Detailed information for compound 1187525

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.96 | Formula: C25H29ClF2N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1C[C@H]([C@@H](C1)c1ccc(cc1F)F)C(=O)N1C[C@H](C)[C@@]([C@@H](C1)C)(O)c1ccc(cc1)Cl
  • InChi: 1S/C25H29ClF2N2O2/c1-15-11-30(12-16(2)25(15,32)17-4-6-18(26)7-5-17)24(31)22-14-29(3)13-21(22)20-9-8-19(27)10-23(20)28/h4-10,15-16,21-22,32H,11-14H2,1-3H3/t15-,16+,21-,22+,25-/m0/s1
  • InChiKey: HBCBDBJOYXEMJV-GIEZCARCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0118 0.051 0.199
Schistosoma mansoni histamine h1 receptor 0.0011 0.0006 0.0006
Brugia malayi neuropeptide F receptor 0.0011 0.0006 0.0022
Toxoplasma gondii beta tubulin 0.0027 0.0081 0.0925
Loa Loa (eye worm) hypothetical protein 0.0032 0.0104 0.0407
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0131 0.0319
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0081 0.0195
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0014 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.004 0.0108
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0031
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.004 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0013 0.0973
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0013 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1264
Mycobacterium ulcerans hypothetical protein 0.0118 0.051 0.1913
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0006 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.125 0.5888 0.5888
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Echinococcus granulosus snurportin 1 0.0313 0.1437 0.1437
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0023
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0126 0.2377
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0131 0.0131
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1167 0.4551
Leishmania major hypothetical protein, conserved 0.0037 0.0126 0.1476
Brugia malayi Pre-SET motif family protein 0.0213 0.0965 0.3762
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0131 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.007 0.1264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus granulosus allatostatin A receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0013 0.0011 0.0011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0013 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0397 0.1549
Brugia malayi Tubulin beta-1 chain 0.0027 0.0081 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0029 0.0088 0.0342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0006 0.0006
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi beta-lactamase family protein 0.0118 0.051 0.199
Loa Loa (eye worm) hypothetical protein 0.0065 0.0259 0.101
Loa Loa (eye worm) tubulin beta-4 chain 0.0027 0.0081 0.0316
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.004
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0065 0.0259 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0013 0.0013
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0121 0.0121
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0005 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0006 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.0294
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0357 0.0981
Toxoplasma gondii P-type ATPase4, putative 0.0013 0.0011 0.0068
Echinococcus granulosus beta tubulin 0.0027 0.0081 0.0081
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0319
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0013 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.0118 0.051 0.1913
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0032 0.0104 0.0946
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0013 0.0011 0.0068
Onchocerca volvulus 0.0011 0.0006 0.0052
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0118 0.051 0.1688
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0116 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0018
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0033 0.0109 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0049
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0006 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.0818 1
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.0818 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis sex peptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Toxoplasma gondii ABC1 family protein 0.0118 0.051 0.621
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0006 0.0022
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0013 0.0006
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0013 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Brugia malayi neuropeptide F receptor 0.0011 0.0006 0.0022
Brugia malayi CXXC zinc finger family protein 0.0088 0.0368 0.1435
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0088
Brugia malayi hypothetical protein 0.0025 0.007 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0117 0.0508 0.1982
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.004 0.004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0669
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0131 0.0319
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.0565
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Brugia malayi Dopamine receptor 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.032 0.1246
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0013 0.0088
Echinococcus granulosus protein C ets 2 0.0011 0.0005 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.051 0.051
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0182 0.0182
Trypanosoma brucei trypanothione reductase 0.0038 0.0129 0.2448
Onchocerca volvulus 0.0011 0.0006 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0131 0.0319
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.009 0.009
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0064 0.0153
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Loa Loa (eye worm) glutaminase 2 0.055 0.2564 1
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Toxoplasma gondii exonuclease III APE 0.0019 0.004 0.0415
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0357 0.0981
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.0502 0.1956
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.004 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Leishmania major trypanothione reductase 0.0038 0.0129 0.152
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0006 0.0022
Brugia malayi G-protein coupled receptor 0.0011 0.0006 0.0022
Loa Loa (eye worm) tubulin beta-1 chain 0.0027 0.0081 0.0316
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0013 0.0011 0.0044
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Brugia malayi Ets-domain containing protein 0.0078 0.032 0.1246
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0056
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.006 0.006
Onchocerca volvulus 0.0065 0.0259 0.2348
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Brugia malayi ORL1-like opioid receptor 0.0011 0.0006 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0006 0.0006
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0562 0.262 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0014 0.0131
Echinococcus granulosus tubulin beta 4A class IVa 0.0027 0.0081 0.0081
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0065 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0066 0.0266 0.1038
Onchocerca volvulus 0.0011 0.0006 0.0052
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0104 0.0104
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis beta tubulin 0.0027 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Brugia malayi G protein-coupled receptor 0.0011 0.0006 0.0022
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0013 0.0011 0.0011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0163 0.0635
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0149 0.0362
Echinococcus multilocularis cpg binding protein 0.0093 0.0392 0.0392
Loa Loa (eye worm) fli-1 protein 0.0236 0.107 0.4171
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Loa Loa (eye worm) beta-tubulin 0.0027 0.0081 0.0316
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.051 0.1417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0131 0.0131
Brugia malayi larval opioid receptor 0.0011 0.0006 0.0022
Brugia malayi Ets-domain containing protein 0.0011 0.0005 0.0018
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0502 0.0502
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0014 0.0031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0131 0.0309
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0006 0.0006
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.051 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0129 0.0331
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0065 0.0259 0.101
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0006 0.0022
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0126 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.051 0.199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0013 0.0006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0006 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0093
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0085 0.0085
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0116 0.0502 0.6102
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0013 0.0011 0.0011
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Schistosoma mansoni importin beta-1 0.0029 0.009 0.009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0131 0.0459
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0011 0.0006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0223
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.032 0.032
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0013 0.0011 0.085
Loa Loa (eye worm) hypothetical protein 0.0029 0.009 0.0352
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.051 0.1417
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0129 0.2364
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0013 0.0013
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0014 0.0172
Echinococcus granulosus importin subunit beta 1 0.0029 0.009 0.009
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus tumor protein p63 0.0355 0.1637 0.1637
Schistosoma mansoni cpg binding protein 0.0093 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Onchocerca volvulus 0.0088 0.0368 0.3336
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.004 0.3036
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0004
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0121 0.0294
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0005 0.0005
Loa Loa (eye worm) tubulin beta-2A chain 0.0027 0.0081 0.0316
Onchocerca volvulus 0.0052 0.0198 0.1794
Brugia malayi Pre-SET motif family protein 0.0032 0.0104 0.0407
Loa Loa (eye worm) inositol-1 0.0038 0.0131 0.0512
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0289
Schistosoma mansoni ets 0.0011 0.0005 0.0005
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.051 0.051
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0006 0.0006
Schistosoma mansoni elf1 0.0011 0.0005 0.0005
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0081 0.0316
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0006 0.0006
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0006 0.0052
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0032 0.0104 0.0355
Echinococcus multilocularis beta tubulin 0.0027 0.0081 0.0081
Brugia malayi beta-tubulin, identical 0.0027 0.0081 0.0316
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0357 0.0981
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.006 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0397 0.0397
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0121 0.0294
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0422 0.1957 0.5537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus neuropeptide receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0006 0.0022
Leishmania major hypothetical protein, conserved 0.0025 0.007 0.0785
Brugia malayi Importin beta-1 subunit 0.0029 0.009 0.0352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0006 0.0022
Echinococcus multilocularis tubulin beta 1 chain 0.0027 0.0081 0.0081
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.051 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.051 0.1417
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0006 0.0006
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.051 0.1913
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0013 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0006 0.0006
Onchocerca volvulus 0.0011 0.0006 0.0052
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0716 0.2793
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.051 0.1254
Plasmodium vivax tubulin beta chain, putative 0.0027 0.0081 0.1394
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.0313 0.1437 0.1437
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0126 0.0126
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.004 0.0093
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0013 0.0973
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0046 0.0108
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0006 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0131 0.0319
Trypanosoma brucei glucosidase, putative 0.0036 0.0121 0.2283
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0006 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0121 0.1418
Loa Loa (eye worm) hypothetical protein 0.0121 0.0527 0.2053
Schistosoma mansoni ap endonuclease 0.0019 0.004 0.004
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0006 0.0022
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0014 0.0107
Entamoeba histolytica tubulin family protein 0.0027 0.0081 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.2283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0065 0.0259 0.0259
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.007 0.1264
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0104 0.0104
Onchocerca volvulus 0.0093 0.0394 0.3568
Brugia malayi glutathione reductase 0.0038 0.0129 0.0504
Toxoplasma gondii beta-tubulin, putative 0.0027 0.0081 0.0925
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.004 0.0154
Echinococcus multilocularis somatostatin receptor 0.0011 0.0006 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.007 0.1167
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0131 0.1544
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.006 0.006
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0084 0.0327
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0131 0.0131
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0131 0.1542
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi Serotonin receptor 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni alpha-glucosidase 0.0139 0.061 0.061
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0006 0.0022
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0749 0.6788
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Plasmodium falciparum glutathione reductase 0.0013 0.0013 0.0973
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.006 0.006
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.0502 0.0502
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0131 0.0131
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0126 0.9722
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium ulcerans glutaminase 0.055 0.2564 0.9785
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0006 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0011 0.0011
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1879
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0033 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Onchocerca volvulus 0.0243 0.1103 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0818 0.3093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0397 0.1549
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0006 0.0006
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0403 0.111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.006 0.006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0129 0.2448
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0163 0.0635
Brugia malayi putative neuropeptide receptor 0.0011 0.0006 0.0022
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0131 0.0319
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0013 0.0142
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0013 0.0011 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.007 0.0785
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Brugia malayi Membrane calcium atpase protein 3 0.0013 0.0011 0.0044
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0508 0.1982
Plasmodium falciparum importin beta, putative 0.0029 0.009 0.6979
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus multilocularis serotonin receptor 0.0011 0.0006 0.0006
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Leishmania major importin beta-1 subunit, putative 0.0024 0.0064 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus neuropeptide receptor 0.0011 0.0006 0.0006
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0126 0.049
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0013 0.0013
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Brugia malayi AKH receptor 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1392
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Onchocerca volvulus 0.0011 0.0006 0.0052
Plasmodium falciparum glutathione reductase 0.0038 0.0129 1
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0006 0.0006
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0562 0.262 0.7427
Echinococcus granulosus somatostatin receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0112 0.0283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0029 0.0088 0.0342
Toxoplasma gondii thioredoxin reductase 0.0038 0.0129 0.152
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.032 0.032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0397 0.0397
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0033 0.0109 0.0109
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0081 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0006 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0121 0.0294
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0013 0.0011 0.0011
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0131 0.0131
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0172
Brugia malayi Dopamine receptor protein 1 0.0011 0.0006 0.0022
Echinococcus multilocularis nervana 2 0.0065 0.0259 0.0259
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0005 0.0018
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0006 0.0006
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0013 0.0088
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0013 0.0013
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus granulosus calcium transporting atpase 0.0013 0.0011 0.0011
Trypanosoma brucei calcium-translocating P-type ATPase 0.0013 0.0011 0.011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0126 0.1476
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0126 0.2377
Echinococcus multilocularis importin subunit beta 1 0.0029 0.009 0.009
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0006 0.0052
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0006 0.0006
Toxoplasma gondii beta-1 tubulin, putative 0.0027 0.0081 0.0925
Leishmania major calcium motive p-type ATPase, putative 0.0013 0.0011 0.0068
Schistosoma mansoni neuropeptide receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0081 0.0195
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1103 0.2716
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0013 0.0027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0104 0.0104
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1437 0.5603
Brugia malayi hypothetical protein 0.0016 0.0028 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0016 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0149 0.0362
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis esterase, putative 0.0118 0.051 0.1254
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.051 0.1913
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Brugia malayi beta-lactamase 0.0118 0.051 0.199
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0005 0.0005
Loa Loa (eye worm) tubulin beta chain 0.0027 0.0081 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0006 0.0006
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0006 0.0006
Echinococcus granulosus tubulin beta 1 chain 0.0027 0.0081 0.0081
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0006 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.125 0.5888 0.5888
Brugia malayi sulfakinin receptor protein 0.0011 0.0006 0.0022
Entamoeba histolytica tubulin family protein 0.0027 0.0081 0.0199
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0965 0.3762
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.004 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0006 0.0006
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0126 0.2377
Plasmodium falciparum thioredoxin reductase 0.0038 0.0129 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0129 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Brugia malayi Ets-domain containing protein 0.0078 0.032 0.1246
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0131 0.0131
Onchocerca volvulus 0.0011 0.0006 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0013 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0121 0.0472
Echinococcus multilocularis Tubulin beta 2C chain 0.0027 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis tubulin, putative 0.0027 0.0081 0.0195
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0011 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Brugia malayi Fli-1 protein 0.0236 0.107 0.4171
Brugia malayi Thioredoxin reductase 0.0038 0.0129 0.0504
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis helicase, putative 0.002 0.0046 0.0108
Treponema pallidum fructose-bisphosphate aldolase 0.0865 0.4057 1
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0013 0.0011 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.004 0.0415
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0562 0.262 1
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.051 0.1417
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.009 0.1676
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0006 0.0006
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.0297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0104 0.0104
Mycobacterium leprae Probable lipase LipE 0.0118 0.051 0.1688
Schistosoma mansoni myosin xvIII 0.0011 0.0006 0.0006
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Onchocerca volvulus 0.0118 0.051 0.4626
Schistosoma mansoni gabp alpha 0.0078 0.032 0.032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0088
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0131 0.0131
Schistosoma mansoni cpg binding protein 0.0088 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Giardia lamblia Beta tubulin 0.0027 0.0081 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0397 0.0397
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0112 0.012
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0182 0.0182
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0006 0.0006
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0131 0.0511
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0792 0.1948
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.0746 0.9112
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0006 0.0006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0013 0.0142
Schistosoma mansoni ATPase 0.0011 0.0006 0.0006
Schistosoma mansoni alpha-glucosidase 0.0139 0.061 0.061
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0357 0.1085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0118 0.051 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Schistosoma mansoni adenoreceptor 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0752 0.3524 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.051 0.051
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0508 0.1982
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.051 0.051
Plasmodium vivax importin-beta 2, putative 0.0029 0.009 0.1583
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0013 0.0018
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.051 0.1417
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0121 0.0294
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0065 0.0259 0.2348
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0121 0.2283
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0163 0.0163
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0132 0.0132
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1167 0.4551
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni ets-related 0.0236 0.107 0.107
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0014 0.0031
Echinococcus granulosus dnaJ subfamily B 0.125 0.5888 0.5888
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0013 0.0142
Schistosoma mansoni tubulin subunit beta 0.0027 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus multilocularis tubulin subunit beta 0.0027 0.0081 0.0081
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.004 0.2249
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Echinococcus granulosus fmrfamide receptor 0.0011 0.0006 0.0006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0131 0.0323
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0403 0.1264
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Echinococcus granulosus Na:K ATPase alpha subunit 0.0033 0.0109 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0131 0.0131
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0126 0.2377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.051 0.1417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis glutaminase, putative 0.055 0.2564 0.6319
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.004 0.0669
Brugia malayi GnHR receptor homolog 0.0011 0.0006 0.0022
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0131 0.0131
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Brugia malayi Augmenter of liver regeneration 0.0037 0.0126 0.049
Schistosoma mansoni transmemberane protein 0.0065 0.0259 0.0259
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Onchocerca volvulus 0.0011 0.0006 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.051 0.1254
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0005 0.0018
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0006 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0163 0.0163
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0013 0.0011 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0006 0.0006
Brugia malayi Na,K-ATPase alpha subunit 0.0033 0.0109 0.0427
Brugia malayi Serotonin receptor 0.0011 0.0006 0.0022
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0422 0.1957 0.7457
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0005 0.0018
Echinococcus multilocularis calcium transporting atpase 0.0013 0.0011 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0135 0.0526
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0006 0.0006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.2486
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0013 0.0142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.004 0.004
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0132 0.0132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0865 0.4057 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0153
Onchocerca volvulus Huntingtin homolog 0.0121 0.0527 0.4772
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0064 0.0153
Echinococcus multilocularis protein C ets 2 0.0011 0.0005 0.0005
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Schistosoma mansoni hypothetical protein 0.0011 0.0005 0.0005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0006 0.0022
Plasmodium falciparum tubulin beta chain 0.0027 0.0081 0.6248
Loa Loa (eye worm) glutathione reductase 0.0038 0.0129 0.0504
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Giardia lamblia Fructose-bisphosphate aldolase 0.0865 0.4057 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.0502 0.1879
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0013 0.0011 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0013 0.0142
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0006 0.0006
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0006 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0465 0.1812
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0818 0.0818
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0006 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0792 0.1948
Plasmodium falciparum calcium-transporting ATPase 0.0013 0.0011 0.085
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0014 0.0172
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0368 0.1435
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0046 0.0108
Mycobacterium tuberculosis Probable reductase 0.0086 0.0357 0.0981
Trichomonas vaginalis tubulin gamma chain, putative 0.0027 0.0081 0.0195
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0013 0.0142
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0013 0.0032
Onchocerca volvulus 0.0011 0.0006 0.0052
Echinococcus granulosus tubulin subunit beta 0.0027 0.0081 0.0081
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0005 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0014 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0109 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0397 0.0397
Schistosoma mansoni amine GPCR 0.0011 0.0006 0.0006
Loa Loa (eye worm) glutaminase 0.055 0.2564 1
Brugia malayi hypothetical protein 0.0121 0.0527 0.2053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Schistosoma mansoni alpha glucosidase 0.0036 0.0121 0.0121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0716 0.2793
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0716 0.0716
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0005 0.0005
Trichomonas vaginalis tubulin epsilon chain, putative 0.0027 0.0081 0.0195
Schistosoma mansoni ATPase 0.0011 0.0006 0.0006
Plasmodium vivax glutathione reductase, putative 0.0038 0.0129 0.2364
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.009 0.1041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Brugia malayi RNA, U transporter 1 0.0083 0.0347 0.1353
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0064 0.1155
Mycobacterium ulcerans lipase LipD 0.0118 0.051 0.1913
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0403 0.111
Onchocerca volvulus 0.0011 0.0006 0.0052
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.1418
Brugia malayi Inositol-1 0.0038 0.0131 0.0512
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.0006 0.001
Onchocerca volvulus 0.0118 0.051 0.4626
Onchocerca volvulus 0.0032 0.0104 0.0941
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Mycobacterium tuberculosis Conserved protein 0.0118 0.051 0.1417
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1167 0.2873
Onchocerca volvulus Huntingtin homolog 0.0121 0.0527 0.4772
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Onchocerca volvulus 0.0011 0.0006 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0131 0.0511
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0131 0.0322
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0065 0.0259 0.0259
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0121 0.0297
Schistosoma mansoni cpg binding protein 0.0093 0.0392 0.0392
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0142
Echinococcus granulosus nervana 2 0.0065 0.0259 0.0259
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0006 0.0006
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0131 0.2483
Brugia malayi beta-lactamase family protein 0.0118 0.051 0.199
Echinococcus multilocularis ets variant gene 4 0.0011 0.0005 0.0005
Echinococcus granulosus g protein coupled receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0357 0.0981
Loa Loa (eye worm) hypothetical protein 0.0121 0.0527 0.2053
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0033 0.0109 0.0427
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0005 0.0005
Brugia malayi hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0006 0.0006
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.051 0.1417
Brugia malayi transcription factor E74 isoform 0.0011 0.0005 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.051 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0104 0.1213
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0013 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0013 0.0013
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0198 0.0198
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0014 0.0031
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0013 0.5
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0011 0.0006 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0824 0.3864 0.3864
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0006 0.0022
Brugia malayi G-protein coupled receptor 0.0011 0.0006 0.0022
Echinococcus granulosus orexin receptor type 2 0.0011 0.0006 0.0006
Echinococcus granulosus sex peptide receptor 0.0011 0.0006 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0011 0.0023
Loa Loa (eye worm) BEN-1 protein 0.0027 0.0081 0.0316
Schistosoma mansoni biogenic amine receptor 0.0011 0.0006 0.0006
Leishmania major calcium-transporting ATPase, putative 0.0013 0.0011 0.0068
Brugia malayi Melatonin receptor type 1A 0.0011 0.0006 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0397 0.0397
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0422 0.1957 0.7386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Schistosoma mansoni ets-related 0.0011 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0126 0.1476
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0121 0.0472
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0006 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.5367
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0013 0.0011 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.004 0.0154
Echinococcus multilocularis tumor protein p63 0.0355 0.1637 0.1637
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0013 0.0011 0.0011
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0131 0.1544
Echinococcus granulosus beta tubulin 0.0027 0.0081 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0187 0.0841 0.0841
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0006 0.0006
Echinococcus granulosus hypothetical protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0118 0.051 0.199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0046 0.0108
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0027 0.0081 0.0081
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus granulosus cpg binding protein 0.0093 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0052 0.0198 0.0772
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.009 0.1676
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.004 0.0669
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0065 0.0259 0.0259
Echinococcus granulosus serotonin receptor 0.0011 0.0006 0.0006
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0006 0.0006
Brugia malayi RE15519p 0.0011 0.0006 0.0022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0403 0.111
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0006
Plasmodium falciparum thioredoxin reductase 0.0013 0.0013 0.0973
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0865 0.4057 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.004 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0192
Schistosoma mansoni inositol monophosphatase 0.0038 0.0131 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0006 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0865 0.4057 1
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.051 0.1254
Trypanosoma brucei beta tubulin 0.0027 0.0081 0.1489
Plasmodium vivax SET domain protein, putative 0.0032 0.0104 0.1864
Onchocerca volvulus 0.0118 0.051 0.4626
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0818 0.0818
Echinococcus multilocularis serotonin receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0006 0.0022
Brugia malayi Dopamine receptor protein 2 0.0011 0.0006 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.007 0.5367
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0013 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0271
Echinococcus multilocularis snurportin 1 0.0313 0.1437 0.1437
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0006 0.0006
Trypanosoma cruzi beta tubulin, putative 0.0027 0.0081 0.1489
Onchocerca volvulus 0.0011 0.0006 0.0052
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Schistosoma mansoni opsin-like receptor 0.0011 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0118 0.051 0.621
Schistosoma mansoni glutaminase 0.055 0.2564 0.2564
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0126 0.2292
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0749 0.1842
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0046 0.0108
Brugia malayi glutaminase DH11.1 0.055 0.2564 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0357 0.0981
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0013 0.0011 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0006 0.0052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.0818 0.2294
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0013 0.0027
Echinococcus granulosus Tubulin beta 2C chain 0.0027 0.0081 0.0081
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.051 0.199
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0121 0.0121
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0033 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0024 0.0064 0.0157
Leishmania major P-type ATPase, putative 0.0013 0.0011 0.0068
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0011 0.0006 0.0013
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0013 0.0088
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0005 0.0018
Leishmania major beta tubulin 0.0027 0.0081 0.0925
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0006 0.0006
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0085 0.0333

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 130 nM Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay ChEMBL. 20329799
Emax (functional) = 77 % Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay relative to melanocortin 2 ChEMBL. 20329799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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