TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.279 | Formula: C15H16N3O4P
H donors: 3 H acceptors: 4 LogP: 0.57 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Nc1cccc2c1nc(n2CC1CC1)c1ccc(o1)P(=O)(O)O
InChi: 1S/C15H16N3O4P/c16-10-2-1-3-11-14(10)17-15(18(11)8-9-4-5-9)12-6-7-13(22-12)23(19,20)21/h1-3,6-7,9H,4-5,8,16H2,(H2,19,20,21)
InChiKey: DXNHZHONQZWSAR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fructose-1,6-bisphosphatase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	fructose 16 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma mansoni	fructose-16-bisphosphatase-related	Get druggable targets OG5_127400	All targets in OG5_127400
Schistosoma japonicum	ko:K03841 fructose-1,6-bisphosphatase I, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania infantum	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Toxoplasma gondii	fructose-bisphospatase II	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania braziliensis	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma congolense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei gambiense	fructose-1,6-bisphosphate, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Brugia malayi	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania donovani	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Trypanosoma brucei	fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania major		Get druggable targets OG5_127400	All targets in OG5_127400
Neospora caninum	Fructose-1 6-biphosphatase, related	Get druggable targets OG5_127400	All targets in OG5_127400
Leishmania mexicana	fructose-1,6-bisphosphatase, cytosolic, putative	Get druggable targets OG5_127400	All targets in OG5_127400
Candida albicans	similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase	Get druggable targets OG5_127400	All targets in OG5_127400

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	fructose-bisphospatase I	fructose-1,6-bisphosphatase 1	338 aa	326 aa	31.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ap endonuclease	0.0022	0.0596	0.0596
Entamoeba histolytica	hypothetical protein	0.0023	0.0631	1
Giardia lamblia	Alcohol dehydrogenase	0.0007	0.0092	0.1407
Loa Loa (eye worm)	kap beta 3 protein	0.0005	0.0041	0.0031
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0005	0.0041	0.0031
Schistosoma mansoni	ap endonuclease	0.0022	0.0596	0.0596
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0596	0.7326
Brugia malayi	fructose-1,6-bisphosphatase	0.0189	0.6294	1
Plasmodium vivax	transportin, putative	0.0005	0.0041	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0172	0.5703	0.5699
Schistosoma mansoni	aldehyde dehydrogenase	0.0007	0.0092	0.0092
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0189	0.6294	1
Mycobacterium tuberculosis	Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde	0.0007	0.0092	0.0204
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0009	0.0009
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0811	0.0802
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.406	1
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Trichomonas vaginalis	helicase, putative	0.0006	0.0081	0.1145
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.056	0.0876
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0394	0.0385
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0596	0.1271
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0.0092	0.1328
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0394	0.0612
Mycobacterium tuberculosis	Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH)	0.0007	0.0092	0.0204
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0123	0.406	1
Schistosoma mansoni	cpg binding protein	0.003	0.0886	0.0886
Leishmania major	hypothetical protein, conserved	0.0005	0.0041	0.005
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.056	0.9379
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0596	0.0588
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0631	0.0989
Trichomonas vaginalis	hypothetical protein	0.0005	0.0041	0.0501
Plasmodium falciparum	importin beta, putative	0.0028	0.0811	1
Echinococcus granulosus	fructose 16 bisphosphatase 1	0.0189	0.6294	0.629
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.007	0.2253	0.357
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0298	1	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0596	0.9442
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0092	0.0083
Echinococcus multilocularis	transportin 1	0.0005	0.0041	0.0031
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0394	0.0612
Mycobacterium leprae	PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT	0.0007	0.0092	0.5
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0.0092	0.0131
Echinococcus multilocularis	fructose 1,6 bisphosphatase 1	0.0189	0.6294	0.629
Brugia malayi	aldehyde dehydrogenase	0.0007	0.0092	0.0131
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.056	0.0876
Leishmania major	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0.0092	0.0131
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0811	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Toxoplasma gondii	sedoheptulose-1,7-bisphosphatase	0.007	0.2253	0.357
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0631	1
Echinococcus granulosus	cpg binding protein	0.003	0.0886	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0811	0.0802
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0007	0.0092	0.0131
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0631	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Schistosoma mansoni	ran	0.0021	0.056	0.056
Schistosoma mansoni	delta 1-pyrroline-5-carboxylate synthetase	0.0007	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Brugia malayi	CXXC zinc finger family protein	0.0028	0.083	0.1306
Echinococcus multilocularis	muscleblind protein 1	0.0172	0.5703	0.5699
Echinococcus granulosus	muscleblind protein	0.0172	0.5703	0.5699
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0394	0.4803
Toxoplasma gondii	gamma-glutamyl phosphate reductase, putative	0.0007	0.0092	0.0131
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0596	0.0934
Toxoplasma gondii	aldehyde dehydrogenase (NAD) family protein	0.0007	0.0092	0.0131
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0005	0.0041	0.005
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.056	0.0876
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0811	0.1275
Leishmania major	GTP-binding protein, putative	0.0021	0.056	0.0876
Echinococcus granulosus	importin 5	0.0005	0.0041	0.0031
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.056	0.6871
Echinococcus multilocularis	muscleblind protein	0.0172	0.5703	0.5699
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0394	0.0385
Brugia malayi	Aldehyde dehydrogenase protein 4	0.0007	0.0092	0.0131
Schistosoma mansoni	nocturnin	0.0004	0.0009	0.0009
Schistosoma mansoni	synaptojanin	0.0004	0.0009	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0596	0.0934
Mycobacterium tuberculosis	Probable pyrroline-5-carboxylate dehydrogenase RocA	0.0007	0.0092	0.0204
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0157	0.0235
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0161	0.0152
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0596	0.9442
Echinococcus multilocularis	aldehyde dehydrogenase family 3 member B1	0.0007	0.0092	0.0083
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0811	0.1275
Trypanosoma cruzi	pyrroline-5-carboxylate synthetase-like protein, putative	0.0007	0.0092	0.0131
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0081	0.1145
Echinococcus multilocularis	betaine aldehyde dehydrogenase	0.0007	0.0092	0.0083
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.0041	0.005
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0596	0.0588
Trypanosoma cruzi	sedoheptulose-1,7-bisphosphatase, putative	0.007	0.2253	0.357
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase AldC	0.0007	0.0092	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0005	0.0041	0.005
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0102	0.0092
Onchocerca volvulus		0.0028	0.083	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.0041	0.005
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0161	0.0152
Treponema pallidum	gamma-glutamyl phosphate reductase	0.0007	0.0092	0.1407
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0102	0.0092
Schistosoma mansoni	aldehyde dehydrogenase	0.0007	0.0092	0.0092
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0394	0.0612
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.406	1
Schistosoma mansoni	hypothetical protein	0.0007	0.0092	0.0092
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0394	0.0612
Leishmania major	pyrroline-5-carboxylate synthetase-like protein	0.0007	0.0092	0.0131
Schistosoma mansoni	cpg binding protein	0.0028	0.083	0.083
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1698	0.2686
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0009	0.0009
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.056	0.6871
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0394	0.0612
Schistosoma mansoni	importin beta-1	0.0028	0.0811	0.0811
Echinococcus multilocularis	importin 5	0.0005	0.0041	0.0031
Schistosoma mansoni	aldehyde dehydrogenase	0.0007	0.0092	0.0092
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0009	0.0009
Brugia malayi	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor	0.0007	0.0092	0.0131
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0596	0.7326
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.406	0.4054
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0394	0.0612
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0007	0.0092	0.0204
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0.0092	0.0131
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.406	0.406
Trichomonas vaginalis	succinate semialdehyde dehydrogenase, putative	0.0007	0.0092	0.1328
Schistosoma mansoni	aldehyde dehydrogenase	0.0007	0.0092	0.0092
Trypanosoma brucei	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0.0092	0.0131
Echinococcus granulosus	Fatty aldehyde dehydrogenase	0.0007	0.0092	0.0083
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Toxoplasma gondii	exonuclease III APE	0.0022	0.0596	0.0934
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0007	0.0092	0.0131
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.406	0.6445
Loa Loa (eye worm)	hypothetical protein	0.0172	0.5703	0.5699
Schistosoma mansoni	synaptojanin	0.0004	0.0009	0.0009
Schistosoma mansoni	importin-beta 2	0.0005	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0631	0.0989
Echinococcus multilocularis	Fatty aldehyde dehydrogenase	0.0007	0.0092	0.0083
Echinococcus multilocularis	translational activator gcn1	0.0005	0.0041	0.0031
Toxoplasma gondii	NADP-dependent succinate-semialdehyde dehydrogenase	0.0007	0.0092	0.0131
Leishmania major	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	0.0007	0.0092	0.0204
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0102	0.0092
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0596	1
Entamoeba histolytica	aldehyde dehydrogenase 1, putative	0.0007	0.0092	0.1328
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0394	0.0612
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.056	0.0551
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0394	0.0394
Echinococcus granulosus	translational activator gcn1	0.0005	0.0041	0.0031
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.406	0.4054
Toxoplasma gondii	fructose-bisphospatase I	0.007	0.2253	0.357
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0394	0.0385
Trypanosoma cruzi	pyrroline-5-carboxylate synthetase-like protein, putative	0.0007	0.0092	0.0131
Trypanosoma cruzi	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0.0092	0.0131
Schistosoma mansoni	hypothetical protein	0.0298	1	1
Mycobacterium tuberculosis	Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2	0.0007	0.0092	0.0204
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0596	0.0588
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.056	0.0876
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0007	0.0092	0.0092
Schistosoma mansoni	fructose-16-bisphosphatase-related	0.0189	0.6294	0.6294
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0007	0.0092	0.0083
Toxoplasma gondii	fructose-bisphospatase II	0.0189	0.6294	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0102	0.0092
Schistosoma mansoni	cript-related	0.0004	0.0009	0.0009
Echinococcus granulosus	transportin 1	0.0005	0.0041	0.0031
Loa Loa (eye worm)	aldehyde dehydrogenase	0.0007	0.0092	0.0083
Trypanosoma brucei	fructose-1,6-bisphosphatase	0.0189	0.6294	1
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0.0092	0.1328
Entamoeba histolytica	HEAT repeat domain containing protein	0.0005	0.0041	0.0501
Echinococcus multilocularis	cpg binding protein	0.003	0.0886	0.0877
Brugia malayi	Succinate semialdehyde dehydrogenase, mitochondrial precursor	0.0007	0.0092	0.0131
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0394	0.4803
Loa Loa (eye worm)	delta-1-pyrroline-5-carboxylate dehydrogenase	0.0007	0.0092	0.0083
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0596	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.056	0.0551
Trypanosoma cruzi	aldehyde dehydrogenase family, putative	0.0007	0.0092	0.0131
Entamoeba histolytica	Ran family GTPase	0.0021	0.056	0.8856
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0102	0.0102
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.406	0.406
Toxoplasma gondii	methylmalonate-semialdehyde dehydrogenase [acylating], putative	0.0007	0.0092	0.0131
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase (NAD+) dependent	0.0007	0.0092	0.0204
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0394	0.0612
Brugia malayi	Muscleblind-like protein	0.0172	0.5703	0.9059
Trypanosoma cruzi	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0007	0.0092	0.0131
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.406	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0596	0.0934
Leishmania major	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Schistosoma mansoni	cpg binding protein	0.003	0.0886	0.0886
Brugia malayi	RNA, U transporter 1	0.0079	0.2562	0.4061
Leishmania major	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Plasmodium falciparum	transportin	0.0005	0.0041	0.0389
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])	0.0007	0.0092	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.056	0.0876
Loa Loa (eye worm)	fructose-1,6-bisphosphatase	0.0189	0.6294	0.629
Echinococcus granulosus	aldehyde dehydrogenase family 3 member B1	0.0007	0.0092	0.0083
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.083	0.0822
Schistosoma mansoni	aldehyde dehydrogenase	0.0007	0.0092	0.0092
Trypanosoma cruzi	fructose-1,6-bisphosphatase, cytosolic, putative	0.0189	0.6294	1
Trypanosoma brucei	sedoheptulose-1,7-bisphosphatase	0.007	0.2253	0.357
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0092	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Leishmania major		0.0189	0.6294	1
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0007	0.0092	0.0131
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0394	0.0385
Brugia malayi	Importin beta-1 subunit	0.0028	0.0811	0.1275
Loa Loa (eye worm)	aldehyde dehydrogenase 4	0.0007	0.0092	0.0083
Echinococcus granulosus	betaine aldehyde dehydrogenase	0.0007	0.0092	0.0083
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0811	0.1275
Schistosoma mansoni	ran	0.0021	0.056	0.056
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0161	0.0152
Schistosoma mansoni	hypothetical protein	0.0004	0.0009	0.0009
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1917	0.1917
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0081	0.1145
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0007	0.0092	0.5
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.406	0.6445
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0631	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0394	0.0385
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0596	0.0934
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0394	0.0612
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0596	0.9442
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0394	0.0385
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Brugia malayi	kap beta 3 protein	0.0005	0.0041	0.005
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0081	0.1145
Entamoeba histolytica	aldehyde-alcohol dehydrogenase 2, putative	0.0007	0.0092	0.1328
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0394	0.0385
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0596	0.1449
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.056	0.0551
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0007	0.0092	0.0083
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0596	1
Onchocerca volvulus	Aldehyde dehydrogenase homolog	0.0007	0.0092	0.1006
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.0007	0.0092	0.0083
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0811	0.0802
Echinococcus multilocularis	snurportin 1	0.0298	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0081	0.1145
Trichomonas vaginalis	ran, putative	0.0021	0.056	0.8856
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0394	0.095
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0596	0.0934
Mycobacterium leprae	PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE	0.0007	0.0092	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.8 uM	Inhibition of human liver FBPase 1	ChEMBL.	20055427
IC50 (binding)	= 20 uM	Inhibition of rat liver FBPase 1	ChEMBL.	20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL583908

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1084999