TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 413.13 | Formula: C14H11Br2N3S
H donors: 2 H acceptors: 0 LogP: 4.46 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C(/c1cccc(c1)Br)\c1ccc(cc1)Br
InChi: 1S/C14H11Br2N3S/c15-11-6-4-9(5-7-11)13(18-19-14(17)20)10-2-1-3-12(16)8-10/h1-8H,(H3,17,19,20)/b18-13+
InChiKey: QZFQNEKEZHCGLR-QGOAFFKASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0032	0.0505	1
Onchocerca volvulus		0.0032	0.0505	0.0592
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0505	0.0549
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.1208	0.1125
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0188	0.0194
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0188	0.0479
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0634	0.0545
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0126	0.0059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Entamoeba histolytica	hypothetical protein	0.0037	0.0635	0.8146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.1177	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0542	0.0431
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0176	0.0061
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0737	0.5544
Echinococcus multilocularis	cysteine protease	0.0032	0.0505	0.0415
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.0505	0.0415
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0126	0.001
Toxoplasma gondii	cathepsin B	0.006	0.1177	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.016	0.0067
Brugia malayi	jmjC domain containing protein	0.0065	0.1297	0.3296
Echinococcus granulosus	cathepsin l1	0.0032	0.0505	0.0415
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.1177	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3867	0.4899
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Plasmodium vivax	vivapain-3	0.0019	0.0188	0.1659
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0334	0.7811	1
Onchocerca volvulus		0.0032	0.0505	0.0592
Echinococcus multilocularis	snurportin 1	0.0334	0.7811	0.779
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0134	0.0069
Echinococcus multilocularis	musashi	0.0031	0.0482	0.0392
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0345	0.0612
Brugia malayi	intermediate filament protein	0.0031	0.0482	0.1225
Schistosoma mansoni	bromodomain containing protein	0.0067	0.1362	0.126
Echinococcus granulosus	cathepsin b	0.0171	0.3867	0.3809
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0453	0.0482
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0932	0.0846
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0289	0.0175
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0126	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0505	0.0549
Entamoeba histolytica	hypothetical protein	0.0037	0.0635	0.8146
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0188	0.0073
Echinococcus multilocularis	ubiquitin specific protease 41	0.0042	0.0737	0.0649
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0064	0.1272	0.1189
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0505	0.1037
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0215	0.0122
Onchocerca volvulus		0.0031	0.0482	0.0529
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0482	0.052
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0932	0.0826
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3867	0.3795
Onchocerca volvulus		0.0031	0.0482	0.0529
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Brugia malayi	PHD-finger family protein	0.0028	0.0398	0.1012
Brugia malayi	jmjC domain containing protein	0.0016	0.0126	0.0319
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0505	0.0592
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0489	0.3512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Schistosoma mansoni	zinc finger protein	0.0022	0.0264	0.015
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1261	0.1159
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0289	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0126	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0094	0.0018
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0482	0.1225
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	lysine specific demethylase 5A	0.0065	0.1297	0.1215
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0489	0.0398
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0188	0.0194
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0188	0.0194
Echinococcus multilocularis	lamin	0.0031	0.0482	0.0392
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0126	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0188	0.0684
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0126	0.001
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0126	0.001
Giardia lamblia	Cathepsin B precursor	0.006	0.1177	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0176	0.0082
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0188	0.0479
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0489	0.3512
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.016	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0126	0.0032
Echinococcus multilocularis	lamin dm0	0.0031	0.0482	0.0392
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0505	0.5773
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0737	0.0649
Onchocerca volvulus		0.0032	0.0505	0.0592
Giardia lamblia	Cathepsin B precursor	0.006	0.1177	1
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0505	0.0592
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0505	0.0394
Schistosoma mansoni	hypothetical protein	0.0334	0.7811	0.7785
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.1208	0.1105
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0188	0.0194
Brugia malayi	hypothetical protein	0.0037	0.0635	0.1613
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0489	0.3452
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0042	0.0737	0.0628
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Onchocerca volvulus		0.0032	0.0505	0.0592
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0126	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1507	0.1846
Loa Loa (eye worm)	hypothetical protein	0.003	0.0469	0.0502
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0188	0.0073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0176	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0065	0.1297	0.1195
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.025	0.0219
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.3867	0.9823
Entamoeba histolytica	hypothetical protein	0.0037	0.0635	0.8146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0932	0.0846
Loa Loa (eye worm)	cathepsin B	0.006	0.1177	0.1419
Echinococcus granulosus	cathepsin b	0.0171	0.3867	0.3809
Onchocerca volvulus		0.0032	0.0505	0.0592
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.0505	0.3666
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0339	0.0226
Brugia malayi	Bromodomain containing protein	0.004	0.0693	0.1761
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0505	0.0415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0188	0.0684
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0489	0.0398
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Loa Loa (eye worm)	fibroinase	0.0032	0.0505	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0126	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0505	0.1037
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0065	0.1297	0.1195
Schistosoma mansoni	lamin	0.0031	0.0482	0.0371
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0932	0.1102
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0635	0.0546
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0345	0.2163
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0482	0.052
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.0505	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3867	0.3795
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.0505	1
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0126	0.0032
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.0505	1
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Echinococcus multilocularis	cysteine protease	0.0032	0.0505	0.0415
Onchocerca volvulus		0.0032	0.0505	0.0592
Echinococcus granulosus	zinc finger protein	0.0022	0.0264	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0176	0.0123
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0188	0.1659
Onchocerca volvulus		0.0032	0.0505	0.0592
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0737	0.1655
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0635	0.0546
Schistosoma mansoni	hypothetical protein	0.0424	1	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0339	0.0247
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0126	0.0032
Echinococcus multilocularis	dnaJ subfamily B	0.0424	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0289	0.1018
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.0505	0.0592
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.1177	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	lamin dm0	0.0031	0.0482	0.0392
Echinococcus granulosus	cysteine protease	0.0019	0.0188	0.0095
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0126	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Schistosoma mansoni	cpg binding protein	0.003	0.0453	0.0341
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0505	0.0415
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.1208	0.1125
Echinococcus multilocularis	cathepsin b	0.0171	0.3867	0.3809
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0932	0.0846
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0042	0.0737	0.5849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0505	0.0415
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0505	0.1037
Echinococcus multilocularis	cpg binding protein	0.0033	0.0542	0.0452
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0345	0.1588
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0339	0.0247
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0188	0.0073
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0932	0.2368
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0188	0.0095
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.1177	0.2829
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0489	0.0528
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.1177	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0542	0.0431
Schistosoma mansoni	lamin	0.0031	0.0482	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0737	0.5544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0737	0.0649
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.016	0.0045
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0489	0.9569
Giardia lamblia	Cathepsin B precursor	0.006	0.1177	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0505	0.0394
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0042	0.0737	0.1871
Loa Loa (eye worm)	hypothetical protein	0.004	0.0695	0.0795
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0289	0.0735
Echinococcus granulosus	cathepsin l1	0.0023	0.0289	0.0197
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0505	0.3201
Brugia malayi	CXXC zinc finger family protein	0.003	0.0453	0.115
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0126	0.0091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.0505	0.0415
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0175	0.0123
Brugia malayi	jmjC domain containing protein	0.0016	0.0126	0.0319
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0064	0.1272	0.1189
Onchocerca volvulus		0.003	0.0453	0.0449
Echinococcus granulosus	cathepsin L	0.0019	0.0188	0.0095
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0215	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0755	0.0872
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0126	0.0026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0932	0.0826
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0737	0.1655
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0126	0.0032
Echinococcus granulosus	snurportin 1	0.0334	0.7811	0.779
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.1297	0.1574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	intermediate filament protein	0.0031	0.0482	0.0392
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0042	0.0737	0.5544
Echinococcus multilocularis	zinc finger protein	0.0022	0.0264	0.0172
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0634	0.0545
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0932	0.0846
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0505	0.0415
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0042	0.0737	0.0628
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0126	0.0032
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0188	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0289	0.027
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0505	0.1037
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0505	0.1283
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0345	0.1588
Brugia malayi	Importin beta-1 subunit	0.0031	0.0489	0.1241
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.3867	0.3795
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0844	0.0987
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0289	0.0462
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0289	0.1837
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0482	0.052
Plasmodium vivax	vivapain-2	0.0032	0.0505	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0345	0.1588
Echinococcus multilocularis	cathepsin b	0.0171	0.3867	0.3809
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0505	0.1283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0505	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0174	0.3937	0.4989
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0126	0.001
Brugia malayi	jmjC domain containing protein	0.0016	0.0126	0.0319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0134	0.034
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0042	0.0737	0.0649
Onchocerca volvulus		0.0174	0.3937	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0289	0.0735
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.0505	0.0549
Brugia malayi	jmjC domain containing protein	0.0016	0.0126	0.0319
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0505	0.5773
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0289	0.027
Brugia malayi	Bromodomain containing protein	0.0079	0.1656	0.4206
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0737	0.0849
Schistosoma mansoni	hypothetical protein	0.0021	0.025	0.0135
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0505	0.1037
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1157	0.981
Echinococcus granulosus	cpg binding protein	0.0033	0.0542	0.0452
Loa Loa (eye worm)	ctsf protein	0.0032	0.0505	0.0549
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0042	0.0737	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0289	0.0735
Plasmodium vivax	unspecified product	0.0019	0.0188	0.1659
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0635	0.0525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201
Echinococcus granulosus	lamin	0.0031	0.0482	0.0392
Brugia malayi	jmjC domain containing protein	0.0061	0.1208	0.3069
Leishmania major	hypothetical protein, conserved	0.0016	0.0126	0.0091
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.1208	0.1125
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.016	0.0067
Brugia malayi	hypothetical protein	0.0174	0.3937	1
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Echinococcus granulosus	ubiquitin specific protease 41	0.0042	0.0737	0.0649
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.3867	0.3795
Schistosoma mansoni	importin beta-1	0.0031	0.0489	0.0377
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0505	0.5773
Echinococcus multilocularis	cathepsin L	0.0019	0.0188	0.0095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0505	0.3666
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0126	0.0032
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0176	0.0061
Leishmania major	cathepsin L-like protease	0.0032	0.0505	0.3666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0126	0.0059
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0042	0.0737	0.0649
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0482	0.0371
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0505	0.3201
Loa Loa (eye worm)	cysteine protease	0.0032	0.0505	0.0549
Entamoeba histolytica	hypothetical protein	0.0025	0.0345	0.2864
Brugia malayi	cathepsin L-like precursor	0.0023	0.0289	0.0735
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0042	0.0737	0.5849
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0289	0.027
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0126	0.0032
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.3867	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0635	0.0525
Toxoplasma gondii	cathepsin CPL	0.0032	0.0505	0.3608
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0126	0.0059
Plasmodium falciparum	importin beta, putative	0.0031	0.0489	0.9569
Entamoeba histolytica	hypothetical protein	0.0037	0.0635	0.8146
Brugia malayi	RNA, U transporter 1	0.0089	0.1884	0.4786
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0932	0.0826
Plasmodium vivax	vivapain-1	0.0019	0.0188	0.1659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0505	0.3201

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin L	ChEMBL.	20089402
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin B	ChEMBL.	20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL601662

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1099257