TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.3 | Formula: C16H15FN2O3
H donors: 3 H acceptors: 3 LogP: 2.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)/C=N/CCNC(=O)c1ccccc1O)O
InChi: 1S/C16H15FN2O3/c17-12-5-6-14(20)11(9-12)10-18-7-8-19-16(22)13-3-1-2-4-15(13)21/h1-6,9-10,20-21H,7-8H2,(H,19,22)/b18-10+
InChiKey: LOBCVAQKYDOJMN-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	3-oxoacyl-[acyl-carrier-protein] synthase III	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium berghei	apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Chlamydia trachomatis	oxoacyl-ACP synthase III	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	Get druggable targets OG5_129509	All targets in OG5_129509
Neospora caninum	3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	Get druggable targets OG5_129509	All targets in OG5_129509
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	Get druggable targets OG5_129509	All targets in OG5_129509
Plasmodium knowlesi	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	Get druggable targets OG5_129509	All targets in OG5_129509

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Conserved hypothetical protein	3-oxoacyl-[acyl-carrier-protein] synthase III	317 aa	265 aa	26.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0315	0.5915	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0084	0.1198	0.261
Schistosoma mansoni	phosphatidylserine receptor	0.0031	0.0107	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0107	0.0091
Brugia malayi	Heterochromatin protein 1	0.0072	0.0935	0.1033
Plasmodium falciparum	phd finger protein, putative	0.0096	0.1439	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0471	0.051
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0412	0.0442
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0935	0.0887
Plasmodium falciparum	glutathione reductase	0.0046	0.0412	0.0425
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0375	0.0388
Echinococcus granulosus	PHD finger protein rhinoceros	0.0096	0.1439	0.2433
Echinococcus granulosus	intermediate filament protein	0.0028	0.0038	0.0065
Echinococcus granulosus	chromobox protein 1	0.0072	0.0935	0.1581
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.0935	0.0887
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.0489	0.5
Onchocerca volvulus	Alhambra homolog	0.0096	0.1439	0.1406
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0375	0.0634
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0316	0.6836
Echinococcus granulosus	lysine specific demethylase 5A	0.0119	0.1898	0.3208
Brugia malayi	Thioredoxin reductase	0.0046	0.0412	0.0431
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0031	0.0115	0.006
Brugia malayi	chromobox protein homolog 3	0.004	0.0292	0.0292
Onchocerca volvulus		0.0147	0.2477	0.2449
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.1617	0.1863
Brugia malayi	Bromodomain containing protein	0.0044	0.0369	0.0381
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0316	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0115	0.01
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1129	0.1267
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0383	0.7304	1
Leishmania major	hypothetical protein, conserved	0.0041	0.0316	0.6836
Echinococcus multilocularis	musashi	0.0028	0.0038	0.0065
Echinococcus multilocularis	lysine specific demethylase 6a	0.0031	0.0107	0.018
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0375	0.0634
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0314	0.0531
Brugia malayi	jmjC domain containing protein	0.0031	0.0107	0.0079
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.1617	0.1863
Brugia malayi	beta-lactamase family protein	0.0041	0.0316	0.0319
Onchocerca volvulus		0.0077	0.1038	0.1004
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0063	0.075	0.1267
Schistosoma mansoni	hypothetical protein	0.0031	0.0115	0.025
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.1857	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0096	0.1439	0.2433
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0412	0.2294
Brugia malayi	PHD-finger family protein	0.0029	0.0055	0.002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.062	0.067
Echinococcus granulosus	JmjC domain containing protein 4	0.0031	0.0107	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0292	0.0241
Plasmodium vivax	hypothetical protein, conserved	0.0096	0.1439	0.1851
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0314	0.0531
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0119	0.1898	0.4134
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0456	0.0481
Loa Loa (eye worm)	jmjC domain-containing protein	0.0199	0.3534	0.4032
Onchocerca volvulus		0.0048	0.0456	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0316	0.0533
Echinococcus granulosus	chromobox protein 1	0.0072	0.0935	0.1581
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0375	0.0634
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0316	0.6836
Echinococcus multilocularis	jumonji domain containing protein	0.0134	0.2209	0.3735
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0068	0.0871	0.1472
Echinococcus multilocularis	lamin	0.0028	0.0038	0.0065
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0034	0.0163	0.0356
Echinococcus multilocularis	phd:f box containing protein	0.0031	0.0107	0.018
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0316	0.029
Brugia malayi	jmjC domain containing protein	0.0031	0.0107	0.0079
Schistosoma mansoni	lamin	0.0028	0.0038	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0257	0.0263
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0107	0.0091
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0033	0.0151	0.0256
Brugia malayi	jmjC domain containing protein	0.0031	0.0107	0.0079
Schistosoma mansoni	chromobox protein	0.0072	0.0935	0.2037
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0038	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0147	0.2477	0.2818
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0065	0.0798	0.135
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0383	0.7304	0.5
Brugia malayi	Pre-SET motif family protein	0.0065	0.0798	0.0875
Loa Loa (eye worm)	jmjC domain-containing protein	0.0119	0.1898	0.2151
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0038	0.0083
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0354	0.0303
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0412	0.0697
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0065	0.0798	0.5193
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0412	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0316	0.0319
Leishmania major	trypanothione reductase	0.0046	0.0412	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.062	0.0681
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0315	0.5915	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0452	0.8722	1
Brugia malayi	hypothetical protein	0.0147	0.2477	0.2809
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0935	0.1581
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.1857	0.2205
Echinococcus granulosus	lamin dm0	0.0028	0.0038	0.0065
Onchocerca volvulus		0.0041	0.0316	0.0278
Loa Loa (eye worm)	hypothetical protein	0.004	0.0292	0.0304
Schistosoma mansoni	lamin	0.0028	0.0038	0.0083
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0412	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0426	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0371	0.0395
Echinococcus granulosus	lamin	0.0028	0.0038	0.0065
Echinococcus multilocularis	jumonji domain containing 1A	0.0031	0.0107	0.018
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.1617	0.1863
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0316	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0159	0.0151
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0375	0.0817
Echinococcus granulosus	peregrin	0.0099	0.1494	0.2526
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Schistosoma mansoni	chromobox protein	0.0072	0.0935	0.2037
Echinococcus granulosus	histone lysine methyltransferase setb	0.0084	0.1198	0.2026
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0096	0.1439	0.3134
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.0489	0.5
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0383	0.7304	1
Trichomonas vaginalis	set domain proteins, putative	0.0515	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0115	0.0011
Brugia malayi	F/Y-rich N-terminus family protein	0.0036	0.0208	0.0196
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0316	0.0687
Onchocerca volvulus		0.0031	0.0115	0.0077
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0412	0.0697
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0316	0.0533
Echinococcus multilocularis	geminin	0.0198	0.352	0.5951
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.1857	0.2205
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0316	0.0264
Toxoplasma gondii	PHD-finger domain-containing protein	0.0096	0.1439	1
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.0489	0.5
Loa Loa (eye worm)	PHD-finger family protein	0.0096	0.1439	0.1623
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0354	0.0317
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0119	0.1898	0.4134
Echinococcus multilocularis	JmjC domain containing protein 4	0.0031	0.0107	0.018
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0316	0.0331
Trypanosoma brucei	trypanothione reductase	0.0046	0.0412	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0257	0.0559
Brugia malayi	jmjC domain containing protein	0.0315	0.5915	0.6767
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0031	0.0115	0.0262
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0115	0.006
Plasmodium vivax	SET domain protein, putative	0.0065	0.0798	0.0961
Echinococcus multilocularis	lysine specific demethylase 5A	0.0116	0.1853	0.3132
Brugia malayi	Bromodomain containing protein	0.0099	0.1494	0.1677
Schistosoma mansoni	jumonji domain containing protein	0.025	0.4591	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.1617	0.1863
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0412	0.0425
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0316	0.6836
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0412	0.0425
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.0489	0.5
Brugia malayi	glutathione reductase	0.0046	0.0412	0.0431
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0383	0.7304	1
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.4296	0.7263
Schistosoma mansoni	hypothetical protein	0.0198	0.352	0.7668
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0316	0.0264
Brugia malayi	Pre-SET motif family protein	0.0452	0.8722	1
Echinococcus granulosus	geminin	0.0198	0.352	0.5951
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0107	0.0091
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0375	0.0817
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0375	0.0634
Brugia malayi	PHD-finger family protein	0.0096	0.1439	0.1613
Echinococcus multilocularis	peregrin	0.0099	0.1494	0.2526
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1198	0.1346
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0077	0.1038	0.2261
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0383	0.7304	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0316	0.0687
Echinococcus granulosus	lysine specific demethylase 6a	0.0031	0.0107	0.018
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.4863	0.6508
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0038	0.0012
Trichomonas vaginalis	esterase, putative	0.0041	0.0316	0.0264
Echinococcus granulosus	phd:f box containing protein	0.0031	0.0107	0.018
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0068	0.0871	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0236	0.4296	0.4909
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0354	0.0303
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.062	0.067
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Schistosoma mansoni	hypothetical protein	0.0198	0.352	0.7668
Echinococcus multilocularis	chromobox protein 1	0.0072	0.0935	0.1581
Schistosoma mansoni	bromodomain containing protein	0.0073	0.0955	0.208
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0412	0.0425
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0031	0.0115	0.0011
Brugia malayi	AF-10 protein	0.0031	0.0115	0.0088
Brugia malayi	PHD-finger family protein	0.0034	0.0159	0.014
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.4296	0.7263
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0292	0.0241
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0383	0.7304	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0316	0.0264
Giardia lamblia	PHD finger protein 15	0.0096	0.1439	0.5
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0456	0.0993
Schistosoma mansoni	protein phosphatase 2C	0.0031	0.0107	0.0232
Schistosoma mansoni	hypothetical protein	0.0048	0.0456	0.0993
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.0935	0.1044
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0292	0.0255
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0375	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0316	0.0331
Echinococcus granulosus	jumonji domain containing protein	0.0134	0.2209	0.3735
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0107	0.0091
Brugia malayi	beta-lactamase	0.0041	0.0316	0.0319
Onchocerca volvulus		0.0041	0.0316	0.0278
Schistosoma mansoni	jumonji domain containing protein	0.0031	0.0107	0.0232
Brugia malayi	Bromodomain containing protein	0.0086	0.1229	0.1372
Echinococcus granulosus	jumonji domain containing 1A	0.0031	0.0107	0.018
Loa Loa (eye worm)	hypothetical protein	0.0056	0.062	0.0681
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0084	0.1198	0.261
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0031	0.0107	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1439	0.1623
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.1617	0.1863
Brugia malayi	jmjC domain containing protein	0.0031	0.0107	0.0079
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0412	0.0138
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.0798	0.1739
Schistosoma mansoni	phd/f-box containing protein	0.0031	0.0107	0.0232
Loa Loa (eye worm)	jmjC domain-containing protein	0.0031	0.0107	0.0091
Mycobacterium tuberculosis	Probable reductase	0.0105	0.1617	0.1863
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0375	0.0817
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0316	0.0264
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0031	0.0115	0.0262
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0316	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0038	0.0012
Toxoplasma gondii	ABC1 family protein	0.0041	0.0316	0.1568
Brugia malayi	jmjC domain containing protein	0.0119	0.1898	0.2141
Schistosoma mansoni	hypothetical protein	0.0096	0.1439	0.3134
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0383	0.7304	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0257	0.0251
Echinococcus multilocularis	lamin dm0	0.0028	0.0038	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0165	0.2844	0.324
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0084	0.1198	0.2026
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0383	0.7304	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.1857	0.2205
Brugia malayi	hypothetical protein	0.0236	0.4296	0.4903
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.1617	0.8446
Onchocerca volvulus		0.0041	0.0316	0.0278
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0033	0.0151	0.0256
Entamoeba histolytica	fatty acid elongase, putative	0.005	0.0489	0.5
Toxoplasma gondii	PHD-finger domain-containing protein	0.0096	0.1439	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10.35 ug ml-1	Inhibition of Escherichia coli Beta-ketoacyl-ACP synthase III expressed in Escherichia coli BL21 (DE3) by liquid scintillation counting	ChEMBL.	19884012

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL595276

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1091866