Detailed information for compound 1133508

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 402.452 | Formula: C21H22N8O
  • H donors: 3 H acceptors: 4 LogP: 1.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(Nc2ccc(cc2)C(=O)N2CCNCC2)c2n(c1)c(cn2)c1c[nH]nc1
  • InChi: 1S/C21H22N8O/c1-14-13-29-18(16-10-24-25-11-16)12-23-20(29)19(26-14)27-17-4-2-15(3-5-17)21(30)28-8-6-22-7-9-28/h2-5,10-13,22H,6-9H2,1H3,(H,24,25)(H,26,27)
  • InChiKey: JNAHXDJEKAMVMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine kinase 6 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Leishmania major hypothetical protein, conserved protein tyrosine kinase 6 134 aa 127 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.1802 0.4168
Schistosoma mansoni tyrosine kinase 0.0019 0.0854 0.1975
Giardia lamblia Aurora kinase 0.0068 0.4002 0.5
Brugia malayi serine/threonine protein kinase 6 0.0068 0.4002 0.4002
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Brugia malayi Src substrate cortactin 0.0013 0.048 0.048
Loa Loa (eye worm) AUR protein kinase 0.0068 0.4002 0.4002
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0013 0.048 0.1111
Echinococcus granulosus ectonucleotide 0.0029 0.146 0.146
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Entamoeba histolytica unconventional myosin IB 0.0013 0.048 0.12
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0162 1 1
Leishmania major protein kinase, putative 0.0068 0.4002 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Schistosoma mansoni sorting nexin 0.0013 0.048 0.1111
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.4002 0.5
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0073 0.4324 0.4324
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0019 0.0854 0.0854
Onchocerca volvulus 0.0013 0.048 0.1111
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0772 0.0772
Brugia malayi protein-tyrosine kinase 0.0013 0.048 0.048
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0772 0.1786
Echinococcus granulosus expressed protein 0.0013 0.048 0.048
Schistosoma mansoni Dab2-interacting protein-like 0.0013 0.048 0.1111
Echinococcus granulosus muscleblind protein 0.0162 1 1
Echinococcus granulosus src region 0.0013 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0029 0.146 0.146
Echinococcus multilocularis muscleblind protein 1 0.0162 1 1
Schistosoma mansoni hypothetical protein 0.0073 0.4324 1
Schistosoma mansoni apoptosis stimulating of P53 0.0013 0.048 0.1111
Onchocerca volvulus 0.0014 0.0516 0.1193
Brugia malayi Guanylate kinase family protein 0.0013 0.048 0.048
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Loa Loa (eye worm) p53BP2 0.0013 0.048 0.048
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0019 0.0854 0.0854
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.048 0.12
Entamoeba histolytica protein kinase, putative 0.0068 0.4002 1
Schistosoma mansoni hypothetical protein 0.0013 0.048 0.1111
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0013 0.048 0.1111
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.4002 0.9255
Schistosoma mansoni formin binding protein and related proteins 0.0013 0.048 0.1111
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.4002 1
Echinococcus multilocularis aurora kinase A 0.0068 0.4002 0.4002
Entamoeba histolytica BAR/SH3 domain containing protein 0.0013 0.048 0.12
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0013 0.048 0.1111
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0013 0.048 0.048
Leishmania major endonuclease G, putative 0.002 0.0933 0.1287
Onchocerca volvulus 0.0034 0.1802 0.4168
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.4002 1
Schistosoma mansoni tyrosine kinase 0.0019 0.0854 0.1975
Schistosoma mansoni eps8-related protein 0.0013 0.048 0.1111
Trichomonas vaginalis AGC family protein kinase 0.0068 0.4002 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.4002 1
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Echinococcus multilocularis expressed protein 0.0013 0.048 0.048
Brugia malayi endonuclease G, mitochondrial precursor 0.002 0.0933 0.0933
Brugia malayi serine/threonine kinase 12 0.0068 0.4002 0.4002
Echinococcus multilocularis muscleblind protein 0.0162 1 1
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0013 0.048 0.1111
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.1802 0.4168
Entamoeba histolytica protein kinase , putative 0.0068 0.4002 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Schistosoma mansoni dynamin-associated protein 0.0013 0.048 0.1111
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Echinococcus granulosus tyrosine protein kinase Lyn 0.002 0.089 0.089
Trichomonas vaginalis AGC family protein kinase 0.0068 0.4002 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0034 0.1802 0.1802
Echinococcus multilocularis ectonucleotide 0.0029 0.146 0.146
Loa Loa (eye worm) hypothetical protein 0.0034 0.1802 0.1802
Echinococcus granulosus nostrin 0.0013 0.048 0.048
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0029 0.146 0.146
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0029 0.146 0.146
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0.0933 0.1287
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0772 0.1786
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0013 0.048 0.048
Brugia malayi Myosin tail family protein 0.0013 0.048 0.048
Schistosoma mansoni run and tbc1 domain containing 0.0013 0.048 0.1111
Brugia malayi Thrombospondin type 1 domain containing protein 0.0073 0.4324 0.4324
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Trypanosoma brucei aurora B kinase 0.0068 0.4002 1
Echinococcus granulosus NCK adaptor protein 0.0018 0.0772 0.0772
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0854 0.1975
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0013 0.048 0.048
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0013 0.048 0.048
Schistosoma mansoni dreadlocks/dock 0.0013 0.048 0.1111
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0772 0.0772
Trypanosoma cruzi endonuclease G, putative 0.002 0.0933 0.1287
Trypanosoma cruzi endonuclease G, putative 0.002 0.0933 0.1287
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0013 0.048 0.048
Echinococcus granulosus Spectrin alpha actinin 0.0013 0.048 0.048
Trypanosoma brucei endonuclease G, putative 0.002 0.0933 0.1287
Schistosoma mansoni tyrosine kinase 0.0019 0.0854 0.1975
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0772 0.0772
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.4002 1
Schistosoma mansoni nck2/grb4 0.0018 0.0772 0.1786
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0013 0.048 0.048
Echinococcus multilocularis transfer RNA-Ala 0.0013 0.048 0.048
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0854 0.0854
Echinococcus multilocularis Endonuclease G 0.002 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Echinococcus multilocularis nostrin 0.0013 0.048 0.048
Echinococcus multilocularis Spectrin alpha actinin 0.0013 0.048 0.048
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.002 0.0933 0.1287
Toxoplasma gondii aurora kinase 0.0068 0.4002 1
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0013 0.048 0.1111
Brugia malayi Spectrin alpha chain 0.0013 0.048 0.048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Entamoeba histolytica protein kinase, putative 0.0068 0.4002 1
Echinococcus granulosus epidermal growth factor receptor kinase 0.0013 0.048 0.048
Brugia malayi Fes/CIP4 homology domain containing protein 0.0013 0.048 0.048
Brugia malayi Tyrosine-protein kinase abl-1 0.0019 0.0854 0.0854
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Schistosoma mansoni protein kinase 0.0068 0.4002 0.9255
Onchocerca volvulus Putative cortactin 0.0013 0.048 0.1111
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.1802 0.4168
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0772 0.0772
Schistosoma mansoni endonuclease related 0.002 0.0933 0.2159
Brugia malayi SH3 domain containing protein 0.0013 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0034 0.1802 0.1802
Echinococcus granulosus intersectin 2 0.0013 0.048 0.048
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.048 0.048
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0.0933 0.1287
Echinococcus granulosus tyrosine protein kinase Src42A 0.0019 0.0854 0.0854
Onchocerca volvulus 0.0013 0.048 0.1111
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0019 0.0854 0.0854
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0013 0.048 0.048
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.4002 0.4002
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0013 0.048 0.048
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Onchocerca volvulus 0.0073 0.4324 1
Loa Loa (eye worm) SRC-1 0.0019 0.0854 0.0854
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0013 0.048 0.048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.4002 0.4002
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Schistosoma mansoni C-fyn 0.0013 0.048 0.1111
Schistosoma mansoni tyrosine kinase 0.0019 0.0854 0.1975
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0854 0.0854
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0019 0.0854 0.0854
Onchocerca volvulus 0.0013 0.048 0.1111
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Entamoeba histolytica protein kinase, putative 0.0013 0.048 0.12
Trypanosoma brucei endonuclease G, putative 0.002 0.0933 0.1287
Schistosoma mansoni cell polarity protein 0.0013 0.048 0.1111
Trypanosoma brucei endonuclease G, putative 0.002 0.0933 0.1287
Echinococcus multilocularis intersectin 2 0.0013 0.048 0.048
Loa Loa (eye worm) AUR protein kinase 0.0068 0.4002 0.4002
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0854 0.0854
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0034 0.1802 0.1802
Entamoeba histolytica BAR/SH3 domain containing protein 0.0013 0.048 0.12
Echinococcus multilocularis endophilin A3 0.0013 0.048 0.048
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0772 0.0772
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.4002 1
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0562 0.13
Onchocerca volvulus 0.0013 0.048 0.1111
Schistosoma mansoni sorbin 0.0013 0.048 0.1111
Schistosoma mansoni adapter molecule crk 0.0018 0.0772 0.1786
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0019 0.0854 0.0854
Loa Loa (eye worm) protein-tyrosine kinase 0.0013 0.048 0.048
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.4002 0.4002
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0013 0.048 0.048
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0772 0.1786
Brugia malayi SRC-1 0.0019 0.0854 0.0854
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0034 0.1802 0.4168
Schistosoma mansoni hypothetical protein 0.0013 0.048 0.1111
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0013 0.048 0.048
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.4002 0.5
Entamoeba histolytica hypothetical protein 0.0013 0.048 0.12
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0019 0.0854 0.0854
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0772 0.0772
Onchocerca volvulus 0.0034 0.1802 0.4168
Trichomonas vaginalis AGC family protein kinase 0.0068 0.4002 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0019 0.0854 0.0854
Echinococcus granulosus tyrosine protein kinase Src64B 0.0019 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0013 0.048 0.048
Echinococcus granulosus tyrosine protein kinase Fyn 0.0019 0.0854 0.0854
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Echinococcus multilocularis tyrosine protein kinase Abl 0.0019 0.0854 0.0854
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0013 0.048 0.048
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.4002 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0019 0.0854 0.0854
Echinococcus granulosus aurora kinase A 0.0068 0.4002 0.4002
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0013 0.048 0.048
Loa Loa (eye worm) AUR protein kinase 0.0068 0.4002 0.4002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0034 0.1802 0.1802
Loa Loa (eye worm) thyroid receptor interactor 0.0013 0.048 0.048
Echinococcus granulosus fch and double sh3 domains protein 2 0.0013 0.048 0.048
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Brugia malayi Variant SH3 domain containing protein 0.0013 0.048 0.048
Echinococcus granulosus Endonuclease G 0.002 0.0933 0.0933
Brugia malayi Peripheral plasma membrane protein CASK 0.0013 0.048 0.048
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.048 0.12
Echinococcus granulosus endophilin A3 0.0013 0.048 0.048
Loa Loa (eye worm) guanylate kinase 0.0013 0.048 0.048
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0772 0.0772

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 15 nM Inhibition of BRK pretreated for 30 mins by microplate reader ChEMBL. 21855335
IC50 (functional) = 167 nM Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrs ChEMBL. 21855335
IC50 (binding) = 232 nM Inhibition of AurB ChEMBL. 21855335
IC50 (binding) = 603 nM Inhibition of LCK ChEMBL. 21855335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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