Detailed information for compound 1179426

Basic information

Technical information
  • TDR Targets ID: 1179426
  • Name: (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R, 13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-penta methyl-17-[(2E)-6-methylhepta-2,5-dien-2-yl]- 2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H- cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxy methyl)oxane-3,4,5-triol
  • MW: 620.857 | Formula: C36H60O8
  • H donors: 6 H acceptors: 6 LogP: 5.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2C[C@]3(C)[C@@H]([C@@]4([C@@H]2C(C)(C)[C@@H](O)CC4)C)C[C@H]([C@H]2[C@@]3(C)CC[C@@H]2/C(=C/CC=C(C)C)/C)O)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C36H60O8/c1-19(2)10-9-11-20(3)21-12-15-35(7)27(21)22(38)16-25-34(6)14-13-26(39)33(4,5)31(34)23(17-36(25,35)8)43-32-30(42)29(41)28(40)24(18-37)44-32/h10-11,21-32,37-42H,9,12-18H2,1-8H3/b20-11+/t21-,22-,23+,24-,25-,26+,27+,28-,29+,30-,31+,32-,34-,35-,36-/m1/s1
  • InChiKey: OZTXYFOXQFKYRP-TXRYYSRHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(1E)-1,5-dimethylhexa-1,4-dienyl]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
  • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(1E)-1,5-dimethylhexa-1,4-dienyl]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-methylol-tetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0144 0.0264
Brugia malayi putative neuropeptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Echinococcus multilocularis geminin 0.0199 0.4084 0.7501
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0075 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0288 0.2172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0144 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0569 0.4297
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Onchocerca volvulus 0.0022 0.0144 0.0277
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Echinococcus granulosus acetylcholinesterase 0.0066 0.1123 0.2062
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Brugia malayi Sugar transporter family protein 0.011 0.2116 0.3886
Echinococcus multilocularis lamin 0.0032 0.0359 0.0659
Onchocerca volvulus 0.0042 0.0595 0.1146
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Mycobacterium ulcerans lipase LipD 0.0042 0.0595 0.2364
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0359 0.0359
Brugia malayi GnHR receptor homolog 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0023 0.0162 0.0162
Trypanosoma brucei glucose transporter 2A 0.0034 0.0417 0.3151
Brugia malayi hypothetical protein 0.0019 0.0085 0.0155
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) heat shock protein 90 0.0036 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0351 0.0577
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0144 0.0264
Leishmania major glucose transporter, lmgt2 0.0034 0.0417 0.1658
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1123 0.1123
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0142 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0243 0.1836
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0352 0.0578
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3332 0.3577
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.2231 0.4098
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0351 0.0351
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1325 0.2551
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0595 0.2364
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0144 0.0264
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus sex peptide receptor 0.0022 0.0144 0.0264
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.1786
Schistosoma mansoni lipoxygenase 0.0116 0.2231 0.5463
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) sugar transporter 0.011 0.2116 0.2116
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0595 0.105
Echinococcus multilocularis heat shock protein 0.0036 0.045 0.0826
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0144 0.0144
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.2518 0.4138
Echinococcus granulosus intermediate filament protein 0.0032 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni ap endonuclease 0.0044 0.0637 0.156
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0144 0.0264
Echinococcus granulosus RUN 0.0019 0.0085 0.0155
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0351 0.2648
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0637 0.1227
Toxoplasma gondii exonuclease III APE 0.0044 0.0637 0.1047
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2116 0.4075
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0351 0.0351
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.2518 0.6165
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0569 0.226
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.045 0.3395
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0359 0.0659
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.2116 0.3886
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3332 0.3577
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0144 0.0264
Schistosoma mansoni inositol monophosphatase 0.0075 0.1325 0.3243
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0351 0.0644
Onchocerca volvulus Huntingtin homolog 0.0135 0.2654 0.5111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0595 0.0639
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0352 0.0646
Schistosoma mansoni heat shock protein 0.0036 0.045 0.1101
Schistosoma mansoni hypothetical protein 0.0051 0.0784 0.192
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Loa Loa (eye worm) hypothetical protein 0.0135 0.2654 0.2654
Echinococcus multilocularis somatostatin receptor 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0032 0.0359 0.0691
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0144 0.0264
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0351 0.0675
Loa Loa (eye worm) hypothetical protein 0.0066 0.1123 0.1123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0144 0.0352
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1123 0.2062
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0144 0.0264
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus hypothetical protein 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.026 0.5445 0.5445
Echinococcus multilocularis transcription factor eb 0.0119 0.2297 0.4219
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0144 0.0144
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0337 0.0618
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Schistosoma mansoni loxhd1 0.0019 0.0085 0.0207
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0144 0.0144
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0595 0.105
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0144 0.0264
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0643
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni intermediate filament proteins 0.0032 0.0359 0.0879
Echinococcus multilocularis lamin dm0 0.0032 0.0359 0.0659
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Onchocerca volvulus 0.0032 0.0359 0.0691
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0595 0.4493
Loa Loa (eye worm) hypothetical protein 0.0118 0.2284 0.2284
Treponema pallidum exodeoxyribonuclease (exoA) 0.0044 0.0637 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0162 0.0174
Onchocerca volvulus 0.0042 0.0595 0.1146
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0162 0.0297
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0144 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0044 0.0637 0.117
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.045 0.2476
Plasmodium vivax hexose transporter 0.011 0.2116 0.2272
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0569 0.1096
Echinococcus granulosus inositol monophosphatase 1 0.0075 0.1325 0.2433
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.004 0.0545 0.1334
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0144 0.0264
Trichomonas vaginalis esterase, putative 0.0042 0.0595 0.1146
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis General substrate transporter 0.0095 0.177 0.3251
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0144 0.0264
Schistosoma mansoni adenoreceptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.0243
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0352 0.0646
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0569 0.1045
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0085 0.015
Brugia malayi hypothetical protein 0.026 0.5445 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 0.9314 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2311 0.2311
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus transcription factor eb 0.0119 0.2297 0.4219
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0085 0.0155
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0351 0.0351
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Brugia malayi Cytochrome P450 family protein 0.0018 0.0049 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0144 0.0352
Schistosoma mansoni lamin 0.0032 0.0359 0.0879
Mycobacterium leprae Probable lipase LipE 0.0042 0.0595 0.4791
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus granulosus fmrfamide receptor 0.0022 0.0144 0.0264
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0144 0.0264
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0957 0.1758
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Schistosoma mansoni hypothetical protein 0.0053 0.0835 0.2044
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0288 0.2172
Leishmania major glucose transporter, lmgt3 0.0034 0.0417 0.1658
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0243 0.1836
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Trypanosoma brucei glucosidase, putative 0.0041 0.0569 0.4297
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0637 0.0684
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0162 0.5
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0017 0.0034 0.0063
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0417 0.0804
Echinococcus multilocularis RUN 0.0019 0.0085 0.0155
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Leishmania major glucose transporter, lmgt1 0.0034 0.0417 0.1658
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.2231 0.4098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0351 0.0577
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0351 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0569 0.0569
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0835 0.1534
Loa Loa (eye worm) hypothetical protein 0.0031 0.0346 0.0346
Schistosoma mansoni alpha-glucosidase 0.0159 0.3204 0.7846
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0144 0.0264
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0032 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Echinococcus multilocularis inositol monophosphatase 1 0.0075 0.1325 0.2433
Brugia malayi Inositol-1 0.0075 0.1325 0.2433
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Onchocerca volvulus Huntingtin homolog 0.0135 0.2654 0.5111
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0044 0.0637 0.1124
Brugia malayi ORL1-like opioid receptor 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0022 0.0144 0.0277
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0144 0.0144
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0288 0.1142
Loa Loa (eye worm) hypothetical protein 0.0058 0.0957 0.0957
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 0.526
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.115 1
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0075 0.1325 0.2551
Plasmodium vivax endoplasmin, putative 0.0036 0.045 0.0483
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0288 0.1902
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0337 0.0337
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0595 0.1146
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Echinococcus multilocularis musashi 0.0032 0.0359 0.0659
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0071 0.0538
Brugia malayi Melatonin receptor type 1A 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0569 0.4297
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0066 0.0066
Echinococcus granulosus endoplasmin 0.0028 0.0288 0.0528
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0351 0.0577
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Echinococcus multilocularis serotonin receptor 0.0022 0.0144 0.0264
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0351 0.0377
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus granulosus survival motor neuron protein 1 0.026 0.5445 1
Loa Loa (eye worm) endoplasmin 0.0036 0.045 0.045
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0099 0.0191
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0085 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi Endoplasmin precursor 0.0036 0.045 0.0826
Brugia malayi hypothetical protein 0.004 0.0535 0.0982
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0351 0.0377
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Trichomonas vaginalis set domain proteins, putative 0.0248 0.5193 1
Brugia malayi Carboxylesterase family protein 0.0066 0.1123 0.2062
Brugia malayi Cytochrome P450 family protein 0.0018 0.0049 0.0091
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0122
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0144 0.0352
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0307 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0144 0.0264
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0545 0.1001
Loa Loa (eye worm) hypothetical protein 0.0135 0.2654 0.2654
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0308 0.0565
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0144 0.0264
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0144 0.0264
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Onchocerca volvulus 0.0022 0.0144 0.0277
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.115 0.2028
Brugia malayi neuropeptide F receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0049 0.0049
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0308 0.0565
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0144 0.0264
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0044 0.0637 0.4811
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0337 0.1503
Onchocerca volvulus 0.0022 0.0144 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0417 0.0804
Echinococcus multilocularis serotonin receptor 0.0022 0.0144 0.0264
Brugia malayi exodeoxyribonuclease III family protein 0.0044 0.0637 0.117
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.3779 0.694
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0595 0.1146
Entamoeba histolytica protein kinase, putative 0.0031 0.0351 0.1625
Brugia malayi Dopamine receptor 0.0022 0.0144 0.0264
Brugia malayi AKH receptor 0.0022 0.0144 0.0264
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0142 0.0274
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0144 0.0144
Onchocerca volvulus 0.0022 0.0144 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Brugia malayi Pre-SET motif family protein 0.0031 0.0352 0.0646
Schistosoma mansoni inositol monophosphatase 0.0075 0.1325 0.3243
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.2518 0.4625
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0085
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0144 0.0264
Echinococcus granulosus lamin 0.0032 0.0359 0.0659
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0019 0.0085 0.0207
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0352 0.0861
Echinococcus granulosus neuropeptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0049 0.0049
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0595 0.1093
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni rab6-interacting 0.0019 0.0085 0.0207
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0144 0.0264
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.2518 0.4625
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0144 0.0264
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0144 0.0352
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0162 0.0297
Echinococcus granulosus orexin receptor type 2 0.0022 0.0144 0.0264
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.045 0.3395
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0569 0.1096
Plasmodium falciparum protein kinase 7 0.0288 0.6085 0.6533
Echinococcus granulosus g protein coupled receptor 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0135 0.2654 0.4874
Onchocerca volvulus 0.0107 0.204 0.3928
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0144 0.0264
Brugia malayi beta-lactamase 0.0042 0.0595 0.1093
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0359 0.0359
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Schistosoma mansoni alpha-glucosidase 0.0159 0.3204 0.7846
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0595 0.105
Schistosoma mansoni myosin xvIII 0.0022 0.0144 0.0352
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Schistosoma mansoni rab6-interacting 0.0019 0.0085 0.0207
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0044 0.0637 0.2531
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0162 0.1222
Toxoplasma gondii ABC1 family protein 0.0042 0.0595 0.0978
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.3779 0.694
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0049 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Schistosoma mansoni endoplasmin 0.0036 0.045 0.1101
Echinococcus multilocularis sex peptide receptor 0.0022 0.0144 0.0264
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0085 0.015
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0075 0.1325 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0085 0.0155
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0144 0.0352
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0049 0.0196
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0049 0.0372
Echinococcus granulosus acetylcholinesterase 0.0066 0.1123 0.2062
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0569 0.1096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0209
Echinococcus granulosus heat shock protein 90 0.0036 0.045 0.0826
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0595 0.4493
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0595 0.4791
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Brugia malayi neuropeptide F receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi Cytochrome P450 family protein 0.0029 0.0307 0.0564
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0162 0.1222
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus granulosus allatostatin A receptor 0.0022 0.0144 0.0264
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0337 0.0618
Brugia malayi MH2 domain containing protein 0.0119 0.2311 0.4245
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0044 0.0637 0.4811
Echinococcus multilocularis GPCR, family 2 0.0018 0.0066 0.0122
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1123 0.2062
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0144 0.0352
Entamoeba histolytica protein kinase, putative 0.0031 0.0351 0.1625
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0162 0.0174
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0044 0.0637 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0044 0.0637 0.117
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0162 0.072
Loa Loa (eye worm) hypothetical protein 0.0066 0.1123 0.1123
Brugia malayi Serotonin receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis heat shock protein 90 0.0028 0.0288 0.0528
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0326 0.0599
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0595 0.105
Onchocerca volvulus 0.0053 0.0835 0.1608
Brugia malayi Doublecortin family protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0119 0.2297 0.4219
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0144 0.0352
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni survival motor neuron protein 0.0053 0.0835 0.2044
Leishmania major cytochrome p450-like protein 0.0018 0.0049 0.0196
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.2116 0.3478
Loa Loa (eye worm) hypothetical protein 0.004 0.0545 0.0545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0018 0.0066 0.0162
Brugia malayi beta-lactamase family protein 0.0042 0.0595 0.1093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0044 0.0637 0.2531
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.045 0.3395
Schistosoma mansoni ap endonuclease 0.0044 0.0637 0.156
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Brugia malayi larval opioid receptor 0.0022 0.0144 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi G-protein coupled receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0243 0.04
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0535 0.0982
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Onchocerca volvulus 0.0022 0.0144 0.0277
Schistosoma mansoni histamine h1 receptor 0.0022 0.0144 0.0352
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.045 0.1786
Echinococcus multilocularis heat shock protein 90 0.0036 0.045 0.0826
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0337 0.2362
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.045 0.3396
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.0935
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0144 0.0352
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0044 0.0637 0.4811
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0569 0.1045
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus granulosus serotonin receptor 0.0022 0.0144 0.0264
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.045 0.3395
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0144 0.0264
Plasmodium falciparum endoplasmin, putative 0.0022 0.0142 0.0153
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0288 0.4514
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0351 0.0644
Echinococcus granulosus heat shock protein 90 0.0028 0.0288 0.0528
Brugia malayi Dopamine receptor protein 2 0.0022 0.0144 0.0264
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0351 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) inositol-1 0.0075 0.1325 0.1325
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0243 0.0261
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0417 0.0804
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0351 0.0377
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Brugia malayi Carboxylesterase family protein 0.0066 0.1123 0.2062
Onchocerca volvulus 0.0022 0.0144 0.0277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0957 0.0957
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0144 0.0264
Brugia malayi G protein-coupled receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0144 0.0352
Loa Loa (eye worm) carboxylesterase 0.0066 0.1123 0.1123
Toxoplasma gondii heat shock protein HSP90 0.0036 0.045 0.0739
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0243 0.1836
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0144 0.0352
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0144 0.0352
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0957 0.1758
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0044 0.0637 0.0684
Schistosoma mansoni polycystin 1-related 0.0019 0.0085 0.0207
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0351 0.0377
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0144 0.0264
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0337 0.0618
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0144 0.0264
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.3779 0.694
Trypanosoma brucei glucose transporter 1E 0.0034 0.0417 0.3151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.3779 0.3779
Plasmodium falciparum hexose transporter 0.011 0.2116 0.2272
Plasmodium vivax SET domain protein, putative 0.0031 0.0352 0.0378
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1123 0.2062
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0144 0.0264
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0288 0.1142
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Schistosoma mansoni hypothetical protein 0.0199 0.4084 1
Brugia malayi beta-lactamase family protein 0.0042 0.0595 0.1093
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0288 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0417 0.0804
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0595 0.0595
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi hypothetical protein 0.0026 0.0243 0.0447
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.045 0.2476
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0044 0.0637 0.4089
Schistosoma mansoni hypothetical protein 0.011 0.2116 0.5181
Echinococcus granulosus geminin 0.0199 0.4084 0.7501
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0144 0.0264
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.3503
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0144 0.0144
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0162 0.0266
Onchocerca volvulus 0.0031 0.0352 0.0678
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Schistosoma mansoni glucose transport protein 0.011 0.2116 0.5181
Trypanosoma cruzi hexose transporter 0.0034 0.0417 0.3151
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.2518 0.4443
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.5445 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.3779 0.694
Loa Loa (eye worm) hypothetical protein 0.0032 0.0359 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.045 0.0739
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) beta-lactamase 0.0042 0.0595 0.0595
Onchocerca volvulus 0.0022 0.0144 0.0277
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0144 0.0264
Schistosoma mansoni amine GPCR 0.0022 0.0144 0.0352
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.2518 1
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0124 0.0933
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Plasmodium falciparum heat shock protein 90 0.0036 0.045 0.0483
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0288 0.2172
Plasmodium vivax heat shock protein 86, putative 0.0036 0.045 0.0483
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Echinococcus granulosus GPCR family 2 0.0018 0.0066 0.0122
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0351 0.0377
Brugia malayi Pre-SET motif family protein 0.0218 0.452 0.8302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0144 0.0264
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.045 0.7057
Mycobacterium ulcerans beta-lactamase 0.0042 0.0595 0.2364
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0144 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0337 0.5282
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0595 0.1093
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0569 0.1096
Schistosoma mansoni alpha glucosidase 0.0041 0.0569 0.1393
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0144 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2311 0.2311
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0595 0.2364
Echinococcus multilocularis endoplasmin 0.0028 0.0288 0.0528
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0144 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0595 0.1457
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0085 0.0091
Schistosoma mansoni lamin 0.0032 0.0359 0.0879
Echinococcus granulosus heat shock protein 0.0036 0.045 0.0826
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0066 0.0122
Schistosoma mansoni hypothetical protein 0.004 0.0535 0.131
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0337 0.0824
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Brugia malayi Dopamine receptor protein 1 0.0022 0.0144 0.0264
Mycobacterium ulcerans hypothetical protein 0.0042 0.0595 0.2364
Brugia malayi heat shock protein 90 0.0036 0.045 0.0826
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0162 0.2539
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0162 0.0297
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0312
Brugia malayi sulfakinin receptor protein 0.0022 0.0144 0.0264
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0085 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Onchocerca volvulus 0.0019 0.0085 0.0163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0122
Entamoeba histolytica hypothetical protein 0.004 0.0535 0.3208
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1123 0.2062
Onchocerca volvulus 0.0042 0.0595 0.1146
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0144 0.0352
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0417 0.0804
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0075 0.1325 1
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0144 0.0264
Plasmodium falciparum proline--tRNA ligase 0.0036 0.045 0.0483
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0066 0.0122
Trichomonas vaginalis inositol monophosphatase, putative 0.0075 0.1325 0.2551
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0066 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0066
Onchocerca volvulus 0.0022 0.0144 0.0277
Schistosoma mansoni heat shock protein 0.0036 0.045 0.1101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0595 0.105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Schistosoma mansoni hypothetical protein 0.0199 0.4084 1
Echinococcus granulosus lamin dm0 0.0032 0.0359 0.0659
Brugia malayi intermediate filament protein 0.0032 0.0359 0.0659
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0595 0.105
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0162 0.0643
Trypanosoma brucei heat shock protein, putative 0.0036 0.045 0.3395
Schistosoma mansoni endoplasmin 0.0036 0.045 0.1101
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0595 0.1457
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0144 0.0264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0066 0.0122
Echinococcus granulosus somatostatin receptor 0.0022 0.0144 0.0264
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0351 0.0859
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.045 0.0739
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0144 0.0144
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.045 0.0483
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0351 0.0644
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0144 0.0264
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0044 0.0637 0.0637
Brugia malayi G-protein coupled receptor 0.0022 0.0144 0.0264
Giardia lamblia Grp94/Hsp90 0.0028 0.0288 0.4514
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0595 0.105
Plasmodium falciparum protein kinase 6 0.0433 0.9314 1
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0144 0.0144
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0417 0.1658
Trichomonas vaginalis heat shock protein, putative 0.0036 0.045 0.0866
Leishmania major hypothetical protein, conserved 0.0026 0.0243 0.0966
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.452 0.452
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0569 0.3503
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3332 0.5476
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0144 0.0264
Mycobacterium tuberculosis Conserved protein 0.0042 0.0595 0.105
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0351 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0162 0.0396
Brugia malayi hypothetical protein 0.0019 0.0085 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0595 0.4493
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0337 0.0824
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0144 0.0264
Schistosoma mansoni hypothetical protein 0.0022 0.0144 0.0352
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.045 0.3395
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.2518 0.6165
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0162 0.0643
Trichomonas vaginalis ap endonuclease, putative 0.0044 0.0637 0.1227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2116 0.3886
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0144 0.0264
Brugia malayi hypothetical protein 0.0022 0.0144 0.0264
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.2518 1
Schistosoma mansoni protein kinase 0.0031 0.0351 0.0859
Loa Loa (eye worm) hypothetical protein 0.0019 0.0085 0.0085
Schistosoma mansoni neuropeptide receptor 0.0022 0.0144 0.0352
Brugia malayi Serotonin receptor 0.0022 0.0144 0.0264
Echinococcus granulosus neuropeptide receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0337 0.0337
Onchocerca volvulus 0.0022 0.0144 0.0277
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.045 0.3395
Onchocerca volvulus 0.0022 0.0144 0.0277
Schistosoma mansoni opsin-like receptor 0.0022 0.0144 0.0352
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0075 0.1325 0.2177
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0144 0.0264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0595 0.1093
Leishmania major heat shock protein 83-1 0.0036 0.045 0.1786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0032 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0352 0.0646
Echinococcus granulosus General substrate transporter 0.0095 0.177 0.3251
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0595 0.0595
Toxoplasma gondii protein kinase, putative 0.0288 0.6085 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0118 0.2284 0.2284
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0535 0.131
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0144 0.0352
Brugia malayi RE15519p 0.0022 0.0144 0.0264
Onchocerca volvulus 0.0019 0.0085 0.0163
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0144 0.0264
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0144 0.0264
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0144 0.0264
Brugia malayi Cam kinase protein 1 0.0031 0.0351 0.0644
Loa Loa (eye worm) hypothetical protein 0.0022 0.0144 0.0144
Schistosoma mansoni lipoxygenase 0.0081 0.1456 0.3564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0352 0.0861
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0144 0.0264
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0144 0.0264
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0144 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0595 0.1146
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0144 0.0277
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0144 0.0352
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0144 0.0264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0352 0.0352
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0075 0.1325 0.526
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0144 0.0264
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0351 0.0377
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0144 0.0264
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0144 0.0144
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.5668 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1123 0.2749
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0049 0.0372
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0569 0.1096
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0144 0.0264
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0049 0.0049
Leishmania major hypothetical protein, conserved 0.0042 0.0595 0.2364
Onchocerca volvulus 0.0248 0.5193 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0044 0.0637 0.4811
Trypanosoma brucei glucose transporter, putative 0.0034 0.0417 0.3151
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0535 0.0982
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0028 0.0288 0.0507
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0337 0.0648
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0144 0.0264
Leishmania major protein kinase, putative 0.0031 0.0351 0.1393
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0144 0.0352
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0337 0.0618
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0569 0.1045
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0417 0.3151
Schistosoma mansoni biogenic amine receptor 0.0022 0.0144 0.0352
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0288 0.0528

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 8 % Hepatoprotective activity in mouse hepatocytes assessed protection against D-galactosamine/TNFalpha-induced cell death at 50 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Activity (functional) = 24.8 % Hepatoprotective activity in mouse hepatocytes assessed protection against D-galactosamine/TNFalpha-induced cell death at 100 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Activity (functional) = 35.1 % Hepatoprotective activity in mouse hepatocytes assessed protection against D-galactosamine/TNFalpha-induced cell death at 200 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
IC50 (functional) = 97 uM Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Inhibition (functional) = 13.7 % Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death at 50 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Inhibition (functional) = 50.6 % Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death at 100 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Inhibition (functional) = 67.1 % Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death at 200 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs ChEMBL. 11325227
Survival (functional) = 34 % Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in mouse hepatocytes assessed cell survival rate at 50 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs by MTT assay ChEMBL. 11325227
Survival (functional) = 45 % Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in mouse hepatocytes assessed cell survival rate at 100 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs by MTT assay ChEMBL. 11325227
Survival (functional) = 50 % Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in mouse hepatocytes assessed cell survival rate at 200 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs by MTT assay ChEMBL. 11325227

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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