TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.476 | Formula: C21H30N2O
H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN(C(=O)C1(CC1)c1ccccc1)[C@H]1CCCC[C@H]1N1CCCC1
InChi: 1S/C21H30N2O/c1-22(18-11-5-6-12-19(18)23-15-7-8-16-23)20(24)21(13-14-21)17-9-3-2-4-10-17/h2-4,9-10,18-19H,5-8,11-16H2,1H3/t18-,19+/m0/s1
InChiKey: MGMPZCNAKUKYJV-RBUKOAKNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sigma non-opioid intracellular receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1512	0.1889	0.1889
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4279	0.5411	0.5408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.093	0.1148	0.1148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.628	0.7959	0.7958
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.013	0.0129	0.0129
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0542	0.0654	0.0654
Onchocerca volvulus		0.052	0.0626	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0032	0.0032
Schistosoma mansoni	nuclear hormone receptor	0.013	0.0129	0.0129
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0542	0.0654	0.0651
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0275	0.0314	0.0314
Brugia malayi	hypothetical protein	0.0145	0.0149	0.0149
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0542	0.0654	0.0649
Trichomonas vaginalis	PIKK family atypical protein kinase	0.672	0.8519	0.8518
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.0022	0.0022
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0542	0.0654	0.0879
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Loa Loa (eye worm)	phosphatidylinositol 3	0.052	0.0626	0.0626
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0178	0.0191	0.0142
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0735	0.09	0.09
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.013	0.0129	0.0129
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0178	0.0191	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0275	0.0314	0.0314
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1512	0.1889	0.1848
Brugia malayi	Steroid receptor seven-up type 2	0.0275	0.0314	0.0314
Onchocerca volvulus		0.013	0.0129	0.1988
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0043	0.0043
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.0348	0.0348
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0275	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0275	0.0314	0.0314
Echinococcus multilocularis	lysine specific demethylase 5A	0.004	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.1597	0.1997	0.1997
Loa Loa (eye worm)	phosphatidylinositol 3	0.0885	0.1091	0.1091
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0666	0.0811	0.0807
Schistosoma mansoni	hypothetical protein	0.0029	0.0001	0.0001
Entamoeba histolytica	hypothetical protein	0.1512	0.1889	0.1886
Giardia lamblia	GTOR	0.7884	1	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.013	0.0129	0.1988
Schistosoma mansoni	hypothetical protein	0.0029	0.0001	0.0001
Echinococcus multilocularis	serine protein kinase ATM	0.1512	0.1889	0.1889
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2732	0.3442	0.3409
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0275	0.0314	0.0314
Entamoeba histolytica	hypothetical protein	0.052	0.0626	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0445	0.053	0.053
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0612	0.0743	0.074
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.052	0.0626	0.0626
Onchocerca volvulus		0.0275	0.0314	0.497
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0043	0.0043
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.1684	0.2107	0.2107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.003	0.003
Brugia malayi	Bromodomain containing protein	0.0033	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Leishmania major	fk506-binding protein 1-like protein	0.0178	0.0191	0.0092
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0032	0.0005	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2675	0.337	0.3366
Schistosoma mansoni	nuclear receptor	0.013	0.0129	0.0129
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0275	0.0314	0.0314
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0032	0.0005	0.0005
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0032	0.0005	0.0005
Entamoeba histolytica	hypothetical protein	0.052	0.0626	0.0623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4683	0.5926	0.5924
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0275	0.0314	0.0314
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0588	0.0712	0.0712
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Entamoeba histolytica	hypothetical protein	0.069	0.0842	0.0839
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0992	0.1227	0.1227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4712	0.5962	0.596
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.013	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Schistosoma mansoni	immunophilin	0.0154	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0044	0.0044
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.052	0.0626	0.0626
Brugia malayi	nuclear receptor NHR-67	0.013	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0275	0.0314	0.0314
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.081	0.0995	0.0995
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1512	0.1889	0.1889
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0178	0.0191	0.0185
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.052	0.0626	0.0621
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0275	0.0314	0.0314
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.7884	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0164	0.0173	0.0173
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Echinococcus granulosus	thyroid hormone receptor alpha	0.013	0.0129	0.0129
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.052	0.0626	0.0841
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0275	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0275	0.0314	0.0314
Toxoplasma gondii	AGC kinase	0.0031	0.0004	0.0005
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0145	0.0149	0.0149
Loa Loa (eye worm)	DR-78	0.013	0.0129	0.0129
Echinococcus granulosus	geminin	0.0311	0.036	0.036
Schistosoma mansoni	jumonji domain containing protein	0.0086	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0178	0.0191	0.0186
Brugia malayi	RNA, U transporter 1	0.008	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0063	0.0044	0.0044
Schistosoma mansoni	retinoic acid receptor RXR	0.0275	0.0314	0.0314
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.7884	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0047	0.0025	0.0025
Schistosoma mansoni	gabp alpha	0.0062	0.0043	0.0043
Brugia malayi	TAR-binding protein	0.0062	0.0043	0.0043
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0154	0.016	0.016
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0992	0.1227	0.1182
Echinococcus granulosus	serine protein kinase ATM	0.1512	0.1889	0.1889
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0178	0.0191	0.0191
Onchocerca volvulus	Protein ultraspiracle homolog	0.0275	0.0314	0.497
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.003	0.003
Brugia malayi	nuclear receptor RXR	0.013	0.0129	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4272	0.5403	0.54
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4712	0.5962	0.596
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0032	0.0005	0.0005
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0004	0.0004
Echinococcus multilocularis	fk506 binding protein	0.0178	0.0191	0.0191
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2732	0.3442	0.3442
Echinococcus granulosus	microtubule associated protein 2	0.0585	0.0709	0.0709
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0992	0.1227	0.1222
Echinococcus multilocularis	microtubule associated protein 2	0.0585	0.0709	0.0709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2675	0.337	0.3366
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7884	1	1
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0178	0.0191	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.003	0.003
Brugia malayi	tailless protein	0.013	0.0129	0.0129
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.3287	0.4148	0.4148
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0275	0.0314	0.0314
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0588	0.0712	0.0707
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0043	0.0043
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0178	0.0191	0.2921
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.0022	0.0022
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.013	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor-like 1	0.0275	0.0314	0.0314
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.052	0.0626	0.0626
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.7884	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0063	0.0044	0.0044
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0178	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0149	0.0149
Brugia malayi	nuclear hormone receptor family member odr-7	0.013	0.0129	0.0129
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0032	0.0005	0.0005
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0275	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor E75	0.013	0.0129	0.0129
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.052	0.0626	0.0626
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0145	0.0149	0.0149
Schistosoma mansoni	hypothetical protein	0.0311	0.036	0.036
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.003	0.003
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	0.053	0.0482
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0178	0.0191	0.0142
Trypanosoma brucei	polo-like protein kinase	0.0107	0.01	0.01
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0032	0.0005	0.0005
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0032	0.0005	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.052	0.0626	0.0626
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.7884	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Echinococcus granulosus	FTZ F1 alpha	0.0275	0.0314	0.0314
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0006	0.0008
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2688	0.3385	0.3385
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0588	0.0712	0.0712
Echinococcus multilocularis	GA binding protein alpha chain	0.0062	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0145	0.0145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.003	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.628	0.7959	0.7958
Schistosoma mansoni	zinc finger protein	0.013	0.0129	0.0129
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0542	0.0654	0.0654
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0275	0.0314	0.0314
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0657	0.08	0.08
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0588	0.0712	0.0712
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.7884	1	1
Brugia malayi	nuclear receptor NHR-88	0.0275	0.0314	0.0314
Brugia malayi	hypothetical protein	0.013	0.0129	0.0129
Echinococcus granulosus	Nuclear hormone receptor HR96	0.013	0.0129	0.0129
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.0031	0.0026
Plasmodium vivax	hypothetical protein	0.052	0.0626	0.9566
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.013	0.0129	0.0129
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0542	0.0654	0.0654
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0092	0.0081	0.0081
Schistosoma mansoni	voltage-gated potassium channel	0.0032	0.0005	0.0005
Plasmodium vivax	hypothetical protein, conserved	0.052	0.0626	0.9566
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0542	0.0654	0.0607
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0275	0.0314	0.497
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0195	0.0213	0.0213
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0178	0.0191	0.0191
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0043	0.0043
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0542	0.0654	0.056
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0275	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0006	0.0006
Schistosoma mansoni	nuclear receptor	0.013	0.0129	0.0129
Schistosoma mansoni	ets-related	0.0189	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0657	0.08	0.08
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0006	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0275	0.0314	0.0314
Brugia malayi	Fli-1 protein	0.0189	0.0204	0.0204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7884	1	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.052	0.0626	0.0579
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0107	0.01	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4712	0.5962	0.596
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.0101	0.0101
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.0149	0.0149
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0006	0.0008
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.7884	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.003	0.003
Leishmania major	C-8 sterol isomerase-like protein	0.0445	0.053	0.0435
Schistosoma mansoni	voltage-gated potassium channel	0.0179	0.0192	0.0192
Brugia malayi	serine/threonine-protein kinase plk-2	0.0107	0.01	0.01
Entamoeba histolytica	protein kinase, putative	0.0033	0.0007	0.0003
Schistosoma mansoni	nuclear hormone receptor	0.0275	0.0314	0.0314
Schistosoma mansoni	immunophilin	0.0178	0.0191	0.0191
Entamoeba histolytica	hypothetical protein	0.052	0.0626	0.0623
Trichomonas vaginalis	PIKK family atypical protein kinase	0.628	0.7959	0.7958
Giardia lamblia	Phosphatidylinositol 4-kinase	0.052	0.0626	0.0621
Schistosoma mansoni	hypothetical protein	0.0031	0.0003	0.0003
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.069	0.0842	0.0839
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0032	0.0005	0.0005
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0032	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	jmjC domain containing protein	0.004	0.0015	0.0015
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.003	0.003
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.9566
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0063	0.0063
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.013	0.0129	0.1988
Brugia malayi	FAT domain containing protein	0.1164	0.1445	0.1445
Brugia malayi	hypothetical protein	0.0145	0.0149	0.0149
Loa Loa (eye worm)	phosphatidylinositol 3	0.0068	0.005	0.005
Leishmania major	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.0531
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.052	0.0626	0.0626
Brugia malayi	nuclear receptor RXR	0.0145	0.0149	0.0149
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0275	0.0314	0.0314
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0154	0.016	0.016
Brugia malayi	hypothetical protein	0.0031	0.0003	0.0003
Onchocerca volvulus		0.013	0.0129	0.1985
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	0.01	0.005
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0735	0.09	0.0895
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0275	0.0314	0.0314
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0735	0.09	0.0854
Loa Loa (eye worm)	phosphatidylinositol 3	0.7884	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.013	0.0129	0.0129
Toxoplasma gondii	target of rapamycin (TOR), putative	0.5876	0.7444	1
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.003	0.003
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0164	0.0173	0.0173
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0275	0.0314	0.0314
Leishmania major	phosphatidylinositol kinase, putative	0.052	0.0626	0.0531
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0007	0.0007
Echinococcus granulosus	hyperpolarization activated cyclic	0.0032	0.0005	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0275	0.0314	0.0314
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0043	0.0043
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0275	0.0314	0.0314
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.005	0.005
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0178	0.0191	0.0188
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.013	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1524	0.1904	0.19
Brugia malayi	hypothetical protein	0.013	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0036	0.0036
Loa Loa (eye worm)	phosphatidylinositol 3	0.052	0.0626	0.0626
Schistosoma mansoni	hypothetical protein	0.0029	0.0001	0.0001
Echinococcus granulosus	GPCR family 2	0.0029	0.0001	0.0001
Leishmania major	peptidylprolyl isomerase-like protein	0.0178	0.0191	0.0092
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1512	0.1889	0.1848
Loa Loa (eye worm)	phosphatidylinositol 3	0.2688	0.3385	0.3385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4272	0.5403	0.54
Schistosoma mansoni	hypothetical protein	0.0311	0.036	0.036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4279	0.5411	0.5408
Onchocerca volvulus		0.052	0.0626	1
Schistosoma mansoni	voltage-gated potassium channel	0.0179	0.0192	0.0192
Brugia malayi	jmjC domain containing protein	0.0108	0.0101	0.0101
Trypanosoma cruzi	hypothetical protein, conserved	0.0103	0.0095	0.0045
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.081	0.0995	0.0995
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0178	0.0191	0.0186
Brugia malayi	conserved hypotetical protein	0.013	0.0129	0.0129
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0107	0.01	0.0097
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0006	0.009
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0154	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.1164	0.1445	0.1445
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0145	0.0149	0.0149
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2688	0.3385	0.3319
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0542	0.0654	0.0649
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.7884	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.9566
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0542	0.0654	0.0654
Brugia malayi	orphan nuclear receptor NR2E1	0.013	0.0129	0.0129
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0032	0.0005	0.0005
Brugia malayi	ecdysone receptor	0.013	0.0129	0.0129
Brugia malayi	nuclear receptor NHR-88	0.013	0.0129	0.0129
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0047	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0081	0.0081
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.013	0.0129	0.0129
Schistosoma mansoni	microtubule-associated protein tau	0.0585	0.0709	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0149	0.0149
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.013	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4683	0.5926	0.5924
Schistosoma mansoni	nuclear receptor nhr-48	0.013	0.0129	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2117	0.2659	0.2655
Echinococcus multilocularis	ecdysone induced protein 78C	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Echinococcus multilocularis	peregrin	0.0033	0.0006	0.0006
Loa Loa (eye worm)	FKBP5 protein	0.0178	0.0191	0.0191
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0992	0.1227	0.1222
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.052	0.0626	0.9566
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0062	0.0043	0.0043
Trichomonas vaginalis	immunophilin, putative	0.0178	0.0191	0.0186
Brugia malayi	Latrophilin receptor protein 2	0.0029	0.0001	0.0001
Echinococcus granulosus	voltage gated potassium channel	0.0047	0.0025	0.0025
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.052	0.0626	0.0621
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0006	0.0006
Loa Loa (eye worm)	nuclear receptor NHR-67	0.013	0.0129	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.1164	0.1445	0.1441
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0029	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0149	0.0149
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0031	0.0003	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2732	0.3442	0.3442
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1512	0.1889	0.1884
Echinococcus granulosus	peregrin	0.0033	0.0006	0.0006
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.093	0.1148	0.1148
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4272	0.5403	0.54
Loa Loa (eye worm)	phosphatidylinositol kinase	0.052	0.0626	0.0626
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0542	0.0654	0.056
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.1164	0.1445	0.1445
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0735	0.09	0.0895
Loa Loa (eye worm)	steroid hormone receptor	0.0275	0.0314	0.0314
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.003	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0275	0.0314	0.0314
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Leishmania major	hypothetical protein, unknown function	0.052	0.0626	0.0531
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0588	0.0712	0.0709
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0735	0.09	0.0854
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4279	0.5411	0.5408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Brugia malayi	hypothetical protein	0.013	0.0129	0.0129
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.052	0.0626	0.0626
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0145	0.0149	0.0149
Schistosoma mansoni	hypothetical protein	0.0301	0.0348	0.0348
Trypanosoma cruzi	target of rapamycin kinase 3	0.6287	0.7967	0.7957
Echinococcus multilocularis	GPCR, family 2	0.0029	0.0001	0.0001
Echinococcus granulosus	Nuclear hormone receptor HR96	0.013	0.0129	0.0129
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0164	0.0173	0.0173
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1512	0.1889	0.1889
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0004	0.0004
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0178	0.0191	0.0142
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.7884	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0025	0.0025
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0588	0.0712	0.0709
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0542	0.0654	0.0879
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0153	0.0159	0.0154
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0657	0.08	0.08
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.052	0.0626	0.0626
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0275	0.0314	0.0314
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0145	0.0149	0.0149
Brugia malayi	Ets-domain containing protein	0.0062	0.0043	0.0043
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.052	0.0626	0.0623
Schistosoma mansoni	serine/threonine protein kinase	0.0107	0.01	0.01
Echinococcus multilocularis	snurportin 1	0.0301	0.0348	0.0348
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0032	0.0005	0.0005
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.6287	0.7967	0.7967
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0047	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.052	0.0626	0.0626
Trichomonas vaginalis	fk506-binding protein, putative	0.0178	0.0191	0.0186
Loa Loa (eye worm)	hypothetical protein	0.1512	0.1889	0.1889
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0031	0.0003	0.0003
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0565	0.0684	0.0678
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0007	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7884	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.052	0.0626	0.0621
Schistosoma mansoni	immunophilin	0.0178	0.0191	0.0191
Schistosoma mansoni	nuclear hormone receptor	0.013	0.0129	0.0129
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0178	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Brugia malayi	ecdysteroid receptor	0.0275	0.0314	0.0314
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0215	0.0238	0.0235
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0043	0.0043
Loa Loa (eye worm)	fli-1 protein	0.0189	0.0204	0.0204
Echinococcus multilocularis		0.052	0.0626	0.0626
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0178	0.0191	0.2921
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Echinococcus multilocularis	FTZ F1 alpha	0.0275	0.0314	0.0314
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.052	0.0626	0.0841
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.0015	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2675	0.337	0.3366
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0542	0.0654	0.0654
Echinococcus multilocularis	nuclear receptor nhr 48	0.013	0.0129	0.0129
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0029	0.0001	0.0001
Echinococcus multilocularis	Zinc finger, PHD finger	0.0542	0.0654	0.0654
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0275	0.0314	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0275	0.0314	0.0314
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.7884	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0107	0.01	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.052	0.0626	0.0621
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2675	0.337	0.3303
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.0626
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1512	0.1889	0.1889
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.052	0.0626	0.0626
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0029	0.0001	0.0001
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.093	0.1148	0.1148
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0275	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	Ets-domain containing protein	0.0062	0.0043	0.0043
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0735	0.09	0.0897
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.052	0.0626	0.0841
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.0101	0.0101
Brugia malayi	RNA binding protein	0.0062	0.0043	0.0043
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0542	0.0654	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0275	0.0314	0.0314
Echinococcus granulosus	hyperpolarization activated cyclic	0.0032	0.0005	0.0005
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0178	0.0191	0.0188
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0032	0.0005	0.0005
Loa Loa (eye worm)	phosphatidylinositol 3	0.052	0.0626	0.0626
Entamoeba histolytica	protein kinase rad3, putative	0.1512	0.1889	0.1886
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0542	0.0654	0.0651
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.052	0.0626	0.0626
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0588	0.0712	0.0707
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0153	0.0159	0.0154
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1512	0.1889	0.1889
Schistosoma mansoni	hypothetical protein	0.052	0.0626	0.0626
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4279	0.5411	0.5408
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0275	0.0314	0.0314
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0107	0.01	0.01
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.372	0.47	0.47
Brugia malayi	nuclear hormone receptor	0.0275	0.0314	0.0314
Brugia malayi	photoreceptor-specific nuclear receptor	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2688	0.3385	0.3382
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0043	0.0043
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.0314	0.0314
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.7884	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Brugia malayi	nuclear hormone receptor family member nhr-6	0.013	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0043	0.0043
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.0015	0.0015
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.052	0.0626	0.0579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5117	0.6478	0.6476
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0015	0.0015
Brugia malayi	steroid hormone receptor	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2675	0.337	0.3366
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0025	0.0025
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0029	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.628	0.7959	0.7958
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0029	0.0001	0.0001
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2675	0.337	0.337
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.0025	0.0025
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0542	0.0654	0.0649
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2732	0.3442	0.3442
Leishmania major	hypothetical protein, conserved	0.0623	0.0757	0.0664
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0006	0.0006
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2732	0.3442	0.3442
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0275	0.0314	0.0314
Brugia malayi	Nuclear hormone receptor E75	0.013	0.0129	0.0129
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0006	0.0006
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2732	0.3442	0.3409
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0149	0.0149
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	0.053	0.053
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0092	0.0081	0.0081
Echinococcus granulosus	nuclear receptor nhr 48	0.013	0.0129	0.0129
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0588	0.0712	0.0707
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0588	0.0712	0.0665
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.052	0.0626	0.0626
Schistosoma mansoni	RAR-like nuclear receptor	0.0275	0.0314	0.0314
Entamoeba histolytica	protein kinase, putative	0.0031	0.0004	0.0001
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0542	0.0654	0.0654
Entamoeba histolytica	protein kinase, putative	0.0033	0.0007	0.0003
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.6287	0.7967	0.7947
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0149	0.0149
Toxoplasma gondii	FATC domain-containing protein	0.1512	0.1889	0.2537
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1512	0.1889	0.1889
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0032	0.0005	0.0005
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.052	0.0626	0.9566
Loa Loa (eye worm)	hypothetical protein	0.0275	0.0314	0.0314
Echinococcus granulosus	snurportin 1	0.0301	0.0348	0.0348
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0542	0.0654	0.0654
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0107	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0445	0.053	0.053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5289	0.6696	0.6695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.052	0.0626	0.0579
Schistosoma mansoni	hypothetical protein	0.0033	0.0006	0.0006
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.1164	0.1445	0.1445
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0178	0.0191	0.0191
Schistosoma mansoni	coup transcription factor	0.0275	0.0314	0.0314
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1684	0.2107	0.2831
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0005	0.0005
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1524	0.1904	0.1901
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0735	0.09	0.0895
Brugia malayi	PHD-finger family protein	0.0033	0.0006	0.0006
Giardia lamblia	Hypothetical protein	0.052	0.0626	0.0621
Schistosoma mansoni	hypothetical protein	0.0029	0.0001	0.0001
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0092	0.0081	0.0081
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.7884	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0275	0.0314	0.0314
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0178	0.0191	0.0191
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.052	0.0626	0.9566
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0275	0.0314	0.0314
Schistosoma mansoni	kinase	0.0054	0.0033	0.0033
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.0579
Brugia malayi	nuclear hormone receptor	0.013	0.0129	0.0129
Echinococcus granulosus	ecdysone induced protein 78C	0.0275	0.0314	0.0314
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.013	0.0129	0.0129
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.0015	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.1684	0.2107	0.2103
Leishmania major	phosphatidylinositol kinase related protein, putative	0.052	0.0626	0.0531
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0275	0.0314	0.0314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0032	0.0005	0.0005
Mycobacterium tuberculosis	Conserved hypothetical protein	0.052	0.0626	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.013	0.0129	0.0129
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0542	0.0654	0.0607
Echinococcus multilocularis	voltage gated potassium channel	0.0047	0.0025	0.0025
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0542	0.0654	0.0654
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0043	0.0043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5876	0.7444	0.7442
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.052	0.0626	0.0626
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0043	0.0043
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0032	0.0005	0.0005
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.052	0.0626	0.0579
Echinococcus granulosus	GA binding protein alpha chain	0.0062	0.0043	0.0043
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0032	0.0005	0.0005
Schistosoma mansoni	transcription factor LCR-F1	0.0031	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.0107	0.01	0.0095
Giardia lamblia	Kinase, PLK	0.0107	0.01	0.0094
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0666	0.0811	0.0807
Loa Loa (eye worm)	hypothetical protein	0.013	0.0129	0.0129
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0178	0.0191	0.0191
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.013	0.0129	0.0129
Schistosoma mansoni	hypothetical protein	0.1164	0.1445	0.1445
Onchocerca volvulus		0.013	0.0129	0.1988
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0178	0.0191	0.0142
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0032	0.0005	0.0005
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0029	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0275	0.0314	0.0314
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0178	0.0191	0.0191
Trichomonas vaginalis	CAMK family protein kinase	0.0053	0.0031	0.0026
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0107	0.01	0.1516
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0178	0.0191	0.0191
Mycobacterium leprae	conserved hypothetical protein	0.052	0.0626	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.628	0.7959	0.7958
Loa Loa (eye worm)	phosphatidylinositol 3	0.052	0.0626	0.0626
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1512	0.1889	0.1884
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.062	0.0754	0.0748
Onchocerca volvulus	Bile acid receptor homolog	0.0275	0.0314	0.497
Loa Loa (eye worm)	hypothetical protein	0.0657	0.08	0.08
Echinococcus multilocularis	geminin	0.0311	0.036	0.036
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1512	0.1889	0.1889
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0542	0.0654	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0164	0.0173	0.0173
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0178	0.0191	0.0185

Activities

Activity type	Activity value	Assay description	Source	Reference
Control (binding)	= 86.35 %	Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand	ChEMBL.	2172538
Control (binding)	= 106.81 %	Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand	ChEMBL.	2172538
IC50 (binding)	= 6058 nM	Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand	ChEMBL.	2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL606890

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1101789