TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.575 | Formula: C26H35N3O2
H donors: 0 H acceptors: 2 LogP: 4.24 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(COc1ccccc1CN1CCC2(CC1)CCN(CC2)C(=O)c1ccncc1)C
InChi: 1S/C26H35N3O2/c1-21(2)20-31-24-6-4-3-5-23(24)19-28-15-9-26(10-16-28)11-17-29(18-12-26)25(30)22-7-13-27-14-8-22/h3-8,13-14,21H,9-12,15-20H2,1-2H3
InChiKey: GLKFHODDQQHCAX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References
Homo sapiens	chemokine (C-C motif) receptor 8	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0156	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0468	0.0799
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0031	0.0546
Schistosoma mansoni	hypothetical protein	0.001	0.0007	0.0016
Echinococcus multilocularis	cyclic AMP responsive element binding protein	0.001	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0062	0.0334	0.057
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0238	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0042	0.0042
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.01
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0188	0.0321
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.007	0.007
Schistosoma mansoni	nuclear receptor	0.0009	0.0004	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus granulosus	death domain containing protein	0.0062	0.0334	0.0789
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0254	0.0433
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0062	0.0334	0.057
Brugia malayi	CHE-14 protein	0.0083	0.0468	0.0799
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0164	0.028
Onchocerca volvulus	Protein patched homolog	0.0012	0.0018	0.0025
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0152	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0062	0.0334	0.0334
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0162	0.1059
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.01
Brugia malayi	Niemann-Pick C1 protein precursor	0.0194	0.1165	0.1988
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0097	0.3171
Schistosoma mansoni	camp-response element binding protein-related	0.001	0.0007	0.0016
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0009	0.0004	0.0008
Brugia malayi	hypothetical protein	0.0009	0.0004	0.0006
Onchocerca volvulus		0.0014	0.0031	0.0046
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0013	0.0026	0.0061
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0031	0.0657
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0251	0.0593
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0031	0.0546
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0024	0.0097	0.0097
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Brugia malayi	bZIP transcription factor family protein	0.001	0.0007	0.0012
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.007	0.0165
Echinococcus granulosus	cyclic AMP dependent transcription factor ATF 6	0.001	0.0007	0.0016
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0018
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0238	1
Echinococcus multilocularis	cAMP responsive element binding protein 3	0.001	0.0007	0.0007
Brugia malayi	Myosin head containing protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0018
Echinococcus multilocularis	sterol regulatory element binding protein	0.0083	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0238	0.0407
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0031	0.0546
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0238	1
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.007	0.0119
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Brugia malayi	Uncoordinated protein 44	0.0062	0.0334	0.057
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0238	1
Entamoeba histolytica	hypothetical protein	0.0034	0.0162	0.1153
Onchocerca volvulus		0.0012	0.0018	0.0025
Schistosoma mansoni	transcription factor btf3	0.0034	0.0162	0.0382
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0009	0.0004	0.0006
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0009	0.0004	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.007	0.0119
Brugia malayi	nuclear receptor RXR	0.0011	0.0011	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus granulosus	geminin	0.0167	0.0997	0.2356
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.007	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0162	0.345
Brugia malayi	protein C24B5.3	0.0012	0.0018	0.0031
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0194	0.1165	1
Brugia malayi	bZIP transcription factor family protein	0.001	0.0007	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.007	0.0119
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.007	0.0165
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.007	0.0119
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.007	0.0119
Echinococcus granulosus	expressed conserved protein	0.0182	0.1091	0.2579
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0156	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	Patched protein homolog 1	0.0012	0.0018	0.0031
Echinococcus multilocularis	Niemann Pick C1 protein	0.0194	0.1165	0.1165
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0238	0.0407
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0512	0.0873
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0162	0.345
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0004	0.0008
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0162	0.1059
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0062	0.0334	0.0789
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0031	0.0546
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus granulosus	nuclear receptor nhr 48	0.0009	0.0004	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0238	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0024	0.0097	0.3171
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0097	0.0533
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0011	0.0025
Echinococcus multilocularis	nuclear receptor nhr 48	0.0009	0.0004	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.007	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0164	0.028
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0012
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0011	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0238	0.0407
Schistosoma mansoni	hypothetical protein	0.0167	0.0997	0.2356
Trypanosoma cruzi	hypothetical protein, conserved	0.021	0.1266	1
Schistosoma mansoni	netrin receptor unc5	0.0062	0.0334	0.0789
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0238	0.1682
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0232	0.1408	0.2401
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0062	0.0337	0.0797
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0026	0.0061
Schistosoma mansoni	hypothetical protein	0.0071	0.0391	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	beta-NAC-like protein	0.0034	0.0162	0.0276
Brugia malayi	nuclear hormone receptor	0.002	0.007	0.0119
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0164	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.007	0.0119
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.01
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0014	0.0031	0.0844
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.007	0.0119
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.007	0.0119
Onchocerca volvulus		0.0939	0.5863	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0009	0.0004	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus granulosus	cyclic AMP responsive element binding protein	0.001	0.0007	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0164	0.028
Echinococcus granulosus	GPCR family 2	0.0016	0.0042	0.01
Schistosoma mansoni	hypothetical protein	0.008	0.0449	0.1062
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.001	0.0007	0.0016
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0225	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	camp-response element binding protein	0.001	0.0007	0.0016
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0031	0.0546
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0238	0.183
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0031	0.0546
Entamoeba histolytica	hypothetical protein	0.0071	0.0391	0.3171
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.007	0.0165
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.007	0.0165
Schistosoma mansoni	hypothetical protein	0.0047	0.0243	0.0574
Leishmania major	hypothetical protein, conserved	0.021	0.1266	1
Brugia malayi	hypothetical protein	0.001	0.0007	0.0012
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.007	0.0165
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Echinococcus granulosus	jun protein	0.001	0.0007	0.0016
Loa Loa (eye worm)	bZIP transcription factor family protein	0.001	0.0007	0.0012
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0238	1
Onchocerca volvulus		0.0012	0.0018	0.0025
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0238	1
Trypanosoma brucei	hypothetical protein, conserved	0.021	0.1266	1
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.007	0.0119
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.007	0.0165
Brugia malayi	steroid hormone receptor	0.002	0.007	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	hypothetical protein	0.0016	0.0042	0.01
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Trypanosoma cruzi	hypothetical protein, conserved	0.021	0.1266	1
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Echinococcus granulosus	Protein patched homolog 1	0.0083	0.0468	0.1107
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Brugia malayi	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus granulosus	FTZ F1 alpha	0.002	0.007	0.0165
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.007	0.007
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0009	0.0004	0.0006
Brugia malayi	nuclear receptor NHR-88	0.002	0.007	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0031	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0018
Schistosoma mansoni	zinc finger protein	0.0009	0.0004	0.0008
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0254	0.0433
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.007	0.007
Onchocerca volvulus		0.0012	0.0018	0.0025
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0238	1
Brugia malayi	hypothetical protein	0.0071	0.0391	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0586	0.1
Schistosoma mansoni	camp-response element binding protein-related	0.001	0.0007	0.0016
Echinococcus multilocularis	cyclic AMP dependent transcription factor ATF 6	0.001	0.0007	0.0007
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0031	0.0031
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0011	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0026	0.0044
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.007	0.0119
Schistosoma mansoni	hypothetical protein	0.0167	0.0997	0.2356
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.007	0.0165
Schistosoma mansoni	nuclear hormone receptor	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Brugia malayi	bZIP transcription factor family protein	0.001	0.0007	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Echinococcus granulosus	microtubule associated protein 2	0.068	0.4231	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	fos transcription factor-related	0.001	0.0007	0.0016
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0014	0.0031	0.0844
Echinococcus multilocularis	Ankyrin	0.0062	0.0337	0.0337
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0225	0.0225
Echinococcus granulosus	Ankyrin	0.0062	0.0337	0.0797
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0162	0.1059
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Onchocerca volvulus		0.0014	0.0031	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	nuclear receptor NHR-67	0.0009	0.0004	0.0006
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0225	0.0384
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0512	0.0873
Schistosoma mansoni	hypothetical protein	0.008	0.0449	0.1062
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.007	0.0119
Echinococcus granulosus	Niemann Pick C1 protein	0.0277	0.1689	0.3993
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.007	0.0119
Brugia malayi	nuclear receptor RXR	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0238	0.1682
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0009	0.0004	0.0008
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0162	0.9828
Loa Loa (eye worm)	nuclear hormone receptor	0.0009	0.0004	0.0006
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0238	0.1682
Echinococcus granulosus	netrin receptor unc 5	0.0062	0.0334	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0254	0.0433
Echinococcus multilocularis	geminin	0.0167	0.0997	0.0997
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0042	0.0072
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0686	0.117
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0238	1
Loa Loa (eye worm)	patched family protein	0.0012	0.0018	0.0031
Onchocerca volvulus		0.0012	0.0018	0.0025
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0162	0.0276
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Onchocerca volvulus		0.0012	0.0018	0.0025
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0162	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0468	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0164	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0391	0.0391
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0164	0.6617
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0164	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0024	0.0097	0.3171
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.007	0.007
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0004	0.0006
Echinococcus granulosus	sterol regulatory element binding protein	0.0083	0.0468	0.1107
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.007	0.007
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0042	0.0042
Schistosoma mansoni	patched 1	0.0083	0.0468	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0018
Echinococcus granulosus	fos transcription factor	0.001	0.0007	0.0016
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0512	0.1209
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0238	1
Loa Loa (eye worm)	patched family protein	0.0012	0.0018	0.0031
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0251	0.0593
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0162	0.1059
Brugia malayi	nuclear hormone receptor	0.0009	0.0004	0.0006
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0011	0.0025
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0207	0.4416
Schistosoma mansoni	thyroid hormone receptor	0.002	0.007	0.0165
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.001	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0334	0.057
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0031	0.0546
Brugia malayi	cyclic AMP-response element binding protein 1 gamma 1, putative	0.0939	0.5863	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0009	0.0004	0.0006
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0024	0.0097	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0194	0.1165	0.1988
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0337	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0164	0.028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.007	0.0119
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0097	0.0533
Echinococcus multilocularis	voltage gated potassium channel	0.0013	0.0026	0.0026
Loa Loa (eye worm)	bZIP transcription factor family protein	0.001	0.0007	0.0012
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0011	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.007	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	microtubule-associated protein tau	0.068	0.4231	1
Brugia malayi	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0083	0.0468	0.0799
Brugia malayi	tailless protein	0.0009	0.0004	0.0006
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0164	0.6421
Schistosoma mansoni	camp-response element binding protein-related	0.001	0.0007	0.0016
Schistosoma mansoni	hypothetical protein	0.008	0.0449	0.1062
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.007	0.0119
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0031	0.0073
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0013	0.0026	0.0044
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0316	0.194	0.194
Brugia malayi	hypothetical protein	0.0011	0.0011	0.0018
Brugia malayi	bZIP transcription factor family protein	0.001	0.0007	0.0012
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0162	0.9828
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.007	0.0119
Echinococcus multilocularis	fos transcription factor	0.001	0.0007	0.0007
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0031	0.0052
Onchocerca volvulus		0.0012	0.0018	0.0025
Echinococcus multilocularis	microtubule associated protein 2	0.068	0.4231	0.4231
Echinococcus multilocularis	expressed conserved protein	0.0182	0.1091	0.1091
Onchocerca volvulus	Netrin receptor homolog	0.0062	0.0334	0.0564
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.007	0.0165
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0316	0.194	0.4585
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0152	0.6071
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0031	0.0858
Brugia malayi	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0013	0.0026	0.0026
Echinococcus granulosus	cyclic AMP responsive element binding protein	0.001	0.0007	0.0016
Onchocerca volvulus		0.0047	0.0238	0.0401
Brugia malayi	nuclear hormone receptor family member odr-7	0.0009	0.0004	0.0006
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0512	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	ankyrin 23/unc44	0.0062	0.0334	0.0789
Echinococcus granulosus	cAMP responsive element binding protein 3	0.001	0.0007	0.0016
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0031	0.0052
Echinococcus granulosus	citrate lyase subunit beta protein	0.0024	0.0097	0.0228
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.007	0.0119
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.007	0.0165
Loa Loa (eye worm)	bZIP transcription factor family protein	0.001	0.0007	0.0012
Brugia malayi	MH2 domain containing protein	0.0118	0.0686	0.117
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	hypothetical protein	0.0011	0.0011	0.0018
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0512	0.0512
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.007	0.007
Echinococcus multilocularis	Niemann Pick C1 protein	0.0277	0.1689	0.1689
Brugia malayi	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0238	0.0407
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0512	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0238	0.0407
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0031	0.0546
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.007	0.0119
Brugia malayi	Patched related family protein 4	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0238	0.183
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0031	0.0546
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0238	0.183
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0042	0.01
Echinococcus multilocularis	expressed protein	0.001	0.0007	0.0007
Onchocerca volvulus		0.0014	0.0031	0.0046
Echinococcus granulosus	Niemann Pick C1 protein	0.0194	0.1165	0.2754
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.1408	0.3328
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0152	0.6071
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0512	0.0512
Brugia malayi	Patched related family protein 12	0.0012	0.0018	0.0031
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.001	0.0007	0.0016
Onchocerca volvulus		0.0012	0.0018	0.0025
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.007	0.0165
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.007	0.0113
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0009	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0238	0.0407
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.007	0.0119
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0152	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.007	0.0165
Schistosoma mansoni	hypothetical protein	0.001	0.0007	0.0016
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0004	0.0008
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0197	0.1184	0.2799
Onchocerca volvulus	Protein patched homolog	0.0012	0.0018	0.0025
Schistosoma mansoni	hypothetical protein	0.0034	0.0156	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Onchocerca volvulus		0.002	0.007	0.0113
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Brugia malayi	Patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0018
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0042	0.01
Onchocerca volvulus		0.0014	0.0031	0.0046
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0031	0.0858
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.007	0.0165
Brugia malayi	Patched related family protein 10	0.0012	0.0018	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0162	0.345
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0243	0.0414
Brugia malayi	orphan nuclear receptor NR2E1	0.0009	0.0004	0.0006
Brugia malayi	ecdysone receptor	0.0009	0.0004	0.0006
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.001	0.0007	0.0007
Brugia malayi	Protein kinase domain containing protein	0.0062	0.0334	0.057
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0009	0.0004	0.0008
Loa Loa (eye worm)	DR-78	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.007	0.0119
Schistosoma mansoni	thyroid hormone receptor	0.002	0.007	0.0165
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0024	0.0097	0.3171
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.007	0.0165
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0004	0.0008
Onchocerca volvulus		0.0047	0.0243	0.0409
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0686	0.117
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0207	0.4416
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0042	0.0072
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0004	0.0008
Brugia malayi	Death domain containing protein	0.0062	0.0334	0.057
Entamoeba histolytica	hypothetical protein	0.0071	0.0391	0.3171
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0004	0.0006
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.007	0.007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0009	0.0004	0.0004
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0097	0.0533
Echinococcus granulosus	expressed protein	0.001	0.0007	0.0016
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0026	0.0061
Loa Loa (eye worm)	patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0011	0.0018
Schistosoma mansoni	jun-related protein	0.001	0.0007	0.0016
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0031	0.0546
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0024	0.0097	0.2063
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Schistosoma mansoni	hypothetical protein	0.008	0.0449	0.1062
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0238	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0225	0.0532
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.1408	0.1408
Echinococcus granulosus	transcription factor btf3	0.0034	0.0162	0.0382
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0238	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.007	0.0119
Mycobacterium tuberculosis	Conserved protein	0.0024	0.0097	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Onchocerca volvulus		0.001	0.0007	0.0006
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0243	0.0574
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0031	0.0657
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0391	0.0923
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0031	0.0546
Loa Loa (eye worm)	patched family protein	0.0012	0.0018	0.0031
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0042	0.0072
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0164	0.028
Entamoeba histolytica	hypothetical protein	0.0071	0.0391	0.3171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0512	0.1209
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0031	0.0052
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.007	0.007
Echinococcus multilocularis	protein patched	0.0083	0.0468	0.0468
Echinococcus granulosus	voltage gated potassium channel	0.0013	0.0026	0.0061
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.007	0.0119
Echinococcus multilocularis	protein dispatched 1	0.0095	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1408	0.2401
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0004	0.0008
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0097	0.3171
Echinococcus multilocularis	jun protein	0.001	0.0007	0.0007
Brugia malayi	bZIP transcription factor family protein	0.001	0.0007	0.0012
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0254	0.0433
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0031	0.0073
Schistosoma mansoni	hypothetical protein	0.0062	0.0334	0.0789
Schistosoma mansoni	coup transcription factor	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Entamoeba histolytica	hypothetical protein	0.0071	0.0391	0.3171
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0004	0.0006
Brugia malayi	hypothetical protein	0.0009	0.0004	0.0006
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0031	0.0858
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.007	0.0113
Loa Loa (eye worm)	hypothetical protein	0.002	0.007	0.0119
Brugia malayi	protein C24B5.3	0.0012	0.0018	0.0031
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0391	0.0923
Echinococcus granulosus	thyroid hormone receptor alpha	0.0009	0.0004	0.0008
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0042	0.0072
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0162	0.1153
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.007	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0939	0.5863	1
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.001	0.0007	0.0012
Brugia malayi	conserved hypotetical protein	0.0009	0.0004	0.0006
Brugia malayi	ecdysteroid receptor	0.002	0.007	0.0119
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.007	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0512	0.1209
Loa Loa (eye worm)	patched family protein	0.0012	0.0018	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0031
Echinococcus multilocularis	netrin receptor unc 5	0.0062	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0031	0.0052
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0031	0.0052
Schistosoma mansoni	nuclear receptor	0.0009	0.0004	0.0008

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.82	Displacement of [3H]dofetilide from human recombinant ERG expressed in HEK293 cells by patch clamp method	ChEMBL.	19954248
IC50 (binding)	= 5.72	Inhibition of wild type human ERG expressed in CHOK1 cells by whole-cell plate-based electrophysiology	ChEMBL.	19954248
IC50 (functional)	= 6.97	Antagonist activity at human CCR8	ChEMBL.	19954248

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL567419

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1069420