0312 0.5712 0.5711
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.029 0.3477
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0527 0.6805
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0249 0.0448
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0249 0.0247
Echinococcus granulosus metabotropic glutamate receptor 5 0.0011 0.004 0.0037
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0527 0.802
Echinococcus granulosus nmda type glutamate receptor 0.0312 0.5712 0.5711
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0026 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0249 0.0834
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Echinococcus granulosus glutamate receptor 2 0.0011 0.004 0.0037
Entamoeba histolytica hypothetical protein 0.0028 0.036 0.5033
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0454 0.0452
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0249 0.0247
Schistosoma mansoni cpg binding protein 0.0032 0.0426 0.0508
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.029 0.3477
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.029 0.3477
Brugia malayi hypothetical protein 0.0011 0.0026 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0249 0.0448
Brugia malayi tailless protein 0.0011 0.0026 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1148 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.029 0.0335
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0307 0.103
Brugia malayi nuclear hormone receptor 0.0022 0.0249 0.0834
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.005 0.003
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0134 0.0456
Schistosoma mansoni hypothetical protein 0.0022 0.0242 0.0274
Brugia malayi Calcitonin receptor-like protein seb-1 0.008 0.1345 0.4511
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.029 0.4118
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0249 0.0247
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0022 0.0242 0.024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0186 0.2268
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0043 0.0041
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0022 0.0242 0.024
Onchocerca volvulus 0.0011 0.0042 0.023
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0026 0.0024
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0527 0.6805
Echinococcus multilocularis geminin 0.0151 0.2677 0.2675
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0056 0.089 0.7577
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0242 0.0274
Schistosoma mansoni metabotropic glutamate receptor 0.0011 0.004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.024 0.0433
Brugia malayi Metabotropic glutamate receptor precursor. 0.0011 0.004 0.0133
Echinococcus granulosus dnaJ subfamily B 0.0428 0.7904 0.7903
Loa Loa (eye worm) hypothetical protein 0.0024 0.0284 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0249 0.0834
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.004 0.0037
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.005 0.0086
Brugia malayi Cytochrome P450 family protein 0.0014 0.0085 0.0286
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0042 0.004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0249 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0249 0.0448
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0249 0.0834
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.024 0.0238
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0026 0.0043
Brugia malayi hypothetical protein 0.0024 0.0284 0.0952
Mycobacterium tuberculosis Conserved protein 0.0025 0.029 0.0588
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0249 0.0247
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0032 0.0029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0754 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0249 0.0247
Schistosoma mansoni hypothetical protein 0.0011 0.0043 0.0022
Schistosoma mansoni ap endonuclease 0.0016 0.0134 0.0137
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0022 0.0242 0.024
Echinococcus multilocularis pyruvate kinase 0.0019 0.0186 0.0184
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0249 0.3151
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.005 0.0167
Brugia malayi Cytochrome P450 family protein 0.0014 0.0085 0.0286
Schistosoma mansoni ran 0.0021 0.0218 0.0244
Echinococcus multilocularis glutamate receptor NMDA 0.0233 0.4233 0.4232
Brugia malayi nuclear receptor NHR-67 0.0011 0.0026 0.0087
Loa Loa (eye worm) glutamate receptor 2 0.0022 0.0242 0.0435
Echinococcus granulosus cathepsin l1 0.0011 0.0042 0.004
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0011 0.0043 0.0018
Schistosoma mansoni importin beta-1 0.0028 0.0359 0.0423
Schistosoma mansoni tyrosine kinase 0.0011 0.004 0.0017
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0026 0.0024
Onchocerca volvulus 0.0028 0.0359 0.4708
Giardia lamblia Pyruvate kinase 0.0037 0.0527 0.7234
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.004 0.0068
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0043 0.0041
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0085 0.0151
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0043 0.0145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0307 0.0305
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Echinococcus granulosus RUN 0.0022 0.024 0.0238
Leishmania major cathepsin L-like protease 0.0011 0.0042 0.0023
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0454 0.0452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0307 0.0305
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0043 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0249 0.0283
Echinococcus granulosus pyruvate kinase 0.0019 0.0186 0.0184
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Leishmania major cathepsin L-like protease 0.0011 0.0042 0.0023
Schistosoma mansoni pyruvate kinase 0.0037 0.0527 0.0636
Mycobacterium tuberculosis Conserved protein 0.0025 0.029 0.0588
Loa Loa (eye worm) hypothetical protein 0.0028 0.0349 0.063
Loa Loa (eye worm) DR-78 0.0011 0.0026 0.0043
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.029 0.3477
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0218 0.2777
Echinococcus multilocularis neuropeptide receptor A26 0.0538 1 1
Leishmania major GTP-binding protein, putative 0.0021 0.0218 0.1613
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0733 1
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0242 0.0274
Schistosoma mansoni brg-1 associated factor 0.0011 0.0043 0.0022
Brugia malayi Cytochrome P450 family protein 0.0023 0.0254 0.0851
Loa Loa (eye worm) RNA binding protein 0.012 0.2096 0.3804
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0754 0.6439
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0157 0.2784 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0084 0.0081
Entamoeba histolytica hypothetical protein 0.0028 0.036 0.5033
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0086
Echinococcus multilocularis tar DNA binding protein 0.012 0.2096 0.2094
Onchocerca volvulus Cathepsin L homolog 0.0011 0.0042 0.023
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0754 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Leishmania major cathepsin L-like protease 0.0043 0.0647 0.548
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0527 0.4382
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0186 0.1302
Brugia malayi hypothetical protein 0.0012 0.005 0.0167
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0258 0.3035
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0733 0.0731
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.005 0.0167
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0527 0.6805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0249 0.0283
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.004 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0026 0.0024
Echinococcus multilocularis tyrosine kinase 0.0011 0.004 0.0037
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0527 0.708
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0249 0.0247
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0454 0.0452
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0527 1
Entamoeba histolytica hypothetical protein 0.0028 0.036 0.5033
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0218 0.0216
Brugia malayi metabotropic glutamate receptor type 2 0.0011 0.004 0.0133
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0394 0.0712
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.005 0.0047
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0022 0.0242 0.024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0249 0.0283
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Schistosoma mansoni ap endonuclease 0.0016 0.0134 0.0137
Brugia malayi hypothetical protein 0.0016 0.0122 0.0409
Echinococcus granulosus beta LACTamase domain containing family member 0.0025 0.029 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0134 0.1288
Schistosoma mansoni pyruvate kinase 0.0037 0.0527 0.0636
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0677 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.004 0.0068
Brugia malayi Papain family cysteine protease containing protein 0.0011 0.0042 0.0141
Brugia malayi TAR-binding protein 0.012 0.2096 0.7033
Mycobacterium tuberculosis Probable esterase LipL 0.0025 0.029 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Schistosoma mansoni hypothetical protein 0.0025 0.0307 0.0357
Echinococcus granulosus pyruvate kinase 0.0019 0.0186 0.0184
Echinococcus granulosus snurportin 1 0.0301 0.5506 0.5505
Schistosoma mansoni hypothetical protein 0.0055 0.0864 0.1064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.036 0.0358
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0249 0.0247
Loa Loa (eye worm) hypothetical protein 0.0022 0.024 0.0433
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.298 0.2979
Schistosoma mansoni glutamate receptor AMPA 0.0022 0.0242 0.0274
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0026 0.0024
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0527 0.0953
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0249 0.0834
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.1148 0.1146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0249 0.0247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0249 0.0283
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0249 0.0247
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.004 0.0068
Leishmania major cathepsin L-like protease 0.0011 0.0042 0.0023
Schistosoma mansoni glutamate receptor kainate 0.0022 0.0242 0.0274
Schistosoma mansoni tar DNA-binding protein 0.012 0.2096 0.2628
Echinococcus granulosus pyruvate kinase 0.0019 0.0186 0.0184
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.004 0.0133
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0026 0.0087
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Entamoeba histolytica cysteine protease, putative 0.0011 0.0042 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0026 0.0024
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0242 0.024
Brugia malayi hypothetical protein 0.0022 0.024 0.0807
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0043 0.0145
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.024 0.0238
Schistosoma mansoni ran 0.0021 0.0218 0.0244
Echinococcus multilocularis pyruvate kinase 0.0037 0.0527 0.0525
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0026 0.0024
Schistosoma mansoni protein kinase 0.0011 0.004 0.0017
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0011 0.004 0.0068
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0677 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0085 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Schistosoma mansoni lipoxygenase 0.0092 0.1557 0.1943
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0284 0.402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0249 0.0834
Echinococcus multilocularis GPCR, family 2 0.0025 0.0307 0.0305
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0025 0.029 0.0588
Mycobacterium tuberculosis Probable hydrolase 0.0025 0.029 0.0588
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0025 0.029 0.1923
Brugia malayi nuclear receptor NHR-88 0.0022 0.0249 0.0834
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0134 0.0862
Echinococcus granulosus lamin 0.0028 0.0359 0.0357
Schistosoma mansoni loxhd1 0.0022 0.024 0.0272
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.029 0.3477
Echinococcus multilocularis cathepsin L cysteine protease 0.0011 0.0042 0.004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0011 0.0042 0.0072
Schistosoma mansoni hypothetical protein 0.0151 0.2677 0.3365
Onchocerca volvulus 0.003 0.0394 0.5203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0249 0.0448
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0134 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0359 0.4869
Schistosoma mansoni hypothetical protein 0.0022 0.024 0.0272
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0249 0.0247
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0284 0.3393
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0042 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0056 0.089 1
Loa Loa (eye worm) beta-lactamase 0.0025 0.029 0.0522
Loa Loa (eye worm) hypothetical protein 0.0048 0.0733 0.1328
Mycobacterium ulcerans esterase/lipase LipP 0.0025 0.029 0.1923
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.024 0.2786
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0056 0.089 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0359 0.0648
Onchocerca volvulus 0.0025 0.029 0.373
Entamoeba histolytica hypothetical protein 0.0028 0.036 0.5033
Brugia malayi latrophilin 2 splice variant baaae 0.0055 0.0864 0.29
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0026 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.008 0.1345 0.4511
Schistosoma mansoni tar DNA-binding protein 0.012 0.2096 0.2628
Leishmania major cathepsin L-like protease 0.0011 0.0042 0.0023
Echinococcus granulosus tyrosine kinase 0.0011 0.004 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0134 0.0132
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0454 0.0452
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0022 0.0242 0.024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.005 0.003
Schistosoma mansoni glutamate receptor AMPA 0.0022 0.0242 0.0274
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.1148 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0134 0.1444
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0026 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.008 0.1329 0.241
Schistosoma mansoni tyrosine kinase 0.0011 0.004 0.0017
Brugia malayi ecdysone receptor 0.0011 0.0026 0.0087
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0284 0.3806
Brugia malayi CXXC zinc finger family protein 0.003 0.0394 0.1322
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0043 0.002
Schistosoma mansoni tar DNA-binding protein 0.012 0.2096 0.2628
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0677 1
Schistosoma mansoni hypothetical protein 0.0028 0.036 0.0425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0249 0.0834
Schistosoma mansoni cpg binding protein 0.003 0.0394 0.0467
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0112 0.0375
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0249 0.0283
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0039 0.0129
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0011 0.0042 0.004
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0026 0.0024
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0859 0.2881
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0056 0.089 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.004 0.0037
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0011 0.0043 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0134 0.0449
Brugia malayi Doublecortin family protein 0.0022 0.024 0.0807
Loa Loa (eye worm) hypothetical protein 0.0013 0.0074 0.013
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0471 0.711
Mycobacterium tuberculosis Conserved protein 0.0025 0.029 0.0588
Toxoplasma gondii ABC1 family protein 0.0025 0.029 0.2239
Brugia malayi hypothetical protein 0.0022 0.024 0.0807
Schistosoma mansoni hypothetical protein 0.0011 0.0043 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0527 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0249 0.0834
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0134 0.0239
Echinococcus granulosus cathepsin l cysteine peptidase 0.0011 0.0042 0.004
Echinococcus granulosus lamin dm0 0.0028 0.0359 0.0357
Echinococcus multilocularis pyruvate kinase 0.0037 0.0527 0.0525
Schistosoma mansoni rab6-interacting 0.0022 0.024 0.0272
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0218 0.1594
Brugia malayi RNA, U transporter 1 0.008 0.134 0.4495
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0042 0.0042
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0859 0.0857
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0359 0.2864
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0249 0.3151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.008 0.1329 0.4459
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.004 0.0037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0859 0.0857
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0359 0.4869
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0043 0.0075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0859 0.1556
Schistosoma mansoni hypothetical protein 0.0301 0.5506 0.6956
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0307 0.103
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0258 0.3035
Loa Loa (eye worm) ctsf protein 0.0011 0.0042 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0249 0.0448
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1148 0.1424
Echinococcus granulosus GPCR family 2 0.0025 0.0307 0.0305
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0978 0.8468
Echinococcus multilocularis glutamate receptor 2 0.0011 0.004 0.0037
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0527 0.1767
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0026 0.0024
Toxoplasma gondii exonuclease III APE 0.0016 0.0134 0.0829
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0249 0.0283
Leishmania major pyruvate kinase 0.0037 0.0527 0.4395
Brugia malayi nuclear hormone receptor 0.0011 0.0026 0.0087
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0359 0.0357
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0249 0.0283
Leishmania major cathepsin L-like protease 0.0043 0.0647 0.548
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0078 0.1305 0.1303
Echinococcus multilocularis nmda type glutamate receptor 0.0245 0.4446 0.4445
Onchocerca volvulus 0.0011 0.0042 0.023
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0249 0.0834
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0218 0.0216
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.5506 1
Brugia malayi nuclear receptor RXR 0.0011 0.0026 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0284 0.402
Loa Loa (eye worm) TAR-binding protein 0.012 0.2096 0.3804
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0733 0.0731
Echinococcus multilocularis lamin 0.0028 0.0359 0.0357
Brugia malayi nuclear receptor RXR 0.0012 0.005 0.0167
Leishmania major hypothetical protein, conserved 0.0025 0.029 0.2257
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0754 0.0752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.1329 0.1654
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0454 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.1329 0.1327
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0218 0.2475
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0859 0.0857
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0011 0.004 0.0037
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.298 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Brugia malayi beta-lactamase family protein 0.0025 0.029 0.0972
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0307 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0043 0.0018
Echinococcus multilocularis cysteine protease 0.0011 0.0042 0.004
Echinococcus multilocularis cathepsin L cysteine protease 0.0011 0.0042 0.004
Onchocerca volvulus Cathepsin L homolog 0.0011 0.0042 0.023
Echinococcus granulosus glutamate receptor 2 0.0033 0.0454 0.0452
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0527 0.802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.1329 0.1654
Plasmodium vivax hypothetical protein, conserved 0.0025 0.029 0.3477
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0527 0.0953
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0733 0.0898
Loa Loa (eye worm) glutamate receptor 1 0.0022 0.0242 0.0435
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0249 0.0283
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0026 0.0024
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0025 0.029 0.0972
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Echinococcus multilocularis snurportin 1 0.0301 0.5506 0.5505
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.1329 0.1654
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Schistosoma mansoni hypothetical protein 0.0025 0.0307 0.0357
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0218 0.0733
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.036 0.0425
Echinococcus granulosus glutamate receptor NMDA 0.0233 0.4233 0.4232
Echinococcus multilocularis musashi 0.0028 0.0359 0.0357
Loa Loa (eye worm) fibroinase 0.0011 0.0042 0.0072
Echinococcus multilocularis NMDA receptor 0.0022 0.0242 0.024
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0527 0.4154
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0454 0.0452
Loa Loa (eye worm) cysteine protease 0.0011 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0011 0.0042 0.004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.103 0.1274
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0056 0.089 0.2855
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0754 0.6439
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Loa Loa (eye worm) brahma associated protein 0.0011 0.0043 0.0075
Brugia malayi Importin beta-1 subunit 0.0028 0.0359 0.1204
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0043 0.0011
Brugia malayi mbt repeat family protein 0.0048 0.0733 0.246
Echinococcus multilocularis pyruvate kinase 0.0019 0.0186 0.0184
Giardia lamblia Pyruvate kinase 0.0019 0.0186 0.0962
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0134 0.1478
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.004 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.1329 0.1327
Schistosoma mansoni hypothetical protein 0.0151 0.2677 0.3365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0134 0.1288
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.036 0.0358
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0043 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.029 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0249 0.0834
Schistosoma mansoni polycystin 1-related 0.0022 0.024 0.0272
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.2301 0.23
Leishmania major pyruvate kinase 0.0037 0.0527 0.4395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0359 0.0648
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0249 0.0247
Echinococcus granulosus intermediate filament protein 0.0028 0.0359 0.0357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.1329 0.1327
Brugia malayi hypothetical protein 0.0011 0.0026 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0647 1
Echinococcus multilocularis lamin dm0 0.0028 0.0359 0.0357
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.004 0.0133
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0043 0.0145
Leishmania major cytochrome p450-like protein 0.0014 0.0085 0.0413
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0134 0.1551
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0249 0.0834
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Onchocerca volvulus 0.0025 0.029 0.373
Brugia malayi Glutamate receptor 1 precursor 0.0022 0.0242 0.0811
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0022 0.0242 0.024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.1148 0.1146
Schistosoma mansoni lipoxygenase 0.0131 0.2301 0.2888
Trichomonas vaginalis ran, putative 0.0021 0.0218 0.2475
Loa Loa (eye worm) hypothetical protein 0.0055 0.0864 0.1566
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0134 0.0132
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0026 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0249 0.0834
Loa Loa (eye worm) pigment dispersing factor receptor c 0.008 0.1345 0.2439
Entamoeba histolytica hypothetical protein 0.0023 0.0258 0.343
Leishmania major cathepsin L-like protease 0.0043 0.0647 0.548
Plasmodium vivax importin-beta 2, putative 0.0028 0.0359 0.4448
Echinococcus granulosus nmda type glutamate receptor 0.0245 0.4446 0.4445
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0359 0.1204
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0186 0.2022
Loa Loa (eye worm) acetyltransferase 0.0167 0.298 0.5411
Onchocerca volvulus 0.0011 0.0042 0.023
Schistosoma mansoni hypothetical protein 0.0428 0.7904 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.004 0.0068
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0249 0.3151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0249 0.0834
Loa Loa (eye worm) hypothetical protein 0.0037 0.0527 0.0953
Brugia malayi beta-lactamase 0.0025 0.029 0.0972
Loa Loa (eye worm) doublecortin family protein 0.0022 0.024 0.0433
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0134 0.1288
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.3461 0.3459
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0647 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0379 0.0377
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0026 0.0043
Echinococcus granulosus tar DNA binding protein 0.012 0.2096 0.2094
Onchocerca volvulus 0.0025 0.029 0.373
Schistosoma mansoni lamin 0.0028 0.0359 0.0423
Loa Loa (eye worm) hypothetical protein 0.008 0.1345 0.2439
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0134 0.1551
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0249 0.0448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0042 0.0072
Echinococcus granulosus glutamate NMDA receptor subunit 0.0022 0.0242 0.024
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0859 0.1057
Loa Loa (eye worm) MBCTL1 0.0055 0.0859 0.1556
Brugia malayi beta-lactamase family protein 0.0025 0.029 0.0972
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0218 0.2944
Echinococcus multilocularis cysteine protease 0.0011 0.0042 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0249 0.0448
Loa Loa (eye worm) hypothetical protein 0.0014 0.0084 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.029 0.0335
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0043 0.0041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.012 0.2096 0.3804
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0026 0.0087
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0454 0.0452
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0527 0.708
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0218 0.1557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0043 0.0647 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0025 0.029 0.0522
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0085 0.0151
Plasmodium falciparum importin beta, putative 0.0028 0.0359 0.4989
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0043 0.0018
Schistosoma mansoni cpg binding protein 0.0032 0.0426 0.0508
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0011 0.004 0.0194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0249 0.0283
Entamoeba histolytica Ran family GTPase 0.0021 0.0218 0.2805
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0086
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0218 0.2368
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0647 1
Chlamydia trachomatis glutamine binding protein 0.0056 0.089 1
Echinococcus multilocularis RUN 0.0022 0.024 0.0238
Schistosoma mansoni hypothetical protein 0.0295 0.5399 0.6821
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.1329 0.1327
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.2892 0.289
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0249 0.0247
Schistosoma mansoni ATP-binding cassette transporter 0.0022 0.0242 0.0274
Echinococcus multilocularis pyruvate kinase 0.0019 0.0186 0.0184
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0527 0.1483
Schistosoma mansoni rab6-interacting 0.0022 0.024 0.0272
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0307 0.0305
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.024 0.0238
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0249 0.0283
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0254 0.0457
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.024 0.0238
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0527 0.708
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0249 0.0283
Echinococcus granulosus cathepsin L cysteine proteinase 0.0011 0.0042 0.004
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0249 0.0247
Brugia malayi hypothetical protein 0.0028 0.036 0.1209
Onchocerca volvulus 0.0011 0.004 0.0194
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0859 0.0857
Brugia malayi conserved hypotetical protein 0.0011 0.0026 0.0087
Mycobacterium ulcerans beta-lactamase 0.0025 0.029 0.1923
Onchocerca volvulus 0.0022 0.024 0.3034
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0043 0.0041
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0242 0.0274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0249 0.0247
Brugia malayi Cathepsin L-like precursor 0.0011 0.0042 0.0141
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.004 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0249 0.0834
Schistosoma mansoni hypothetical protein 0.0011 0.0043 0.0022
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.7904 0.7903
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0733 0.0731
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0022 0.0242 0.024
Chlamydia trachomatis pyruvate kinase 0.0037 0.0527 0.5706
Schistosoma mansoni tar DNA-binding protein 0.012 0.2096 0.2628
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0043
Loa Loa (eye worm) hypothetical protein 0.0022 0.0249 0.0448
Onchocerca volvulus 0.0022 0.024 0.3034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0249 0.0283
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0733 0.0898
Brugia malayi steroid hormone receptor 0.0022 0.0249 0.0834
Brugia malayi Glutamate receptor 2 precursor 0.0022 0.0242 0.0811
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1148 1
Onchocerca volvulus 0.0028 0.0359 0.4708
Loa Loa (eye worm) hypothetical protein 0.0028 0.0359 0.0648
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.029 0.3638
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0112 0.0199
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0258 0.3035
Leishmania major cathepsin L-like protease 0.0011 0.0042 0.0023
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0032 0.0029
Schistosoma mansoni lamin 0.0028 0.0359 0.0423
Brugia malayi nuclear receptor NHR-88 0.0011 0.0026 0.0087
Onchocerca volvulus 0.0011 0.0043 0.0247

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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