Detailed information for compound 1132942

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 397.363 | Formula: C17H24N3O6P
  • H donors: 5 H acceptors: 6 LogP: -0.52 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCC(=O)N(CCCP(=O)(O)O)O)CCCc1c[nH]c2c1cccc2
  • InChi: 1S/C17H24N3O6P/c21-16(19-12-17(22)20(23)9-4-10-27(24,25)26)8-3-5-13-11-18-15-7-2-1-6-14(13)15/h1-2,6-7,11,18,23H,3-5,8-10,12H2,(H,19,21)(H2,24,25,26)
  • InChiKey: WPUOWEOYBGYCKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.1043 1
Schistosoma mansoni hypothetical protein 0.0042 0.0308 0.069
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0077 0.0089
Brugia malayi hypothetical protein 0.0019 0.0022 0.0067
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0305 0.0284
Loa Loa (eye worm) hypothetical protein 0.0148 0.1603 0.3855
Leishmania major importin beta-1 subunit, putative 0.0027 0.0127 0.1052
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.6122 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0277 0.0255
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Brugia malayi hypothetical protein 0.0038 0.0256 0.0768
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.1053 0.2493
Brugia malayi hypothetical protein 0.004 0.0288 0.0864
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0077 0.0306
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.0471
Schistosoma mansoni nuclear hormone receptor 0.004 0.0277 0.0615
Echinococcus granulosus expressed protein 0.0049 0.0396 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0277 0.0831
Schistosoma mansoni intermediate filament proteins 0.0031 0.0177 0.0375
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0327 0.0786
Echinococcus granulosus tumor protein p63 0.038 0.4422 0.7207
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0277 0.0843
Onchocerca volvulus 0.0031 0.0177 0.0514
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.6122 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.0491
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0077 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0277 0.0666
Brugia malayi RNA, U transporter 1 0.0095 0.0957 0.2873
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0077 0.004
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0022 0.0067
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0077 0.004
Echinococcus multilocularis snurportin 1 0.0358 0.4157 0.4144
Schistosoma mansoni importin beta-1 0.0034 0.0204 0.0439
Loa Loa (eye worm) RNA binding protein 0.0065 0.0592 0.1425
Entamoeba histolytica acyl-coA synthetase, putative 0.0079 0.0754 0.7083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0277 0.0417
Brugia malayi Muscleblind-like protein 0.0148 0.1603 0.4811
Loa Loa (eye worm) hypothetical protein 0.0079 0.0754 0.1814
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0754 0.1156
Echinococcus granulosus snurportin 1 0.0358 0.4157 0.6773
Schistosoma mansoni thyroid hormone receptor 0.004 0.0277 0.0615
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.01 0.0078
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0305 0.0917
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0138 0.1473 0.3543
Loa Loa (eye worm) hypothetical protein 0.0138 0.1473 0.3543
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0204 0.0439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0473 0.3401
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0217 0.0523
Brugia malayi MH2 domain containing protein 0.0119 0.124 0.3721
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0022 0.0067
Onchocerca volvulus Alhambra homolog 0.0033 0.0194 0.057
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0745
Brugia malayi Carboxylesterase family protein 0.0067 0.0607 0.1822
Schistosoma mansoni hypothetical protein 0.0075 0.0707 0.1656
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0077 0.3257
Loa Loa (eye worm) hypothetical protein 0.0079 0.0754 0.1814
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.041
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0277 0.0831
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0277 0.0255
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0204 0.0249
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Echinococcus multilocularis expressed conserved protein 0.0096 0.0959 0.0939
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0278 0.0619
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0754 0.7083
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0077 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.005 0.0149
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0053 0.0118
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0277 0.0615
Schistosoma mansoni lamin 0.0031 0.0177 0.0375
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0194 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.6122 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0277 0.0255
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0277 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0277 0.0831
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.124 0.2982
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0096 0.0288
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0277 0.0615
Echinococcus granulosus muscleblind protein 0.0148 0.1603 0.2589
Echinococcus multilocularis geminin 0.0191 0.2116 0.2098
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0278 0.0257
Trichomonas vaginalis ran, putative 0.0025 0.0096 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0277 0.0666
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0096 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0217 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0277 0.0831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1129 0.3389
Brugia malayi conserved hypotetical protein 0.0019 0.0022 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.224 0.6672
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.6122 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0077 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0204 0.0439
Plasmodium falciparum phd finger protein, putative 0.0033 0.0194 0.0233
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0077 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.1019 0.2451
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0059 0.0512 0.0756
Echinococcus granulosus expressed conserved protein 0.0096 0.0959 0.1534
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0754 0.1121
Brugia malayi ecdysone receptor 0.0019 0.0022 0.0067
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.0607 0.0586
Brugia malayi hypothetical protein 0.0021 0.005 0.0149
Loa Loa (eye worm) hypothetical protein 0.011 0.1129 0.2716
Brugia malayi Bromodomain containing protein 0.0033 0.0194 0.0584
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0096 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0077 0.0306
Brugia malayi nuclear receptor RXR 0.0021 0.005 0.0149
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0077 0.004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0053 0.0127
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.01 0.0078
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0096 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0277 0.0417
Leishmania major hypothetical protein, conserved 0.0025 0.01 0.0677
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0754 0.2264
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0277 0.0417
Echinococcus multilocularis muscleblind protein 0.0148 0.1603 0.1584
Brugia malayi intermediate filament protein 0.0031 0.0177 0.0533
Onchocerca volvulus 0.0023 0.0077 0.018
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.005 0.0027
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.1034 0.1014
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0305 0.0416
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0607 0.1414
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0077 0.0231
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0327 0.0499
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.0607 0.146
Onchocerca volvulus 0.0023 0.0077 0.018
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1603 0.1584
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0077 0.0231
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0473 0.3401
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0277 0.0831
Echinococcus multilocularis neuropeptide s receptor 0.052 0.6127 0.6118
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0277 0.0255
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0204 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0277 0.0831
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.01 0.6431
Brugia malayi TAR-binding protein 0.0065 0.0592 0.1778
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.1379
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0096 0.012
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0022 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0277 0.0666
Schistosoma mansoni hypothetical protein 0.004 0.0288 0.0642
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0754 0.1156
Brugia malayi nuclear receptor NHR-88 0.0019 0.0022 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0277 0.0255
Loa Loa (eye worm) hypothetical protein 0.0067 0.0607 0.146
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0277 0.0615
Mycobacterium ulcerans hypothetical protein 0.0079 0.0754 0.1156
Brugia malayi nuclear hormone receptor 0.004 0.0277 0.0831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0305 0.0416
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0754 0.1156
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0277 0.0615
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0277 0.0831
Loa Loa (eye worm) hypothetical protein 0.0042 0.0305 0.0735
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0277 0.0831
Plasmodium vivax importin-beta 2, putative 0.0034 0.0204 0.0249
Entamoeba histolytica hypothetical protein 0.004 0.0288 0.2374
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0177 0.0427
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0077 0.004
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0607 0.0586
Brugia malayi hypothetical protein 0.0019 0.0022 0.0067
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0022 0.0054
Brugia malayi nuclear receptor NHR-67 0.0019 0.0022 0.0067
Onchocerca volvulus 0.0266 0.3039 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0592 0.1425
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.0471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0204 0.0439
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0277 0.0615
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0288 0.0642
Onchocerca volvulus Glucosylceramidase homolog 0.0191 0.2115 0.6939
Echinococcus multilocularis neuropeptide receptor A26 0.052 0.6127 0.6118
Schistosoma mansoni hypothetical protein 0.0033 0.0194 0.0416
Brugia malayi ecdysteroid receptor 0.004 0.0277 0.0831
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1019 0.0999
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0077 0.004
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0022 0.0067
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.005 0.0066
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.005 0.012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0079 0.0754 0.1156
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0351 0.0329
Echinococcus granulosus intermediate filament protein 0.0031 0.0177 0.0254
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0396 0.0566
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.012
Loa Loa (eye worm) hypothetical protein 0.0056 0.048 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0277 0.0831
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0127 0.0225
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1129 0.3389
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.0396 0.0904
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0053 0.005
Schistosoma mansoni thyroid hormone receptor 0.004 0.0277 0.0615
Echinococcus multilocularis protein patched 0.0044 0.0327 0.0305
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0077 0.0343
Entamoeba histolytica hypothetical protein 0.004 0.0288 0.2374
Onchocerca volvulus 0.004 0.0277 0.0843
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0277 0.0255
Brugia malayi jmjC domain containing protein 0.004 0.0278 0.0836
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0194 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0204 0.0439
Entamoeba histolytica acyl-CoA synthetase, putative 0.0079 0.0754 0.7083
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1231
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0277 0.0831
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.1043 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.1379
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.012
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0103 0.1043 0.3384
Schistosoma mansoni hypothetical protein 0.0191 0.2116 0.5062
Loa Loa (eye worm) hypothetical protein 0.0025 0.01 0.0241
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.0396 0.0953
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.1034 0.3104
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0096 0.5854
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0834 0.1963
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.6122 1
Schistosoma mansoni hypothetical protein 0.0358 0.4157 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1019 0.1633
Brugia malayi nuclear receptor RXR 0.0019 0.0022 0.0067
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0077 0.3257
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0305 0.0917
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0079 0.0754 0.1156
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0077 0.0073
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0396 0.0566
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0077 0.0132
Brugia malayi PHD-finger family protein 0.0033 0.0194 0.0584
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0079 0.0754 0.5602
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0077 0.004
Loa Loa (eye worm) hypothetical protein 0.0067 0.0607 0.146
Schistosoma mansoni ran 0.0025 0.0096 0.0178
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0096 0.286
Brugia malayi hypothetical protein 0.0025 0.01 0.0301
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0217 0.0652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0277 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Brugia malayi steroid hormone receptor 0.004 0.0277 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0277 0.0831
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0327 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0204 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0327 0.0836
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.062 0.149
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0327 0.0499
Echinococcus granulosus geminin 0.0191 0.2116 0.3429
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0754 1
Entamoeba histolytica heat shock transcription factor, putative 0.0103 0.1043 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0217 0.0195
Onchocerca volvulus 0.0079 0.0754 0.2426
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0277 0.0666
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1019 0.1633
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0607 0.0586
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0277 0.0615
Echinococcus granulosus neuropeptide s receptor 0.052 0.6127 1
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Onchocerca volvulus Huntingtin homolog 0.0138 0.1473 0.4808
Echinococcus multilocularis peregrin 0.0033 0.0194 0.0172
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0077 0.0243
Echinococcus granulosus carboxylesterase 5A 0.0067 0.0607 0.0957
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0277 0.0255
Onchocerca volvulus 0.0031 0.0177 0.0514
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.1034 0.9911
Loa Loa (eye worm) hypothetical protein 0.0103 0.1043 0.2509
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0053 0.0158
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0707 0.2122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0277 0.0417
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0204 1
Echinococcus granulosus GPCR family 2 0.0035 0.0217 0.0319
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1566 0.1547
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Echinococcus granulosus tar DNA binding protein 0.0065 0.0592 0.0934
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1019 0.241
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.0396 0.0566
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0217 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1019 0.241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1019 0.241
Schistosoma mansoni hypothetical protein 0.0191 0.2116 0.5062
Echinococcus multilocularis GPCR, family 2 0.0035 0.0217 0.0195
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.0471
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Loa Loa (eye worm) hypothetical protein 0.0075 0.0707 0.1701
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0127 0.0225
Schistosoma mansoni hypothetical protein 0.0042 0.0305 0.0684
Plasmodium vivax SET domain protein, putative 0.0034 0.0204 0.0249
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.01 0.0078
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0217 0.0652
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0127 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0277 0.0831
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Loa Loa (eye worm) hypothetical protein 0.0044 0.0327 0.0786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0473 0.3401
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.0523
Brugia malayi CHE-14 protein 0.0044 0.0327 0.0981
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0277 0.0843
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0077 0.0073
Echinococcus multilocularis musashi 0.0031 0.0177 0.0155
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0077 0.0185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.1019 0.3059
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.0396 0.1189
Schistosoma mansoni ap endonuclease 0.0021 0.0053 0.0073
Onchocerca volvulus 0.0023 0.0077 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0754 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0277 0.0615
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0077 0.0343
Schistosoma mansoni hypothetical protein 0.0042 0.0308 0.069
Onchocerca volvulus 0.0056 0.0472 0.1492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0277 0.0831
Onchocerca volvulus 0.0034 0.0204 0.0602
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0305 0.0917
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0053 0.003
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0204 0.0182
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0277 0.0417
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0754 0.2264
Echinococcus granulosus acetylcholinesterase 0.0067 0.0607 0.0957
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0077 0.0306
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0204 0.0182
Loa Loa (eye worm) hypothetical protein 0.0102 0.1034 0.2488
Giardia lamblia PHD finger protein 15 0.0033 0.0194 1
Loa Loa (eye worm) oxidoreductase 0.0023 0.0077 0.0185
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.6122 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0077 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0277 0.0615
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0277 0.0831
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0079 0.0754 0.1156
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0351 0.0538
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0194 0.0282
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.0305 0.0416
Brugia malayi hypothetical protein 0.0021 0.005 0.0149
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0077 0.0306
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.005 0.0149
Loa Loa (eye worm) hypothetical protein 0.0056 0.0472 0.1137
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0472 0.1088
Leishmania major GTP-binding protein, putative 0.0025 0.0096 0.0616
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.224 0.6672
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0077 0.0306
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0077 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Brugia malayi RNA binding protein 0.0065 0.0592 0.1778
Loa Loa (eye worm) hypothetical protein 0.0034 0.0204 0.049
Echinococcus multilocularis tumor protein p63 0.038 0.4422 0.4409
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0194 0.0233
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0288 0.0266
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0077 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0079 0.0754 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1129 0.2716
Brugia malayi hypothetical protein 0.0138 0.1473 0.4421
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0592 0.0571
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0077 0.0231
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0096 0.0231
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0204 0.0182
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.01 0.3142
Echinococcus granulosus lamin 0.0031 0.0177 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0096 0.305
Loa Loa (eye worm) hypothetical protein 0.0054 0.0447 0.1074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0127 0.0225
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0077 0.004
Brugia malayi Pre-SET motif family protein 0.0234 0.2645 0.794
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1231
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0077 0.0343
Brugia malayi hypothetical protein 0.0038 0.0256 0.0768
Entamoeba histolytica Ran family GTPase 0.0025 0.0096 0.0436
Echinococcus multilocularis protein dispatched 1 0.005 0.0402 0.038
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0396 0.0566
Echinococcus granulosus acetylcholinesterase 0.0067 0.0607 0.0957
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0077 0.004
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0194 0.0172
Plasmodium vivax acyl-CoA synthetase, putative 0.0059 0.0512 0.0756
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0077 0.0231
Echinococcus granulosus importin subunit beta 1 0.0034 0.0204 0.0297
Schistosoma mansoni hypothetical protein 0.0042 0.0308 0.069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0079 0.0754 0.1121
Loa Loa (eye worm) hypothetical protein 0.004 0.0277 0.0666
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.6122 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0077 0.0306
Brugia malayi tailless protein 0.0019 0.0022 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.005 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0217 0.0195
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0427
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0096 0.5854
Echinococcus granulosus neuropeptide receptor A26 0.052 0.6127 1
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0277 0.0843
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0185
Loa Loa (eye worm) carboxylesterase 0.0067 0.0607 0.146
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.6122 1
Brugia malayi Carboxylesterase family protein 0.0067 0.0607 0.1822
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0194 0.0468
Echinococcus multilocularis lamin dm0 0.0031 0.0177 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0077 0.0231
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0277 0.0615
Plasmodium falciparum acyl-CoA synthetase 0.0059 0.0512 0.0756
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0077 0.0306
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.1317 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0079 0.0754 0.5602
Loa Loa (eye worm) hypothetical protein 0.0033 0.0194 0.0468
Echinococcus granulosus lamin dm0 0.0031 0.0177 0.0254
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0077 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0077 0.0306
Loa Loa (eye worm) DR-78 0.0019 0.0022 0.0054
Schistosoma mansoni ap endonuclease 0.0021 0.0053 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0277 0.0666
Echinococcus multilocularis expressed protein 0.0049 0.0396 0.0374
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0592 0.1778
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0291 0.3331 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0077 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1103 0.1083
Mycobacterium ulcerans acyl-CoA synthetase 0.0079 0.0754 0.1156
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0754 0.2264
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0278 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0277 0.0417
Schistosoma mansoni hypothetical protein 0.0035 0.0217 0.0471
Trichomonas vaginalis glucosylceramidase, putative 0.0291 0.3331 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0754 0.1814
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.01 0.6431
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0277 0.0666
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.124 0.2982
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0177 0.0427
Brugia malayi Pre-SET motif family protein 0.0034 0.0204 0.0612
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.2115 0.6291
Echinococcus multilocularis lamin 0.0031 0.0177 0.0155
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0077 0.0306
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0204 0.0297
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0189 0.0273
Brugia malayi Importin beta-1 subunit 0.0034 0.0204 0.0612
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0096 0.0071
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1231
Schistosoma mansoni patched 1 0.0044 0.0327 0.0736
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0177 0.0533
Echinococcus granulosus FTZ F1 alpha 0.004 0.0277 0.0417
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0194 0.0416
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0022 0.0067
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0358 0.4157 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0059 0.0512 0.3706
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0022 0.0054
Entamoeba histolytica hypothetical protein 0.004 0.0288 0.2374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0277 0.0666
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0022 0.0067
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.1034 0.1657
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1231
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0592 0.1425
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0077 0.3257
Onchocerca volvulus 0.0023 0.0077 0.018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Brugia malayi jmjC domain containing protein 0.0107 0.1103 0.331
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0278 0.0619
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0291 0.3331 0.8013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0277 0.0831
Brugia malayi HSF-type DNA-binding domain containing protein 0.0103 0.1043 0.3131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0277 0.0666
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0288 0.0435
Trichomonas vaginalis set domain proteins, putative 0.0266 0.3039 0.9107
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.005 0.0045
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0077 0.1591
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0077 0.004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0077 0.0231
Loa Loa (eye worm) hypothetical protein 0.0059 0.0512 0.1231
Schistosoma mansoni coup transcription factor 0.004 0.0277 0.0615
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1566 0.2528
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.01 0.0078
Onchocerca volvulus Huntingtin homolog 0.0138 0.1473 0.4808
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0277 0.0255
Plasmodium falciparum importin beta, putative 0.0034 0.0204 0.0249
Loa Loa (eye worm) hypothetical protein 0.0148 0.1603 0.3855
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0077 0.3257
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.1379
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.2645 0.6362
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0277 0.0255
Schistosoma mansoni ran 0.0025 0.0096 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0056 0.0473 0.3401
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0077 0.1591
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.1379
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0077 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1019 0.0999
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0277 0.0417
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0592 0.1379
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0278 0.067
Schistosoma mansoni hypothetical protein 0.0042 0.0308 0.069
Entamoeba histolytica hypothetical protein 0.004 0.0288 0.2374
Brugia malayi nuclear hormone receptor 0.0019 0.0022 0.0067
Echinococcus granulosus peregrin 0.0033 0.0194 0.0282
Schistosoma mansoni lamin 0.0031 0.0177 0.0375
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1103 0.177
Brugia malayi nuclear receptor NHR-88 0.004 0.0277 0.0831

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -4.77 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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