Detailed information for compound 1096358

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.513 | Formula: C14H19N3O5S3
  • H donors: 3 H acceptors: 5 LogP: 3.1 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCc1sc(cc1C)S(=O)(=O)NC(=O)Nc1nc(c(s1)OC)CC
  • InChi: 1S/C14H19N3O5S3/c1-4-9-12(22-3)24-14(15-9)16-13(19)17-25(20,21)11-7-8(2)10(23-11)5-6-18/h7,18H,4-6H2,1-3H3,(H2,15,16,17,19)
  • InChiKey: RDOOMXMPQGODOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus fructose bisphosphatase 1 Starlite/ChEMBL References
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Toxoplasma gondii fructose-bisphospatase I fructose bisphosphatase 1 338 aa 326 aa 29.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0316 0.1027 0.1023
Echinococcus multilocularis mitogen activated protein kinase 14 0.026 0.0834 0.083
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0252 0.0247
Mycobacterium leprae PROBABLE HYDROLASE 0.0051 0.0117 0.0355
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.02 0.1842
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0142 0.0137
Echinococcus granulosus mitogen activated protein kinase 14 0.026 0.0834 0.083
Brugia malayi Hemopexin family protein 0.006 0.0146 0.0555
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0085 0.0231 0.0227
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.0063 0.0616
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Echinococcus multilocularis aldo keto reductase 0.0031 0.0046 0.0042
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0154 0.0469 0.0464
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0046 0.0167
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0129 0.0386 0.1475
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0115 0.0816
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0214
Mycobacterium ulcerans malate dehydrogenase 0.0085 0.0231 0.0652
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0051 0.0115 0.0435
Echinococcus granulosus snurportin 1 0.0316 0.1027 0.1023
Schistosoma mansoni ap endonuclease 0.0076 0.02 0.0196
Entamoeba histolytica hypothetical protein 0.0075 0.0197 0.3623
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Loa Loa (eye worm) hypothetical protein 0.012 0.0354 0.1353
Echinococcus multilocularis snurportin 1 0.0316 0.1027 0.1023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0173 0.0536 0.8129
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0115 0.0816
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0063 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0202 0.0636 0.0632
Echinococcus granulosus muscleblind protein 0.077 0.2589 0.2585
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0857 0.2887 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0173 0.0536 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0017 0.0056
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0202 0.0636 0.0632
Schistosoma mansoni malate dehydrogenase 0.0085 0.0231 0.0227
Loa Loa (eye worm) MBCTL1 0.0058 0.0142 0.0531
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0154 0.0469 0.0464
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0051 0.0115 0.0244
Echinococcus granulosus dnaJ subfamily B 0.0441 0.1456 0.1452
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0063 0.0233
Entamoeba histolytica aldose reductase, putative 0.0031 0.0046 0.0781
Brugia malayi hypothetical protein 0.0075 0.0197 0.0751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0092 0.0088
Onchocerca volvulus Matrilysin homolog 0.0094 0.0263 0.478
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0092 0.0346
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0115 0.0435
Schistosoma mansoni microtubule-associated protein tau 0.2925 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0092 0.0088
Brugia malayi nuclear receptor NHR-88 0.0021 0.0012 0.0036
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0092 0.0088
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Brugia malayi lactate dehydrogenase. 0.0036 0.0063 0.0231
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.0689 0.0685
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0092 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0313 0.1018 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0225
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.02 0.1508
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0857 0.2887 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0051 0.0115 0.0244
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0115 0.0816
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0017 0.0013
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.124 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0017 0.0013
Onchocerca volvulus 0.0031 0.0047 0.0662
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0122 0.0361 0.5228
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0063 0.0227
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.02 0.1508
Onchocerca volvulus 0.0031 0.0046 0.0646
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0166 0.0162
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0429
Schistosoma mansoni hypothetical protein 0.008 0.0217 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.006 0.0214
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0092 0.0088
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0046 0.025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0004 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0092 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0115 0.0429
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0051 0.0115 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0092 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0012 0.0008
Onchocerca volvulus 0.0044 0.0092 0.1533
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Brugia malayi nuclear hormone receptor 0.0021 0.0012 0.0036
Toxoplasma gondii aldose reductase, putative 0.0031 0.0046 0.0107
Echinococcus multilocularis aldo keto reductase 0.0031 0.0046 0.0042
Echinococcus granulosus hypothetical protein 0.0031 0.0046 0.0042
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0117 0.0113
Loa Loa (eye worm) oxidoreductase 0.0031 0.0046 0.0161
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.02 0.1965
Schistosoma mansoni pol-related 0.0031 0.0046 0.0042
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.0217 0.0213
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0092 0.0341
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0092 0.0341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0092 0.0088
Brugia malayi P38 map kinase family protein 2 0.026 0.0834 0.3214
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Echinococcus granulosus importin subunit beta 1 0.003 0.0042 0.0038
Schistosoma mansoni importin beta-1 0.003 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0129 0.0386 0.1475
Brugia malayi AMP-binding enzyme family protein 0.0173 0.0536 0.2062
Leishmania major 4-coumarate:coa ligase-like protein 0.0173 0.0536 0.4251
Brugia malayi AMP-binding enzyme family protein 0.0173 0.0536 0.2062
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0313 0.1018 0.3924
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0046 0.0452
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0051 0.0115 0.115
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0042 0.0086 0.0081
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0378 0.124 0.4783
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0063 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.006 0.0055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.02 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0021 0.0069
Brugia malayi nuclear receptor NHR-67 0.0021 0.0012 0.0036
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0012 0.0036
Onchocerca volvulus Matrilysin homolog 0.0042 0.0086 0.1404
Entamoeba histolytica hypothetical protein 0.0075 0.0197 0.3623
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0857 0.2887 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0092 0.0346
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.02 0.1508
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0012 0.0036
Loa Loa (eye worm) oxidoreductase 0.0031 0.0046 0.0161
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0051 0.0115 0.0816
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0314
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0117 0.0436
Mycobacterium ulcerans hydrolase 0.0051 0.0117 0.0251
Echinococcus multilocularis microtubule associated protein 2 0.2925 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0313 0.1018 0.8188
Brugia malayi steroid hormone receptor 0.0044 0.0092 0.0346
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0017 0.005
Plasmodium vivax malate dehydrogenase, putative 0.0036 0.0063 0.0165
Loa Loa (eye worm) matrix metalloproteinase 0.0042 0.0086 0.0314
Echinococcus multilocularis mitogen activated protein kinase 14 0.026 0.0834 0.083
Brugia malayi nuclear receptor RXR 0.0023 0.0021 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0173 0.0536 0.1726
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Plasmodium vivax acyl-CoA synthetase, putative 0.0129 0.0386 0.1289
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0092 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0092 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0117 0.0113
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0037 0.0179
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0051 0.0115 0.115
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0063 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Loa Loa (eye worm) hypothetical protein 0.077 0.2589 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0173 0.0536 0.1726
Echinococcus granulosus mitogen activated protein kinase 3 0.0313 0.1018 0.1014
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Leishmania major malate dehydrogenase, putative 0.0036 0.0063 0.0387
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0857 0.2887 1
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0378 0.124 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.026 0.0834 0.321
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Trichomonas vaginalis antibiotic synthetase, putative 0.0051 0.0115 0.1132
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0063
Echinococcus multilocularis cpg binding protein 0.0033 0.0053 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0092 0.0088
Onchocerca volvulus 0.0031 0.0046 0.0646
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0021 0.0063
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0023 0.0225
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0252 0.0247
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0012 0.0008
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0004 0.0006
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0046 0.025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.02 0.0643
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.077 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Onchocerca volvulus 0.0051 0.0115 0.1969
Entamoeba histolytica malate dehydrogenase, putative 0.0036 0.0063 0.1096
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.0214 0.021
Brugia malayi PXA domain containing protein 0.0019 0.0004 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0037 0.0076
Loa Loa (eye worm) matrixin family protein 0.0094 0.0263 0.0999
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.02 0.3679
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0173 0.0536 0.1814
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0314
Echinococcus multilocularis lactate dehydrogenase a 0.0036 0.0063 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0092 0.0346
Echinococcus granulosus cytosolic malate dehydrogenase 0.0085 0.0231 0.0227
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.02 0.0643
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.124 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0051 0.0115 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0092 0.0341
Echinococcus multilocularis mitogen activated protein kinase 0.0313 0.1018 0.1014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0063
Leishmania major malate dehydrogenase 0.0036 0.0063 0.0387
Giardia lamblia Aldose reductase 0.0031 0.0046 0.0306
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0012 0.0008
Echinococcus multilocularis malate dehydrogenase 0.0036 0.0063 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0035 0.006 0.022
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0004 0.0044
Leishmania major mitochondrial malate dehydrogenase 0.0036 0.0063 0.0387
Brugia malayi fructose-1,6-bisphosphatase 0.0378 0.124 0.4786
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0012 0.0036
Brugia malayi Matrixin family protein 0.0042 0.0086 0.032
Brugia malayi hypothetical protein 0.0021 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0115 0.115
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.0424 0.3335
Giardia lamblia Kinase, CMGC MAPK 0.0313 0.1018 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0021 0.0016
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0036 0.0063 0.0387
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0042 0.0219
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0004 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0122 0.0361 0.5228
Schistosoma mansoni hypothetical protein 0.0866 0.2918 0.2915
Onchocerca volvulus 0.0031 0.0046 0.0646
Schistosoma mansoni malate dehydrogenase 0.0036 0.0063 0.0058
Trypanosoma brucei malate dehydrogenase-related 0.0036 0.0063 0.0387
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.02 0.0763
Echinococcus granulosus geminin 0.0866 0.2918 0.2915
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0092 0.0346
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0037 0.0076
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0092 0.1533
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0051 0.0115 0.0348
Schistosoma mansoni L-lactate dehydrogenase 0.0036 0.0063 0.0058
Onchocerca volvulus 0.0031 0.0046 0.0646
Echinococcus multilocularis aldo keto reductase 0.0031 0.0046 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0313 0.1018 1
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0092 0.0346
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0092 0.0088
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0051 0.0115 0.0816
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0173 0.0536 0.1726
Mycobacterium ulcerans hypothetical protein 0.0173 0.0536 0.1726
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0051 0.0115 0.0244
Schistosoma mansoni hypothetical protein 0.0441 0.1456 0.1452
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.026 0.0834 0.6682
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0063 0.039
Leishmania major 0.0378 0.124 1
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0085 0.0231 0.1763
Echinococcus granulosus aldo keto reductase 0.0031 0.0046 0.0042
Brugia malayi ecdysone receptor 0.0021 0.0012 0.0036
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0046 0.0167
Schistosoma mansoni aldo-keto reductase 0.0031 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0857 0.2887 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0017 0.005
Loa Loa (eye worm) hypothetical protein 0.011 0.0318 0.1213
Leishmania major prostaglandin f synthase, putative 0.0031 0.0046 0.025
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0036 0.0063 0.0387
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0092 0.0346
Schistosoma mansoni hypothetical protein 0.0075 0.0199 0.0194
Trichomonas vaginalis ran, putative 0.0022 0.0015 0.015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0092 0.0088
Schistosoma mansoni nuclear receptor 0.0021 0.0012 0.0008
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0036 0.0063 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Echinococcus multilocularis geminin 0.0866 0.2918 0.2915
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0202 0.0636 0.2445
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0036 0.0063 0.0387
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0115 0.0435
Giardia lamblia Malate dehydrogenase 0.0085 0.0231 0.2154
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0046 0.025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0092 0.0088
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0012 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0092 0.0088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0092 0.1533
Echinococcus granulosus aldo keto reductase 0.0031 0.0046 0.0042
Entamoeba histolytica malate dehydrogenase, putative 0.0085 0.0231 0.4267
Leishmania major aldo-keto reductase-like protein 0.0031 0.0046 0.025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0063 0.039
Onchocerca volvulus Matrix metalloproteinase homolog 0.0094 0.0263 0.478
Brugia malayi MAP kinase sur-1 0.0313 0.1018 0.3927
Schistosoma mansoni serine/threonine protein kinase 0.0313 0.1018 0.1014
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0051 0.0115 0.115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0092 0.0346
Schistosoma mansoni hypothetical protein 0.008 0.0217 0.0213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0129 0.0386 0.1195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0202 0.0636 0.0632
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0313 0.1018 0.8188
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0085 0.0231 0.2272
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0036 0.0063 0.0058
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.0252 0.0824
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0202 0.0636 0.0632
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0012 0.0008
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0051 0.0117 0.1183
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Loa Loa (eye worm) hypothetical protein 0.0129 0.0386 0.1475
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.0689 0.0685
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0092 0.0088
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0115 0.0429
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0857 0.2887 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0092 0.0346
Echinococcus multilocularis dnaJ subfamily B 0.0441 0.1456 0.1452
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0202 0.0636 0.2449
Leishmania major acetyl-CoA synthetase, putative 0.0051 0.0115 0.0816
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.026 0.0834 0.6682
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0063
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0051 0.0115 0.0348
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0129 0.0386 0.5631
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0051 0.0115 0.115
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0141 0.0424 0.3335
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Brugia malayi hypothetical protein 0.0023 0.0021 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Mycobacterium ulcerans acyl-CoA synthetase 0.0173 0.0536 0.1726
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0046 0.0167
Brugia malayi hypothetical protein 0.0019 0.0004 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0202 0.0636 0.0632
Leishmania major cytosolic malate dehydrogenase 0.0085 0.0231 0.1763
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0051 0.0117 0.0443
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0085 0.0231 0.2272
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0085 0.0231 0.3074
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Schistosoma mansoni hypothetical protein 0.0075 0.0197 0.0193
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0015 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0197 0.0193
Loa Loa (eye worm) matrixin family protein 0.0102 0.0292 0.1111
Echinococcus granulosus lactate dehydrogenase protein 0.0036 0.0063 0.0058
Echinococcus granulosus mitogen activated protein kinase 11 0.026 0.0834 0.083
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0142 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0173 0.0536 0.2062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0142 0.0137
Entamoeba histolytica hypothetical protein 0.0075 0.0197 0.3623
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0037 0.0179
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0051 0.0115 0.115
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.02 0.1508
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0085 0.0231 0.2272
Echinococcus multilocularis malate dehydrogenase 0.0036 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Brugia malayi Muscleblind-like protein 0.077 0.2589 1
Schistosoma mansoni malate dehydrogenase 0.0036 0.0063 0.0058
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0046 0.0167
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Echinococcus granulosus malate dehydrogenase 0.0036 0.0063 0.0058
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0063 0.0059
Toxoplasma gondii lactate dehydrogenase LDH2 0.0036 0.0063 0.0165
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0197 0.0193
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0146
Trypanosoma brucei cytosolic malate dehydrogenase 0.0085 0.0231 0.1763
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0012 0.0036
Onchocerca volvulus 0.0051 0.0117 0.2004
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0092 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0092 0.0346
Echinococcus granulosus lactate dehydrogenase a 0.0036 0.0063 0.0058
Schistosoma mansoni cpg binding protein 0.0033 0.0053 0.0048
Echinococcus multilocularis muscleblind protein 1 0.077 0.2589 0.2585
Onchocerca volvulus 0.0042 0.0086 0.1404
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0046 0.0452
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Leishmania major 4-coumarate:coa ligase-like protein 0.0173 0.0536 0.4251
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.0217 0.0823
Trypanosoma cruzi malate dehydrogenase, putative 0.0036 0.0063 0.0387
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0055
Echinococcus multilocularis aldehyde reductase 0.0022 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0092 0.0088
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.0042
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0092 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0122 0.0361 0.5228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0115 0.0244
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0046 0.025
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0173 0.0536 0.1726
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0117 0.0113
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0022 0.0017 0.0015
Onchocerca volvulus Huntingtin homolog 0.012 0.0354 0.6524
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Echinococcus granulosus GPCR family 2 0.0035 0.006 0.0055
Trichomonas vaginalis malate dehydrogenase, putative 0.0066 0.0169 0.1656
Schistosoma mansoni hypothetical protein 0.008 0.0217 0.0213
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0042 0.0219
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0046 0.025
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0085 0.0231 0.0227
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.02 0.2555
Echinococcus multilocularis mitogen activated protein kinase 3 0.0313 0.1018 0.1014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0122 0.0361 0.5228
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0129 0.0386 0.1475
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0092 0.0088
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0021 0.0016
Plasmodium falciparum importin beta, putative 0.003 0.0042 0.0094
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0046 0.0452
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.02 0.0542
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0015 0.0048
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Onchocerca volvulus 0.0173 0.0536 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0092 0.0341
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0313 0.1018 0.3493
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0429
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0012 0.0036
Trypanosoma brucei glycosomal malate dehydrogenase 0.0036 0.0063 0.0387
Brugia malayi hypothetical protein 0.012 0.0354 0.1358
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0115 0.0435
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0055
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0042 0.0094
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0063 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0092 0.0341
Plasmodium vivax acetyl-CoA synthetase, putative 0.0051 0.0115 0.0348
Entamoeba histolytica Ran family GTPase 0.0022 0.0015 0.0204
Loa Loa (eye worm) hypothetical protein 0.008 0.0217 0.0823
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0017 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0173 0.0536 0.1726
Onchocerca volvulus 0.0051 0.0115 0.1969
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0197 0.0193
Echinococcus granulosus expressed protein 0.0363 0.1188 0.1184
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0117 0.0113
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0313 0.1018 0.8188
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0051 0.0115 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0313 0.1018 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1757 0.5984 0.5982
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.0217 0.0829
Toxoplasma gondii fructose-bisphospatase II 0.0378 0.124 0.4267
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0021 0.0069
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0051 0.0115 0.0111
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Echinococcus multilocularis lactate dehydrogenase protein 0.0036 0.0063 0.0058
Onchocerca volvulus 0.0031 0.0046 0.0646
Echinococcus granulosus cpg binding protein 0.0033 0.0053 0.0048
Echinococcus granulosus lactate dehydrogenase a 0.0036 0.0063 0.0058
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Plasmodium falciparum L-lactate dehydrogenase 0.0036 0.0063 0.0165
Entamoeba histolytica acyl-coA synthetase, putative 0.0173 0.0536 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0173 0.0536 1
Leishmania major hypothetical protein, conserved 0.0028 0.0037 0.0179
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0092 0.0088
Leishmania major acetyl-CoA synthetase, putative 0.0051 0.0115 0.0816
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.02 0.0486
Brugia malayi nuclear receptor NHR-88 0.0044 0.0092 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0173 0.0536 0.2058
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.0217 0.0213
Schistosoma mansoni coup transcription factor 0.0044 0.0092 0.0088
Plasmodium vivax lactate dehydrogenase 0.0036 0.0063 0.0165
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0063 0.0059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Echinococcus granulosus L lactate dehydrogenase B chain 0.0036 0.0063 0.0058
Brugia malayi mbt repeat family protein 0.0051 0.0117 0.0442
Echinococcus granulosus malate dehydrogenase 0.0036 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0127
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0161
Loa Loa (eye worm) hypothetical protein 0.0091 0.0252 0.0957
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.006 0.022
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0063 0.0059
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0115 0.115
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0857 0.2887 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.026 0.0834 0.6682
Brugia malayi Matrixin family protein 0.0042 0.0086 0.032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0173 0.0536 0.1814
Loa Loa (eye worm) hypothetical protein 0.0075 0.0199 0.0751
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0046 0.0452
Brugia malayi CXXC zinc finger family protein 0.0031 0.0047 0.017
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0117 0.0113
Schistosoma mansoni hypothetical protein 0.0866 0.2918 0.2915
Brugia malayi conserved hypotetical protein 0.0021 0.0012 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0092 0.0346
Leishmania major importin beta-1 subunit, putative 0.0024 0.0023 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0037 0.0076
Schistosoma mansoni zinc finger protein 0.0021 0.0012 0.0008
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0117 0.0113
Loa Loa (eye worm) malate dehydrogenase 0.0085 0.0231 0.0878
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0047 0.0164
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.026 0.0834 0.6682
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0117 0.2004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.006 0.0055
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0012 0.0008
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0012 0.003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0023 0.0225
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.0214 0.021
Schistosoma mansoni apoptosis regulator bax 0.008 0.0217 0.0213
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0046 0.025
Echinococcus multilocularis lactate dehydrogenase a 0.0036 0.0063 0.0058
Schistosoma mansoni nuclear receptor 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.012 0.0354 0.1353
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0012 0.0008
Echinococcus multilocularis GPCR, family 2 0.0035 0.006 0.0055
Loa Loa (eye worm) oxidoreductase 0.0031 0.0046 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0313 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0085 0.0231 0.0752
Trypanosoma brucei protein kinase, putative 0.0313 0.1018 0.8188
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0313 0.1018 0.8188
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.0214 0.0816
Brugia malayi ecdysteroid receptor 0.0044 0.0092 0.0346
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0012 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.0347
Toxoplasma gondii fructose-bisphospatase I 0.0141 0.0424 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0173 0.0536 0.1726
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0021 0.0016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0318 0.1218
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0051 0.0115 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0437
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0142 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0378 0.124 0.1237
Echinococcus multilocularis mitogen activated protein kinase 11 0.026 0.0834 0.083
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0063 0.039
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Echinococcus multilocularis lactate dehydrogenase a 0.0036 0.0063 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0318 0.1213
Loa Loa (eye worm) DR-78 0.0021 0.0012 0.003
Schistosoma mansoni ran 0.0022 0.0015 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0202 0.0636 0.0632
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0142 0.0137
Echinococcus granulosus cytosolic malate dehydrogenase 0.0085 0.0231 0.0227
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0055
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0051 0.0115 0.2085
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0021 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0092 0.0341
Leishmania major pantothenate kinase subunit, putative 0.0022 0.0017 0.0015
Echinococcus multilocularis mitogen activated protein kinase 11 0.026 0.0834 0.083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.02 0.0196
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0012 0.0008
Mycobacterium ulcerans acetyl-CoA synthetase 0.0051 0.0115 0.0244
Plasmodium vivax importin-beta 2, putative 0.003 0.0042 0.0094
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.0252 0.0247
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0063 0.039
Brugia malayi Matrixin family protein 0.0102 0.0292 0.1117
Schistosoma mansoni cpg binding protein 0.0031 0.0047 0.0042
Toxoplasma gondii propionate-CoA ligase 0.0051 0.0115 0.0348
Leishmania major glycosomal malate dehydrogenase 0.0036 0.0063 0.0387
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0313 0.1018 0.8188
Echinococcus granulosus mitogen activated protein kinase 0.0313 0.1018 0.1014
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0051 0.0117 0.0436
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0092 0.0088
Brugia malayi isocitrate dehydrogenase 0.0036 0.0063 0.0233
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0012 0.0008
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Leishmania major malate dehydrogenase, putative 0.0036 0.0063 0.0387
Trichomonas vaginalis antibiotic synthetase, putative 0.0051 0.0115 0.1132
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.0252 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0017 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0092 0.0088
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0046 0.0452
Onchocerca volvulus Huntingtin homolog 0.012 0.0354 0.6524
Onchocerca volvulus 0.0051 0.0115 0.1969
Brugia malayi nuclear hormone receptor 0.0044 0.0092 0.0346
Brugia malayi Importin beta-1 subunit 0.003 0.0042 0.0152
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0857 0.2887 1
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0004 0.0006
Trypanosoma cruzi malate dehydrogenase, putative 0.0036 0.0063 0.0387
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0051 0.0115 0.115
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0092 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0092 0.0088
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.0012 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.02 0.0757
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0046 0.0107
Loa Loa (eye worm) malate dehydrogenase 0.0036 0.0063 0.0226
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0046 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0092 0.0088
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0051 0.0115 0.0244
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Schistosoma mansoni malate dehydrogenase 0.0085 0.0231 0.0227
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0092 0.0088
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0115 0.0348
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0044 0.0092 0.0341
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.1027 0.3957
Onchocerca volvulus 0.0031 0.0046 0.0646
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0051 0.0115 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0012 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0037 0.0179
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0012 0.0008
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0142 0.0536
Entamoeba histolytica aldose reductase, putative 0.0031 0.0046 0.0781
Echinococcus multilocularis muscleblind protein 0.077 0.2589 0.2585
Schistosoma mansoni ap endonuclease 0.0076 0.02 0.0196
Brugia malayi hypothetical protein 0.0028 0.0037 0.0133
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0173 0.0536 0.8129
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Schistosoma mansoni aldo-keto reductase 0.0031 0.0046 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0037 0.0076
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0318 0.1218
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.02 0.1965
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0063 0.0166
Brugia malayi Matrixin family protein 0.0042 0.0086 0.032
Toxoplasma gondii exonuclease III APE 0.0076 0.02 0.0643
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0115 0.115
Onchocerca volvulus 0.006 0.0146 0.2562
Giardia lamblia Aldose reductase 0.0031 0.0046 0.0306
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0051 0.0115 0.0816
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0017 0.0013
Plasmodium falciparum malate dehydrogenase 0.0036 0.0063 0.0165
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0378 0.124 0.1237
Trichomonas vaginalis malate dehydrogenase, putative 0.0085 0.0231 0.2272
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0004 0.0044
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0085 0.0231 0.2272
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0036 0.0063 0.0231
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0012 0.0008
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.0214 0.0811
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0046 0.0452
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0085 0.0231 0.1763
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0092 0.1533
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0141 0.0424 0.1423
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0051 0.0115 0.0244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0092 0.0088
Echinococcus multilocularis aldo keto reductase 0.0031 0.0046 0.0042
Loa Loa (eye worm) oxidoreductase 0.0031 0.0046 0.0161
Schistosoma mansoni acetyl-CoA synthetase 0.0051 0.0115 0.0111
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0173 0.0536 0.2058
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0063 0.0283
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0117 0.0113
Brugia malayi Matrixin family protein 0.0042 0.0086 0.032
Brugia malayi hypothetical protein 0.0021 0.0012 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0129 0.0386 0.1289
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0085 0.0231 0.0883
Echinococcus multilocularis importin subunit beta 1 0.003 0.0042 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0115 0.0435
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0063 0.039
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.0252 0.2358
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0046 0.0042
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0023 0.0062
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0378 0.124 0.1237
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0063
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0092 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0092 0.0346
Brugia malayi nuclear receptor RXR 0.0021 0.0012 0.0036
Schistosoma mansoni ran 0.0022 0.0015 0.0011
Onchocerca volvulus 0.0051 0.0115 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0092 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0092 0.0088
Brugia malayi hypothetical protein 0.0023 0.0021 0.0069
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0063 0.0166
Brugia malayi PXA domain containing protein 0.0019 0.0004 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0173 0.0536 0.4251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0092 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0092 0.0088
Brugia malayi hypothetical protein 0.0019 0.0004 0.0006
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0051 0.0115 0.0435
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0115 0.115
Entamoeba histolytica hypothetical protein 0.0075 0.0197 0.3623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0202 0.0636 0.0632
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0051 0.0115 0.0816
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0063 0.0166
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0046 0.0452
Loa Loa (eye worm) hypothetical protein 0.0058 0.0142 0.0531
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0313 0.1018 0.8188
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0115 0.115
Schistosoma mansoni L-lactate dehydrogenase 0.0036 0.0063 0.0058
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0012 0.003
Brugia malayi tailless protein 0.0021 0.0012 0.0036
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0206 0.0649 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0092 0.0088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0129 0.0386 0.0581
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0313 0.1018 0.8188
Echinococcus multilocularis expressed protein 0.0363 0.1188 0.1184
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0063 0.0059
Loa Loa (eye worm) oxidoreductase 0.0051 0.0115 0.0429
Echinococcus granulosus aldehyde reductase 0.0022 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0129 0.0386 0.1475
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0199 0.0756
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.0424 0.3335
Loa Loa (eye worm) hypothetical protein 0.0173 0.0536 0.2058
Loa Loa (eye worm) oxidoreductase 0.0031 0.0046 0.0161
Schistosoma mansoni hypothetical protein 0.0328 0.1067 0.1063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0086 0.0314
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0115 0.0244
Toxoplasma gondii lactate dehydrogenase LDH1 0.0036 0.0063 0.0165
Brugia malayi RNA, U transporter 1 0.0084 0.023 0.0878
Loa Loa (eye worm) hypothetical protein 0.0036 0.0063 0.0226
Schistosoma mansoni hypothetical protein 0.006 0.0146 0.0142
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0085 0.0231 0.4267
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.0217 0.0213
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0051 0.0115 0.0348
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0091 0.0746
Toxoplasma gondii malate dehydrogenase MDH 0.0036 0.0063 0.0165
Entamoeba histolytica aldose reductase, putative 0.0031 0.0046 0.0781
Plasmodium falciparum lactate dehydrogenase, putative 0.0036 0.0063 0.0165
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0092 0.0088
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0036 0.0063 0.0387
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0142 0.0137
Schistosoma mansoni cpg binding protein 0.0033 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.003
Echinococcus granulosus aldo keto reductase 0.0031 0.0046 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0092 0.0346
Brugia malayi mbt repeat family protein 0.0051 0.0117 0.0442

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 9.2 uM Inhibition of FBPase in mouse liver ChEMBL. 19969452
IC50 (binding) = 0.26 uM Inhibition of FBPase in human liver ChEMBL. 19969452

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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