Detailed information for compound 1126146

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.361 | Formula: C18H19N3O5
  • H donors: 3 H acceptors: 5 LogP: 0.69 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@@H]1O)O)n1ncc2c1nccc2OCc1ccccc1
  • InChi: 1S/C18H19N3O5/c22-9-14-15(23)16(24)18(26-14)21-17-12(8-20-21)13(6-7-19-17)25-10-11-4-2-1-3-5-11/h1-8,14-16,18,22-24H,9-10H2/t14-,15-,16-,18?/m1/s1
  • InChiKey: CQMQPILFEPGWIC-FLZRJIMASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0005 0.0013
Leishmania major cathepsin L-like protease 0.0042 0.0398 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0098 0.0893
Loa Loa (eye worm) hypothetical protein 0.0048 0.0468 0.4274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0098 0.0241
Onchocerca volvulus 0.0018 0.0098 0.2879
Loa Loa (eye worm) intermediate filament protein 0.002 0.0117 0.107
Brugia malayi beta-lactamase 0.0036 0.0319 0.2913
Schistosoma mansoni hypothetical protein 0.004 0.0374 0.0968
Schistosoma mansoni coup transcription factor 0.0018 0.0098 0.0253
Brugia malayi beta-lactamase family protein 0.0036 0.0319 0.2913
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Brugia malayi intermediate filament protein 0.002 0.0117 0.107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0092 0.0227
Brugia malayi Bromodomain containing protein 0.0038 0.0348 0.3178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0098 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0098 0.0893
Leishmania major cathepsin L-like protease 0.0011 0.0005 0.0125
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0005 0.0013
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0092 0.0227
Loa Loa (eye worm) hypothetical protein 0.0034 0.03 0.2735
Echinococcus granulosus dna polymerase eta 0.0034 0.03 0.0764
Echinococcus multilocularis geminin 0.0316 0.3864 0.3861
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0294 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1115 0.2884
Trichomonas vaginalis DNA polymerase eta, putative 0.0034 0.03 0.7592
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0294 0.7386
Leishmania major cathepsin L-like protease 0.0011 0.0005 0.0125
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0101 0.2532
Trypanosoma brucei unspecified product 0.0024 0.0165 0.4142
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Brugia malayi steroid hormone receptor 0.0018 0.0098 0.0893
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.03 0.7531
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0098 0.0893
Loa Loa (eye worm) hypothetical protein 0.0038 0.0349 0.3186
Schistosoma mansoni patched 1 0.0042 0.0393 0.1017
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0319 0.0814
Loa Loa (eye worm) hypothetical protein 0.0071 0.0757 0.691
Schistosoma mansoni hypothetical protein 0.0015 0.0058 0.015
Schistosoma mansoni zinc finger protein 0.0015 0.0058 0.015
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0373
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0319 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0011 0.0005 0.0045
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1096 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0294 0.7386
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Mycobacterium ulcerans lipase LipD 0.0036 0.0319 0.0342
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0098 0.0253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0318 0.0812
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0101 0.0108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0144 0.0139
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0098 0.0253
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0319 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0042 0.0398 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0319 0.2913
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.008 0.0075
Schistosoma mansoni lipoxygenase 0.0107 0.1225 0.3169
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.0747 0.6822
Schistosoma mansoni hypothetical protein 0.0021 0.0125 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0098 0.0893
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Schistosoma mansoni DNA polymerase eta 0.0034 0.03 0.0775
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.3678
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.03 0.0775
Schistosoma mansoni lamin 0.002 0.0117 0.0303
Echinococcus granulosus lamin dm0 0.002 0.0117 0.0291
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0393 0.3589
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0101 0.3156
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0319 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0319 0.0022
Echinococcus multilocularis protein dispatched 1 0.0048 0.0468 0.0463
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0319 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0098 0.0893
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.008 0.0208
Leishmania major hypothetical protein, conserved 0.0036 0.0319 0.8022
Toxoplasma gondii cathepsin CPL 0.0011 0.0005 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0098 0.2879
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0098 0.0893
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0098 0.0093
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0034 0.03 0.7531
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.107
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0319 0.8094
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0088 0.0803
Onchocerca volvulus 0.0018 0.0092 0.2712
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Schistosoma mansoni hypothetical protein 0.004 0.0374 0.0968
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0393 0.1006
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0101 0.3428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0319 0.0314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0749 0.9336 1
Plasmodium vivax vivapain-2 0.0011 0.0005 0.0156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0327 0.2989
Brugia malayi hypothetical protein 0.0019 0.0101 0.092
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0393 0.0388
Trypanosoma brucei unspecified product 0.0024 0.0165 0.4142
Onchocerca volvulus 0.0036 0.0319 0.9745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0098 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0098 0.0093
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0319 0.2913
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0098 0.0241
Schistosoma mansoni hypothetical protein 0.0048 0.0468 0.1212
Leishmania major hypothetical protein, conserved 0.0034 0.0294 0.7386
Plasmodium vivax vivapain-2 0.0011 0.0005 0.0156
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0398 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0098 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0098 0.0893
Brugia malayi Doublecortin family protein 0.0018 0.0092 0.0844
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.03 0.0295
Brugia malayi Augmenter of liver regeneration 0.0034 0.0294 0.2682
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0107 0.1225 0.122
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.03 0.2702
Brugia malayi CHE-14 protein 0.0042 0.0393 0.3589
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0319 0.0826
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0038 0.0352 0.8838
Trypanosoma brucei ISWI complex protein 0.0015 0.0058 0.1459
Mycobacterium tuberculosis Conserved protein 0.0036 0.0319 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0117 0.107
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0098 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0098 0.0893
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1096 1
Echinococcus granulosus tumor protein p63 0.025 0.3024 0.7822
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0 0.0002
Echinococcus multilocularis lamin 0.002 0.0117 0.0112
Leishmania major hypothetical protein, conserved 0.0015 0.0058 0.1459
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0092 0.0844
Echinococcus granulosus RUN 0.0018 0.0092 0.0227
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0098 0.0893
Leishmania major DNA polymerase kappa, putative 0.0034 0.03 0.7531
Trypanosoma cruzi ISWI complex protein 0.0015 0.0058 0.1459
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0319 0.8094
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0319 0.8094
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0098 0.0253
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1624 0.162
Loa Loa (eye worm) hypothetical protein 0.007 0.0747 0.6822
Loa Loa (eye worm) cysteine protease 0.0011 0.0005 0.0045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0144 0.1317
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1096 0.2826
Schistosoma mansoni lamin 0.002 0.0117 0.0303
Echinococcus granulosus GPCR family 2 0.0022 0.0144 0.0361
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0319 0.0826
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0098 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.008 0.0208
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Onchocerca volvulus 0.002 0.0117 0.3481
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0318 0.0313
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0011 0.0005 0.0169
Echinococcus granulosus intermediate filament protein 0.002 0.0117 0.0291
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0149 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0113 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0098 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0098 0.0253
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0098 0.0241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0098 0.0241
Leishmania major cathepsin L-like protease 0.0042 0.0398 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0165 0.4142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0144 0.0361
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0319 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0144 0.1317
Schistosoma mansoni hypothetical protein 0.0316 0.3864 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.03 0.7531
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0098 0.0253
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0098 0.0253
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0319 0.0022
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.008 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0393 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0294 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.03 0.0775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0098 0.0893
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.03 0.0321
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0098 0.0253
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0749 0.9336 1
Onchocerca volvulus 0.0018 0.0092 0.2712
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.03 0.7531
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0319 0.2913
Brugia malayi hypothetical protein 0.0018 0.0092 0.0844
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1624 0.4194
Echinococcus multilocularis protein patched 0.0042 0.0393 0.0388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.03 0.0764
Leishmania major cathepsin L-like protease 0.0011 0.0005 0.0125
Brugia malayi nuclear receptor NHR-88 0.0018 0.0098 0.0893
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0098 0.0241
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0098 0.0241
Loa Loa (eye worm) hypothetical protein 0.0019 0.0101 0.092
Leishmania major DNA polymerase eta, putative 0.0034 0.03 0.7531
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0098 0.0893
Echinococcus granulosus dna polymerase kappa 0.0034 0.03 0.0764
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0144 0.0139
Brugia malayi hypothetical protein 0.0018 0.0092 0.0844
Loa Loa (eye worm) hypothetical protein 0.0051 0.0512 0.4673
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.03 0.7531
Schistosoma mansoni loxhd1 0.0018 0.0092 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Onchocerca volvulus 0.002 0.0117 0.3481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0092 0.0227
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0098 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Brugia malayi beta-lactamase family protein 0.0036 0.0319 0.2913
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0098 0.2879
Schistosoma mansoni hypothetical protein 0.0316 0.3864 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0011 0.0005 0.0169
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0749 0.9336 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0098 0.0253
Leishmania major cathepsin L-like protease 0.0011 0.0005 0.0125
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0005 0.0125
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0092 0.0087
Echinococcus multilocularis dna polymerase kappa 0.0034 0.03 0.0295
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0393 0.1006
Echinococcus granulosus expressed conserved protein 0.0091 0.1021 0.2633
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.0844
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0098 0.0893
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0294 0.7386
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0327 0.0847
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0294 0.0315
Trypanosoma cruzi ISWI complex protein 0.0015 0.0058 0.1459
Echinococcus granulosus geminin 0.0316 0.3864 1
Mycobacterium ulcerans DNA polymerase IV 0.0034 0.03 0.0321
Echinococcus multilocularis dna polymerase eta 0.0034 0.03 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Schistosoma mansoni rab6-interacting 0.0018 0.0092 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0098 0.0893
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0373
Onchocerca volvulus 0.0036 0.0319 0.9745
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0294 0.2682
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0398 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0319 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.03 0.7531
Mycobacterium tuberculosis Conserved protein 0.0036 0.0319 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.03 0.2735
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1096 0.1091
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0092 0.3145
Echinococcus multilocularis GPCR, family 2 0.0022 0.0144 0.0139
Giardia lamblia DINP protein human, muc B family 0.0034 0.03 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0319 0.8022
Echinococcus granulosus zinc finger protein 0.002 0.0112 0.0277
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0092 0.2895
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0373
Echinococcus multilocularis lamin dm0 0.002 0.0117 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0098 0.0893
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0294 0.0749
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0098 0.0253
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.008 0.0208
Loa Loa (eye worm) hypothetical protein 0.0097 0.1096 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0319 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0098 0.0893
Brugia malayi Papain family cysteine protease containing protein 0.0011 0.0005 0.0045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0098 0.2879
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0125 0.1144
Toxoplasma gondii pantoate-beta-alanine ligase 0.0749 0.9336 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0098 0.0893
Schistosoma mansoni polycystin 1-related 0.0018 0.0092 0.0239
Schistosoma mansoni intermediate filament proteins 0.002 0.0117 0.0303
Brugia malayi hypothetical protein 0.0012 0.0017 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.0468 0.4274
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0294 0.0289
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0107 0.1225 0.3161
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0034 0.03 0.7592
Loa Loa (eye worm) fibroinase 0.0011 0.0005 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Brugia malayi Bromodomain containing protein 0.0075 0.0811 0.7402
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0294 0.7386
Brugia malayi nuclear hormone receptor 0.0018 0.0098 0.0893
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0319 0.8094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Schistosoma mansoni rab6-interacting 0.0018 0.0092 0.0239
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.03 0.2735
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0393 0.3589
Schistosoma mansoni bromodomain containing protein 0.0063 0.0663 0.1716
Echinococcus multilocularis RUN 0.0018 0.0092 0.0087
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0149 0.0145
Trypanosoma cruzi major cysteine proteinase, putative 0.0033 0.0284 0.7134
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.0747 0.6822
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0149 0.0387
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0294 0.9207
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.008 0.0075
Trypanosoma brucei unspecified product 0.0034 0.03 0.7531
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.03 0.7531
Schistosoma mansoni lipoxygenase 0.0075 0.0816 0.2111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0144 0.1317
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0098 0.0893
Schistosoma mansoni hypothetical protein 0.0018 0.0092 0.0239
Mycobacterium ulcerans hypothetical protein 0.0036 0.0319 0.0342
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0101 0.2532
Echinococcus granulosus lamin 0.002 0.0117 0.0291
Leishmania major hypothetical protein, conserved 0.0019 0.0101 0.2532
Leishmania major cysteine peptidase A (CPA) 0.0011 0.0005 0.0125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2766 0.273
Leishmania major cathepsin L-like protease 0.0042 0.0398 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0098 0.0893
Loa Loa (eye worm) hypothetical protein 0.0041 0.0379 0.3458
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0092 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0319 0.8022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0144 0.0361
Brugia malayi PHD-finger family protein 0.0025 0.0179 0.1636
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.2913
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.03 0.2735
Schistosoma mansoni hypothetical protein 0.004 0.0374 0.0968
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.008 0.0208
Schistosoma mansoni zinc finger protein 0.002 0.0112 0.029
Loa Loa (eye worm) ctsf protein 0.0011 0.0005 0.0045
Echinococcus multilocularis tumor protein p63 0.025 0.3024 0.302
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0005 0.0045
Brugia malayi Cathepsin L-like precursor 0.0011 0.0005 0.0045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.1317
Toxoplasma gondii ABC1 family protein 0.0036 0.0319 0.0342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0618 0.1589
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0373
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0618 0.0613
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0011 0.0005 0.0169
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0117 0.107
Onchocerca volvulus 0.0037 0.0327 1
Echinococcus multilocularis zinc finger protein 0.002 0.0112 0.0107
Trichomonas vaginalis esterase, putative 0.0036 0.0319 0.8094
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0098 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0319 0.8094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.0747 0.6822
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.008 0.0732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0893
Onchocerca volvulus 0.0036 0.0319 0.9745
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.03 0.7531
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0098 0.0241
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0098 0.0893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0319 0.8022
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0098 0.0241
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.03 0.7531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0042 0.0398 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0165 0.4142
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0098 0.0893
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0398 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.1021 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0165 0.4142
Echinococcus multilocularis musashi 0.002 0.0117 0.0112
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0101 0.3428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0045
Mycobacterium ulcerans beta-lactamase 0.0036 0.0319 0.0342
Leishmania major cathepsin L-like protease 0.0011 0.0005 0.0125
Mycobacterium tuberculosis Conserved protein 0.0036 0.0319 0.0022
Schistosoma mansoni hypothetical protein 0.004 0.0374 0.0968
Brugia malayi ecdysteroid receptor 0.0018 0.0098 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.03 0.7531
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0098 0.0893
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0098 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.0844
Trypanosoma cruzi DNA polymerase kappa, putative 0.0034 0.03 0.7531
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0098 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0098 0.0893
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0101 0.2532
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.008 0.0195

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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