Detailed information for compound 109275

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.331 | Formula: C18H16N2O4
  • H donors: 1 H acceptors: 3 LogP: 2.78 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c2c1oc(c2)C(=O)C)C(=O)Nc1ncccc1C
  • InChi: 1S/C18H16N2O4/c1-10-5-4-8-19-17(10)20-18(22)12-6-7-14(23-3)16-13(12)9-15(24-16)11(2)21/h4-9H,1-3H3,(H,19,20,22)
  • InChiKey: DMEAFSHMAYVGOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 4A, cAMP-specific References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References
Rattus norvegicus Monocarboxylate transporter 1 No references
Homo sapiens phosphodiesterase 4B, cAMP-specific References
Rattus norvegicus Phosphodiesterase 4 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4C, cAMP-specific References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus SH3 domain-binding glutamic acid-rich protein homolog Phosphodiesterase 4   536 aa 527 aa 52.6 %
Candida albicans similar to S. cerevisiae MCH4 (YOL119C) monocarboxylate permease-like protein that does not act as a transporter Monocarboxylate transporter 1   494 aa 444 aa 22.5 %
Candida albicans similar to S. cerevisiae MCH4 (YOL119C) monocarboxylate permease-like protein that does not act as a transporter Monocarboxylate transporter 1   494 aa 442 aa 22.2 %
Candida albicans Putative monocarboxylate permease. Monocarboxylate transporter 1   494 aa 489 aa 21.5 %
Echinococcus multilocularis monocarboxylate transporter Monocarboxylate transporter 1   494 aa 533 aa 21.8 %
Echinococcus granulosus monocarboxylate transporter Monocarboxylate transporter 1   494 aa 533 aa 22.3 %
Onchocerca volvulus Monocarboxylate transporter 1   494 aa 465 aa 24.3 %
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Phosphodiesterase 4   536 aa 456 aa 27.2 %
Echinococcus multilocularis monocarboxylate transporter Monocarboxylate transporter 1   494 aa 468 aa 23.5 %
Echinococcus granulosus monocarboxylate transporter Monocarboxylate transporter 1   494 aa 462 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Trypanosoma cruzi metacaspase, putative 0.0053 0.0632 0.7452
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Brugia malayi CXXC zinc finger family protein 0.0029 0.0274 0.0389
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0046 0.0056
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.004 0.0438 0.5163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0046 0.0065
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.004 0.0438 0.1895
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0046 0.0056
Schistosoma mansoni caspase-3 (C14 family) 0.0199 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Loa Loa (eye worm) hypothetical protein 0.002 0.0142 0.0177
Giardia lamblia Grp94/Hsp90 0.0052 0.0613 0.0709
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0046 0.0046
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0046 0.0007
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0243 0.0243
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.051 0.6009
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0807 0.9521
Brugia malayi Temporarily assigned gene name protein 44 0.0027 0.0252 0.0357
Brugia malayi Trypsin family protein 0.0013 0.0046 0.0065
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0013 0.0046 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0046 0.0046
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.004 0.0438 0.1895
Onchocerca volvulus 0.005 0.0579 0.173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.03 0.03
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0068 0.0848 0.1055
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0848 0.2431
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0547
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2921 0.3634
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0807 0.1004
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.004 0.0438 0.0438
Brugia malayi intermediate filament protein 0.0027 0.0248 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0848 0.2431
Schistosoma mansoni lamin 0.0027 0.0248 0.0248
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0807 0.9521
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0154 0.2115 0.2115
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0848 0.1204
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0068 0.0848 0.0848
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.1592 0.1592
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0199 0.2771 0.2771
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.03 0.03
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus granulosus enteropeptidase 0.0013 0.0046 0.0046
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0053 0.0632 0.0632
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0046 0.0138
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Schistosoma mansoni lipoxygenase 0.0119 0.1592 0.1592
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0142 0.0142
Onchocerca volvulus 0.0048 0.0561 0.1677
Plasmodium vivax SET domain protein, putative 0.0031 0.03 0.1226
Schistosoma mansoni cpg binding protein 0.003 0.0298 0.0298
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0807 0.9521
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Echinococcus multilocularis endoplasmin 0.0052 0.0613 0.0613
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0068 0.0848 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.0046 0.0046
Brugia malayi hypothetical protein 0.0036 0.038 0.054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0192
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni loxhd1 0.002 0.0142 0.0142
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.051 0.0724
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0243 0.2861
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus multilocularis heat shock protein 90 0.0065 0.0807 0.0807
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.1587
Schistosoma mansoni cpg binding protein 0.003 0.0298 0.0298
Giardia lamblia Rab geranylgeranyltransferase 0.004 0.0438 0.0491
Brugia malayi hypothetical protein 0.0027 0.0252 0.0357
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0807 0.1004
Echinococcus multilocularis musashi 0.0027 0.0248 0.0248
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0046 0.0535
Schistosoma mansoni hypothetical protein 0.0027 0.0251 0.0251
Trypanosoma cruzi metacaspase, putative 0.0053 0.0632 0.7452
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0722 0.0722
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0848 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0135 0.027
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0046 0.0741
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Loa Loa (eye worm) doublecortin family protein 0.002 0.0142 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Plasmodium vivax heat shock protein, putative 0.0027 0.0243 0.0952
Onchocerca volvulus 0.0013 0.0046 0.0137
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0068 0.0848 0.0848
Plasmodium falciparum heat shock protein 90 0.0065 0.0807 0.368
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.3329 0.3329
Echinococcus granulosus cpg binding protein 0.003 0.0298 0.0298
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0142 0.0466
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Plasmodium falciparum phosphodiesterase delta, putative 0.0068 0.0848 0.3876
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0613 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.2115 0.2631
Onchocerca volvulus 0.002 0.0142 0.0426
Toxoplasma gondii hypothetical protein 0.0114 0.1528 0.19
Brugia malayi Cell death protein 3 precursor 0.0053 0.0632 0.0897
Loa Loa (eye worm) hypothetical protein 0.0068 0.0848 0.1055
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0068 0.0848 0.1055
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0046 0.0057
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0243 0.0302
Brugia malayi Trypsin family protein 0.0013 0.0046 0.0065
Trypanosoma brucei metacaspase MCA2 0.0053 0.0632 0.7452
Echinococcus granulosus heat shock protein 0.0065 0.0807 0.0807
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.038 0.038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0046 0.0056
Echinococcus multilocularis caspase 8 0.0053 0.0632 0.0632
Trichomonas vaginalis rotamase, putative 0.0033 0.0331 0.0864
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0438 0.5163
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0613 0.7223
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0027 0.0248 0.0741
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0103
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0046 0.0065
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0274 0.0274
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0558 0.8039 0.8039
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0046 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0438 0.5163
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0438 0.5163
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni hypothetical protein 0.0027 0.0251 0.0251
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0142 0.0466
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0046 0.0741
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0632 0.0785
Loa Loa (eye worm) hypothetical protein 0.0068 0.0848 0.1055
Onchocerca volvulus 0.0013 0.0046 0.0137
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0084 0.0119
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0068 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Schistosoma mansoni polycystin 1-related 0.002 0.0142 0.0142
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0763 0.0763
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0046 0.0535
Echinococcus granulosus tumor protein p63 0.0339 0.4821 0.4821
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0154 0.2115 0.6272
Echinococcus granulosus protein prenyltransferase alpha subunit 0.004 0.0438 0.0438
Trypanosoma brucei unspecified product 0.0013 0.0047 0.0547
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0613 0.1718
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Plasmodium falciparum metacaspase 1 0.0053 0.0632 0.2833
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0438 0.5163
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0068 0.0848 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0613 1
Brugia malayi Pre-SET motif family protein 0.0031 0.03 0.0425
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0044
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Onchocerca volvulus 0.0029 0.0274 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0547
Loa Loa (eye worm) hypothetical protein 0.005 0.0579 0.072
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.004 0.0438 0.0622
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Onchocerca volvulus 0.0013 0.0046 0.0137
Schistosoma mansoni rab6-interacting 0.002 0.0142 0.0142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.0046 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0135 0.1573
Brugia malayi Trypsin-like protease protein 5 0.0013 0.0046 0.0065
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0243 0.0952
Schistosoma mansoni lipoxygenase 0.0083 0.1069 0.1069
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0199 0.2771 0.2771
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0558 0.8039 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0046 0.0535
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0613 0.1718
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus multilocularis caspase 3 0.0146 0.199 0.199
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0632 0.2833
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0154 0.2115 1
Plasmodium falciparum metacaspase-like protein 0.0053 0.0632 0.2833
Echinococcus granulosus dna polymerase eta 0.0045 0.051 0.051
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0243 0.0727
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.049 0.7042 0.7042
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0068 0.0848 0.1204
Trypanosoma brucei unspecified product 0.0013 0.0047 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0135 0.0135
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.004 0.0438 0.1189
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0142 0.0142
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0243 0.2861
Schistosoma mansoni hypothetical protein 0.002 0.0142 0.0142
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0142 0.0142
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.3876
Leishmania major DNA polymerase eta, putative 0.0032 0.0314 0.3699
Echinococcus multilocularis RUN 0.002 0.0142 0.0142
Leishmania major DNA topoisomerase ii 0.0013 0.0046 0.0535
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0807 0.9521
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0848 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0632 0.0785
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Schistosoma mansoni heat shock protein 0.0027 0.0243 0.0243
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0046 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.051 0.6009
Trichomonas vaginalis endoplasmin, putative 0.004 0.0438 0.1188
Loa Loa (eye worm) hypothetical protein 0.0558 0.8039 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0848 0.1204
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0046 0.0046
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0848 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0613 0.7223
Leishmania major cAMP-specific phosphodiesterase, putative 0.0068 0.0848 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0114 0.1528 0.4493
Brugia malayi hypothetical protein 0.0088 0.1147 0.1629
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0343 0.0486
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Giardia lamblia DINP protein human, muc B family 0.0019 0.0135 0.0111
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0068 0.0848 0.0848
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Echinococcus granulosus lamin dm0 0.0027 0.0248 0.0248
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0807 0.9521
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0135 0.1573
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.1587
Loa Loa (eye worm) hypothetical protein 0.002 0.0142 0.0177
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0243 0.0952
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.098
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.0046 0.0046
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.3876
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0046 0.5
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.004 0.0438 0.0438
Schistosoma mansoni heat shock protein 0.0065 0.0807 0.0807
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0807 0.9521
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus multilocularis lamin 0.0027 0.0248 0.0248
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma brucei unspecified product 0.0019 0.0135 0.1587
Brugia malayi tumor suppressor. 0.0322 0.4581 0.6505
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Entamoeba histolytica hypothetical protein 0.0036 0.038 0.1617
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0068 0.0848 0.3876
Giardia lamblia Hypothetical protein 0.0068 0.0848 0.1003
Brugia malayi Doublecortin family protein 0.002 0.0142 0.0202
Brugia malayi heat shock protein 90 0.0065 0.0807 0.1146
Onchocerca volvulus 0.0031 0.03 0.0896
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0046 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.03 0.03
Brugia malayi Trypsin family protein 0.0013 0.0046 0.0065
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0807 0.368
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0135 0.0135
Echinococcus granulosus hypothetical protein 0.0027 0.0251 0.0251
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0848 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0331 0.3899
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0331 0.0411
Loa Loa (eye worm) tumor suppressor 0.0322 0.4581 0.5698
Leishmania major DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0142 0.0142
Echinococcus multilocularis lamin dm0 0.0027 0.0248 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Leishmania major hypothetical protein, conserved 0.0068 0.0848 1
Echinococcus multilocularis dna polymerase eta 0.0045 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0044
Schistosoma mansoni cpg binding protein 0.0029 0.0274 0.0274
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.0046 0.0046
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0046 0.0535
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0046 0.0138
Echinococcus granulosus heat shock protein 90 0.0065 0.0807 0.0807
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0807 0.368
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0154 0.2115 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.03 0.0372
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Leishmania major hypothetical protein, conserved 0.0068 0.0848 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.1578
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0046 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0848 1
Trypanosoma brucei Metacaspase-4 0.0053 0.0632 0.7452
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Plasmodium vivax endoplasmin, putative 0.0065 0.0807 0.368
Loa Loa (eye worm) trypsin family protein 0.0013 0.0046 0.0057
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0084 0.098
Echinococcus granulosus caspase 8 0.0053 0.0632 0.0632
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0807 0.368
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0046 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0579 0.0579
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.0046 0.0046
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0068 0.0848 0.0848
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Brugia malayi isocitrate dehydrogenase 0.0016 0.0084 0.0119
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0046 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Plasmodium falciparum endoplasmin, putative 0.004 0.0438 0.1894
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0613 0.0613
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0135
Toxoplasma gondii hypothetical protein 0.004 0.0438 0.0544
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0046 0.0007
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0046 0.0535
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.2115 0.6272
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0632 0.7452
Loa Loa (eye worm) hypothetical protein 0.0027 0.0248 0.0308
Brugia malayi hypothetical protein 0.002 0.0142 0.0202
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0084 0.0104
Trypanosoma cruzi metacaspase, putative 0.0053 0.0632 0.7452
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0252 0.0313
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0558 0.8039 0.8039
Echinococcus granulosus protein quaking 0.0027 0.0251 0.0251
Schistosoma mansoni rotamase 0.0033 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0057
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus multilocularis cpg binding protein 0.003 0.0298 0.0298
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.049 0.7042 0.7042
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0046 0.0007
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0068 0.0848 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus multilocularis Mastin 0.0013 0.0046 0.0046
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0084 0.0103
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0068 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0088 0.1147 0.1427
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0068 0.0848 0.0848
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0243 0.0597
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0314 0.039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0084 0.0182
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0248 0.0308
Schistosoma mansoni hypothetical protein 0.0036 0.038 0.038
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0084 0.0182
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0613 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0068 0.0848 0.3876
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0848 0.0848
Onchocerca volvulus 0.0238 0.3344 1
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0613 0.7223
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0848 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0068 0.0848 0.0848
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0438 0.5163
Trichomonas vaginalis heat shock protein, putative 0.004 0.0438 0.1188
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.049 0.7042 0.876
Trypanosoma brucei metacaspase 0.0053 0.0632 0.7452
Echinococcus granulosus lamin 0.0027 0.0248 0.0248
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Loa Loa (eye worm) PDE1B protein 0.0068 0.0848 0.1055
Echinococcus granulosus endoplasmin 0.0052 0.0613 0.0613
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0053 0.0632 0.0897
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.038 0.038
Echinococcus multilocularis heat shock protein 0.0065 0.0807 0.0807
Schistosoma mansoni survival motor neuron protein 0.0048 0.0561 0.0561
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0848 0.2431
Giardia lamblia Rab geranylgeranyltransferase 0.0154 0.2115 0.2588
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0068 0.0848 0.0848
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0807 0.9521
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0046 0.0007
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus granulosus heat shock protein 90 0.0052 0.0613 0.0613
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus multilocularis enteropeptidase 0.0013 0.0046 0.0046
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0848 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Leishmania major hypothetical protein, conserved 0.0013 0.0046 0.0535
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Trypanosoma brucei metacaspase MCA3 0.0053 0.0632 0.7452
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0046 0.0007
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.3876
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0068 0.0848 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.0046 0.0046
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0613 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0561 0.0796
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0084 0.0084
Schistosoma mansoni endoplasmin 0.0065 0.0807 0.0807
Schistosoma mansoni hypothetical protein 0.041 0.5867 0.5867
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0274 0.0341
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0053
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0068 0.0848 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0064 0.0079
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.3329 0.3329
Giardia lamblia hypothetical protein 0.0068 0.0848 0.1003
Leishmania major metacaspase, putative 0.0053 0.0632 0.7452
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0046 0.0535
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.0046 0.0046
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0243 0.0952
Brugia malayi hypothetical protein 0.002 0.0142 0.0202
Echinococcus granulosus caspase 0.0199 0.2771 0.2771
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Echinococcus multilocularis caspase 2 0.0053 0.0632 0.0632
Echinococcus granulosus expressed protein 0.0033 0.0343 0.0343
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.1592 0.1592
Plasmodium vivax phosphodiesterase gamma, putative 0.0068 0.0848 0.3876
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0248 0.0352
Echinococcus granulosus RUN 0.002 0.0142 0.0142
Schistosoma mansoni endoplasmin 0.0065 0.0807 0.0807
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0331 0.3899
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0807 0.0952
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.1578
Loa Loa (eye worm) hypothetical protein 0.0045 0.051 0.0634
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0068 0.0848 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0047 0.0547
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0558 0.8039 0.8039
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0046 0.0535
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0135 0.0135
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0558 0.8039 0.8039
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0243 0.0243
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni DNA polymerase eta 0.0045 0.051 0.051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0416 0.4898
Schistosoma mansoni eyes absent homolog 0.0088 0.1147 0.1147
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0046 0.0046
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0046 0.0535
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0248 0.0308
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0135 0.1587
Echinococcus granulosus intermediate filament protein 0.0027 0.0248 0.0248
Schistosoma mansoni caspase-7 (C14 family) 0.0199 0.2771 0.2771
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0243 0.0302
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3344 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0068 0.0848 0.0848
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Schistosoma mansoni intermediate filament proteins 0.0027 0.0248 0.0248
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0068 0.0848 0.0848
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Brugia malayi hypothetical protein 0.0237 0.3329 0.4727
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0088 0.1147 0.1427
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.004 0.0438 0.0438
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0135 0.0431
Echinococcus multilocularis expressed protein 0.0033 0.0343 0.0343
Schistosoma mansoni caspase-7 (C14 family) 0.0053 0.0632 0.0632
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0848 0.1204
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0613 0.1718
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0084 0.0084
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0243 0.0952
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0046 0.5
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0438 0.5163
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.004 0.0438 0.5163
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0046 0.0046
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0807 0.2308
Onchocerca volvulus 0.0013 0.0046 0.0137
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0046 0.0065
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0046 0.0046
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0064 0.0091
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0084 0.0084
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0331 0.3899
Onchocerca volvulus Cell death protein 3 homolog 0.0053 0.0632 0.189
Plasmodium vivax metacaspase 1, putative 0.0053 0.0632 0.2833
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.004 0.0438 0.1895
Leishmania major protein farnesyltransferase alpha subunit, putative 0.004 0.0438 0.5163
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.03 0.03
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0343 0.0899
Leishmania major DNA polymerase eta, putative 0.0045 0.051 0.6009
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0046 0.0056
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0154 0.2115 0.2631
Echinococcus multilocularis caspase 0.0199 0.2771 0.2771
Echinococcus multilocularis protein quaking 0.0027 0.0251 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Loa Loa (eye worm) endoplasmin 0.0065 0.0807 0.1004
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0046 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0135 0.0168
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0848 0.0848
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Loa Loa (eye worm) hypothetical protein 0.0031 0.03 0.0373
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0068 0.0848 0.3876
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0046 0.0535
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.098
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0046 0.0535
Trichomonas vaginalis rotamase, putative 0.0033 0.0343 0.0899
Echinococcus granulosus Mastin 0.0013 0.0046 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0314 0.3699
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Mycobacterium ulcerans putative regultory protein 0.0013 0.0046 0.0007
Entamoeba histolytica hypothetical protein 0.0036 0.038 0.1617
Echinococcus granulosus caspase 3 0.0146 0.199 0.199
Brugia malayi Hsp90 protein 0.0027 0.0243 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0046 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0848 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0053 0.0632 0.0785
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.049 0.7042 1
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Onchocerca volvulus 0.004 0.0438 0.131
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma cruzi metacaspase, putative 0.0053 0.0632 0.7452
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0084 0.098
Leishmania major heat shock protein, putative 0.0027 0.0243 0.2861
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0243 0.0302
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0154 0.2115 0.2115
Trypanosoma brucei metacaspase 5, putative 0.0053 0.0632 0.7452
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0084 0.0084
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0142 0.0142
Echinococcus granulosus dnaJ subfamily B 0.041 0.5867 0.5867
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0135
Trypanosoma cruzi metacaspase 5, putative 0.0053 0.0632 0.7452
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Echinococcus multilocularis tumor protein p63 0.0339 0.4821 0.4821
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.038 0.038
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.004 0.0438 0.5163
Schistosoma mansoni hypothetical protein 0.0048 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0053 0.0632 0.0786
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0046 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.0046 0.0046
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0084 0.0664
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0068 0.0848 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0142 0.0142
Entamoeba histolytica hypothetical protein 0.0036 0.038 0.1617
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0613 0.0709
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 1
Brugia malayi Endoplasmin precursor 0.0065 0.0807 0.1146
Schistosoma mansoni heat shock protein 0.0065 0.0807 0.0807
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.2115 0.6272
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0848 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.0046 0.0046
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0068 0.0848 1
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0848 0.2431
Onchocerca volvulus 0.002 0.0142 0.0426
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0558 0.8039 1
Echinococcus multilocularis dnaJ subfamily B 0.041 0.5867 0.5867
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.3876
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0046 0.0007
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.2431
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0331 0.1377
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0154 0.2115 0.2115
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.004 0.0438 0.0545
Onchocerca volvulus 0.0013 0.0046 0.0137
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0848 0.2431
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0632 0.1777
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0154 0.2115 0.3003
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0807 0.9521
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0154 0.2115 1
Entamoeba histolytica hypothetical protein 0.0036 0.038 0.1617
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0046 0.0535
Brugia malayi hypothetical protein 0.0013 0.0046 0.0065
Onchocerca volvulus 0.0013 0.0046 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.03 0.03
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0848 1
Onchocerca volvulus 0.0027 0.0248 0.0741
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0848 0.1054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.1587
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0331 0.3899
Leishmania major heat shock protein 83-1 0.0065 0.0807 0.9521
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0343 0.0426
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0848 0.0848
Treponema pallidum heat shock protein 90 0.0052 0.0613 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0068 0.0848 0.1204
Loa Loa (eye worm) hypothetical protein 0.0053 0.0632 0.0786
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0668 0.083
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.1587
Loa Loa (eye worm) hypothetical protein 0.0237 0.3329 0.4141
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0043 0.0043
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0807 0.1004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0053 0.0632 0.1777
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0848 0.3876
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0135 0.027
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0848 0.2431
Schistosoma mansoni rab6-interacting 0.002 0.0142 0.0142
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0046 0.0138
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Echinococcus multilocularis heat shock protein 90 0.0052 0.0613 0.0613
Brugia malayi Pre-SET motif family protein 0.0209 0.2921 0.4148
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0046 0.0741
Brugia malayi Trypsin family protein 0.0013 0.0046 0.0065
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0084 0.098
Trypanosoma brucei heat shock protein, putative 0.0065 0.0807 0.9521
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0558 0.8039 0.8039
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0046 0.0065
Echinococcus granulosus caspase 2 0.0053 0.0632 0.0632

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.345 Inhibition of PDE4 in Homo sapiens (human) U937 cells ChEMBL. No reference
IC50 (binding) = 7.6 nM Inhibition Assay BINDINGDB. No reference
IC50 (binding) = 0.452 uM Inhibition of Phosphodiesterase 4 from human U937 cells ChEMBL. 10999488
IC50 (binding) = 0.452 uM Inhibition of Phosphodiesterase 4 from human U937 cells ChEMBL. 10999488
IC50 (binding) = 1.85 uM Inhibition of rolipram binding in rat brain tissue ChEMBL. 10999488
IC50 (binding) = 1.85 uM Inhibition of rolipram binding in rat brain tissue ChEMBL. 10999488
Ratio (binding) = 0.24 Relative activity aginst human Phosphodiesterase type 4 (PDE4) and rat rolipram binding protein (RBA) ChEMBL. 10999488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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