Detailed information for compound 1132899

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 798.997 | Formula: C42H70O14
  • H donors: 10 H acceptors: 10 LogP: 1.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O[C@@H]([C@@H]2O)C)O[C@H]2CC[C@]3(C([C@]2(C)CO)CC[C@@]2(C3[C@H](O)CC3[C@@]2(C)C[C@@H]([C@@]2(C3=CC(C)(C)CC2)CO)O)C)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C42H70O14/c1-20-28(48)33(56-35-31(51)30(50)29(49)24(17-43)54-35)32(52)36(53-20)55-27-9-10-38(4)25(39(27,5)18-44)8-11-40(6)34(38)23(46)14-21-22-15-37(2,3)12-13-42(22,19-45)26(47)16-41(21,40)7/h15,20-21,23-36,43-52H,8-14,16-19H2,1-7H3/t20-,21?,23-,24-,25?,26+,27+,28+,29-,30+,31-,32-,33+,34?,35+,36+,38+,39+,40-,41-,42-/m1/s1
  • InChiKey: WTDAWGUIRRPECW-BUODEGSQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0051 0.0397 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.1078 0.104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0056 0.0452 0.1454
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1254 0.3962
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0025 0.0092 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0155 0.1613 0.5189
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0194 0.0197
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0109 0.1079 0.347
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.1254 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.057 0.2021
Onchocerca volvulus 0.0127 0.1288 0.4266
Onchocerca volvulus 0.0112 0.1108 0.3647
Loa Loa (eye worm) matrixin family protein 0.0199 0.2125 0.3626
Onchocerca volvulus 0.009 0.0851 0.2769
Echinococcus multilocularis protein kinase c iota type 0.0049 0.0378 0.0337
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0194 0.3828
Onchocerca volvulus 0.0076 0.0694 0.2232
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0056 0.0452 0.0412
Plasmodium falciparum phd finger protein, putative 0.0033 0.0194 0.3828
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0112 0.1108 0.3647
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0021 0.005 0.0085
Brugia malayi Hr1 repeat family protein 0.0029 0.0141 0.0452
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0029 0.0141 0.0099
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0346 0.0305
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0051 0.0397 0.0462
Echinococcus multilocularis 6 phosphofructokinase 0.0124 0.1254 0.1217
Schistosoma mansoni hypothetical protein 0.012 0.1203 0.1511
Toxoplasma gondii AGC kinase 0.0029 0.0141 0.2771
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0169 0.0543
Brugia malayi hypothetical protein 0.0041 0.0285 0.0916
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0068 0.0039
Brugia malayi MBOAT family protein 0.0051 0.0397 0.1276
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0197 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.002 0.0042 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1254 0.3962
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0051 0.0397 0.2924
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0051 0.0397 1
Loa Loa (eye worm) MBCTL1 0.0127 0.1288 0.2197
Schistosoma mansoni polycystin 1-related 0.0023 0.0068 0.0034
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.1254 0.1578
Loa Loa (eye worm) hypothetical protein 0.0469 0.5269 0.8991
Loa Loa (eye worm) blistered cuticle protein 3 0.0076 0.0694 0.1184
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0092 0.0064
Onchocerca volvulus 0.0031 0.0169 0.0433
Echinococcus granulosus sterol O acyltransferase 1 0.052 0.5861 0.8778
Onchocerca volvulus 0.0076 0.0694 0.2232
Schistosoma mansoni peroxidasin 0.0076 0.0694 0.0849
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0053 0.0427 0.0728
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0197 0.4357
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.2001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0189 0.0221
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0051 0.0397 0.0677
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0029 0.0141 0.0099
Echinococcus granulosus peroxidasin 0.0076 0.0694 0.0983
Schistosoma mansoni hypothetical protein 0.0041 0.0285 0.0316
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Trypanosoma brucei glycerol uptake protein, putative 0.0051 0.0397 0.23
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0276 0.0352
Brugia malayi Pre-SET motif family protein 0.0034 0.0203 0.0654
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0141 0.0099
Schistosoma mansoni lamin 0.0031 0.0169 0.0165
Echinococcus granulosus 6 phosphofructokinase 0.0124 0.1254 0.1828
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0285 0.0366
Brugia malayi Pre-SET motif family protein 0.0238 0.258 0.8297
Echinococcus multilocularis serine:threonine protein kinase 38 0.0029 0.0141 0.0099
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0051 0.0397 0.0356
Echinococcus granulosus SAM and MBT domain containing protein 0.0112 0.1108 0.1607
Trichomonas vaginalis set domain proteins, putative 0.0271 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0194 0.0331
Onchocerca volvulus Chorion peroxidase homolog 0.0076 0.0694 0.2232
Brugia malayi Matrixin family protein 0.009 0.0851 0.2737
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0068 0.0039
Loa Loa (eye worm) RhoGAP domain-containing protein 0.002 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0156
Brugia malayi RhoGAP domain containing protein 0.002 0.0042 0.0136
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0029 0.0141 0.024
Onchocerca volvulus Alhambra homolog 0.0033 0.0194 0.0519
Onchocerca volvulus 0.0025 0.0092 0.0169
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0197 0.0224
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0197 0.4357
Echinococcus multilocularis peregrin 0.0033 0.0194 0.0152
Loa Loa (eye worm) animal heme peroxidase 0.0076 0.0694 0.1184
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0194 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0397 0.0931
Echinococcus granulosus serine:threonine protein kinase N2 0.0029 0.0141 0.0148
Echinococcus multilocularis survival motor neuron protein 1 0.0284 0.3109 0.308
Loa Loa (eye worm) hypothetical protein 0.009 0.0851 0.1452
Echinococcus granulosus o acyltransferase membrane bound domain 0.0051 0.0397 0.0535
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0051 0.0397 0.2924
Loa Loa (eye worm) phosphofructokinase 0.0124 0.1254 0.214
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0068 0.0116
Schistosoma mansoni 6-phosphofructokinase 0.0124 0.1254 0.1578
Loa Loa (eye worm) hypothetical protein 0.0153 0.1589 0.2711
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0817 0.1008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0203 0.454
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1613 0.2046
Brugia malayi Matrixin family protein 0.009 0.0851 0.2737
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0397 0.0931
Onchocerca volvulus Peroxidase homolog 0.0076 0.0694 0.2232
Echinococcus granulosus Protein kinase C brain isozyme 0.0186 0.1973 0.2913
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0203 0.021
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0276 0.0234
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0124 0.1254 1
Echinococcus granulosus RNA directed DNA polymerase 0.0133 0.1352 0.1975
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.005 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0124 0.1254 1
Schistosoma mansoni zinc finger protein 0.0051 0.0397 0.0462
Echinococcus granulosus lamin dm0 0.0031 0.0169 0.0191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0169 0.0288
Brugia malayi RhoGAP domain containing protein 0.002 0.0042 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0056 0.0452 0.0618
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0124 0.1254 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0194 0.0331
Onchocerca volvulus 0.0031 0.0169 0.0433
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0116
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0051 0.0397 0.0535
Echinococcus multilocularis polycomb protein SCMH1 0.0112 0.1108 0.107
Brugia malayi MBOAT family protein 0.0051 0.0397 0.1276
Loa Loa (eye worm) hypothetical protein 0.0127 0.1288 0.2197
Echinococcus granulosus intermediate filament protein 0.0031 0.0169 0.0191
Loa Loa (eye worm) AGC/NDR protein kinase 0.0029 0.0141 0.024
Loa Loa (eye worm) MBOAT family protein 0.0051 0.0397 0.0677
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0197 0.5
Echinococcus multilocularis serine:threonine protein kinase N2 0.0029 0.0141 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1613 0.2046
Brugia malayi Matrixin family protein 0.0217 0.2334 0.7506
Trichomonas vaginalis porcupine, putative 0.0051 0.0397 0.0931
Echinococcus granulosus dnaJ subfamily C 6 0.007 0.0622 0.0874
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0092 0.0064
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0051 0.0397 0.0356
Schistosoma mansoni hypothetical protein 0.0127 0.1288 0.1622
Brugia malayi latrophilin 2 splice variant baaae 0.012 0.1203 0.3868
Schistosoma mansoni lamin 0.0031 0.0169 0.0165
Brugia malayi hypothetical protein 0.0023 0.0068 0.0219
Echinococcus multilocularis sterol O acyltransferase 1 0.052 0.5861 0.5843
Echinococcus multilocularis conserved hypothetical protein 0.0284 0.3106 0.3077
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0042 0.0072
Entamoeba histolytica protein kinase, putative 0.0029 0.0141 0.081
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Echinococcus multilocularis unc 13 (munc13) 0.0025 0.0092 0.0049
Brugia malayi C1-like domain containing protein 0.0021 0.005 0.0159
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0203 0.0243
Schistosoma mansoni atypical protein kinase C 0.0049 0.0378 0.0437
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Echinococcus granulosus histone acetyltransferase MYST2 0.0127 0.1288 0.1879
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0771
Brugia malayi Variant SH3 domain containing protein 0.002 0.0042 0.0136
Onchocerca volvulus Matrix metalloproteinase homolog 0.0199 0.2125 0.713
Schistosoma mansoni sex comb on midleg homolog 0.0112 0.1108 0.1387
Brugia malayi PHD-finger family protein 0.0033 0.0194 0.0624
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0197 0.3914
Brugia malayi MBOAT family protein 0.0051 0.0397 0.1276
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0051 0.0397 0.0356
Loa Loa (eye worm) hypothetical protein 0.009 0.0851 0.1452
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0051 0.0397 0.0462
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0068 0.0039
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0051 0.0397 0.0535
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0051 0.0397 0.0535
Brugia malayi RhoGEF domain containing protein 0.002 0.0042 0.0136
Loa Loa (eye worm) animal heme peroxidase 0.0076 0.0694 0.1184
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0051 0.0397 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Brugia malayi Protein kinase domain containing protein 0.0029 0.0141 0.0452
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0127 0.1288 0.1879
Echinococcus granulosus survival motor neuron protein 1 0.0284 0.3109 0.4627
Echinococcus granulosus geminin 0.059 0.6671 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0127 0.1288 0.4142
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0133 0.1352 0.1315
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0155 0.1613 0.2753
Loa Loa (eye worm) hypothetical protein 0.0051 0.0397 0.0677
Echinococcus granulosus unc 13 munc13 0.0025 0.0092 0.0074
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0051 0.0397 0.0677
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.024
Echinococcus multilocularis musashi 0.0031 0.0169 0.0127
Onchocerca volvulus 0.0023 0.0068 0.0088
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0194 0.4277
Loa Loa (eye worm) hhat protein 0.0051 0.0397 0.0677
Schistosoma mansoni hypothetical protein 0.059 0.6671 0.8631
Onchocerca volvulus 0.0051 0.0397 0.1214
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Schistosoma mansoni hypothetical protein 0.0056 0.0452 0.0534
Schistosoma mansoni hypothetical protein 0.0056 0.0452 0.0534
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0021 0.005 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1254 0.3962
Brugia malayi diacylglycerol kinase 0.002 0.0042 0.0136
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.057 0.0796
Echinococcus multilocularis SAM and MBT domain containing protein 0.0112 0.1108 0.107
Echinococcus granulosus protein kinase c iota type 0.0049 0.0378 0.0506
Brugia malayi hypothetical protein 0.0284 0.3109 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0029 0.0141 0.0099
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Loa Loa (eye worm) hypothetical protein 0.0034 0.0203 0.0347
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Leishmania major ATP-dependent phosphofructokinase 0.0124 0.1254 1
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1254 1
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0197 0.4357
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1973 0.2514
Brugia malayi diacylglycerol acyltransferase 0.0051 0.0397 0.1276
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0095 0.0909 0.1129
Onchocerca volvulus Dual oxidase homolog 0.0076 0.0694 0.2232
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0479 0.1541
Brugia malayi Hhat protein 0.0051 0.0397 0.1276
Treponema pallidum alginate O-acetylation protein (algI) 0.0051 0.0397 0.1891
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0346 0.0458
Schistosoma mansoni hypothetical protein 0.0056 0.0452 0.0534
Schistosoma mansoni peroxidasin 0.0076 0.0694 0.0849
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0021 0.005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Onchocerca volvulus 0.0076 0.0694 0.2232
Brugia malayi Protein kinase domain containing protein 0.0021 0.005 0.0159
Brugia malayi MBOAT family protein 0.0051 0.0397 0.1276
Brugia malayi phosphofructokinase 0.0124 0.1254 0.4034
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0127 0.1288 0.1251
Brugia malayi p70 ribosomal S6 kinase beta 0.0029 0.0141 0.0452
Brugia malayi protein kinase C II. 0.0053 0.0427 0.1373
Brugia malayi hypothetical protein 0.0023 0.0068 0.0219
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0051 0.0397 0.0356
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0541 0.0753
Brugia malayi Calcitonin receptor-like protein seb-1 0.0176 0.185 0.5949
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0197 0.3914
Brugia malayi Doublecortin family protein 0.0023 0.0068 0.0219
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0029 0.0141 0.024
Brugia malayi Protein kinase domain containing protein 0.0029 0.0141 0.0452
Loa Loa (eye worm) MBOAT family protein 0.0051 0.0397 0.0677
Schistosoma mansoni hypothetical protein 0.0119 0.1185 0.1488
Loa Loa (eye worm) hypothetical protein 0.012 0.1203 0.2052
Echinococcus granulosus protein kinase c epsilon type 0.0053 0.0427 0.058
Onchocerca volvulus Matrilysin homolog 0.0199 0.2125 0.713
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0203 0.021
Loa Loa (eye worm) hypothetical protein 0.0133 0.1352 0.2306
Brugia malayi 6-phosphofructokinase 0.0124 0.1254 0.4034
Schistosoma mansoni lipoxygenase 0.0063 0.0541 0.065
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0051 0.0397 0.0462
Onchocerca volvulus Peroxidasin homolog 0.0076 0.0694 0.2232
Brugia malayi Latrophilin receptor protein 2 0.0056 0.0452 0.1454
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.2001
Schistosoma mansoni hypothetical protein 0.059 0.6671 0.8631
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0029 0.0141 0.024
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.057 0.0687
Echinococcus granulosus GPCR family 2 0.0056 0.0452 0.0618
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0327 0.3608 0.3581
Schistosoma mansoni hypothetical protein 0.0033 0.0194 0.0197
Brugia malayi mbt repeat family protein 0.0112 0.1108 0.3562
Brugia malayi Animal haem peroxidase family protein 0.0076 0.0694 0.2232
Loa Loa (eye worm) AGC/AKT protein kinase 0.0029 0.0141 0.024
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0068 0.0026
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0051 0.0397 0.0356
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0276 0.0304
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0021 0.005 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0141 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0141 0.0128
Onchocerca volvulus 0.0271 0.2963 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.057 0.053
Echinococcus multilocularis GPCR, family 2 0.0056 0.0452 0.0412
Echinococcus multilocularis conserved hypothetical protein 0.0284 0.3106 0.3077
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.258 0.4402
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0441 0.4937 0.7385
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0203 0.021
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.1254 0.214
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0141 0.0128
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.005 0.0009
Mycobacterium ulcerans hydrolase 0.0109 0.1079 0.7439
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.1613 0.1578
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0056 0.0452 0.0412
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0029 0.0141 0.0148
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0051 0.0397 0.0462
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.2001
Onchocerca volvulus Peroxidase homolog 0.0076 0.0694 0.2232
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Loa Loa (eye worm) hypothetical protein 0.0023 0.0068 0.0116
Schistosoma mansoni sterol O-acyltransferase 1 0.052 0.5861 0.7576
Loa Loa (eye worm) 6-phosphofructokinase 0.0124 0.1254 0.214
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0608 0.1037
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Schistosoma mansoni protein kinase C mu 0.0021 0.005 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Schistosoma mansoni survival motor neuron protein 0.0058 0.0479 0.0569
Brugia malayi intermediate filament protein 0.0031 0.0169 0.0543
Loa Loa (eye worm) hypothetical protein 0.0051 0.0397 0.0677
Schistosoma mansoni hypothetical protein 0.0058 0.0479 0.0569
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0029 0.0141 0.0148
Entamoeba histolytica protein kinase, putative 0.0029 0.0141 0.081
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0276 0.0304
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Echinococcus granulosus o acyltransferase membrane bound domain 0.0051 0.0397 0.0535
Entamoeba histolytica vacuolar protein sorting 26 0.0051 0.0397 0.2924
Brugia malayi Protein kinase domain containing protein 0.0029 0.0141 0.0452
Trichomonas vaginalis protein kinase inhibitor, putative 0.007 0.0622 0.1727
Brugia malayi Animal haem peroxidase family protein 0.0076 0.0694 0.2232
Schistosoma mansoni glucose-6-phosphatase 0.0285 0.3128 0.4017
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0029 0.0141 0.024
Brugia malayi Protein kinase c protein 2 0.0158 0.1645 0.5291
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Brugia malayi Animal haem peroxidase family protein 0.0076 0.0694 0.2232
Echinococcus multilocularis lamin 0.0031 0.0169 0.0127
Schistosoma mansoni hypothetical protein 0.007 0.0622 0.0755
Echinococcus multilocularis RNA directed DNA polymerase 0.0133 0.1352 0.1315
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0051 0.0397 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0397 0.0931
Schistosoma mansoni rab6-interacting 0.0023 0.0068 0.0034
Trypanosoma brucei RNA helicase, putative 0.0119 0.1185 0.9379
Schistosoma mansoni myelin transcription factor 1 myt1 0.0127 0.1288 0.1622
Brugia malayi jmjC domain containing protein 0.0109 0.1078 0.3468
Echinococcus granulosus protein kinase C gamma type 0.0166 0.1736 0.2555
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0141 0.0128
Echinococcus granulosus polycomb protein SCMH1 0.0112 0.1108 0.1607
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0051 0.0397 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.1613 0.237
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0197 0.3914
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0285 0.0316
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0025 0.0092 0.0074
Echinococcus granulosus RUN 0.0023 0.0068 0.0039
Schistosoma mansoni hypothetical protein 0.0023 0.0068 0.0034
Onchocerca volvulus Peroxidasin homolog 0.0076 0.0694 0.2232
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0541 0.0501
Echinococcus granulosus NDR protein kinase 0.0029 0.0141 0.0148
Loa Loa (eye worm) DnaJ domain-containing protein 0.007 0.0622 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1973 0.2514
Echinococcus granulosus peregrin 0.0033 0.0194 0.0229
Loa Loa (eye worm) hypothetical protein 0.009 0.0851 0.1452
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0051 0.0397 0.0356
Schistosoma mansoni hypothetical protein 0.0056 0.0452 0.0534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0203 0.0162
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.0176 0.185 0.3156
Echinococcus granulosus lamin 0.0031 0.0169 0.0191
Echinococcus multilocularis RUN 0.0023 0.0068 0.0026
Loa Loa (eye worm) mbt repeat family protein 0.0112 0.1108 0.189
Loa Loa (eye worm) hypothetical protein 0.0112 0.1108 0.189
Onchocerca volvulus 0.0058 0.0479 0.1496
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0427 0.0501
Loa Loa (eye worm) RasGEF domain-containing protein 0.002 0.0042 0.0072
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0051 0.0397 0.0356
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0441 0.4937 0.4916
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.057 0.1833
Loa Loa (eye worm) hypothetical protein 0.0051 0.0397 0.0677
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0068 0.0026
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0051 0.0397 0.0535
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0176 0.185 0.5949
Mycobacterium ulcerans 6-phosphofructokinase 0.0124 0.1254 1
Brugia malayi Peroxidasin 0.0076 0.0694 0.2232
Brugia malayi hypothetical protein 0.0076 0.0694 0.2232
Echinococcus multilocularis serine threonine protein kinase 0.0166 0.1736 0.1701
Schistosoma mansoni rab6-interacting 0.0023 0.0068 0.0034
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0021 0.005 0.0159
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0194 0.4277
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0138 0.1408 0.2403
Echinococcus multilocularis protein kinase c epsilon type 0.0053 0.0427 0.0386
Brugia malayi DnaJ domain containing protein 0.007 0.0622 0.2
Plasmodium vivax SET domain protein, putative 0.0034 0.0203 0.4111
Entamoeba histolytica hypothetical protein 0.0051 0.0397 0.2924
Echinococcus multilocularis histone acetyltransferase MYST2 0.0127 0.1288 0.1251
Trichomonas vaginalis transmembrane protein nessy, putative 0.0051 0.0397 0.0931
Schistosoma mansoni protein kinase C 0.0025 0.0092 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0276 0.047
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Loa Loa (eye worm) hypothetical protein 0.052 0.5861 1
Echinococcus multilocularis geminin 0.059 0.6671 0.6657
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0203 0.0162
Loa Loa (eye worm) latrophilin receptor protein 2 0.0056 0.0452 0.0771
Brugia malayi Hemopexin family protein 0.0127 0.1288 0.4143
Echinococcus multilocularis peroxidasin 0.0076 0.0694 0.0655
Onchocerca volvulus Matrilysin homolog 0.009 0.0851 0.2769
Brugia malayi diacylglycerol kinase 0.002 0.0042 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Brugia malayi Pleckstrin Homology Domain 0.002 0.0042 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0285 0.0244
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0051 0.0397 0.0535
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0051 0.0397 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0203 0.021
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0169 0.0288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.1613 0.1578
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.009 0.0851 0.1053
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0072
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0197 0.5
Loa Loa (eye worm) matrixin family protein 0.0217 0.2334 0.3982
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0519 0.0885
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0197 0.3914
Brugia malayi Animal haem peroxidase family protein 0.0076 0.0694 0.2232
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0051 0.0397 0.0462
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Echinococcus multilocularis lamin dm0 0.0031 0.0169 0.0127
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0197 0.1274
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0112 0.1108 0.1387
Onchocerca volvulus 0.0034 0.0203 0.0551
Schistosoma mansoni lipoxygenase 0.0023 0.0068 0.0034
Entamoeba histolytica hypothetical protein 0.0041 0.0285 0.2001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0124 0.1254 1
Entamoeba histolytica protein kinase, putative 0.0029 0.0141 0.081
Schistosoma mansoni loxhd1 0.0023 0.0068 0.0034
Schistosoma mansoni hypothetical protein 0.0051 0.0397 0.0462
Brugia malayi mbt repeat family protein 0.0112 0.1108 0.3562
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0288
Echinococcus multilocularis dnaJ subfamily C 6 0.007 0.0622 0.0582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.1613 0.237
Schistosoma mansoni intermediate filament proteins 0.0031 0.0169 0.0165
Loa Loa (eye worm) hypothetical protein 0.0284 0.3109 0.5305
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0194 0.0229
Brugia malayi Matrixin family protein 0.009 0.0851 0.2737
Echinococcus granulosus o acyltransferase membrane bound domain 0.0051 0.0397 0.0535
Loa Loa (eye worm) hhat protein 0.0051 0.0397 0.0677
Loa Loa (eye worm) hypothetical protein 0.0109 0.1079 0.1841
Schistosoma mansoni hypothetical protein 0.068 0.7722 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0056 0.0452 0.0618
Brugia malayi 6-phosphofructokinase 0.0124 0.1254 0.4034
Schistosoma mansoni sex comb on midleg homolog 0.0112 0.1108 0.1387
Loa Loa (eye worm) animal heme peroxidase 0.0076 0.0694 0.1184
Loa Loa (eye worm) hypothetical protein 0.0076 0.0694 0.1184
Loa Loa (eye worm) matrix metalloproteinase 0.009 0.0851 0.1452
Loa Loa (eye worm) MBOAT family protein 0.0051 0.0397 0.0677
Onchocerca volvulus 0.0023 0.0068 0.0088
Brugia malayi Matrixin family protein 0.009 0.0851 0.2737
Loa Loa (eye worm) hypothetical protein 0.0031 0.0162 0.0277
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.1078 0.1563
Brugia malayi jmjC domain containing protein 0.004 0.0276 0.0887
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0051 0.0397 0.2924
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1254 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0472 0.0805
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0124 0.1254 0.3962
Brugia malayi protein kinase C3,putative 0.0021 0.005 0.0159
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Brugia malayi Animal haem peroxidase family protein 0.0076 0.0694 0.2232
Brugia malayi MBOAT family protein 0.0051 0.0397 0.1276
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0029 0.0141 0.0148
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0109 0.1079 0.7439
Loa Loa (eye worm) animal heme peroxidase 0.0076 0.0694 0.1184
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0141 0.0026
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0051 0.0397 0.0462
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0176 0.185 0.3156
Entamoeba histolytica phosphofructokinase, putative 0.0124 0.1254 1
Brugia malayi Blistered cuticle protein 3 0.0076 0.0694 0.2232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.1613 0.2046
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0186 0.1973 0.1939
Brugia malayi Ras association domain family 1 isoform A 0.002 0.0042 0.0136
Schistosoma mansoni serine/threonine kinase 0.0029 0.0141 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0197 0.0224
Loa Loa (eye worm) AGC/PKN protein kinase 0.0029 0.0141 0.024
Loa Loa (eye worm) raf kinase 0.002 0.0042 0.0072
Brugia malayi Bromodomain containing protein 0.0033 0.0194 0.0624
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0327 0.3608 0.5379
Entamoeba histolytica hypothetical protein, conserved 0.0051 0.0397 0.2924
Entamoeba histolytica protein kinase, putative 0.0029 0.0141 0.081
Trypanosoma brucei glycerol uptake protein, putative 0.0051 0.0397 0.23
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0068 0.0026

Activities

Activity type Activity value Assay description Source Reference
s-GOT level (functional) = 1209 Karmen units Inhibitory effect on D-GalN/LPS (injected i.p. dose of 350 mg/kg and 10 microg/kg) induced hepatic injury in mice at 10mg/kg, ip ChEMBL. No reference
s-GPT level (functional) = 1265 Karmen units Inhibitory effect on D-GalN/LPS (injected i.p. dose of 350 mg/kg and 10 microg/kg) induced hepatic injury in mice at 10mg/kg, ip ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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