Detailed information for compound 1149240

Basic information

Technical information
  • TDR Targets ID: 1149240
  • Name: N-[3-[4-[bis(2-chloroethyl)amino]phenyl]sulfa nylpropyl]acridin-9-amine
  • MW: 484.484 | Formula: C26H27Cl2N3S
  • H donors: 1 H acceptors: 1 LogP: 7.38 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN(c1ccc(cc1)SCCCNc1c2ccccc2nc2c1cccc2)CCCl
  • InChi: 1S/C26H27Cl2N3S/c27-14-17-31(18-15-28)20-10-12-21(13-11-20)32-19-5-16-29-26-22-6-1-3-8-24(22)30-25-9-4-2-7-23(25)26/h1-4,6-13H,5,14-19H2,(H,29,30)
  • InChiKey: FSJFMSCJJZGVHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[[4-[bis(2-chloroethyl)amino]phenyl]thio]propyl]-9-acridinamine
  • acridin-9-yl-[3-[[4-[bis(2-chloroethyl)amino]phenyl]thio]propyl]amine
  • 130031-49-1
  • N-(3-((4-(Bis(2-chloroethyl)amino)phenyl)thio)propyl)-9-acridinamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0018 0.0227
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Onchocerca volvulus 4.1 G protein, putative homolog 0.0129 0.0359 0.1314
Leishmania major importin beta-1 subunit, putative 0.0023 0.0017 0.0219
Entamoeba histolytica protein tyrosine phosphatase, putative 0.084 0.2647 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0026 0.0027 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0064 0.024
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0018 0.0025
Entamoeba histolytica kinesin, putative 0.0406 0.125 0.4703
Onchocerca volvulus Huntingtin homolog 0.0142 0.04 0.1471
Echinococcus multilocularis GPCR, family 2 0.0085 0.0217 0.0217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0217 0.0217
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.001 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0064 0.035
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0038 0.0302
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0021 0.0012 0.0017
Giardia lamblia Kinesin-5 0.0406 0.125 0.4723
Echinococcus multilocularis hypothetical protein 0.0129 0.0359 0.0359
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0142 0.0198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0708 0.3906
Schistosoma mansoni protein tyrosine phosphatase 0.0138 0.0387 0.0446
Onchocerca volvulus 0.0037 0.0064 0.0194
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.004 0.004
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Brugia malayi Thrombospondin type 1 domain containing protein 0.0056 0.0123 0.0172
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0439
Onchocerca volvulus 0.0129 0.0359 0.1314
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0163 0.0614
Brugia malayi Protein-tyrosine phosphatase 0.0129 0.0359 0.0499
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0001 0.0007
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0129 0.0359 0.0359
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.001 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.2249 0.7184 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0034 0.0048
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.2249 0.7184 0.8264
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Echinococcus multilocularis pyruvate kinase 0.0035 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0163 0.0225
Schistosoma mansoni lamin 0.0062 0.0142 0.0164
Brugia malayi latrophilin 2 splice variant baaae 0.0183 0.0534 0.0743
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0064 0.035
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0001 0.0001
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Brugia malayi beta-lactamase 0.0037 0.0064 0.0088
Toxoplasma gondii kinesin motor domain-containing protein 0.0406 0.125 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0064 0.0088
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0581 0.1814 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0217 0.03
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.037 0.037
Echinococcus multilocularis pyruvate kinase 0.0035 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0424 0.0488
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.054 0.1683 0.2341
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.001 0.001
Loa Loa (eye worm) STAT protein 0.0178 0.0517 0.0718
Echinococcus granulosus lamin dm0 0.0062 0.0142 0.0142
Onchocerca volvulus 0.0026 0.0027 0.0056
Brugia malayi Thioredoxin reductase 0.005 0.0106 0.0147
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0084 0.0215 0.0778
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0372 0.0428
Entamoeba histolytica hypothetical protein 0.0082 0.0208 0.0751
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.001 0.0132
Schistosoma mansoni pyruvate kinase 0.0068 0.0163 0.0187
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0016
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0163 0.2092
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0038 0.0302
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0018 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0138 0.0387 0.0387
Mycobacterium ulcerans lipase LipD 0.0037 0.0064 0.024
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.2249 0.7184 0.7184
Mycobacterium ulcerans hypothetical protein 0.0037 0.0064 0.024
Loa Loa (eye worm) hypothetical protein 0.006 0.0139 0.0191
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.001 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0064 0.035
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.084 0.2647 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0023
Entamoeba histolytica hypothetical protein 0.0023 0.0017 0.0026
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0183 0.0534 0.0614
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.0424 0.059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0016
Echinococcus multilocularis pyruvate kinase 0.0035 0.0056 0.0056
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0017 0.022
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0129 0.0359 0.4614
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0018 0.0067
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0106 0.0146
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0129 0.0359 0.4614
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0018 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.024
Schistosoma mansoni lamin 0.0062 0.0142 0.0164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0017 0.0064
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0204 0.0284
Schistosoma mansoni protein tyrosine phosphatase 0.0129 0.0359 0.0412
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0138 0.0387 0.0446
Echinococcus granulosus survival motor neuron protein 1 0.054 0.1683 0.1683
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0084 0.0215 0.0814
Onchocerca volvulus Huntingtin homolog 0.0142 0.04 0.1471
Loa Loa (eye worm) hypothetical protein 0.0142 0.04 0.0555
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0163 0.057
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.084 0.2647 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0068 0.0163 0.2092
Onchocerca volvulus 0.011 0.0299 0.1086
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0064 0.0817
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0129 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0138 0.0387 0.0446
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0084 0.0215 0.0814
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus granulosus intermediate filament protein 0.0062 0.0142 0.0142
Onchocerca volvulus 0.0081 0.0204 0.0728
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0138 0.0387 0.0538
Loa Loa (eye worm) hypothetical protein 0.0268 0.0807 0.1121
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0215 0.2772
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0129 0.0359 0.0359
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0018 0.0141
Schistosoma mansoni pcd6 interacting protein-related 0.0129 0.0359 0.0412
Schistosoma mansoni ran 0.0021 0.001 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0372 0.4791
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0355 0.1955
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0138 0.0387 0.0387
Echinococcus multilocularis 0.0129 0.0359 0.0359
Loa Loa (eye worm) protein tyrosine phosphatase 0.0129 0.0359 0.0497
Schistosoma mansoni hypothetical protein 0.0082 0.0208 0.024
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0204 0.0204
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0018 0.0018
Schistosoma mansoni DNA helicase recq5 0.0023 0.0018 0.002
Brugia malayi Protein-tyrosine phosphatase 1 0.0129 0.0359 0.0499
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0129 0.0359 0.0359
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.003 0.0042 0.0057
Onchocerca volvulus 0.0062 0.0142 0.0493
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0208 0.024
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.0424 0.0589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0268 0.0807 0.1123
Brugia malayi hypothetical protein 0.0142 0.04 0.0557
Schistosoma mansoni ran 0.0021 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.014 0.0393 0.0546
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0129 0.0359 0.0359
Echinococcus granulosus pyruvate kinase 0.0035 0.0056 0.0056
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.084 0.2647 0.3683
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.084 0.2647 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0138 0.0387 0.0446
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0138 0.0387 0.0387
Schistosoma mansoni protein tyrosine phosphatase 0.0129 0.0359 0.0412
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0106 0.1362
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.037 0.037
Echinococcus granulosus snurportin 1 0.0299 0.0908 0.0908
Trichomonas vaginalis pyruvate kinase, putative 0.0068 0.0163 0.0614
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.001 0.0082
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Loa Loa (eye worm) hypothetical protein 0.0085 0.0217 0.03
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Loa Loa (eye worm) hypothetical protein 0.0268 0.0808 0.1123
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0215 0.2772
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0142 0.0196
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0259 0.0777 0.2936
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0018 0.0018
Echinococcus multilocularis ectonucleotide 0.0022 0.0014 0.0014
Echinococcus multilocularis kinesin family 1 0.3124 1 1
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0096 0.0327
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0064 0.0087
Loa Loa (eye worm) hypothetical protein 0.014 0.0393 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0048
Onchocerca volvulus 0.0056 0.0123 0.0421
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0106 0.0106
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0129 0.0359 0.0412
Entamoeba histolytica hypothetical protein 0.0082 0.0208 0.0751
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0132 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0085 0.0217 0.0249
Brugia malayi hypothetical protein 0.0129 0.0359 0.0499
Plasmodium falciparum importin beta, putative 0.0028 0.0034 0.0273
Echinococcus multilocularis survival motor neuron protein 1 0.054 0.1683 0.1683
Leishmania major GTP-binding protein, putative 0.0021 0.001 0.0132
Brugia malayi hypothetical protein 0.0129 0.0359 0.0499
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.011 0.0299 0.0416
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0129 0.0359 0.0412
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0056 0.0449
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Brugia malayi hypothetical protein 0.0082 0.0208 0.029
Plasmodium falciparum kinesin-5 0.0406 0.125 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0914 0.2888 0.2888
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0018 0.0023
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0313 0.8778
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0217 0.0302
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0018 0.0018
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0129 0.0359 0.0499
Schistosoma mansoni DNA helicase recq1 0.0023 0.0018 0.002
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0016
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0017 0.105
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.0136
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0018 0.0067
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0017 0.0136
Echinococcus granulosus bloom syndrome protein 0.0023 0.0018 0.0018
Plasmodium falciparum thioredoxin reductase 0.005 0.0106 0.0847
Schistosoma mansoni hypothetical protein 0.0085 0.0217 0.0249
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0068 0.0163 0.0225
Trypanosoma brucei pyruvate kinase 1 0.0068 0.0163 0.2092
Loa Loa (eye worm) glutathione reductase 0.005 0.0106 0.0146
Trichomonas vaginalis ran, putative 0.0021 0.001 0.0039
Echinococcus multilocularis pyruvate kinase 0.0054 0.0117 0.0117
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0163 0.057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0268 0.0807 0.1123
Schistosoma mansoni kinesin eg-5 0.0406 0.125 0.1438
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0439
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0034 0.0273
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0138 0.0387 0.0387
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0132 0.037 0.0425
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0138 0.0387 0.0387
Plasmodium vivax glutathione reductase, putative 0.005 0.0106 0.0847
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0424 0.0424
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0001 0.001
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0018 0.0067
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0016
Onchocerca volvulus 0.0062 0.0142 0.0493
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.2718 0.8694 1
Leishmania major hypothetical protein, conserved 0.0259 0.0777 1
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0142 0.0196
Schistosoma mansoni importin beta-1 0.0028 0.0034 0.0039
Mycobacterium leprae Probable lipase LipE 0.0037 0.0064 0.1376
Loa Loa (eye worm) hypothetical protein 0.0142 0.04 0.0555
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0217 0.0217
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Entamoeba histolytica protein tyrosine phosphatase, putative 0.084 0.2647 1
Brugia malayi hypothetical protein 0.0129 0.0359 0.0499
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Plasmodium falciparum pyruvate kinase 0.0068 0.0163 0.13
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Schistosoma mansoni inositol monophosphatase 0.0084 0.0215 0.0248
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0017 0.022
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0064 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0064 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.0777 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus granulosus pyruvate kinase 0.0035 0.0056 0.0056
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.084 0.2647 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 0.0136
Plasmodium vivax importin-beta 2, putative 0.0028 0.0034 0.0273
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0313 0.1728
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0132 0.037 0.037
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.084 0.2647 1
Schistosoma mansoni intermediate filament proteins 0.0062 0.0142 0.0164
Chlamydia trachomatis pyruvate kinase 0.0068 0.0163 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0076 0.0187 0.1031
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0084 0.0215 0.1723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0372 0.1407
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0129 0.0359 0.0359
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0129 0.0359 0.0412
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0026 0.0027 0.0031
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0138 0.0387 0.0387
Echinococcus granulosus pyruvate kinase 0.0035 0.0056 0.0056
Onchocerca volvulus 0.0149 0.0422 0.1556
Toxoplasma gondii ABC1 family protein 0.0037 0.0064 0.0508
Brugia malayi hypothetical protein 0.0021 0.0012 0.0017
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0129 0.0359 0.0359
Brugia malayi hypothetical protein 0.0129 0.0359 0.0499
Schistosoma mansoni survival motor neuron protein 0.011 0.0299 0.0343
Brugia malayi hypothetical protein 0.054 0.1683 0.2342
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0064 0.035
Schistosoma mansoni pyruvate kinase 0.0035 0.0056 0.0065
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0017 0.0064
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0129 0.0359 0.0359
Trypanosoma cruzi hypothetical protein, conserved 0.0259 0.0777 1
Entamoeba histolytica hypothetical protein 0.0082 0.0208 0.0751
Giardia lamblia Pyruvate kinase 0.0035 0.0056 0.0212
Echinococcus multilocularis geminin 0.0191 0.0559 0.0559
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0129 0.0359 0.0412
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0313 0.1728
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0001 0.0001
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0129 0.0359 0.0412
Loa Loa (eye worm) beta-lactamase 0.0037 0.0064 0.0087
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0313 0.1728
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0424 0.0488
Loa Loa (eye worm) hypothetical protein 0.0062 0.0142 0.0196
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0355 0.1955
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis inositol monophosphatase 1 0.0084 0.0215 0.0215
Onchocerca volvulus Pyruvate kinase homolog 0.0068 0.0163 0.057
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0056 0.0123 0.017
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.001 0.0082
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0018 0.0141
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.035
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0064 0.1376
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0017 0.0219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.084 0.2647 1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0001 0.001
Brugia malayi Pyruvate kinase, M2 isozyme 0.0068 0.0163 0.0226
Echinococcus granulosus pyruvate kinase 0.0068 0.0163 0.0163
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0129 0.0359 0.1321
Mycobacterium ulcerans beta-lactamase 0.0037 0.0064 0.024
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0056 0.0449
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Schistosoma mansoni hypothetical protein 0.0085 0.0217 0.0249
Echinococcus granulosus ectonucleotide 0.0022 0.0014 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0132 0.037 0.0513
Trypanosoma brucei protein tyrosine phosphatase 1 0.0129 0.0359 0.4614
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0018 0.0141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0016
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0129 0.0359 0.0359
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0053
Onchocerca volvulus 0.0129 0.0359 0.1314
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Brugia malayi isocitrate dehydrogenase 0.0018 0.0001 0.0002
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.084 0.2647 0.3684
Brugia malayi Protein-tyrosine phosphatase 0.0277 0.0837 0.1165
Mycobacterium leprae Probable pyruvate kinase PykA 0.0068 0.0163 0.4311
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0018 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0208 0.0208
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Echinococcus multilocularis pyruvate kinase 0.0068 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Brugia malayi glutathione reductase 0.005 0.0106 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0208 0.0208
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0064 0.0073
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0313 0.1728
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Trypanosoma cruzi pyruvate kinase 2, putative 0.0068 0.0163 0.2092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.001 0.001
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0163 0.0225
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.001 0.0014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.001 0.0132
Brugia malayi Kinesin motor domain containing protein 0.0406 0.125 0.174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0129 0.0359 0.1321
Brugia malayi hypothetical protein 0.0029 0.0038 0.0052
Loa Loa (eye worm) inositol-1 0.0084 0.0215 0.0298
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0021 0.0012 0.0014
Onchocerca volvulus 0.0129 0.0359 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0064 0.0817
Toxoplasma gondii pyruvate kinase PyK1 0.0068 0.0163 0.13
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0064 0.035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0372 0.0372
Leishmania major trypanothione reductase 0.005 0.0106 0.1362
Echinococcus multilocularis musashi 0.0062 0.0142 0.0142
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0106 0.0847
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0204 0.0235
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0106 0.0584
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0018 0.0025
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0064 0.0064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0215 0.2772
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0129 0.0359 0.0412
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0129 0.0359 0.0359
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0001 0.0016
Plasmodium vivax kinesin-5 0.0406 0.125 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0372 0.1407
Onchocerca volvulus 0.0129 0.0359 0.1314
Plasmodium vivax pyruvate kinase, putative 0.0068 0.0163 0.13
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.035
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0129 0.0359 0.0497
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0064 0.0064
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0129 0.0359 0.0497
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0129 0.0359 0.0497
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis snurportin 1 0.0299 0.0908 0.0908
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.001 0.0013
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0372 0.0428
Loa Loa (eye worm) hypothetical protein 0.014 0.0393 0.0546
Schistosoma mansoni hypothetical protein 0.0191 0.0559 0.0643
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0908 0.1262
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0064 0.035
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Schistosoma mansoni hypothetical protein 0.011 0.0299 0.0343
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0038 0.0302
Brugia malayi hypothetical protein 0.0021 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus granulosus geminin 0.0191 0.0559 0.0559
Echinococcus multilocularis aryl hydrocarbon receptor 0.003 0.0042 0.0042
Brugia malayi RNA, U transporter 1 0.008 0.0201 0.0279
Onchocerca volvulus 0.0037 0.0064 0.0194
Trypanosoma brucei trypanothione reductase 0.005 0.0106 0.1362
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Schistosoma mansoni inositol monophosphatase 0.0084 0.0215 0.0248
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0084 0.0215 0.0814
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0138 0.0387 0.0387
Echinococcus granulosus inositol monophosphatase 1 0.0084 0.0215 0.0215
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0038 0.0485
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0021 0.0012 0.0017
Echinococcus multilocularis lamin 0.0062 0.0142 0.0142
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0084 0.0215 0.2772
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Onchocerca volvulus 0.0129 0.0359 0.1314
Brugia malayi hypothetical protein 0.003 0.0042 0.0058
Onchocerca volvulus 0.0129 0.0359 0.1314
Giardia lamblia Protein tyrosine phosphatase 0.0129 0.0359 0.1355
Loa Loa (eye worm) pyruvate kinase 0.0068 0.0163 0.0225
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0129 0.0359 0.0499
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Mycobacterium tuberculosis Conserved protein 0.0037 0.0064 0.035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0064 0.0508
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Brugia malayi Pyruvate kinase, muscle isozyme 0.0068 0.0163 0.0226
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.001 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0064 0.0817
Leishmania major hypothetical protein, conserved 0.0037 0.0064 0.0817
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0355 0.1955
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0034 0.0034
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0038 0.0302
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0038 0.0485
Trichomonas vaginalis esterase, putative 0.0037 0.0064 0.024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0017 0.0064
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0129 0.0359 0.4614
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0792
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0138 0.0387 0.0446
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0001 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Schistosoma mansoni pyruvate kinase 0.0068 0.0163 0.0187
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0129 0.0359 0.0359
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0064 0.024
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.084 0.2647 1
Echinococcus multilocularis lamin dm0 0.0062 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0424 0.0424
Leishmania major hypothetical protein, conserved 0.0029 0.0038 0.0485
Echinococcus granulosus protein tyrosine phosphatase n9 0.0129 0.0359 0.0359
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Toxoplasma gondii thioredoxin reductase 0.005 0.0106 0.0847
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0096 0.0133
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0018 0.0025
Brugia malayi beta-lactamase family protein 0.0037 0.0064 0.0088
Onchocerca volvulus 0.0129 0.0359 0.1314
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0026 0.0027 0.0038
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0129 0.0359 0.0359
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0372 0.1407
Schistosoma mansoni hypothetical protein 0.0056 0.0123 0.0142
Echinococcus granulosus lamin 0.0062 0.0142 0.0142
Onchocerca volvulus 0.0026 0.0027 0.0056
Onchocerca volvulus 0.084 0.2647 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.005 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.024
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0129 0.0359 0.4614
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Leishmania major pyruvate kinase 0.0068 0.0163 0.2092
Brugia malayi hypothetical protein 0.0019 0.0004 0.0006
Onchocerca volvulus 0.0037 0.0064 0.0194
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0022 0.0014 0.0014
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0001 0.001
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Trichomonas vaginalis pten, drome, putative 0.0129 0.0359 0.1355
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0021 0.0012 0.0016
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0259 0.0777 0.2936
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Loa Loa (eye worm) hypothetical protein 0.0047 0.0096 0.0133
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0129 0.0359 0.1321
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0018 0.0227
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0046
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0129 0.0359 0.0359
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Brugia malayi hypothetical protein 0.0129 0.0359 0.0499
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0001 0.0001
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0355 1
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0129 0.0359 0.0412
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0372 0.0372
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) hypothetical protein 0.0081 0.0204 0.0283
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0217 0.0302
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0132 0.037 0.0514
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0001 0.0002
Echinococcus granulosus pyruvate kinase 0.0068 0.0163 0.0163
Echinococcus granulosus importin subunit beta 1 0.0028 0.0034 0.0034
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0084 0.0215 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0129 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0036
Echinococcus multilocularis pyruvate kinase 0.0068 0.0163 0.0163
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0138 0.0387 0.0446
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0268 0.0807 0.1121
Mycobacterium tuberculosis Probable reductase 0.0115 0.0313 0.1728
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0056 0.0449
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0138 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0001 0.0016
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0204 0.0204
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0068 0.0163 0.0896
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0129 0.0359 0.0499
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0022 0.0014 0.0014
Onchocerca volvulus 0.003 0.0042 0.0112
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0026 0.0027 0.0031
Loa Loa (eye worm) RecQ helicase 0.0023 0.0018 0.0023
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0038 0.0485
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0018 0.0067
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0138 0.0387 0.0387
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0064 0.024
Brugia malayi STAT protein, DNA binding domain containing protein 0.0178 0.0517 0.0719
Loa Loa (eye worm) kinesin-like protein KLP2 0.0406 0.125 0.1739
Loa Loa (eye worm) protein-tyrosine phosphatase 0.2249 0.7184 1
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus granulosus GPCR family 2 0.0085 0.0217 0.0217
Trichomonas vaginalis inositol monophosphatase, putative 0.0084 0.0215 0.0814
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0259 0.0777 1
Schistosoma mansoni hypothetical protein 0.0299 0.0908 0.1044
Schistosoma mansoni hypothetical protein 0.0085 0.0217 0.0249
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0313 0.1728
Mycobacterium ulcerans pyruvate kinase 0.0068 0.0163 0.0614
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0064 0.035
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.084 0.2647 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.0424 0.0424
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0001 0.0016
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0129 0.0359 0.0497
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Leishmania major pyruvate kinase 0.0068 0.0163 0.2092
Brugia malayi beta-lactamase family protein 0.0037 0.0064 0.0088
Loa Loa (eye worm) hypothetical protein 0.003 0.0042 0.0057
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.005 0.007
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.004 0.004
Onchocerca volvulus 0.0129 0.0359 0.1314
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0372 0.2978
Plasmodium falciparum glutathione reductase 0.005 0.0106 0.0847
Echinococcus granulosus aryl hydrocarbon receptor 0.003 0.0042 0.0042
Onchocerca volvulus 0.0129 0.0359 0.1314
Onchocerca volvulus 0.0129 0.0359 0.1314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.0424 0.0424
Brugia malayi Inositol-1 0.0084 0.0215 0.03
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0026 0.0027 0.0027
Leishmania major tyrosine specific protein phosphatase, putative 0.0129 0.0359 0.4614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0217 0.0217
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0017 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0064 0.024
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0018 0.0227
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0018 0.0141
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0138 0.0387 0.0387
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0017 0.0136
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0076 0.0187 0.5033
Giardia lamblia Pyruvate kinase 0.0068 0.0163 0.0614
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.2249 0.7184 0.7184
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0372 0.2053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0129 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0036
Entamoeba histolytica hypothetical protein 0.0082 0.0208 0.0751
Onchocerca volvulus 0.0129 0.0359 0.1314
Loa Loa (eye worm) hypothetical protein 0.0183 0.0534 0.0741
Schistosoma mansoni hypothetical protein 0.0191 0.0559 0.0643
Brugia malayi intermediate filament protein 0.0062 0.0142 0.0198
Loa Loa (eye worm) hypothetical protein 0.0129 0.0359 0.0497
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0021 0.0012 0.0017
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0026 0.0027 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.0424 0.0488
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0129 0.0359 0.0359
Entamoeba histolytica hypothetical protein 0.0023 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0087
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0129 0.0359 0.0412

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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