Detailed information for compound 1074312

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.375 | Formula: C16H15N3S
  • H donors: 1 H acceptors: 2 LogP: 3.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(SCCc2ccccc2)nc2c1cccc2
  • InChi: 1S/C16H15N3S/c17-15-13-8-4-5-9-14(13)18-16(19-15)20-11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H2,17,18,19)
  • InChiKey: CKMNCQAVWFBZCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0041 0.0956 0.0956
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0097 0.0209
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0295 0.3425
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0724 0.0724
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0295 0.0295
Schistosoma mansoni zinc finger protein 0.0015 0.0094 0.009
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0154 0.0154
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.0097
Echinococcus granulosus serotonin transporter 0.0091 0.2647 0.2647
Loa Loa (eye worm) hypothetical protein 0.0108 0.3204 0.3204
Loa Loa (eye worm) hypothetical protein 0.0039 0.0876 0.0876
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0097 0.0093
Schistosoma mansoni importin beta-1 0.0029 0.0553 0.0548
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0097 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.1971 0.1971
Loa Loa (eye worm) hypothetical protein 0.0091 0.2647 0.2647
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Loa Loa (eye worm) serotonin transporter b 0.0091 0.2647 0.2647
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0852 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.4454 0.4454
Leishmania major GTP-binding protein, putative 0.0021 0.0295 0.3425
Loa Loa (eye worm) hypothetical protein 0.0043 0.102 0.102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0295 0.2647
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0295 0.5295
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0097 0.0097
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.0005
Onchocerca volvulus 0.0015 0.0097 0.0351
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Schistosoma mansoni ran 0.0021 0.0295 0.029
Schistosoma mansoni hypothetical protein 0.0015 0.0094 0.009
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.0005
Brugia malayi hypothetical protein 0.0015 0.0097 0.0209
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0154 0.0149
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.0091 0.2647 0.2647
Loa Loa (eye worm) hypothetical protein 0.0074 0.2056 0.2056
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0295 0.5295
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0553 0.6049
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.034 0.0335
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.3204 0.7191
Schistosoma mansoni hypothetical protein 0.0034 0.0724 0.072
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.2647 0.2643
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0718 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.0005
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.1095
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0368 0.4288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.4454 0.4454
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0852 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0154 0.0154
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0097 0.1693
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0852 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0852 0.5
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0295 0.0652
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.0005
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0097 0.0093
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0368 0.3612
Brugia malayi Inositol-1 0.0038 0.0852 0.1904
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0724 0.1617
Echinococcus multilocularis zinc finger protein 0.002 0.0239 0.0239
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.0209
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.0209
Onchocerca volvulus 0.0015 0.0097 0.0351
Brugia malayi PHD-finger family protein 0.0025 0.042 0.0933
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0368 0.4288
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0553 0.0553
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0852 0.0852
Brugia malayi Importin beta-1 subunit 0.0029 0.0553 0.1232
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0015 0.0097 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.4454 0.4451
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.2647 0.2647
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0034 0.0724 0.072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.2647 0.5938
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.0209
Onchocerca volvulus 0.0091 0.2647 1
Leishmania major hypothetical protein, conserved 0.0015 0.0094 0.1058
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0174 0.0174
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0097 0.0093
Echinococcus granulosus importin subunit beta 1 0.0029 0.0553 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.4454 0.4451
Brugia malayi Bromodomain containing protein 0.0075 0.2116 0.4745
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0097 0.0097
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0154
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0852 1
Echinococcus multilocularis serotonin transporter 0.0091 0.2647 0.2647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.4454 0.4454
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0097 0.0093
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.034 0.034
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0005 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0724 0.1617
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.4454 0.4454
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0724 0.0724
Loa Loa (eye worm) inositol-1 0.0038 0.0852 0.0852
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0154 0.0149
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0852 0.0852
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.3204 0.3204
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0295 0.5
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0097 0.0093
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0553 0.6467
Entamoeba histolytica hypothetical protein 0.0024 0.0368 0.4288
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.034 0.034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0074 0.2056 0.2052
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.0005
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0793 0.0793
Schistosoma mansoni bromodomain containing protein 0.0064 0.1719 0.1715
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1598 0.1598
Echinococcus granulosus GPCR family 2 0.0034 0.0724 0.0724
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0852 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0005 0.0005
Brugia malayi RNA, U transporter 1 0.0083 0.2353 0.5278
Schistosoma mansoni inositol monophosphatase 0.0038 0.0852 0.0848
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1598 0.1598
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.2647 0.2647
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.4454 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0154 0.0154
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0553 0.6049
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0097 0.1693
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Plasmodium falciparum importin beta, putative 0.0029 0.0553 1
Schistosoma mansoni hypothetical protein 0.0034 0.0724 0.072
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0368 0.4288
Toxoplasma gondii hypothetical protein 0.0015 0.0097 0.1095
Plasmodium falciparum transporter, putative 0.0015 0.0097 0.1693
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.1095
Brugia malayi Bromodomain containing protein 0.0039 0.0873 0.1952
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0852 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0852 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0553 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0852 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0295 0.2647
Trichomonas vaginalis ran, putative 0.0021 0.0295 0.3425
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0097 0.0097
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0097 0.0097
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0015 0.0097 0.0097
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.0005
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0852 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0097 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.4454 0.4454
Onchocerca volvulus 0.0015 0.0097 0.0351
Echinococcus multilocularis GPCR, family 2 0.0034 0.0724 0.0724
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0005 0.0005
Entamoeba histolytica Ran family GTPase 0.0021 0.0295 0.3425
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0724 0.0724
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0553 0.0553
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0718 1
Plasmodium vivax amine transporter, putative 0.0015 0.0097 0.1693
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0275 0.0275
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.2647 0.2643
Toxoplasma gondii hypothetical protein 0.0015 0.0097 0.1095
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0034 0.0724 0.0724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.4454 0.4451
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0005 0.0005
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0097 0.0097
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0852 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0097 0.0097
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0154 0.0154
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0005 0.0005
Schistosoma mansoni zinc finger protein 0.002 0.0239 0.0235
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.2056 0.4611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0154 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0097
Schistosoma mansoni inositol monophosphatase 0.0038 0.0852 0.0848
Schistosoma mansoni ran 0.0021 0.0295 0.029
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0005 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0724 0.0724
Leishmania major importin beta-1 subunit, putative 0.0024 0.0368 0.4288
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0295 0.0295
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0097 0.1095
Schistosoma mansoni hypothetical protein 0.0034 0.0724 0.072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0295 0.2647
Schistosoma mansoni hypothetical protein 0.0021 0.0275 0.027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0295 0.0295
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0154 0.0149
Loa Loa (eye worm) hypothetical protein 0.0091 0.2647 0.2647
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.3204 0.7191
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0097 0.0097
Treponema pallidum sodium- and chloride- dependent transporter 0.0091 0.2647 0.5
Echinococcus granulosus zinc finger protein 0.002 0.0239 0.0239

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.1 uM Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measured after 180 mins by fluorescence assay ChEMBL. 19783433

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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